The relationship of SSRI and SNRI usage with interstitial lung disease and bronchiectasis in an elderly population: a case–control study

BackgroundThere are limited data regarding the relationship between interstitial lung disease (ILD) and the natural course of coronavirus disease 2019 (COVID-19). In this study, we investigate whether patients with ILD are more susceptible to COVID-19 than those without ILD and evaluate the impact of ILD on disease severity in patients with COVID-19.MethodsA nationwide cohort of patients with COVID-19 (n=8070) and a 1:15 age-, sex-, and residence-matched cohort (n=121 050) were constructed between January 1, 2020 and May 30, 2020 in Korea. We performed a nested case-control study to compare the proportions of patients with ILD between the COVID-19 cohort and the matched cohort. Using the COVID-19 cohort, we also evaluated the risk of severe COVID-19 in patients with ILD versus those without ILD.ResultsThe proportion of patients with ILD was significantly higher in the COVID-19 cohort than in the matched cohort (0.8% versus 0.4%, p<0.001). The odds ratio [OR] of having ILD was significantly higher in the COVID-19 cohort than in the matched cohort (adjusted OR=2.02, 95% confidence interval [CI]=1.54–2.61). Among patients in the COVID-19 cohort, patients with ILD were more likely to have severe COVID-19 than patients without ILD (49.3% versus 13.1%), including mortality (13.4% versus 2.8%) (all p<0.01). The risk of severe COVID-19 was significantly higher in patients with ILD than in those without ILD (adjusted OR=2.32, 95% CI=1.24–4.01).ConclusionThe risks of COVID-19 and severe presentation were significantly higher in patients with ILD than in those without ILD.

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Faculty Opinions recommendation of Prognostic significance of anti-aminoacyl-tRNA synthetase antibodies in polymyositis/dermatomyositis-associated interstitial lung disease: a retrospective case control study.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.725395754.793505269 ◽

2015 ◽

Author(s):

Vincent Cottin

Keyword(s):

Interstitial Lung Disease ◽

Lung Disease ◽

Case Control Study ◽

Prognostic Significance ◽

Case Control ◽

Trna Synthetase ◽

Aminoacyl Trna Synthetase ◽

Retrospective Case ◽

Control Study

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The relationship of anterior cruciate ligament injuries with MRI based calculation of femoral notch width, notch width index, notch shape - A randomized control study

Journal of Clinical Orthopaedics and Trauma ◽

10.1016/j.jcot.2021.01.006 ◽

2021 ◽

Vol 17 ◽

pp. 5-10

Author(s):

Sheik Mohammed Fahim ◽

Tushar Dhawan ◽

Nuthan Jagadeesh ◽

Yogesh Putane Ashwathnarayan

Keyword(s):

Cruciate Ligament ◽

Anterior Cruciate Ligament Injuries ◽

Notch Width ◽

Randomized Control ◽

Anterior Cruciate ◽

Relationship Of ◽

The Relationship ◽

Femoral Notch ◽

Notch Width Index ◽

Control Study

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SAT0286 BIOLOGICAL CORRELATES OF RADIOGRAPHIC FEATURES OF INTERSTITIAL LUNG DISEASE IN SYSTEMIC SCLEROSIS: AN IN DEPTH ANALYSIS OF BRONCHOALVEOLAR PROTEINS OF SCLERODERMA LUNG STUDY I PARTICIPANTS

Annals of the Rheumatic Diseases ◽

10.1136/annrheumdis-2020-eular.2526 ◽

2020 ◽

Vol 79 (Suppl 1) ◽

pp. 1087.1-1088

Author(s):

E. Volkmann ◽

D. Tashkin ◽

N. Li ◽

G. Kim ◽

J. Goldin ◽

...

Keyword(s):

Systemic Sclerosis ◽

Growth Factor ◽

Interstitial Lung Disease ◽

Lung Disease ◽

Research Support ◽

Radiographic Features ◽

Depth Analysis ◽

Specific Proteins ◽

Clinical Measures ◽

The Relationship

Background:Systemic sclerosis-related interstitial lung disease (SSc-ILD) involves a combination of inflammation, fibrosis and vascular pathology that is typically assessed on CT imaging as a mixture of ground-glass opacification (GGO) and fibrotic changes. We hypothesized that proteins recovered from bronchoalveolar lavage (BAL) could be used to probe the underlying pathobiology associated with GGO and fibrotic changes.Objectives:(1) To assess the relationship between 68 unique BAL proteins measured in participants of Scleroderma Lung Study (SLS) I1and radiographic and physiologic measures of ILD; (2) To identify inter-correlations among specific proteins to enlighten our understanding of how specific biological pathways contribute to SSc-ILD.Methods:Bronchoscopy was performed on 144 of the 158 participants in SLS I with 103 BAL samples available for analysis. BAL was lyophilized, concentrated 10X and used in a multiplex protein analysis for 68 different cytokines, chemokines and other factors. Kendall tau correlations were performed to assess the relationship between individual proteins and baseline measures of pulmonary function and quantitative CT scores for fibrosis, GGO and total ILD. Those proteins found to correlate significantly with at least 2 clinical measures of ILD were entered into a cluster analysis with inter-correlations expressed as a heatmap.Results:Significant correlations were observed between fibrosis scores and several biologic pathways including pro-fibrotic factors (transforming growth factor beta [TGF-β], platelet-derived growth factor [PDGF]), proteins involved in tissue remodeling (Matrix metallopeptidase [MMP]-1,7,8,9; Hepatocyte growth factor [HGF]), and those involved in monocyte/macrophage migration and activation (Monocyte chemoattractant protein [MCP]-1,3; macrophage colony-stimulating factor [MCSF]). These same pathways correlated with the diffusing capacity for carbon monoxide (DLCO). In contrast, GGO scores correlated primarily with immune and inflammatory mediators (interleukin [IL]-5,8,13,15, IL-1 receptor antagonist and interferon gamma) with only limited overlap to proteins that related to fibrosis. Vascular endothelial growth factor (VEGF) levels were lower in patients with more extensive GGO, fibrosis and diffusion impairment, suggesting that vascular changes are a central feature of SSc-ILD. Specific proteins were highly correlated with one another in a pattern suggesting biologically-related networks (Figure) that might provide additional insight regarding disease pathogenesis.Conclusion:Combining a diverse analysis of BAL proteins with the rich dataset available from SSc-ILD patients participating in SLS I, the study findings suggest the involvement of distinct biologic pathways, inter-related networks, and specific biologic signatures associated with unique radiographic features of ILD. The relationship of these factors to other SSc disease features, patient outcomes and as predictors of treatment responses will be studied in future analyses.References:[1]Tashkin DP, et al. NEJM 2006.Figure.Correlation heatmap of BAL proteins associated with at least 2 clinical measures of ILD in SSc patients. Absolute correlations are depicted, and darker colors signify stronger correlations.Disclosure of Interests:Elizabeth Volkmann Grant/research support from: Forbius, Corbus Pharmaceuticals, Consultant of: Boehringer Ingelheim, Forbius, Speakers bureau: Boehringer Ingelheim, Donald Tashkin: None declared, Ning Li: None declared, Grace Kim: None declared, Jonathan Goldin: None declared, Airi Harui: None declared, Michael Roth Grant/research support from: Genentech/Roche

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How matrix metalloproteinase (MMP)-9 (rs3918242) polymorphism affects MMP-9 serum concentration and associates with autism spectrum disorders: A case-control study in Iranian population

Development and Psychopathology ◽

10.1017/s0954579420002102 ◽

2021 ◽

pp. 1-7

Author(s):

Javid Rezaei Lord ◽

Farhad Mashayekhi ◽

Zivar Salehi

Keyword(s):

Serum Concentration ◽

Matrix Metalloproteinase ◽

Serum Levels ◽

Autism Spectrum ◽

Enzyme Linked Immunosorbent Assay ◽

Mmp9 Expression ◽

Relationship Of ◽

The Relationship ◽

Metalloproteinase 9 ◽

Control Study

Abstract The aim of this project was to evaluate the relationship of matrix metalloproteinase-9 (MMP-9) genetic variation and its serum concentration with autism spectrum disorder (ASD). One hundred ASD and 120 controls were enrolled in this study. Genomic DNA was extracted from blood and MMP-9 polymorphism was determined by polymerase chain reaction restriction fragment length polymorphism and serum levels were measured by enzyme-linked immunosorbent assay. The frequencies of CC, CT, and TT genotypes were 72%, 26%, and 2% in controls and 31%, 57%, and 12% in ASD, respectively. The frequencies of C and T alleles in ASD were 59.5% and 40.5%, and controls were 86% and 14%, respectively. There is a significant increase in serum MMP-9 levels in ASD as compared to controls. We have also shown that TT genotype is significantly associated with increase serum MMP-9 levels in patients (TT, CT, and CC serum levels were 91.77 ± 10.53, 70.66 ± 7.21, and 38.66 ± 5.52 and in controls were 55.55 ± 11.39, 42.66 ± 7.85, and 30.55 ± 6.34 ng/ml, respectively). It is concluded that there is a significant association between rs3918242 MMP-9 polymorphism and its serum concentration with autism. We also suggest that TT genotype is associated with increased MMP9 expression and may be a risk factor for ASD.

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Is Chronic Lung Disease in Low Birth Weight Infants Preventable? A Survey of Eight Centers

PEDIATRICS ◽

10.1542/peds.79.1.26 ◽

1987 ◽

Vol 79 (1) ◽

pp. 26-30 ◽

Cited By ~ 38

Author(s):

Mary Ellen Avery ◽

William H. Tooley ◽

Jacob B. Keller ◽

Suzanne S. Hurd ◽

M. Heather Bryan ◽

...

Keyword(s):

Birth Weight ◽

Low Birth Weight ◽

Lung Disease ◽

San Francisco ◽

Chronic Lung Disease ◽

Multivariate Logistic Regression Analysis ◽

Low Birth Weight Infants ◽

Relationship Of ◽

The Relationship ◽

Prematurely Born Infants

Chronic lung disease in prematurely born infants, defined as the need for increased inspired oxygen at 28 days of age, was thought to be more common in some institutions than in others. To test this hypothesis, we surveyed the experience in the intensive care nurseries at Columbia and Vanderbilt Universities, the Universities of Texas at Dallas, Washington at Seattle, and California at San Francisco, the Brigham and Women's Hospital in Boston, Texas Children's Hospital in Houston, and Mt Sinai Hospital in Toronto. The survey included 1,625 infants with birth weights of 700 to 1,500 g. We confirmed the relationship of risk to low birth weight, white race, and male sex. Significant differences in the incidence of chronic lung disease were found between institutions even when birth weight, race, and sex were taken into consideration through a multivariate logistic regression analysis. Columbia had one of the best outcomes for low birth weight infants and the lowest incidence of chronic lung disease.

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Impact of Lung Function Decline on Time to Hospitalisation Events in Systemic Sclerosis-associated Interstitial Lung Disease (SSc-ILD): a Joint Model Analysis

10.21203/rs.3.rs-562095/v1 ◽

2021 ◽

Author(s):

Michael Kreuter ◽

Francesco Del Galdo ◽

Corinna Miede ◽

Dinesh Khanna ◽

Wim A. Wuyts ◽

...

Keyword(s):

Systemic Sclerosis ◽

Interstitial Lung Disease ◽

Lung Function ◽

Lung Disease ◽

Fold Increase ◽

Phase Iii ◽

Lung Function Decline ◽

Related Hospitalisation ◽

The Relationship ◽

Increase In Risk

Abstract Background: Interstitial lung disease (ILD) is a common organ manifestation in systemic sclerosis (SSc) and is the leading cause of death in patients with SSc. A decline in forced vital capacity (FVC) is an indicator of ILD progression and is associated with mortality in patients with SSc-associated ILD (SSc-ILD). However, the relationship between FVC decline and hospitalisation events in patients with SSc-ILD is largely unknown. The objective of this post-hoc analysis was to investigate the relationship between FVC decline and clinically important hospitalisation endpoints.Methods: We used data from SENSCIS®, a Phase III trial investigating the efficacy and safety of nintedanib in patients with SSc-ILD. Joint models for longitudinal and time-to-event data were used to assess the association between rate of decline in FVC% predicted and hospitalisation-related endpoints (including time to first all-cause hospitalisation or death; time to first SSc-related hospitalisation or death; and time to first admission to an emergency room [ER] or admission to hospital followed by admission to intensive care unit [ICU] or death) during the treatment period, over 52 weeks in patients with SSc-ILD.Results: There was a statistically significant association between FVC decline and the risk of all-cause (n=78) and SSc-related (n=42) hospitalisations or death (both P<0.0001). A decrease of 3% in FVC corresponded to a 1.43-fold increase in risk of all-cause hospitalisation or death (95% confidence interval [CI] 1.24, 1.65) and a 1.48-fold increase in risk of SSc-related hospitalisation or death (95% CI 1.23, 1.77). No statistically significant association was observed between FVC decline and admission to ER or to hospital followed by admission to ICU or death (n=75; P=0.15). The estimated slope difference for nintedanib versus placebo in the longitudinal sub-model was consistent with the primary analysis in SENSCIS®.Conclusions: The association of lung function decline with an increased risk of hospitalisation suggests that slowing FVC decline in patients with SSc-ILD may prevent hospitalisations. Our findings also provide evidence that FVC decline may serve as a surrogate endpoint for clinically relevant hospitalisation-associated endpoints.Trial registration: Clinialtrials.gov, NCT02597933. Registered 8 October 2015, https://clinicaltrials.gov/ct2/show/study/NCT02597933.

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The Relationship of Residential Environment with The Risk of Leptospirosis in Sleman Regency

Journal of Health Science and Prevention ◽

10.29080/jhsp.v1i2.79 ◽

2017 ◽

Vol 1 (2) ◽

pp. 85-92

Author(s):

Maya Sofiyani ◽

M Imron Mawardi ◽

P Sigit Purnomo ◽

Hariza Adnani

Keyword(s):

Environmental Factors ◽

Case Control Study ◽

Case Control ◽

Survey Method ◽

Control Programs ◽

The Government ◽

Relationship Of ◽

The Relationship ◽

Control Study ◽

Made In

The effort of leptospirosis prevention in Sleman currently only limited to counseling and treatment of the patient, while the patient search, ways of transmission of leptospirosis from rats to humans, have never implemented in an integrated manner. The study aimed to investigated the relationship between the environmental residential condition with the risk of leptospirosis in Sleman Regency. The research used a survey method Â with case control study design. The results showed that environmental factors, which are not proved to have a relationship with the risk of leptospirosis were residential condition ({p=0,108} OR=3,818 {95%CI:0,922â€“15,811}), the trash bin condition ({p=1,000} OR=1,138 {95%CI:0,420â€“3,081}) and the sewer condition ({p=0,415} OR=0,551 {95%CI:0,187â€“1,624}). Environmental factors that associated with the risk of leptospirosis was the presence of rats ({p=0,001} OR=13,594 {95%CI:2,754â€“67,107}). The effort should be made in order to prevent the increasement of Leptospirosis cases by sanitation improvement and avoiding direct contact with rats as well as it litter. The Government should be pay more attention in the vector control programs, especially in leptospirosis prone areas so the prevention effort to be able run effectively and efficiently.

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