scholarly journals EVALUATION OF THE ANTIMICROBIAL EFFECT AND BIOACTIVE CONTENT OF MONODORA MYRISTICA SEED

2021 ◽  
Vol 9 (10) ◽  
pp. 1004-1010
Author(s):  
Kwasi Benjamin ◽  
Keyword(s):  
Quantitative Analysis ◽  
Positive Result ◽  
Qualitative Analysis ◽  
Alternative Medicine ◽  
Antimicrobial Effect ◽  
Pharmacological Activities ◽  
Bioactive Content ◽  
Monodora Myristica ◽  
Biological And Pharmacological Activities

For many decades, the area of alternative medicine has attracted considerable attention from researchers worldwide. Interestingly, evidence abounds that affirms the efficacy of alternative medicine in the various healthcare domain. Moreso, the plants properties have been well explored relating to its medicinal compositions. The purpose of the present study was to analyze the antimicrobial and bioactive contents of the M. Myristica seed. The samples were collected and soaked for 24 hrs with different solvents to extract the medicinal component. The qualitative analysis shows the positive result in saponin, glycoside, steroid, and alkaloid, while flavonoid and tannin are negative. The quantitative analysis for M. Myristica seed show 32% to saponins, alkaloid 8.35%, phenol 55.7%, flavonoid 0.0707 mg/ml, and glycoside 5.2% while-tannin is negative. The result shows that M. Myristica can be used to produce vaccines because of saponin, while flavonoids were found to play biological and pharmacological activities, including antioxidants.

scholarly journals PHYTOCHEMICAL ANALYSIS AND MEDICINAL VALUE OF MONODURA MYRISTICA SEED

2021 ◽  
Vol 9 (5) ◽  
pp. 551-554
Author(s):  
John B. Ejeh ◽  
Keyword(s):  
Quantitative Analysis ◽  
Positive Result ◽  
Qualitative Analysis ◽  
Phytochemical Analysis ◽  
Pharmacological Activities ◽  
Ground Sample ◽  
Medicinal Value ◽  
Biological And Pharmacological Activities

The purpose of the present study was to analyze the phytochemicals of M. myristica. The ground sample was soaked for 24 hrs with different solvents in other to extract the medicinal component. The qualitative analysis shows the positive result insaponin, glycoside, steroid, and alkaloid, while flavonoid and Tannin are negative. The quantitative analysis for M. myristicaseed show 32% to saponins, alkaloid 8.35%, phenol 55.7%, flavonoid 0.0707 mg/ml, and glycoside 5.2% while-tannin is negative. The result shows that M. myristicacan be used to produce vaccines because of saponin, while flavonoids were found to be the biological and pharmacological activities, including antioxidant.

scholarly journals Determination of Flavonoids Compounds of Three Species and Different Harvesting Periods in Crataegi folium Based on LC-MS/MS

Molecules ◽  
2021 ◽  
Vol 26 (6) ◽  
pp. 1602
Author(s):  
Ya-Ping Guo ◽  
Hong Yang ◽  
Ya-Li Wang ◽  
Xiao-Xiang Chen ◽  
Ke Zhang ◽  
...  
Keyword(s):  
Quantitative Analysis ◽  
Qualitative Analysis ◽  
Quantitative Method ◽  
Total Content ◽  
Qualitative And Quantitative Analysis ◽  
Pharmacological Activities ◽  
Time Saving ◽  
Qualitative And Quantitative ◽  
First Time

Crataegi folium have been used as medicinal and food materials worldwide due to its pharmacological activities. Although the leaves of Crataegus songorica (CS), Crataegus altaica (CA) and Crataegus kansuensis (CK) have rich resources in Xinjiang, China, they can not provide insights into edible and medicinal aspects. Few reports are available on the qualitative and quantitative analysis of flavonoids compounds of their leaves. Therefore, it is necessary to develop efficient methods to determine qualitative and quantitative flavonoids compounds in leaves of CS, CA and CK. In the study, 28 unique compounds were identified in CS versus CK by qualitative analysis. The validated quantitative method was employed to determine the content of eight flavonoids of the leaves of CS, CA and CK within 6 min. The total content of eight flavonoids was 7.8–15.1 mg/g, 0.1–9.1 mg/g and 4.8–10.7 mg/g in the leaves of CS, CA and CK respectively. Besides, the best harvesting periods of the three species were from 17th to 26th September for CS, from 30th September to 15th October for CA and CK. The validated and time-saving method was successfully implemented for the analysis of the content of eight flavonoids compounds in CS, CA and CK for the first time.

scholarly journals Gastrodia elata Blume Polysaccharides: A Review of Their Acquisition, Analysis, Modification, and Pharmacological Activities

Molecules ◽  
2019 ◽  
Vol 24 (13) ◽  
pp. 2436 ◽  
Author(s):  
Haodong Zhu ◽  
Chen Liu ◽  
Jinjun Hou ◽  
Huali Long ◽  
Bing Wang ◽  
...  
Keyword(s):  
Quantitative Analysis ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Research And Development ◽  
Qualitative Analysis ◽  
Clinical Applications ◽  
Pharmacological Activities ◽  
Gastrodia Elata ◽  
Gastrodia Elata Blume ◽  
Wide Range

Gastrodia elata Blume (G. elata) is a valuable Traditional Chinese Medicine (TCM) with a wide range of clinical applications. G. elata polysaccharides, as one of the main active ingredients of G. elata, have interesting extraction, purification, qualitative analysis, quantitative analysis, derivatization, and pharmacological activity aspects, yet a review of G. elata polysaccharides has not yet been published. Based on this, this article summarizes the progress of G. elata polysaccharides in terms of the above aspects to provide a basis for their further research and development.

scholarly journals The toxic effects of chloroquine and hydroxychloroquine on skeletal muscle: a systematic review and meta-analysis

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Claudia Cristina Biguetti ◽  
Joel Ferreira Santiago Junior ◽  
Matthew William Fiedler ◽  
Mauro Toledo Marrelli ◽  
Marco Brotto
Keyword(s):  
Systematic Review ◽  
Quantitative Analysis ◽  
Qualitative Analysis ◽  
Observational Studies ◽  
Skeletal Muscles ◽  
Case Reports ◽  
Meta Analysis ◽  
Toxic Effects ◽  
Drug Induced ◽  
Qualitative And Quantitative

AbstractThe aim of this systematic review was to perform qualitative and quantitative analysis on the toxic effects of chloroquine (CQ) and hydroxychloroquine (HCQ) on skeletal muscles. We designed the study according to PRISMA guidelines. Studies for qualitative and quantitative analyses were selected according to the following inclusion criteria: English language; size of sample (> 5 patients), adult (> age of 18) patients, treated with CQ/HCQ for inflammatory diseases, and presenting and not presenting with toxic effects on skeletal muscles. We collected data published from 1990 to April 2020 using PubMed, Cochrane Library, EMBASE, and SciELO. Risk of bias for observational studies was assessed regarding the ROBIN-I scale. Studies with less than five patients (case reports) were selected for an additional qualitative analysis. We used the software Comprehensive Meta-Analysis at the confidence level of 0.05. We identified 23 studies for qualitative analysis (17 case-reports), and five studies were eligible for quantitative analysis. From case reports, 21 patients presented muscle weakness and confirmatory biopsy for CQ/HCQ induced myopathy. From observational studies, 37 patients out of 1,367 patients from five studies presented muscle weakness related to the use of CQ/HCQ, and 252 patients presented elevated levels of muscle enzymes (aldolase, creatine phosphokinase, and lactate dehydrogenase). Four studies presented data on 34 patients with confirmatory biopsy for drug-induced myopathy. No study presented randomized samples. The chronic use of CQ/HCQ may be a risk for drug-induced myopathy. There is substantiated need for proper randomized trials and controlled prospective studies needed to assess the clinical and subclinical stages of CQ/HCQ -induced muscle myopathy.

scholarly journals The Discourse on the Praxis and Pragmatics of the Qur’an Retranslations in Turkish

2020 ◽  
Vol 12 (1) ◽  
pp. 74-97
Author(s):  
Sema Üstün Külünk
Keyword(s):  
Discourse Analysis ◽  
Quantitative Analysis ◽  
Qualitative Analysis ◽  
Study Design ◽  
Human Agency ◽  
Source Text ◽  
Religious Text ◽  
Qualitative Analyses

Retranslations of the Qur’an constitute an intriguing site of research with particular premises governing their production, dissemination and/or reception in Turkey. Its inherently religion-oriented context is accompanied by discussions on the sacred status of the source text, arguments on its untranslatability, translatorial human agency vis-à-vis the Holy creator, acknowledged Arabicity of the source text, etc. In this regard, each new translation of the Qur’an in Turkish is released with a motivation to justify its necessity amid abundant retranslations available in the target repertoire. Various approaches towards the conceptualization and instrumentalization of these Qur’anic translations create a meta-narrative on its own right. This study aims at exploring this particular discourse on the retranslations of the Qur’an with a bi-faceted study design composed of quantitative and qualitative analyses. The quantitative analysis focuses on the numeric changes of Qur’anic retranslations in respective decades, whereas the qualitative analysis concentrates on the statements of the translatorial agents on the motives behind their translational production. By shedding light on the discursive narrative postulated upon these retranslations, it is claimed that social, political, cultural and financial concerns have prevailingly governed the reproductions of this canonical work in Turkey. Keywords: Qur’an translation, religious-text translation, retranslation, discourse analysis.  

scholarly journals Synthesis and Biological Activities of Some Pyrimidine Derivatives: A Review

2020 ◽  
Vol 36 (6) ◽  
pp. 1001-1015
Author(s):  
Nadia Ali Ahmed Elkanzi
Keyword(s):  
Nitrogen Atom ◽  
Medicinal Chemistry ◽  
Biological Activities ◽  
Heterocyclic Ring ◽  
Ring System ◽  
Pyrimidine Derivatives ◽  
Pharmacological Activities ◽  
Cardiovascular Agents ◽  
Anti Hiv ◽  
Biological And Pharmacological Activities

Nitrogen containing synthetically and biologically important heterocyclic ring system namely pyrimidine possess both biological and pharmacological activities, and defend as aromatic six heterocyclic with 1and 3 nitrogen atom in ring. Preparation of pyrimidine via different methods offer its importance in fields of medicinal chemistry and Chemistry. Pyrimidines and their derivatives act as anti-inflammatory, anti-malaria, anti-tumor, cardiovascular agents, anti-neoplastic, anti-tubercular, anti- HIV, diuretic ,anti-viral, anti-microbial, ,analgesic .This review give light up on biological and pharmacological activities of pyrimidine nucleus.

scholarly journals The necessitive impersonal REIK(Ė)TI ‘need’: the rise of modal meaning

2017 ◽  
pp. 1-27
Author(s):  
Erika Jasionytė-Mikučionienė ◽  
Jolanta Šinkūnienė
Keyword(s):  
Quantitative Analysis ◽  
Qualitative Study ◽  
Qualitative Analysis ◽  
Frequency Distribution ◽  
Distribution Patterns ◽  
Biomedical Sciences ◽  
Common Features ◽  
Patterns Of Use ◽  
Usage Patterns ◽  
Over Time

The focus of the paper is on the frequency, distribution patterns and semantic profile of the necessitive impersonal reik(ė)ti ‘need’ in old and contemporary Lithuanian texts. The study employs corpus based quantitative and qualitative analysis to investigate the patterns of use of reik(ė)ti ‘need’ in the Database of Old Writings (16th-17th centuries) as well as the fiction sub-corpus of the Corpus of the Contemporary Lithuanian Language and the humanities and biomedical sciences sub-corpora of the Corpus of Academic Lithuanian (CorALit). The study follows van der Auwera and Plungian’s (1998) modality framework. The quantitative analysis shows that the present tense form reikia ‘need.PRS.3’ is the dominating one across all the sub-corpora analysed. The results of the qualitative study indicate that the deontic sub-type of participant external modality is prevailing in the old Lithuanian texts as well as in the fiction sub-corpus and in the biomedical sciences texts of the contemporary Lithuanian. The discourse of the humanities displays a fairly frequent employment of reik(ė)ti ‘need’ for discourse organising functions alongside the deontic uses. Although the usage patterns of reik(ė)ti ‘need’ in the biomedical sciences and the humanities share certain common features, they also point to discipline specific trends of argumentation. It is also important to observe that the objective deontic reik(ė)ti ‘need’ seems to gradually acquire the features of subjective deontic modality over time, which corresponds to the typical subjectification cline (cf. Traugott 1989).

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