scholarly journals The place of combined mucoactive drugs in the treatment of acute respiratory infections in children

2022 ◽  
pp. 225-233
Author(s):  
L. S. Starostina
Keyword(s):  
Respiratory Diseases ◽  
Respiratory Infections ◽  
Acute Respiratory Infections ◽  
Multicenter Studies ◽  
Current Trends ◽  
Drug Substances ◽  
Combination Drugs ◽  
The Russian Federation ◽  
Official Records

The problem of respiratory diseases and their therapy options still retains much of its urgency. Respiratory diseases in children are still super common. According to the data on infectious morbidity among children in the Russian Federation for the period 2018–2020, current trends have not changed, and the acute respiratory infections (ARI) are still ranked number one in terms of the frequency of registered diseases. According to the official records, the frequency of ARI in children among infectious diseases is 71,850.02 per 100,000 population, or 71%. Such well-known symptom as cough is one of the most frequent manifestations of respiratory diseases. It causes the greatest discomfort for both the little patients and their parents, the quality of life of the children and those around them worsens, many domestic and foreign authors mention this symptom in their works. And it is this problem that doctors of various specialties most often face. The cough is currently treated with drugs with different effects depending on the characteristics and manifestations of the disease. Systematic reviews and multicenter studies show that prescription of mucoactive drugs to treat cough in children with underlying ARI is substantiated and feasible. The authors substantiated the necessity of using combinations of various drugs aimed to reduce inflammation of the airways, improve mucociliary clearance, thin out and promote sputum discharge and, accordingly, reduce cough. The article briefly discusses the mechanisms of the development of cough in ARI, the action of drug substances included in the combination drugs used to treat cough in children, the possibility of using the combination of muco- and bronchoactive drugs of synthetic and plant origin.

Current advances on drug delivery nanoparticles for respiratory diseases treatment

2020 ◽  
Author(s):  
Beatriz Rossi Canuto de Menezes ◽  
Karla Faquine Faquine Rodrigues ◽  
Vanessa Modelski Schatkoski ◽  
Raíssa Monteiro Pereira ◽  
Renata Guimarães Ribas ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Respiratory Diseases ◽  
Respiratory Infections ◽  
Life Quality ◽  
Acute Respiratory Infections ◽  
Chronic Respiratory Diseases ◽  
The World

Cases of respiratory diseases have been growing around the world, affecting the health and life quality of millions of people every year. Chronic respiratory diseases (CRDs) and acute respiratory infections...

scholarly journals Monostrain and multistrain probiotics for respiratory diseases in children

2020 ◽  
Vol 4 (11) ◽  
pp. 698-704
Author(s):  
E.S. Dzottsoeva ◽  
◽  
A.V. Gorelov ◽  
◽  
Keyword(s):  
Respiratory Diseases ◽  
Respiratory Infections ◽  
Lactobacillus Rhamnosus ◽  
Human Organism ◽  
High Morbidity ◽  
Acute Respiratory Infections ◽  
Bifidobacterium Lactis ◽  
Impaired Performance ◽  
Vital Functions ◽  
Multistrain Probiotics

Acute respiratory infections (ARIs) in children are common conditions characterized by high morbidity. ARIs account for up to 75% of all cases of antibiotic use. Dysbiosis results in the impaired performance of vital functions, i.e., digestion, synthesis, colonization resistance, and the regulation of immune system. Probiotics are one of the effective tools to affect the composition of gut microbiota and to restore its metabolic activity. Probiotics, their effects on human organism, and their use in various diseases have received an enormous attention. Meanwhile, the use of antibiotics and the etiological diversity of ARIs account for the lack and irrationality of extensive preventive measures (as in flu) and raise the interest in non-specific prophylaxis. Lactobacillus rhamnosus GG (LGG) and Bifidobacterium animalis subsp. Lactis BB-12 are well-studied strains. Lactobacillus plantarum LP01 and LP02, Lactobacillus rhamnosus LR04 and LR05, and Bifidobacterium lactis BS01 used as monostrain probiotics are also of interest. Multistrain probiotics are gaining traction. However, these probiotics are understudied and require more attention. KEYWORDS: microbiome, monostrain probiotics, multistrain probiotics, acute respiratory infections, antibiotic-associated diarrhea, antibiotic-associated syndrome, Lactobacillus rhamnosus, Bifidobacterium lactis. FOR CITATION: Dzottsoeva E.S., Gorelov A.V. Monostrain and multistrain probiotics for respiratory diseases in children. Russian Medical Inquiry. 2020;4(11):698–704. DOI: 10.32364/2587-6821-2020-4-11-698-704.

scholarly journals Place of combination drugs in the therapy of acute bronchitis in children

2020 ◽  
pp. 42-47
Author(s):  
N. G. Kolosova ◽  
I. V. Grebeneva ◽  
V. D. Denisova ◽  
E. M. Maksimova
Keyword(s):  
Respiratory Tract ◽  
Respiratory Infections ◽  
Acute Bronchitis ◽  
Influenza Viruses ◽  
Human Bocavirus ◽  
Acute Respiratory Infections ◽  
Protective Function ◽  
Nonproductive Cough ◽  
Combination Drugs ◽  
Tract Infections

Acute respiratory tract infections accompanied by cough play a significant role in respiratory pathology in childhood. The incidence of acute respiratory infections among children is 4–5 times higher than among the adult population and accounts for more than 90% of all infectious and parasitic diseases registered in Russia. The highest rates of acute respiratory infections are observed among children of preschool age, especially in the first three years of life. As in adults, children’s cough, described as a symptom of «upper respiratory infection» or «acute bronchitis», is the most commonly diagnosed acute manifestation in primary care. These 2 diagnoses represent 75% of all cough cases. The most common etiological agents in acute bronchitis are respiratory viruses: adenovirus, influenza viruses and parainfluenza viruses, respiratory syncytial virus, rhinovirus, human Bocavirus, Coxsackievirus, herpes simplex virus, etc. Drug therapy for coughing is prescribed when there is a nonproductive cough that does not perform its protective function, meaning it does not contribute to the purification of the respiratory tract, and is aimed at dilution of sputum, reducing its adhesiveness (viscosity) and thus increase the effectiveness of coughing. The main groups of mucoactive drugs that are usually considered in this case are mucolytics, mucoregulators, mucokinetics, expectorants, and combination drugs. Combination drugs created to eliminate various elements of pathogenesis of respiratory diseases, accompanied by a nonproductive cough and bronchoobstruction, deserve close attention due to the possibility of using several active substances in fixed drug combinations with accurate dosages and proven clinical effectiveness, reducing the number of simultaneously taken drugs, reducing the risk of developing undesirable events. Oral administration of combined medicines becomes especially important in conditions when inhalation therapy is impossible.

Newer Virus Diseases: Clinical Differentiation of Acute Respiratory Infections

PEDIATRICS ◽  
1961 ◽  
Vol 27 (1) ◽  
pp. 44-44
Author(s):  
DAVID T. KARZON
Keyword(s):  
Respiratory Diseases ◽  
Small Volume ◽  
Respiratory Infections ◽  
Daily Practice ◽  
Clinical Aspects ◽  
Acute Respiratory Infections ◽  
Viral Etiology ◽  
Virus Diseases ◽  
Acute Respiratory Diseases ◽  
Basic Concepts

Acute respiratory diseases, especially those of viral etiology, occupy a goodly proportion of the attention of the pediatrician in his daily practice. In this small volume, Dr. Adams attempts to bring together the rapidly appearing information regarding recent discoveries and innovations in virology and correlate them with clinical aspects of respiratory infection. Sections are devoted to introducing basic concepts in virology and to anatomic and physiologic aspects of the respiratory system in relation to infection.

scholarly journals The herbal preparations in the treatment of cough in children with respiratory infections

2019 ◽  
pp. 82-86 ◽  
Author(s):  
V. М. Deliagin
Keyword(s):  
Herbal Medicine ◽  
Respiratory Diseases ◽  
Respiratory Infections ◽  
Symptomatic Treatment ◽  
Common Symptom ◽  
Acute Respiratory Infections ◽  
It Use ◽  
Herbal Preparations ◽  
Outpatient Practice ◽  
Common Infection

Acute respiratory infections (ARI, commen cold) are the most common infection diseases in children. They account for up 75% of all cases of respiratory diseases. In most cases, ARI are selfterminating diseases that require only symptomatic treatment. The most common symptom of ARI is cough. In outpatient practice justified the use of herbal medicine. As an antisussive well eastablished syrup Gedelix. The effectivnesses of the medicine, the possibility of accuracy dosing, pleasant taste facilitate it use in children.

scholarly journals Acute respiratory diseases: progression features, pharmaceutical therapy

2018 ◽  
pp. 82-88
Author(s):  
N. V. Orlova ◽  
T. G. Suranova
Keyword(s):  
Respiratory Diseases ◽  
Respiratory Infections ◽  
Intracellular Bacteria ◽  
Acute Respiratory Infections ◽  
Pharmaceutical Therapy ◽  
Wide Range ◽  
Acute Respiratory Diseases ◽  
High Concentrations ◽  
Acute Respiratory Viral Infection ◽  
Social Importance

Acute respiratory diseases (ARD) are widespread diseases and are of great social importance. Diagnosis of acute respiratory infections implies the damage to the respiratory system caused by a wide range of pathogens. Among the pathogens of acute respiratory infections are viruses of acute respiratory viral infection (ARVI) group, including influenza, as well as fungal and bacterial pathogens, which include intracellular bacteria: mycoplasma and chlamydia. Diseases caused by intracellular pathogens are treated by antibacterial drugs that can easily penetrate the cells and create there high concentrations.

scholarly journals Using Clinical Vignettes to Assess Quality of Care for Acute Respiratory Infections

2016 ◽  
Vol 53 ◽  
pp. 004695801663653 ◽  
Author(s):  
Courtney A. Gidengil ◽  
Jeffrey A. Linder ◽  
Scott Beach ◽  
Claude M. Setodji ◽  
Gerald Hunter ◽  
...  
Keyword(s):  
Quality Of Care ◽  
Respiratory Infections ◽  
Acute Respiratory Infections ◽  
Clinical Vignettes ◽  
Assess Quality

scholarly journals Fenspiride use in acute respiratory infections in children

2019 ◽  
pp. 120-123
Author(s):  
N. G. Kolosova ◽  
M. D. Shakhnazarova
Keyword(s):  
Safety Profile ◽  
Respiratory Diseases ◽  
Respiratory Infections ◽  
Economic Problem ◽  
Acute Respiratory Infections ◽  
Efficacy And Safety ◽  
High Efficacy ◽  
Acute Respiratory Diseases ◽  
Anti Inflammatory

Acute respiratory infections are the most common pathology in childhood, representing not only a medical but also a socio-economic problem. Numerous studies on the use of anti-inflammatory therapy in ARI have shown high efficacy and safety profile of fenspiride. The combination of anti-inflammatory, antiallergic, and antispasmodic properties ensures the success of fenspiride in the treatment of acute respiratory diseases in children. Fenspiride reduces symptoms of ARI, accelerates recovery, reduces the need for additional prescription of other drugs.

scholarly journals Epidemiologic pattern of respiratory diseases among hospitalized pediatric patients in Khulna, Bangladesh

2021 ◽  
Vol 7 (6) ◽  
pp. 306
Author(s):  
M. Mirajul Islam ◽  
Joy Debnath ◽  
Nadira Naznin Rakhi ◽  
Abdullah Al-Jubayer
Keyword(s):  
Respiratory Diseases ◽  
Pediatric Patients ◽  
Respiratory Infections ◽  
Risk Group ◽  
National Level ◽  
Age Groups ◽  
Hospitalization Rate ◽  
Acute Respiratory Infections ◽  
High Burden ◽  
Interpretative Approach

<p class="abstract"><strong>Background:</strong> High burden of acute respiratory infections (ARIs) with a significant rate of mortality is notable in developing countries including Bangladesh. Despite the frequent reports of ARIs, the exact prevalence and spectrum of ARIs in this country is unknown even at subnational level. The aim of the study was to determine of current spectrum of respiratory diseases of children in Bangladesh.</p><p class="abstract"><strong>Methods:</strong> The current study analyzed 2993 pediatric patients admitted form June 2019 to January 2020 into Khulna Shishu Hospital, Khulna, Bangladesh using a quantitative interpretative approach.  </p><p class="abstract"><strong>Results:</strong> A total of 1382 patients (46.17%) were admitted because of ARIs and were predominately male children (65.77%). Among different ARIs, hospitalization was mainly due to lower tract respiratory infections (LRTI) and the prevalent cases of ARIs could be classified into undifferentiated ARI (20.92%), pneumonia (14.84%) and LRTI other than pneumonia and bronchitis (9.02%), bronchitis (1.40%). Mortality rate was observed 2.51%, although the highest rate of mortality (65%) was recorded among the infant age groups.</p><p class="abstract"><strong>Conclusions:</strong> This study showed the risk group and risk factors of developing severity in ARIs leading to a high hospitalization rate due to ARIs among children in Bangladesh. More such studies at national level are required to develop proper combating strategy to decrease the mortality and the morbidity associated with ARIs in the country.</p>

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