scholarly journals Comparison of effectiveness of parenteral lincomycin/spectinomycin combination and dexpanthenol application in goat kids with contagious ecthyma

2018 ◽  
Vol 74 (1) ◽  
pp. 5994-2018
Author(s):  
SEVIM KASAP ◽  
ETHEM MUTLU TEMIZEL ◽  
ADIL ÖMER KARAKUŞ ◽  
OĞUZHAN AVCI ◽  
ESRA BÜYÜKCANGAZ ◽  
...  
Keyword(s):  
Treatment Options ◽  
Study Groups ◽  
Control Treatment ◽  
Dairy Goat ◽  
Control Group ◽  
Contagious Ecthyma ◽  
Local Antibiotics ◽  
Group A ◽  
Group B ◽  
Comparison Of Effectiveness

Contagious ecthyma (CE) is a highly contagious viral skin disease that is typically self-limited. Treatment options include topical antiseptics, such as KMNO4, local antibiotics and systemic antibiotics to prevent secondary skin infections. The aim of this study was to compare the effectiveness of the lincomycin/spectinomycin combination and dexpanthenol (Dxp) in goat kids with CE. The study was conducted at a Saanen dairy goat farm in Bursa, Turkey. The owner of the goat herd inquired at the veterinary hospital about the appearance of granulomatous lesions on the muzzles of goat kids. In this study, 24 goat kids (1-month-olds) were used. All animals were subjected to the same conditions. Blood and papule samples were taken from the animals’ lips, muzzle and buccal for virological analysis. Swab samples were taken from the lesions for culture and antibiogram. The animals were divided into three groups. Lesions were clinically scored at days 1, 7 and 15 according to a modified previously used scoring system. Goat kids were equally grouped on the basis of lesions on the buccal, lips and muzzle. The animals in group A received 15 mg/kg lincomycin/spectinomycin combination (Lypectin®, Vilsan) intramuscularly for 3 consecutive days, group B received 20 mg/kg Dxp (Bepanthen® amp, Bayer, Germany) intramuscularly for 3 consecutive days, and group C received 0.9% NaCl (2 ml), the control treatment. Clinical recoveries were almost equal in all groups, but by day 14, group A showed better recovery than group B and group C. Both study groups also showed better results than the control group for all days. In conclusion, we believe that the lincomycin/spectinomycin combination or dexpanthenol can be useful in the supplementary treatment of CE in goat kids..

Glycine and L-Arginine supplementation ameliorates gastro-duodenal toxicity in a rat model of NSAID (Diclofenac)-gastroenteropathy via inhibition of oxidative stress

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Akinleye Stephen Akinrinde ◽  
Halimot Olawalarami Hameed
Keyword(s):  
Oxidative Stress ◽  
Total Protein ◽  
Therapeutic Index ◽  
Control Treatment ◽  
Control Group ◽  
Protective Effects ◽  
Serum Total Protein ◽  
Significant Amelioration ◽  
Group A ◽  
Group B

Abstract Objectives This study examined the possible protective roles of exogenous glycine (Gly) and L-Arginine (l-Arg) against Diclofenac (DIC)-induced gastro-duodenal damage in rats. Methods Rats were divided into Group A (control), Group B (DIC group) and Groups C–F which were pre-treated for five days with Gly1 (250 mg/kg), Gly2 (500 mg/kg), l-Arg1 (200 mg/kg) and l-Arg2 (400 mg/kg), respectively, before co-treatment with DIC for another three days. Hematological, biochemical and histopathological analyses were then carried out. Results DIC produced significant (p<0.05) reduction in PCV (13.82%), Hb (46.58%), RBC (30.53%), serum total protein (32.72%), albumin (28.44%) and globulin (38.01%) along with significant (p<0.05) elevation of serum MPO activity (83.30%), when compared with control. In addition, DIC increased gastric H2O2 and MDA levels by 33.93 and 48.59%, respectively, while the duodenal levels of the same parameters increased by 19.43 and 85.56%, respectively. Moreover, SOD, GPx and GST activities in the DIC group were significantly (p<0.05) reduced in the stomach (21.12, 24.35 and 51.28%, respectively) and duodenum (30.59, 16.35 and 37.90%, respectively), compared to control. Treatment with Gly and l-Arg resulted in significant amelioration of the DIC-induced alterations although l-Arg produced better amelioration of RBC (29.78%), total protein (10.12%), albumin (9.93%) and MPO (65.01%), compared to the DIC group. The protective effects of both amino acids against oxidative stress parameters and histological lesions were largely similar. Conclusions The data from this study suggest that Gly or l-Arg prevented DIC-induced gastro-duodenal toxicity and might, therefore be useful in improving the therapeutic index of DIC.

scholarly journals Efficacy of Tamsulosin and Alfuzosin in Management of Distal Ureteral Stones

Med Phoenix ◽  
2021 ◽  
Vol 6 (1) ◽  
pp. 10-13
Author(s):  
Bimochan Piya ◽  
Abhishek Bhattarai
Keyword(s):  
Urinary Tract ◽  
Side Effects ◽  
Diclofenac Sodium ◽  
Study Groups ◽  
Ureteral Stones ◽  
Control Group ◽  
P Value ◽  
Expulsion Rate ◽  
Group A ◽  
Group B

Introduction: Urinary tract calculi are the most frequent condition in urology clinics worldwide. The overall prevalence is about 5 % and lower urinary tract stones account for 70% among them. Medical expulsive therapy has been used to treat distal ureteric stone as it reduces symptoms and facilitates stone expulsion. The aim of this study is to evaluate and compare the efficacy of tamsulosin and alfuzosin as medical therapy in ureteric stones. Materials and Methods: A total of 87 patients with distal ureteral stones of size ≤10 mm were randomly divided into 3 groups. Group A patients (n-30) received 0.4 mg of tamsulosin daily, group B patients (n-29) received 10 mg of alfuzosin daily and group C patients (n-28) received 75 mg of diclofenac sodium. Patients in all groups received diclofenac sodium for one week and then as required. Follow-up was done on a weekly basis for 4 weeks. The stone expulsion rate, time for stone expulsion, and side-effects were recorded in each group. Results: The mean stone size (5.66, 5.79, 5.67) mm and age (29.1, 30.31, 29.4) were comparable in each group. The stone expulsion rate was 83.3%, 79.3%, and 50% in groups A, B, and C respectively.  It showed that both the study groups (Group A and Group B) were effective than the control group (p-value 0.006 and 0.02 respectively) but there was no difference between tamsulosin and alfuzosin (p-value 0.69). The duration of stone expulsion was 11.5 days, 11.8 days, and 17.3 days for Group A, B, and C respectively. The drugs related side effects reported by patients were mild and transient. Conclusion:  The use of tamsulosin and alfuzosin for the medical treatment of ureteric stones proved to be safe and effective and neither did have any significant benefits over the other.

scholarly journals Comparison of Ondansetron and Granisetron for prevention of PONV following elective LUCS

2009 ◽  
Vol 20 (2) ◽  
pp. 61-65 ◽  
Author(s):  
Md Raihan Uddin ◽  
Lutful Aziz ◽  
SN Samad Choudhury
Keyword(s):  
Caesarean Section ◽  
Spinal Anaesthesia ◽  
Postoperative Period ◽  
Elective Caesarean Section ◽  
Study Groups ◽  
Early Postoperative Period ◽  
Control Group ◽  
Group A ◽  
Group B ◽  
Oral Ondansetron

The aim of the study was to compare the antiemetic effects of oral ondansetron (8mg) and granisectron (2mg) for prevention of PONV following elective caesarean section. Ninety parturients scheduled for elective caesarean section under spinal anaesthesia were randomly allocated into three groups. Group A (n=30) were received vitamin tab, group B (n=30) parturients were received oral ondansectron (8mg) & group C (n=30) parturients were received oral granisetron (2mg). Anesthetic procedure was common to all groups. Emetic episodes in early postoperative period (1st 24 hrs.) were recorded and compared in different study groups. Emetic episodes were observed in six parturients (20%) in group A (control), 3 parturients in group B (3%) and 3 parturients in group C (3%). So to conclude, minimal emetic episodes were observed in early postoperative period in parturients who had received ondensetron or granisetron than the control group. Keywords: LUCS, PONV, Ondansetron, and Granisetron. Journal of BSA, Vol. 20, No. 2, July 2007 p.61-65

scholarly journals Comparison of effectiveness of Salvadora Persica whitening toothpaste with commercial whitening toothpaste at removing stain

2009 ◽  
Vol 21 (3) ◽  
Author(s):  
Erlina Sih Mahanani ◽  
Erry Mochamad Arief ◽  
Samantha Victoria Samuel
Keyword(s):  
Drinking Water ◽  
Artificial Saliva ◽  
Visual Assessment ◽  
Control Group ◽  
Salvadora Persica ◽  
Stain Removal ◽  
Wide Range ◽  
Group A ◽  
Group B ◽  
Comparison Of Effectiveness

The miswak, a traditional chewing stick for cleaning teeth, is made from the plant Salvadora persica. It contains a wide range of healthy components in maintaining good oral hygiene. The objective of this study is to determine the effectiveness of whitening toothpaste containing Salvadora persica extract at removing tea and chlorhexidine stain by comparing with one of commercially available whitening toothpaste and drinking water as a control group. A randomized experimental study was done. The standard method cycled clear acrylic specimens through artificial saliva, 0.2% chlorhexidine and tea on the hour 8 times per day and stain were measured using a spectrophotometer to achieve baseline reading. Test interventions were 2 whitening kinds of toothpaste; whitening toothpaste containing Salvadora persica extract (group A), commercial whitening toothpaste (group B) and drinking water as a control group (group C). Treatment interventions were done at 09:00 and 16:00 by exposing the specimens to slurries of each treatment for 2 minutes. The specimens remained in the artificial saliva between each cycles day and night. At the end of the day, the stain was assessed by spectrophotometer and Lobene Stain Index. The comparison of total stain removal assessed by spectrophotometer on day 5 between all groups was significant (p=0.007). The median of total stain removal and visual assessment recording using Lobene stain index showed Salvadora persica whitening toothpaste scored more reduction of staining followed by commercial whitening toothpaste and then control group. As a conclusion, the whitening toothpaste containing Salvadora persica is more effective at removing tea and chlorhexidine stain.

scholarly journals Difensil Immuno Reduces Recurrence and Severity of Tonsillitis in Children: A Randomized Controlled Trial

Nutrients ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 1637 ◽  
Author(s):  
Arianna Di Stadio ◽  
Antonio della Volpe ◽  
Fiammetta M. Korsch ◽  
Antonietta De Lucia ◽  
Massimo Ralli ◽  
...  
Keyword(s):  
Controlled Trial ◽  
Study Groups ◽  
Blood Parameters ◽  
Control Group ◽  
Upper Airways ◽  
Group A ◽  
Volume Blood ◽  
T1 And T2 ◽  
Group B ◽  
Oral Supplements

Oral supplements (OS) support the immune system in fighting upper airways infection. This study aimed to analyze the effect of Difensil Immuno (DI) on the recurrence of tonsillitis and fever in children. A multicentric randomized clinical trial was conducted. One-hundred and twenty children with chronic tonsillitis were randomly assigned to group A, B or control. Patients in group A were treated with 10 mL of DI for 90 consecutive days, patients in group B underwent treatment with 15 mL of DI for 45 consecutive days. The following data were collected at baseline (T0), T1 and T2: tonsillitis and fever episodes, tonsillar volume, blood test results. One-way ANOVA was used to analyze within and between variances. Patients in group A and B statistically improved their clinical parameters (episode of tonsillitis and fever, tonsillar volume) when compared to control group both at T1 and T2. However, T1 variances were more consistent in group A than in group B. All patients in the study groups improved their clinical outcomes. No statistically significant variances were observed in blood parameters both at T1 and T2. Our results suggest that children treated with DI had fewer episodes of tonsillitis and fever and a reduction in their tonsillar volume.

scholarly journals Mifepristone for cervical ripening and induction of labour

2018 ◽  
Vol 7 (12) ◽  
pp. 5041
Author(s):  
Lata G. ◽  
Rana N. ◽  
Mittal R. ◽  
Kumar S.
Keyword(s):  
Study Groups ◽  
Induction Of Labour ◽  
Cervical Ripening ◽  
Control Group ◽  
Time Interval ◽  
Pregnant Females ◽  
Group A ◽  
Scarred Uterus ◽  
Group B ◽  
And Control

Background: The study was aimed to evaluate the efficacy of Mifepristone for induction of labour and in improving the Bishop score at term. The study also aimed to assess induction delivery interval and maternal and fetal outcomes with Mifepristone.Methods: The study was carried out on 200 pregnant females with 2 study groups of 100 each. Group A females received tablet Mifepristone 400mg and   Group B females received placebo. Results: Time interval between induction to onset of labour was 28 hours 54 min and 42 hours 18 min respectively in cases and control group. Mean induction delivery interval was 35 hours 38 min and 49 hours 52 minutes respectively in cases and control group. LSCS rate was less with Mifepristone group.Conclusions: This study showed that treatment with Mifepristone is a simple and effective method of inducing labour in women with term pregnancy with unripe cervix. The use of Mifepristone provides an interesting new alternative to classic uterotonic agents when induction is necessary. The potential advantage of Mifepristone over PGs or oxytocin requires further evaluation in scarred uterus.

The effects of funoran-containing xylitol chewing gum on dental plaque

2014 ◽  
Vol 34 (3) ◽  
pp. 203-208
Author(s):  
Meng-Jiy Wang ◽  
Wei-Jen Chang ◽  
Wei-Fang Lee ◽  
Sheng-Yang Lee ◽  
Joen-Rong Sheu ◽  
...  
Keyword(s):  
Dental Plaque ◽  
Ph Value ◽  
Study Groups ◽  
Mutans Streptococci ◽  
Chewing Gum ◽  
Control Group ◽  
Controlled Clinical Trial ◽  
Plaque Ph ◽  
Group A ◽  
Group B

Abstract The aim of the study was to investigate the efficacy of the addition of funoran to xylitol chewing gum in dental plaque. In a double-blinded randomized controlled clinical trial, 36 health adults (21–30 years old), who volunteered after informed consent, with >105 colony-forming units/ml mutans streptococci (MS) at baseline, were assigned randomly into one of three parallel study groups: xylitol+funoran gum (group A), sucrose gum group (group B), and control group (no gum have been provided; group C). The pH value, flash weight, and MS of dental plaque were recorded at baseline and after 2 weeks of treatment. A statistically significant reduction (p<0.05) of salivary MS was displayed in group A after the intervention when compared with baseline. The weight of plaque was reduced after 2 weeks of treatment (p=0.032) in group A. There was no significance in plaque pH value before and after the treatment in any group. Daily funoran-containing xylitol chewing gum application significantly reduced the dental plaque volume and caries pathogen counts in the oral cavity, suggesting that the use of funoran-containing xylitol chewing gum may be a useful adjunct for caries control.

scholarly journals Bite Force Assessment of Mandibular Interforaminal Fractures Treated with Combination of Microplate and Miniplate—A Randomized Control Study

2018 ◽  
Vol 2 (1) ◽  
pp. s-0038-1646776 ◽  
Author(s):  
D. Anand ◽  
Kavitha Prasad ◽  
RM Lalitha ◽  
K. Ranganath ◽  
BR Rajnikanth ◽  
...  
Keyword(s):  
Randomized Study ◽  
Study Groups ◽  
Bite Force ◽  
Control Group ◽  
Mandibular Fractures ◽  
Clinical Parameters ◽  
Hardware Failure ◽  
Significant Difference ◽  
Group A ◽  
Group B

The purpose of this study was to compare the mechanical behavior of combination of microplate and miniplate with two standard miniplates for fixation of mandibular fractures in the interforaminal region on the basis of bite force and other clinical parameters. A prospective randomized study was conducted on 20 patients with mandibular fracture requiring open reduction and internal fixation (ORIF) who were randomly categorized into Group A and Group B with 10 patients in each group. Ten healthy persons whose age and gender matched with study groups were included in control Group C. Pre- and postoperative bite force was measured at specified intervals in both the study groups and was compared with the control group. The bite force values were comparatively less in Group A than Group B, although there was no statistically significant difference. Also, bite force values were less in both the study groups when compared with the control group. No statistically significant difference was found in other clinical parameters such as infection, fracture mobility, and hardware failure. The results were suggestive that the use of microplate and miniplate combination in management of minimally displaced mandibular fractures in the interforaminal region provides stable fixation comparable to two miniplate combination.

scholarly journals Examination of sheep in which injection of Yeldif® induced sudden death

2017 ◽  
Vol 73 (8) ◽  
pp. 473-478 ◽  
Author(s):  
Ahmet Uyar ◽  
Zabit Yener ◽  
Yildiray Basbugan ◽  
Omer Faruk Keleş ◽  
Turan Yaman
Keyword(s):  
Injection Site ◽  
Study Groups ◽  
Recommended Dose ◽  
Control Group ◽  
High Dose ◽  
Study Group ◽  
Commercial Preparation ◽  
Group A ◽  
The One ◽  
Group B

Two breeders from the Başkale district of the Van province and the Hizan district of the Bitlis province reported deaths of their lambs one day after injection of a commercial preparation containing a combination of Se and Vit E (Yeldif®). Purulent-hemorrhagic-necrotic myositis was detected at the injection site during necropsy of the lambs (2 animals) brought to the Pathology Department of our Faculty by these breeders. This study was conducted to determine whether these post-injection deaths occurred as a result of the drug used or due to a faulty application of the medicine by the breeders. The trial period for this study was 1 week. Eighteen 2-month-old lambs were used in this study. The lambs were divided into three groups (control and 2 study groups) of 6 lambs each. An injection of 1 ml (recommended dose) of the product purchased in the market from the same batch as the one that had caused the deaths was administered I.M. to lambs in the control group. The medicine reported to have caused the deaths by the breeders was administered to the first study group (A) at 1 ml I.M. and to the second study group (B) at 3 ml I.M. (three times the recommended dose). The lambs were bled for biochemical analysis before the administration, on the first day after the administration, and at the end of the trial. Necropsies were performed on dead animals during the trial and on all animals at the end of the trial. At the end of the trial, no clinical-pathological findings were noted in lambs of the control group and group A. However, in all lambs of group B, emphysematous gangrene was detected at the injection site. Cl. chauvoei was isolated and identified in bacteriological and cultural examinations. It was concluded that bacterial contamination occurred as a result of incorrect drug administration by the breeders and injection of a high dose of the contaminated drug.

scholarly journals In vitro comparison of impact of different bleaching Agents on the microhardness of Enamel

2016 ◽  
Vol 17 (3) ◽  
pp. 258-262 ◽  
Author(s):  
Sudarshan C Pujari ◽  
Subhra Dey ◽  
Vinisha Pandey ◽  
Neha Awasthi
Keyword(s):  
Artificial Saliva ◽  
Study Groups ◽  
Knoop Hardness ◽  
Minimal Invasive ◽  
Control Group ◽  
Tooth Structure ◽  
Group A ◽  
Group B ◽  
Group D

ABSTRACT Background Various agents are used these days for increasing the esthetics. One such procedure is bleaching that offers various advantages, as it is minimal invasive and cheap option to color the teeth and remove stain. The altered enamel after the bleaching process shows surface demineralization and porosities. The present study aimed to evaluate the effect of different bleaching agents on the microhardness of enamel. Materials and methods A total of 100 freshly human extracted maxillary premolar teeth were selected for the study. Teeth with sound tooth structure were included for the study. All the specimens were randomly divided into four groups with 25 specimens in each group depending upon the type of bleaching agent used: Group A, artificial saliva (Control group); Group B, 35% hydrogen peroxide (HP); Group C, 25% HP; Group D, 10% carbamide peroxide (CP). Knoop Hardness Number (KHN) was calculated at 24, 48-hour, and 7-week interval. Results Results showed no statistical significant differences between the microhardness of enamel of different groups (p < 0.005). A slight fall in the value of KHN was seen in all the groups, except for the control group, although the results were statistically nonsignificant (p > 0.005). Conclusion Although nonsignificantly, all the bleaching solutions produced some amount of alterations in the microstructure of enamel. More studies with higher study groups and more advanced estimation technologies are required to minimize microstructure alterations and promote for better outcome of bleaching procedures. How to cite this article Dey S, Pandey V, Kumar A, Awasthi N, Sahu A, Pujari SC. In vitro comparison of impact of different bleaching Agents on the microhardness of Enamel. J Contemp Dent Pract 2016;17(3):258-262.

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