scholarly journals The Depuration Effect on Heavy Metals and Total Hydrocarbons Contamination Levels in Donax trunculus and Its Influence on The Expression of Oxidative Stress-Related Genes

2021 ◽  
Vol 13 (1) ◽  
pp. 77-89
Author(s):  
Fadiaو Heiba ◽  
Mohammed Nassef ◽  
Mahy Mona ◽  
Essra El-rashedy
Keyword(s):  
Oxidative Stress ◽  
Heavy Metals ◽  
Donax Trunculus ◽  
Stress Related Genes ◽  
Contamination Levels ◽  
Total Hydrocarbons

Effect of Exposure to Mixture of Heavy Metals Arsenic, Cadmium and Lead on Reproductive Function and Oxidative Stress in Female Rats

2017 ◽  
Vol 9 (03) ◽  
Author(s):  
Choudhuri D. ◽  
Bhattacharjee T.
Keyword(s):  
Oxidative Stress ◽  
Heavy Metals ◽  
Ascorbic Acid ◽  
Reproductive Function ◽  
Reproductive Organs ◽  
Female Rats ◽  
Corpora Lutea ◽  
Oestrus Cycle ◽  
Implantation Sites ◽  
Live Fetus

Background : Toxicological consequences arising from exposure to mixtures of heavy metals especially at low, chronic and environmentally relevant doses are poorly recognised. In the present study, we evaluated effects of chronic exposure to combinations of three metals arsenic (As), cadmium (Cd) and lead (Pb) present frequently in drinking water on reproductive function and oxidative damage caused to reproductive organs of female rats. Method : Female rats were exposed to mixture of metals (As, Cdand Pb) for 90 consecutive days. The gain in body weight and weight of reproductive organs were recorded following autopsy on 91 stday. The oestrus cycle were monitored during entire treatment period. Numbers of corpora lutea, implantation sites, live fetus and survival of the fetus were evaluated in rats mated successfully with untreated male after completion of their respective treatment. Ovarian cholesterol, protein, ascorbic acid and enzyme Δ 5 -3β HSD levels were estimated. Serum levels of steroid hormones oestrogen and progesterone were estimated. Histopathological picture of both ovary and uterus were assessed. Levels of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidise (GPX) activity, amount of reduced glutathione (GSH) and malondyaldehyde (MDA) in blood, ovary and uterus were measured as biomarkers of oxidative stress. Results : The treated rats showed reduced body weight gain and reduction in the weight of ovary and uterus. Oestrus cycle was disrupted with continuous diestrous in treated animals. Number of corpora lutea, implantation sites and live fetus and the survival of fetus evaluate were reduced significantly in treated groups. The levels of ovarian cholesterol and ascorbic acid increased in treated rats with decrease Δ5 -3β HSD level. There was reduction in serum level of both the ovarian steroid hormones oestrogen and progesterone. The protein levels did not differ between the groups. There was a significant increase in levels of MDA and decrease in levels of all the antioxidant enzymes in treated group. Conclusion : The results revealed there was disruption to reproductive functions with decrease in stereoidogenic activity and associated oxidative stress in female rats treated with combination of mixture of metals (Cd, As and Pb) at low dose for 90 consecutive days.

PROBLEM OF HEAVY METAL SURFACE SEDIMENT CONTAMINATION IN THE EASTERN GULF OF FINLAND

2017 ◽  
Author(s):  
N Derugina ◽  
N Derugina ◽  
А Grigoriev ◽  
A Grigoriev ◽  
Дарья Рябчук ◽  
...  
Keyword(s):  
Heavy Metals ◽  
Heavy Metal ◽  
Bottom Sediments ◽  
Late Holocene ◽  
Sediment Contamination ◽  
Gulf Of Finland ◽  
Slow Decline ◽  
Contamination Levels ◽  
The Gulf Of Finland ◽  
Neva Bay

This project defines the pre-industrial quantities of heavy metals in sediment sequences of the Late Holocene from the Eastern Gulf of Finland. A comparative analysis reveals differences and similarities in the current concentrations of heavy metals in bottom sediments and pre-industrial levels. It is found that the maximum concentrations of heavy metals in the bottom sediments of the Gulf of Finland and Neva Bay occurred in the period of 1950-1990. Since the 1990s, the trend has been a slow decline in the contamination levels; however, the concentrations of some heavy metals in bottom sediments remain high.

scholarly journals Nanoencapsulation of Pomegranate Extract to Increase Stability and Potential Dermatological Protection

Pharmaceutics ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 271
Author(s):  
Lucía Yepes-Molina ◽  
José A. Hernández ◽  
Micaela Carvajal
Keyword(s):  
Oxidative Stress ◽  
Heavy Metals ◽  
Protective Effect ◽  
Uv Radiation ◽  
Entrapment Efficiency ◽  
Hacat Cells ◽  
Biotechnological Applications ◽  
Accelerated Stability ◽  
The Stability ◽  
Brassica Oleracea L

Pomegranate extract (PG-E) has been reported to exert a protective effect on the skin due to its antioxidant activity. Ingredients rich in phenolic compounds are unstable in extract solutions, and, therefore, the use of a suitable nanosystem to encapsulate this type of extract could be necessary in different biotechnological applications. Thus, we investigated the capacity of Brassica oleracea L. (cauliflower) inflorescence vesicles (CI-vesicles) to encapsulate PG-E and determined the stability and the antioxidant capacity of the system over time. In addition, the protective effect against UV radiation and heavy metals in HaCaT cells was also tested. The CI-vesicles had an entrapment efficiency of around 50%, and accelerated stability tests did not show significant changes in the parameters tested. The results for the HaCaT cells showed the non-cytotoxicity of the CI-vesicles containing PG-E and their protection against heavy metals (lead acetate and mercuric chloride) and UV-B radiation through a reduction of oxidative stress. The reduction of the percentage of deleted mtDNA (mtDNA4977, “common deletion”) in UV-treated HaCaT cells due to the presence of CI-vesicles containing PG-E indicated the mechanism of protection. Therefore, the effects of CI-vesicles loaded with PG-E against oxidative stress support their utilization as natural cosmeceuticals to protect skin health against external damage from environmental pollution and UV radiation.

Metal-induced oxidative stress level in patients with fibromyalgia syndrome and its contribution to the severity of the disease: A correlational study

2020 ◽  
pp. 1-8
Author(s):  
Varsha Shukla ◽  
Siddharth Kumar Das ◽  
Abbas Ali Mahdi ◽  
Shweta Agarwal ◽  
Ragini Alok ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Heavy Metals ◽  
Fibromyalgia Syndrome ◽  
Positive Association ◽  
Protein Carbonyl ◽  
Essential Metals ◽  
Toxic Heavy Metals ◽  
Essential Trace Elements ◽  
Rheumatological Disease ◽  
Severity Of The Disease

BACKGROUND: Fibromyalgia syndrome (FMS) is an extra-articular rheumatological disease characterised by widespread chronic musculoskeletal pain. Metal-induced oxidative stress contributes to the severity of FMS. AIMS: First, this study evaluated the association between plasma levels of toxic heavy metals and essential metals with oxidative stress (OS) markers. Second, the OS markers and metal contents were correlated with the disease severity by assessing the Fibromyalgia Impact Questioner Revised (FIQR) and tender points (TP). METHOD: A total of 105 FMS patients and 105 healthy controls of similar age and sex were recruited. OS parameter such as lipid peroxidation (LPO), protein carbonyl group (PCG), nitric oxide (NO) and essential metals such as zinc (Zn), magnesium (Mg), manganese (Mn), copper (Cu) and toxic heavy metals such as aluminium (Al), arsenic (As), lead (Pb) were estimated. RESULTS: Levels of LPO, PCG, NO (p< 0.001) and Cu, Mn, and Al (p< 0.001), were significantly higher, and Mg (p< 0.001) and Zn (p< 0.001) were significantly lower in patients compared to controls. A positive association was observed between OS parameters, FIQR and TP with Cu, Al and Mn. A significant negative association was observed between Zn and Mg with FIQR, TP and OS parameters. CONCLUSION: Heavy metals such as Al induce OS parameters and decrease the levels of essential trace elements such as Mg and Zn, which may be responsible for the severity of FMS.

scholarly journals Oxidative Stress Mediates Vascular Tortuosity

Antioxidants ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 926
Author(s):  
Toshio Fumoto ◽  
Shouhei Kinoshita ◽  
Takao Sasaki ◽  
Norihito Shimamura ◽  
Hiroki Ohkuma
Keyword(s):  
Oxidative Stress ◽  
Basilar Artery ◽  
Morphological Changes ◽  
Imaging Techniques ◽  
Pcr Analysis ◽  
Adult Rats ◽  
Vascular Tortuosity ◽  
Bilateral Common Carotid Artery ◽  
Stress Related Genes ◽  
Underlying Mechanisms

Vascular tortuosity is associated with various disorders and is being increasingly detected through advances in imaging techniques. The underlying mechanisms for vascular tortuosity, however, remain unclear. Here, we tested the hypothesis that oxidative stress mediates the generation of tortuous vessels. We used the bilateral common carotid artery (CCA) ligation model to induce vascular tortuosity. Both young and adult rats showed basilar artery tortuous morphological changes one month after bilateral CCA ligation. These tortuous changes were permanent but more pronounced in the adult rats. Microarray and real-time PCR analysis revealed that these tortuous changes were accompanied by the induction of oxidative stress-related genes. Moreover, the indicated model in rabbits showed that tortuous morphological changes to the basilar artery were suppressed by antioxidant treatment. These results are highly suggestive of the significance of oxidative stress in the development of vascular tortuosity. Although further studies will be needed to elucidate the possible mechanisms by which oxidative stress enhances vascular tortuosity, our study also points toward possible prophylaxis and treatment for vascular tortuosity.

scholarly journals A Comparative Study of the Antioxidative Effects of Helichrysum italicum and Helichrysum arenarium Infusions

Antioxidants ◽  
2021 ◽  
Vol 10 (3) ◽  
pp. 380
Author(s):  
Katja Kramberger ◽  
Zala Jenko Pražnikar ◽  
Alenka Baruca Arbeiter ◽  
Ana Petelin ◽  
Dunja Bandelj ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
High Performance ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Morphological Type ◽  
Mass Spectrometry Analysis ◽  
In Vitro Assays ◽  
Spectrometry Analysis ◽  
Stress Related Genes

Helichrysum arenarium (L.) Moench (abbrev. as HA) has a long tradition in European ethnomedicine and its inflorescences are approved as a herbal medicinal product. In the Mediterranean part of Europe, Helichrysum italicum (Roth) G. Don (abbrev. as HI) is more common. Since infusions from both plants are traditionally used, we aimed to compare their antioxidative potential using in vitro assays. Two morphologically distinct HI plants, HIa and HIb, were compared to a commercially available HA product. Genetic analysis using microsatellites confirmed a clear differentiation between HI and HA and suggested that HIb was a hybrid resulting from spontaneous hybridization from unknown HI subspecies. High-performance liquid chromatography–mass spectrometry analysis showed the highest amounts of hydroxycinnamic acids and total arzanol derivatives in HIa, whereas HIb was richest in monohydroxybenzoic acids, caffeic acids, and coumarins, and HA contained the highest amounts of flavonoids, especially flavanones. HIa exhibited the highest radical scavenging activity; it was more efficient in protecting different cell lines from induced oxidative stress and in inducing oxidative stress-related genes superoxide dismutase 1, catalase, and glutathione reductase 1. The antioxidative potential of HI was not only dependent on the morphological type of the plant but also on the harvest date, revealing important information for obtaining the best possible product. Considering the superior properties of HI compared to HA, the evaluation of HI as a medicinal plant could be recommended.

scholarly journals Polymorphisms in oxidative stress-related genes and postmenopausal breast cancer risk

2011 ◽  
Vol 129 (6) ◽  
pp. 1467-1476 ◽  
Author(s):  
Petra Seibold ◽  
Rebecca Hein ◽  
Peter Schmezer ◽  
Per Hall ◽  
Jianjun Liu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Oxidative Stress ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Postmenopausal Breast Cancer ◽  
Postmenopausal Breast Cancer Risk ◽  
Stress Related Genes

scholarly journals Metallothionein and Glutathione Content as Biomarkers of Metal Pollution in Mussels and Local Fishermen in Abu Qir Bay, Egypt

2016 ◽  
Vol 6 (12) ◽  
pp. 50-60 ◽  
Author(s):  
Aziza A. Saad ◽  
Amany El-Sikaily ◽  
Hany Kassem
Keyword(s):  
Oxidative Stress ◽  
Heavy Metals ◽  
Metal Pollution ◽  
The Body ◽  
Metal Exposure ◽  
Control Group ◽  
Blood Levels ◽  
Industrial Workers ◽  
High Concentrations ◽  
Abu Qir Bay

Background. When heavy metals accumulate in air, soil, and water, the risk of human exposure increases among industrial workers, as well as in people living near polluted areas. Heavy metals adversely affect a variety of bodily systems such as the cardiovascular, respiratory, endocrine, immune, and reproductive systems. In addition, long-term exposure and accumulation of heavy metals in the body may disturb oxidative stress genes and thus increase the susceptibility to various diseases. Objectives. The aim of this study is to estimate the metallothionein concentration in both mussel samples from Abu Qir Bay, Egypt and the blood of local fishermen as a biomarker of exposure to metal pollution. Methods. Levels of metallothionein and heavy metals were measured in mussels. Blood levels of metallothionein and heavy metals of local fishermen were measured and compared with a control group. The effect of heavy metal exposure on oxidative stress status was investigated through the determination of malondialdehyde (MDA), catalase and glutathione content. Results. The results of this study showed high concentrations of metallothionein in mussels and in fishermen's blood, accompanied by high concentrations of metals such as cadmium (Cd), copper (Cu), lead (Pb), chromium (Cr), and zinc (Zn). At the same time, a significant decrease in glutathione content and catalase enzyme activity was associated with a significant increase in the malondialdehyde concentrations in sera of fishermen. Conclusions. The present study found that the El Maadiya region is polluted with heavy metals, inducing oxidative stress in fishermen in the vicinity. These results reveal the necessity of further environmental monitoring in the study area in order to evaluate other types of pollutants and their effects on human health.

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