scholarly journals Protective effect of Moringa oleifera and green tea aqueous extract in combination against beta-cyfluthrin induced mutagenicity in albino rats

2020 ◽  
Vol 98 (2) ◽  
pp. 338-347
Author(s):  
Mohamed Noaishi
Keyword(s):  
Protective Effect ◽  
Green Tea ◽  
Aqueous Extract ◽  
Moringa Oleifera ◽  
Albino Rats

scholarly journals Protective effect of Phyllanthus fraternus against cyclophosphamide-induced nephrotoxicity in rats

2017 ◽  
Vol 6 (4) ◽  
pp. 984
Author(s):  
Rakesh Singh Moirangthem ◽  
Ngangom Gunindro ◽  
Dipdeba Singh Takhellambam ◽  
Sucheta Devi Khuraijam ◽  
N. Meena ◽  
...  
Keyword(s):  
Protective Effect ◽  
Aqueous Extract ◽  
Serum Levels ◽  
Albino Rats ◽  
Standard Diet ◽  
Solid Organ ◽  
Group Iii ◽  
Group I ◽  
Ad Libitum ◽  
Phyllanthus Fraternus

Background: Cyclophosphamide is commonly used against malignancies, such as leukemia and solid organ cancers. It can induce nephrotoxicity in cancer patients thereby complicating the initiation of chemotherapy. The study is to evaluate the effect of Phylllanthus fraternus against cyclophosphamide induced nephrotoxicity in albino rats.Methods: In this study, a total of 20 albino rats were divided into four groups of five each. Group I (normal control) received i.p. injection of normal saline. While, group II, III and IV received single dose (200 mg/kg b/w) of cyclophosphamide i.p. on day 1. Group III and IV received 200 mg/kg and 400 mg/kg of aqueous extract of Phyllanthus fraternus respectively p.o. daily for 10 days. All the groups were fed with standard diet and water ad libitum. Serum levels of creatinine, urea and albumin were estimated. Histopathology of renal tissues was compared among the groups.Results: The renal parameters significantly improved in groups III and IV after 10 days of treatment with the extract. The histopathology study also supported the finding.Conclusions: The aqueous extract of Phyllanthus fraternus possesses protective effect against cyclophosphamide induced nephrotoxicity.

Effect of Green Tea and Black Tea Aqueous Extract on Histomorphology of Precentral Gyrus of Cerebral Cortex of Albino Rats

2021 ◽  
Vol 15 (7) ◽  
pp. 1503-1504
Author(s):  
Warisha Iftikhar ◽  
Syeda Shabeeh Rubab ◽  
Raafea Tafweez Kuraishi ◽  
Saira Salman ◽  
Muhammad Ghazi Zafar
Keyword(s):  
Cerebral Cortex ◽  
Green Tea ◽  
Aqueous Extract ◽  
Black Tea ◽  
Albino Rats ◽  
P Value ◽  
Precentral Gyrus ◽  
Group Iii ◽  
Group I ◽  
Medical University

Aim: To compare the histomorphological changes in the precentral gyrus of cerebral cortex of albino rats by taking green tea and black tea aqueous extract. Study design: Experimental Study Duration of study: 30 days study conducted in Animal Experimental Research Laboratory of PGMI and Department of Anatomy, King Edward Medical University, Lahore. Methodology: 90 albino rats were divided into three groups of 30 animals each. Rats in the group I were given distilled water, while group II and group III received green tea and black tea aqueous extract respectively. At the end of 30 days of experiment, brains were removed and studied for histological changes. Results: When comparison among all the three groups was made at 30 days time, p-value was significant for gliosis i.e. p<0.01. However, experimental group III revealed more gliosis among all the three groups. Necrosis was absent in all the groups and was not statistically analyzed. Conclusion: Gliosis caused by black tea is highly significant as compared to green tea. Key words: Cerebral Cortex, Green tea, Black tea, Gliosis, Necrosis.

scholarly journals Aflatoxin induced renal toxicity in Albino rats and the ameliorative effect of green tea aqueous extract: Histological, Morphometric and Immuno-histochemical Study

2018 ◽  
Vol 2 (3) ◽  
pp. 273-285
Author(s):  
Samah Abou Asa ◽  
EL-Shaymaa EL-Nahass ◽  
Walaa A Moselhy ◽  
Nour El-Houda Y. Hassan ◽  
Atef A. Hassan
Keyword(s):  
Green Tea ◽  
Aqueous Extract ◽  
Adult Male ◽  
Male Rats ◽  
Albino Rats ◽  
Ki 67 ◽  
Group 4 ◽  
Group I ◽  
Significant Difference ◽  
Group 1

Tea is the most common drink worldwide besides water. It is rich in antioxidant polyphenolic flavonoids. Further, it has anti-apoptotic, anti-inflammatory, and autoantigen-inhibitory properties. To evaluate the effects of oral administration of aqueous extract of green tea against experimental aflatoxicosis on the renal tissues of adult male albino rats. Twenty five adult male rats were included and they were divided equally into 5 groups: Group 1 (aflatoxin group): the rats received aflatoxins (2.5 mg/kg diet for 15 days), group 2 (aflatoxins and green tea aqueous extract group) for 15 days, group 3, the rats received aflatoxins for 15 days and aqueous extract of the green tea for 30 days, group 4 (green tea aqueous extract group) and group 5(control negative group). Detailed non-traditional histological and morphometrical analyses for renal tissues stained with Hematoxylin and Eosin, Masson's trichrome stain, Periodic Acid Schiff’s (PAS), Alizarin red S stains and immunohistochemical detection of Ki-67 were done. The main observed renal lesions in rats received aflatoxins were dilatation of the renal pelvis, increases in glomerular areas (GA), widening of Bowman's spaces and necrosis of the renal lining epithelium and proliferation of fibrous connective tissues. Morphometric analysis revealed the presence of significant difference between group I and the other experimental groups. Meanwhile, groups 2 and 3 revealed a significant improvement in the histological changes and decrease in most of parameters. The highest percentage of PAS positive reaction was significantly found in group 4. Quantitative analysis of positive reactions of Ki-67 revealed the highest positive immunohistochemical reactions were detected in group 1 which significantly different in groups 4 and 5. In conclusion, green tea has a protective effect against the adverse effects of aflatoxins on renal tissues evidenced by improvement of histopathological alterations and regulation of Ki-67 expressions.  

Protective Effect of Green Tea Aqueous Extract on Acrylamide Induced Neurotoxicity

2015 ◽  
Vol 10 (2) ◽  
Author(s):  
Elahe Esmaeelpanah ◽  
Alireza Rahmatkhah ◽  
Narges Poormahmood ◽  
Bibi Marjan Razavi ◽  
Faezeh Vahdati Hasani ◽  
...  
Keyword(s):  
Protective Effect ◽  
Green Tea ◽  
Aqueous Extract

The Protective Effect Of Ephedra alata Aqueous Extract Against Metribuzin Intoxication On Albino Wistar Rat

2020 ◽  
Vol 10 ◽  
Author(s):  
Ifriqya Medila ◽  
Ikram Toumi ◽  
Aicha Adaika
Keyword(s):  
Adverse Effects ◽  
Protective Effect ◽  
Dose Level ◽  
Aqueous Extract ◽  
Biological Properties ◽  
Albino Rats ◽  
Protective Effects ◽  
Vegetable Crops ◽  
Weed Species ◽  
Plasma Urea

Background: Metribuzin (Mtz) a pesticide often used on vegetable crops to control broadleaf and grassy weed species has shown significant toxicity to humans and animals. Many plant extracts have been reported to have multiple biological properties. Ephedra alata extract might be useful in preventing and protecting the population from getting affected by metribuzin toxicity. Objective: The current study evaluates the protective effect of Ephedra alata aqueous extract against metribuzin (Mtz) pesticide induced adverse effects on biochemical parameters as well as oxidative stress in various tissues of rats. Method : This study was conducted on 24 Albino rats, which were divided into three groups; the first served as a control, the remaining groups were respectively treated with metribuzin 1/5 of the LD50 (440 mg/kg b.w.) and a combination of Mtz and Ephedra alata aqueous extract at the dose level of 200 mg/kg b.w. for 50 days. Results: After 50 days of treatment, a significant increase in glucose levels noticed in the metribuzinexposed group compared to the control. Mtz exposure resulted in the increase in plasma urea and creatinine in rats, suggesting renal failure and caused also a significant induction of oxidative damage in tissues as evidenced by increased activities of AST, ALT and ALP, increased levels of malondialdehyde, decreased levels of reduced glutathione in Mtz group compared to the control. Conclusion: Ephedra alata aqueous extract at the dose level of 200 mg/kg b.w. supplementation has significantly reduced the adverse effects of metribuzin. These findings suggest that Ephedra alata extract may have protective effects by improving the antioxidant status in tissues and ameliorating the harmful effects induced by Mtz.

scholarly journals Protective Effect of N-Acetyl Cysteine on Moringa Oleifera Aqueous Leaf Extract-Induced Hepatic Toxicity in Wistar Albino Rats

2020 ◽  
Vol 8 (3) ◽  
pp. 34-39
Author(s):  
Namaganda Agnes ◽  
Kasolo N Josephine ◽  
Bbosa S. Godfrey ◽  
Lukande Robert ◽  
Kimuli Ivan ◽  
...  
Keyword(s):  
Protective Effect ◽  
Total Protein ◽  
Leaf Extract ◽  
Moringa Oleifera ◽  
Albino Rats ◽  
P Value ◽  
Protein Levels ◽  
Aqueous Leaf Extract ◽  
Acetyl Cysteine ◽  
Wistar Albino Rats

Background: Moringa oleifera (M. oleifera) is a commonly used medicinal and nutritive plant. The aqueous leaf extract from this plant contains a high concentration of alkaloids and they are toxic to body organs especially the liver leading to hepatotoxicity after long term exposure. However, if N-Acetyl cysteine (NAC) is administered together with M. oleifera extract, it may have a hepatotoxic protective effect. Objective: To establish the protective effect of N-Acetyl cysteine against M. oleifera aqueous leaf extract-induced hepatotoxicity in the Wistar albino rats. Methods: An experimental laboratory-based study conducted at department of Physiology Makerere University, College of Health Sciences. Three treatment groups of six Wistar albino rats each, were dosed intragastrically once a day for 28 days. Group I; negative control, received 8.05g/kg bwt of M. oleifera extract plus 1ml of normal saline (NS), Group II; test group, received 8.05g/kg bwt of M. oleifera extract plus 50mg/kg of NAC. Group III; positive control, received 750mg/kg bwt of Paracetamol plus 50mg/kg of NAC. On the 14th and 29th day, three animals selected randomly from each group were sacrificed; blood samples were collected, the liver was harvested for histopathological analysis.  Serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), bilirubin and total protein levels were determined. Results: There was an increase in serum ALT, AST and ALP levels in the M. oleifera extract plus NS group which was a sign of hepatotoxicity. The M. oleifera extract plus NAC group showed normal serum ALT, AST and ALP levels with no significant changes in the bilirubin (P-value = 0.9089) and total protein levels (P-value = 0.8858). Conclusion: The results have provided evidence that NAC administration with M. oleifera extract effectively prevents the occurrence of M. oleifera leaves xtract- induced hepatotoxicity.  

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