scholarly journals Biodegradable Natural Polymers for Biomedical Applications

2019 ◽  
pp. 67-80
Author(s):  
Israt Parveen ◽  
Md. Iqbal Mahmud ◽  
Ruhul A. Khan
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Wound Healing ◽  
Biodegradable Polymers ◽  
Biomedical Applications ◽  
Modern Medicine ◽  
Natural Polymers ◽  
Present Contribution ◽  
Pharmaceutical Applications ◽  
Physical Chemical

Biodegradable polymers as biomaterial are hotcake nowadays especially in medical and pharmaceutical applications. The present contribution comprises an overview of the biodegradable polymers for various biomedical applications. To meet the need of modern medicine, their physical, chemical, functional, biomechanical are highlighted as well as biodegradation properties like non-toxicity, low antigenicity, high bio-activity etc. This review summarizes the emerging and innovative field of biopolymer with the focus on tissue engineering, temporary implants, wound healing, and drug delivery applications etc.

scholarly journals Antibacterial cellulose-based aerogels for wound healing application: A review

2020 ◽  
Vol 7 (10) ◽  
pp. 4032-4040
Author(s):  
Esam Bashir Yahya ◽  
Marwa Mohammed Alzalouk ◽  
Khalifa A. Alfallous ◽  
Abdullah F. Abogmaza
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Wound Healing ◽  
Wound Dressing ◽  
Biomedical Applications ◽  
Inorganic Materials ◽  
Medical Applications ◽  
Tissue Engineering Scaffolds

Aerogels have been steadily developed since its first invention to become one of the most promising materials for various medical and non-medical applications. It has been prepared from organic and inorganic materials, in pure forms or composites. Cellulose-based aerogels are considered one of the promising materials in biomedical applications due to their availability, degradability, biocompatibility and non-cytotoxicity compared to conventional silica or metal-based aerogels. The unique properties of such materials permit their utilization in drug delivery, biosensing, tissue engineering scaffolds, and wound dressing. This review presents a summary of aerogel development as well as the properties and applications of aerogels. Herein, we further discuss the recent works pertaining to utilization of cellulose-based aerogels for antibacterial delivery.

scholarly journals PLGA – THE SMART POLYMER FOR DRUG DELIVERY

2021 ◽  
Vol 9 (5) ◽  
pp. 334-345
Author(s):  
N. Surya ◽  
S. Bhattacharyya
Keyword(s):  
Drug Delivery ◽  
Biodegradable Polymers ◽  
Biomedical Applications ◽  
Drug Delivery Systems ◽  
Glycolic Acid ◽  
Delivery Systems ◽  
Nano Particles ◽  
Natural Polymers ◽  
Smart Polymer ◽  
Novel Drug

Polymers have become an integral part of novel drug delivery system. One such successful biodegradable polymer is poly lactic-co-glycolic acid (PLGA) which consists of polyesters of lactic acid and glycolic acid. It is one of the FDA-approved biodegradable polymers which is extensively used for therapeutic purposes in recent times.The aim. To illuminate researchers on the chemistry, novel properties and applications of PLGA in pharmaceutical fields.Materials and methods. Various internet sources like Science Direct, Scopus, Web of Science, PubMed and google scholar were used as the data source. The key words search was carried out for the following words and combinations: PLGA, Novel drug delivery, PLGA Nano particles, biomedical applications of PLGA.Results. Pharmaceutical and biomedical industries are flooded with the use of synthetic and natural polymers. The mechanical and viscoelastic properties of the polymers make them suitable for the temporal and spatial delivery of therapeutic agents for an extended period. Employment of copolymerization techniques lead to the modification of water solubility of the polymers and make them suitable for various applications of drug delivery systems. Biodegradable polymers due to their biocompatibility and biodegradable property have attracted their use in novel drug delivery systems. PLGA is one of them. PLGA is versatile as it can be fabricated into any size, shape, and can be used to encapsulate small molecules, tissue engineering, and bone repair, etc.Conclusion. The sensitivity and biodegradability of PLGA makes it a smart polymer for targeted and sustained delivery of drugs and in various biomedical applications.

Recent advances of self-assembling peptide-based hydrogels for biomedical applications

Soft Matter ◽  
2019 ◽  
Vol 15 (8) ◽  
pp. 1704-1715 ◽  
Author(s):  
Jieling Li ◽  
Ruirui Xing ◽  
Shuo Bai ◽  
Xuehai Yan
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Wound Healing ◽  
Biomedical Applications ◽  
3D Bioprinting ◽  
Biological Applications ◽  
Antitumor Therapy ◽  
Self Assembling ◽  
Recent Advances

The review introduces several methods for fabrication of robust peptide-based hydrogels and their biological applications in the fields of drug delivery and antitumor therapy, antimicrobial and wound healing materials, and 3D bioprinting and tissue engineering.

scholarly journals Multifunctional Hydrogel Nanocomposites for Biomedical Applications

2021 ◽  
Author(s):  
Emma Barrett-Catton ◽  
Murial L. Ross ◽  
Prashanth Asuri
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Extracellular Matrix ◽  
Wound Healing ◽  
Physical Properties ◽  
Biomedical Applications ◽  
Biochemical Properties ◽  
Broad Applicability ◽  
Hydrogel Nanocomposites

Hydrogels are used for various biomedical applications due to their biocompatibility, capacity to mimic the extracellular matrix, and ability to encapsulate and deliver cells and therapeutics. However, traditional hydrogels have a few shortcomings, especially regarding their physical properties, thereby limiting their broad applicability. Recently, researchers have investigated the incorporation of nanoparticles (NPs) into hydrogels to improve and add to the physical and biochemical properties of hydrogels. This brief review focuses on papers that describe the use of nanoparticles to improve more than one property of hydrogels. Such multifunctional hydrogel nanocomposites have enhanced potential for various applications, including tissue engineering, drug delivery, wound healing, bioprinting and biowearable devices.

scholarly journals Rational Design of Peptide-based Smart Hydrogels for Therapeutic Applications

2021 ◽  
Vol 9 ◽  
Author(s):  
Saurav Das ◽  
Debapratim Das
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Wound Healing ◽  
Biomedical Applications ◽  
Rational Design ◽  
Soft Materials ◽  
Biological Molecules ◽  
3D Bioprinting ◽  
Significant Progress ◽  
Mechanical Stiffness

Peptide-based hydrogels have captivated remarkable attention in recent times and serve as an excellent platform for biomedical applications owing to the impressive amalgamation of unique properties such as biocompatibility, biodegradability, easily tunable hydrophilicity/hydrophobicity, modular incorporation of stimuli sensitivity and other functionalities, adjustable mechanical stiffness/rigidity and close mimicry to biological molecules. Putting all these on the same plate offers smart soft materials that can be used for tissue engineering, drug delivery, 3D bioprinting, wound healing to name a few. A plethora of work has been accomplished and a significant progress has been realized using these peptide-based platforms. However, designing hydrogelators with the desired functionalities and their self-assembled nanostructures is still highly serendipitous in nature and thus a roadmap providing guidelines toward designing and preparing these soft-materials and applying them for a desired goal is a pressing need of the hour. This review aims to provide a concise outline for that purpose and the design principles of peptide-based hydrogels along with their potential for biomedical applications are discussed with the help of selected recent reports.

Microfluidic Biomaterials

MRS Bulletin ◽  
2006 ◽  
Vol 31 (2) ◽  
pp. 114-119 ◽  
Author(s):  
Abraham D. Stroock ◽  
Mario Cabodi
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Mass Transfer ◽  
Wound Healing ◽  
Biomedical Applications ◽  
Wound Dressings ◽  
Living Systems ◽  
Living Tissue ◽  
Hydrodynamic Stresses

Biomedical applications—prostheses, tissue engineering, drug delivery, and wound healing—demand increasingly sophisticated characteristics from the materials that come into contact with living systems in the laboratory and the clinic. With the development of microfluidics, there is an opportunity to create active biomaterials based on embedded microfluidic structures. These structures allow for control of the concentrations of soluble chemicals and hydrodynamic stresses within the material and at its interfaces, and thus allow one to tailor the environment experienced by the living tissue. In this article, we review initial efforts to develop these microfluidic biomaterials and present considerations regarding the required characteristics of the materials and of the microfluidic-mediated mass transfer. As specific examples, we present work toward microfluidic control of mass transfer in scaffolds for tissue engineering and in wound dressings.

scholarly journals Multifunctional Hydrogel Nanocomposites for Biomedical Applications

Polymers ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 856
Author(s):  
Emma Barrett-Catton ◽  
Murial L. Ross ◽  
Prashanth Asuri
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Extracellular Matrix ◽  
Wound Healing ◽  
Physical Properties ◽  
Biomedical Applications ◽  
Biochemical Properties ◽  
Broad Applicability ◽  
Hydrogel Nanocomposites

Hydrogels are used for various biomedical applications due to their biocompatibility, capacity to mimic the extracellular matrix, and ability to encapsulate and deliver cells and therapeutics. However, traditional hydrogels have a few shortcomings, especially regarding their physical properties, thereby limiting their broad applicability. Recently, researchers have investigated the incorporation of nanoparticles (NPs) into hydrogels to improve and add to the physical and biochemical properties of hydrogels. This brief review focuses on papers that describe the use of nanoparticles to improve more than one property of hydrogels. Such multifunctional hydrogel nanocomposites have enhanced potential for various applications including tissue engineering, drug delivery, wound healing, bioprinting, and biowearable devices.

A Review on Cellulose-based Materials for Biomedicine

2022 ◽  
Author(s):  
Hani Nasser Abdelhamid ◽  
Aji P. Mathew
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Wound Healing ◽  
Biomedical Applications ◽  
Chemical Structure ◽  
Antibacterial Agents ◽  
State Of The Art ◽  
Market Demand ◽  
Mechanical And Physical Properties ◽  
Research Findings

There are various biomaterials in nature, but none fulfills all the requirements. Cellulose, eco-friendly material-based biopolymers, have been advanced biomedicine to satisfy most market demand and circumvent many ecological concerns. This review aims to present an overview of the state of the art in cellulose's knowledge and technical biomedical applications. It included an extensive bibliography of recent research findings for fundamental and applied investigations. The chemical structure of cellulose allows modifications and simple conjugation with several materials, including nanoparticles, without tedious efforts. Cellulose-based materials were used for biomedicine applications such as antibacterial agents, antifouling, wound healing, drug delivery, tissue engineering, and bone regeneration. They advanced the applications to be cheap, biocompatible, biodegradable, easy for shaping and processing into different forms, with suitable chemical, mechanical and physical properties.

scholarly journals Carrageenan: Drug Delivery Systems and Other Biomedical Applications

Marine Drugs ◽  
2020 ◽  
Vol 18 (11) ◽  
pp. 583
Author(s):  
Edisson-Mauricio Pacheco-Quito ◽  
Roberto Ruiz-Caro ◽  
María-Dolores Veiga
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Physicochemical Properties ◽  
Biomedical Applications ◽  
Drug Delivery Systems ◽  
Pharmaceutical Formulations ◽  
Delivery Systems ◽  
Marine Resources ◽  
Renewable Source ◽  
Pharmaceutical Applications

Marine resources are today a renewable source of various compounds, such as polysaccharides, that are used in the pharmaceutical, medical, cosmetic, and food fields. In recent years, considerable attention has been focused on carrageenan-based biomaterials due to their multifunctional qualities, including biodegradability, biocompatibility, and non-toxicity, in addition to bioactive attributes, such as their antiviral, antibacterial, antihyperlipidemic, anticoagulant, antioxidant, antitumor, and immunomodulating properties. They have been applied in pharmaceutical formulations as both their bioactive and physicochemical properties make them suitable biomaterials for drug delivery, and recently for the development of tissue engineering. This article provides a review of recent research on the various types of carrageenan-based biomedical and pharmaceutical applications.

scholarly journals Gelatin Based Hydrogels for Tissue Engineering and Drug Delivery Applications

2021 ◽  
pp. 244-270
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Stem Cell ◽  
Biomedical Applications ◽  
Natural Polymers ◽  
Comprehensive Overview ◽  
Alkali Extraction ◽  
Extraction Processes ◽  
Different Sources ◽  
Physical Crosslinking

Gelatin is one of the most popular natural polymers which is widely used in food, pharmaceutical, biomedical and cosmetic industries. The gelatin has been prepared from different sources such as porcine skin, cattle bone, and fish, etc. Depending on the type of acidic and alkali extraction processes the type of gelatin A and B were obtained. This chapter provides a comprehensive overview of preparation of gelatin base hydrogel. Furthermore, we evaluate their method of crosslinking through Schift-base, Mischeal-addition-based, light, UV, chemical, and physical crosslinking. Moreover, due to the unique properties of gelatin they have the ability to immobilize cells and can be applied for stem cell and drug delivery in biomedical applications.

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