The World Against Versatile SARS-Cov-2 Nanomachines; Mythological or Reality?

2021 ◽  
Vol 16 ◽  
Author(s):  
Shima Tavakol ◽  
Hani Tavakol ◽  
Mo S. Alavijeh ◽  
Alexander Seifalian
Keyword(s):  
Tissue Damage ◽  
Inflammatory Responses ◽  
Therapeutic Strategies ◽  
Cell Entry ◽  
Signalling Pathways ◽  
Cell Surfaces ◽  
The World ◽  
Life Threatening ◽  
Similarities And Differences ◽  
To Come

: Nanomachines hold promise for the next generation of emerging technology; however, nanomachines are not a new concept, viruses, nature’s nanomachines, have already existed for thousands of years. In 2019, the whole world has had to come together to confront a life-threatening nanomachine named “SARS-CoV-2”, which causes COVID-19 illness. SARS-CoV-2, a smart nanomachine, attaches itself onto the ACE2 and CD147 receptors present on the cell surfaces of the lungs, kidneys, heart, brain, intestines, and testes, etc. and triggers pathogenesis. Cell entry triggers a cascade of inflammatory responses resulting in tissue damage, with the worst affected cases leading to death. SARS-CoV-2 influences several receptors and signalling pathways; therefore, finding a biomaterial that caps these signalling pathways and ligand sites is of interest. This research aimed to compare the similarities and differences between COVID-19 and its elderly sisters’, MERS and SARS. Furthermore, we glanced at emerging therapeutics that carry potential in eliminating SARS-CoV-2, and the tissue damage it causes. Simple prophylactic and therapeutic strategies for the treatment of COVID-19 infection have been put forward.

SARS-CoV-2 and Tissue Damage: Current Insights and Biomaterial-based Therapeutic Strategies

2021 ◽  
Author(s):  
Himadri Roy ◽  
Rupali Singh ◽  
Deepa Ghosh
Keyword(s):  
Mortality Rate ◽  
High Mortality ◽  
Tissue Damage ◽  
Therapeutic Strategies ◽  
The World ◽  
Rapid Transmission

The effect of SARS-CoV-2 infection on humanity has gained worldwide attention and importance due to its rapid transmission, lack of treatment and high mortality rate. While scientists across the world...

scholarly journals CULTIVATING SPIRITUALITY A NECESSITY FOR PRESENT AND FUTURE GENERATIONS

2021 ◽  
Vol 101 (2(Ч.1)) ◽  
pp. 270-283
Author(s):  
Д. Пол Шафер
Keyword(s):  
Future Generations ◽  
Environmental Crisis ◽  
Systemic Racism ◽  
Protest Movements ◽  
The Arts ◽  
The World ◽  
Other Substances ◽  
Life Threatening ◽  
Disastrous Effect ◽  
To Come

We are going through a very challenging period in human history. Not only has the COVID-19 pandemic had a disastrous effect on people and countries in all parts of the world, but also many other dangerous and life threatening problems have to be addressed and overcome, especially the environmental crisis, huge disparities in income and wealth, systemic racism, and conflicts between different genders, groups, regions, countries, and cultures. In order to come to grips with these problems, and others, it is imperative to make transcendental and not just transformational changes in our lifestyles, values, worldviews, actions, behaviour, and ways of life. The key to this lies in creating an effective balance between materialism and spiritualism, as well as placing a much higher priority on the cultivation of spirituality in our lives in the traditional and contemporary sense. Not only will this make it possible to reduce the colossal demands we are making on the natural environment – largely because most spiritual activities are "human intensive" rather than "material intensive" and therefore don’t consume as many natural resources as most other activities – but also it will enable present and future generations to experience a great deal more exuberance, exhilaration, and ecstasy in life without having to resort to drugs and other substances and devices to create "highs" and "peak experiences" because spiritual activities achieve this naturally. Many of these activities involve participating in causes that are greater than ourselves, joining protest movements aimed at creating more equality and justice in the world, going within ourselves to discover who we really are and what we were intended to realize in life, broaden and deepen our experiences in the arts, cultures, and the cultural heritage of humankind, and engage in explorations in nature and the natural realm that are capable of bringing us into contact with the sublime and possibly even the divine.

scholarly journals Approval and Disapproval Expressions in English and Arabic: A Contrastive Study

2018 ◽  
Vol 4 (3) ◽  
pp. 14
Author(s):  
Abeer Hadi Salih
Keyword(s):  
English Language ◽  
World Wide ◽  
Daily Life ◽  
Arabic Language ◽  
Contrastive Analysis ◽  
Contrastive Study ◽  
The World ◽  
Similarities And Differences ◽  
To Come ◽  
And Linguistics

Any language in the world wide has different expressions and terms that convey approval or disapproval that language speakers may use in their daily life. English language for instance, is full of such expressions and can be found in any situation needs to. The present research studies approval and disapproval in English with their counterparts in Arabic as a contrastive study. It tries to search for those terms or sentences that are used to express approval and disapproval in English with their counterparts in Arabic. It aims to highlight the points of similarities and differences between those expressions that are used to state approval and disapproval in the two languages. Also the study includes a contrastive analysis to the expressions of approval and disapproval in English with their equivalents in Arabic in order to come up with the conclusions. It concluded that the approval and disapproval expressions in English language are similar to their counterparts in Arabic language but differ in two points. Firstly in Arabic language main verbs are used to convey approval and disapproval whereas in English are not. Secondly, in English language the exclamatory style is used to express approval in contrast, Arabic language is not. Researchers, teachers, translators and any who cares about English language and linguistics can get benefit from this study, precisely because it includes a comparison between two languages, English language and Arabic, with several types of expressions and terms that are being actually used to express approval and disapproval.

Recent advancements of nanomaterial-based therapeutic strategies toward sepsis: bacterial eradication, anti-inflammation, and immunomodulation

Nanoscale ◽  
2021 ◽  
Author(s):  
Yi Zhao ◽  
Minju Pu ◽  
Jingwen Zhang ◽  
Yanan Wang ◽  
Xuefeng Yan ◽  
...  
Keyword(s):  
Immune Response ◽  
Organ Dysfunction ◽  
Tissue Damage ◽  
Host Immune Response ◽  
Therapeutic Strategies ◽  
Bacterial Eradication ◽  
Life Threatening ◽  
Anti Inflammation

Sepsis is a life threatening disease that is caused by a dysregulated host immune response to infection, resulting in tissue damage and organ dysfunction, which account for a high in-hospital...

Therapeutic Strategies for Coping with a Life-Threatening Illness: A Personal Testament

2003 ◽  
Vol 11 (2) ◽  
pp. 162-182 ◽  
Author(s):  
Pittu Laungani
Keyword(s):  
Chronic Condition ◽  
High Probability ◽  
Therapeutic Strategies ◽  
Limited Capacity ◽  
Negative Consequences ◽  
Personal Account ◽  
The Past ◽  
Life Threatening Illness ◽  
The World ◽  
Life Threatening

This article is a personal account of the author's experiences with a chronic, life-threatening illness, of which he has been a victim for the past fourteen years. In the article, the author argues that a serious life-threatening illness need not be seen as the end of the world for the sufferer. Such an attitude is self-defeating. It has serious negative consequences for the sufferer, with a high probability of the sufferer experiencing depression, loss of any goal and purpose in life, followed by a ten-dency to give up fighting. These are negative, pessimistic, and self-defeating attitudes. The author outlines definite, practical ways by which one can overcome such feelings and attitudes and transform one's life, making it positive, enjoyable, and happy. The author suggests how, despite one's chronic condition, one can work within one's limited capacity, create a sense of meaning and purpose in one's life, and extract as much fun and pleasure out of it as possible.

scholarly journals CULTURE AS THE FOUNDATION FOR THE DEVELOPMENT OF OUR PERSONALITIES AND LIVES

2020 ◽  
Vol 96 (3) ◽  
pp. 256-268
Author(s):  
Д. Пол Шафер
Keyword(s):  
Racial Violence ◽  
Environmental Crisis ◽  
Cultural Life ◽  
The Arts ◽  
The World ◽  
The Future ◽  
Life Threatening ◽  
Johan Huizinga ◽  
To Come ◽  
Defined Culture

Given all the problems that exist in the world today - from the COVID-19 pandemic and racial violence and prejudice to the environmental crisis and colossal disparities in income and wealth – people everywhere in the world are being severely challenged and thinking a great deal about the development of their personalities and lives. When Edward Burnett Tylor defined culture as "the complex whole," it was apparent that all people live a "cultural life" as a whole made up of many parts. Matthew Arnold went farther in this regard by contending that the challenge in life is to create a "harmonious cultural life" through the development of all our faculties and powers. Johan Huizinga went even further when he provided a powerful and profound insight into this matter by stating that the challenge is to create balance and harmony between the material and non-material dimensions of life, and therefore all the diverse activities and developments in the world and in life. Given the severe imbalances and disharmonies that exist in this area at present as a result of placing a much higher priority on the former dimension compared to the latter dimension, it is clear that this problem can only be resolved and rectified by placing a much higher priority on the development of non-material activities such as the arts, humanities, education, and spirituality going forward into the future. Not only is this the key to coming to grips with many of the world’s most complicated and life-threatening problems and changing directions in the world and in life in the future, but also it is the solution to developing our personalities and lives as balanced and harmonious wholes. This will result in a great deal more caring, sharing, compassion, cooperation, conservation, and creativity in the world, thereby putting us in a much stronger position to come to grips with the problems we will be confronted with in the future, creating more compatible lifestyles and ways of life, achieving sustainable development, and becoming cultural personalities in the realistic and idealistic sense.

The Book of Tribulations: The Syrian Muslim Apocalyptic Tradition'

2017 ◽  
Author(s):  
David Cook ◽  
Nu'aym b. Hammad al-Marwazi
Keyword(s):  
Civil Wars ◽  
The World ◽  
End Of The World ◽  
To Come

“The Book of Tribulations by Nu`aym b. Hammad al-Marwazi (d. 844) is the earliest Muslim apocalyptic work to come down to us. Its contents focus upon the cataclysmic events to happen before the end of the world, the wars against the Byzantines, and the Turks, and the Muslim civil wars. There is extensive material about the Mahdi (messianic figure), the Muslim Antichrist and the return of Jesus, as well as descriptions of Gog and Magog. Much of the material in Nu`aym today is utilized by Salafi-jihadi groups fighting in Syria and Iraq.

LINGUACULTURAL ASPECT OF TEMPORAL NOMINATIONS

2020 ◽  
Vol 2020 (30) ◽  
pp. 200-213
Author(s):  
Anna Shapoval
Keyword(s):  
Sixteenth Century ◽  
Ottoman Empire ◽  
Experimental Analysis ◽  
Information Resource ◽  
Basic System ◽  
Scientific Publications ◽  
Lunar Calendar ◽  
Temporal System ◽  
The World ◽  
To Come

Analysis of linguocultural aspect of temporal nominations is impossible without involving the problems of hrononymic lexics. Chrononyms is an important information resource of a certain linguaculture, some distinctive peculiarities of conceptual picture of the world. The aim of the experimental analysis is a complex examination of the linguacultural aspect of temporal nominations that function in Chinese and Turkish languages reflecting the concepts of the world. The research was based on the material of the novels “Imperial woman” by Pearl Buck and “Roxolana” by Pavlo Zagrebelniy. The analysis of recent scientific publications allowed us to come to the conclusion that the investigation of hrononymic lexics can involve different theoretical and practical principles. Being guided by the existing classifications of chrononyms (N. Podolskaya, M. Torchinsky, S. Remmer) the linguocultural features of the following types of temporal chrononymic lexical units were identified and studied in the research: georthonyms, dynastic chrononyms, tumultonyms, parsonyms and mensonyms. The results of the research demonstrate that not all lexical units of temporal denotation chosen from the above mentioned novels refer to the class of chrononyms. The group under investigation includes the following lexemes: nominations of the lunar calendar, nominations of the solar calendar, nominations of mixed calendar and temporal slots denoting day and night. The basic system of chronology in the linguiacultures under analysis is the dominance of the lunar calendar nominations (Chinese picture of the world — 51,0 %, Turkish — 40,4 %). In the analyzed works the nominations of the solar calendar are used less often in the Chinese picture of the world; the usage of this unit reaches 20 %, and this phenomenon is historically conditioned. Mixed calendar nominations (21 % of temporal units) are rather common, solar calendar nominations are refined by the monthly calendar; it can be explained by the fact that the Chinese mind is conservative towards the new temporal system. In the Turkish picture of the world 45 % of temporal vocabulary belongs to the solar calendar since in the sixteenth century only a lunar calendar operated in the Ottoman Empire. It should be mentioned that significant place in the temporal vocabulary of “Roxolana” is conditioned by the influence of the linguistic personality of the author, who was a Ukrainian.

COMPARATIVE METHOD IN CONSTITUTIONAL LAW: BETWEEN PRESUMPTIONS OF SIMILARITIES AND DIFFERENCES

2019 ◽  
Vol 14 (5) ◽  
pp. 84-113
Author(s):  
ALEXANDRA A. TROITSKAYA
Keyword(s):  
Political Philosophy ◽  
Theoretical Model ◽  
Constitutional Law ◽  
Comparative Method ◽  
Comparative Law ◽  
Middle Level ◽  
Legal Research ◽  
Universal Principles ◽  
The World ◽  
Similarities And Differences

The two main approaches to the use of the comparative method in legal research, functional and cultural, have some "predetermined" considerations regarding the results that will (or should) be discovered by comparing various legal phenomena — should the emphasis be on similarities or differences between these phenomena. These considerations are based on the vision of, respectively, the universal or pluralistic nature of law of various societies, and in fact they are able to correct substantially the process of cognition of legal phenomena using the comparative method, adjusting it to the desired result. In the case of similarities, we can talk about artificially narrowing the circle of countries under investigation. In the case of differences, the isolation of systems and the uniqueness of their cultural characteristics are unreasonably exaggerated. The alternative assumptions presented in the theory of comparative law regarding the existence of universal principles of law or the fundamental uniqueness of each legal system require a critical rethinking of constitutional provisions and practice in comparative studies. The use of the comparative method in constitutional law is not reducible to the implementation of the ideas of political philosophy, and objective conclusions should not be replaced by predetermined normative guidelines. The similarities and differences revealed by the researcher of constitutional ideas, norms and practices can be considered as a result of comparison of independent value.Constitutional law is associated with a variety of substantial constructs existing in the world, not excluding, however, their intercommunication. Understanding these constructions requires attention to both the similarities and the differences in specific legal orders (as well as the reasons for their functioning in this, and not another form). The use of the comparative method in the absence of striving for predetermined results is simultaneously aimed at understanding the laws of development of constitutional institutions and maintaining the horizon of their diversity as an important component of this development. Each time, the researcher should distance himself from his prejudices regarding the similarities or differences between the institutes under study, rechecking whether the obtained results are really the results of applying the comparative method, and not the initial constructions.The logic of a comparative study corresponds to the construction of theories of "middle level", aimed at forming the theoretical model of a particular legal in-stitution, taking into account the practice of implementing this institution in specific states. The focus on middle-level theories within the framework of the comparative method allows one to go beyond the description of single systems, formulate conclusions at the level of generalization that ensure the comparability of the studied objects, and at the same time maintain an understanding of the diversity of constitutional models.

The chronicle of COVID-19: possible strategies to curb the pandemic

2020 ◽  
Vol 27 ◽  
Author(s):  
Rajesh Kumar ◽  
Seetha Harilal ◽  
Abdullah G. Al-Sehemi ◽  
Githa Elizabeth Mathew ◽  
Simone Carradori ◽  
...  
Keyword(s):  
Life Cycle ◽  
Research And Development ◽  
Vaccine Development ◽  
Therapeutic Strategies ◽  
Antiviral Drugs ◽  
Limited Data ◽  
Social Distancing ◽  
The World ◽  
Novel Virus ◽  
Day By Day

: COVID-19, an epidemic that emerged in Wuhan, has become a pandemic affecting worldwide and is in a rapidly evolving condition. Day by day, the confirmed cases and deaths are increasing many folds. SARS-CoV-2 is a novel virus; therefore, limited data are available to curb the disease. Epidemiological approaches, isolation, quarantine, social distancing, lockdown, and curfew are being employed to halt the spread of the disease. Individual and joint efforts all over the world are producing a wealth of data and information which are expected to produce therapeutic strategies against COVID-19. Current research focuses on the utilization of antiviral drugs, repurposing strategies, vaccine development as well as basic to advanced research about the organism and the infection. The review focuses on the life cycle, targets, and possible therapeutic strategies, which can lead to further research and development of COVID-19 therapy.

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