scholarly journals The “Scourge of the Renaissance”. A Short Review About Treponema pallidum infection

2020 ◽  
Vol 20 (3) ◽  
pp. 335-343 ◽  
Author(s):  
Luigi Santacroce ◽  
Lucrezia Bottalico ◽  
Skender Topi ◽  
Francesca Castellaneta ◽  
Ioannis A. Charitos

Background: There is not a time in the history when epidemics did not loom large: infectious diseases have always had civilisation and evolution-altering consequences. Throughout history, there have been a number of pandemics: cholera, bubonic plague, influenza, smallpox are some of the most brutal killers in human history. Historical accounts of pandemics clearly demonstrate that war, unhygienic conditions, social and health inequality create conditions for the transmission of infectious diseases, and existing health disparities can contribute to unequal morbidity and mortality. The Renaissance was a period of European cultural, artistic, political and economic “rebirth” following the Middle Ages, but it was also the time when new infectious disease appeared, such as Syphilis. The epidemic spread of Syphilis began between the late 15th century and early 16th century due to the increased migration of peoples across Europe. The rapid spread of venereal syphilis throughout Europe suggests the introduction of a disease into a population that had not previously been exposed. Syphilis is a type of treponematosis, which includes syphilis, bejel, yaws, and pinta, but, while syphilis is venereal disease, the others are nonvenereal. Syphilis was, at the beginning, a disease of great severity due to its novelty, as the population had no time to gain any immunity against this venereal disease. Methods: The purpose of this study is to investigate the origin of syphilis and the evolution of the treatments from the empiric means to the discovery of penicillin, but also to understand how this venereal disease has largely influenced human lifestyle and evolution. Conclusions: The first of the three hypotheses about its origins is the Columbian hypothesis, which states that Columbus's crew acquired syphilis from Native Americans and carried it back to Europe in 1493 A. D. On the contrary, the second hypothesis (pre-Columbian) asserts that syphilis was present in Europe long before Columbus's voyage and was transferred to the New World by Columbus's men. The Unitarian theory argues that syphilis, bejel, yaws, and pinta are not separate diseases but they represent syndromes caused by slightly different strains of one organism. Nowadays, Syphilis’ origin is still uncertain and remains controversial. However, the large impact on the social behavior and international public health is an important reason to investigate about its origins and how to prevent the transmission.

Author(s):  
Christof Paulus ◽  
Albert Weber

AbstractVenice is considered the best-informed community of the late Middle Ages. The study examines the availability of information for the second half of the 15th century, particularly with regard to the key year 1462/1463, and as a case study concentrates on areas of the supposed Venetian periphery of interest, above all Hungary and the two principalities of Wallachia and Moldavia. The result is a thoroughly differentiated system of information acquisition, verification and control. Means of communication, as well as different areas of interest of the Serenissima, can be identified. A distinction is made between information maps and communication maps. The latter also include the distribution of news from the lagoon city exchanged with foreign envoys. During the period concerned, news was exchanged in an astonishingly liberal way, in turn integrating the Serenissima into the information networks of the other Italian states. The study thus places the „information commodity“ within the research field of late medieval gift exchange and patronage structures. In short, a thoroughly pragmatic Venetian approach to news acquisition and evaluation can be observed. Verification of the quality of the information obtained was subject not least to quantitative and ranking criteria. Ultimately, the informational power of Venice was based above all on its outstanding reputation among its contemporaries.


Author(s):  
David B. Ruderman ◽  
Francesca Bregoli

The term “early modernity” as the name of a period roughly extending from the end of the 15th century to the end of the 18th century has been only recently employed by historians of Jewish culture and society. Despite a plethora of new studies in the last several decades, few attempts have been made to define the period as a whole as a distinct epoch in Jewish history, distinguishable from both the medieval and the modern periods. Some historians have remained indifferent to demarcating the period, have simply designated it as an extension of the Middle Ages, or have labeled it vaguely as a mere transitional stage between medievalism and modernity without properly describing its distinguishing characteristics. A few historians have used the term “Renaissance” to apply to the cultural ambiance of Jews living in Italy in the 15th and 16th centuries alone without delineating the larger period and the more comprehensive geographical area. The bibliographical survey that follows focuses on the entire period of three hundred years and attempts to provide a panoramic view of European and Ottoman Jewries both as distinct subcommunities and in their broader connections with each other.


Author(s):  
Christopher Marlowe A. Caipang

Increasing pace in aquaculture development to meet the growing food requirements of the population has greatly compromised the carrying capacity of the culture environment and has placed the aquacultured animals at heightened risk of getting diseases due to pathogens. At present, chemotherapy is widely used as means to prevent or treat infectious diseases in aquaculture; however, the use of these drugs poses multiple negative impacts on fish and human health, as well as the environment. Recently, research initiatives are focused on the use of plant products and their derivatives as a means of controlling diseases in aquaculture. They are regarded as a promising alternative to the use of chemical treatments for infectious diseases in fish. Plant-derived products or phytogenics have been shown to stimulate appetite and promote weight gain in farmed animals, act as immunostimulants, and possess potent anti-pathogenic properties in fish. Their potency is mediated by the presence of bioactive molecules including alkaloids, terpenoids, saponins, and flavonoids, among others. Moreover, nutritional strategies are geared towards the use of these phytogenics in modulating immune and physiological responses, as well as promoting optimum health and microbial community in the gastrointestinal tract of fish. This review synthesizes the current knowledge on the use of phytogenic feed additives in aquaculture by focusing on how these substances act as modulators of health and bacterial community in the gut of fish.


Author(s):  
Radivoj Radic

In the Middle Ages, people had an ambivalent relationship to the beauty products: some were fully supportive of the attempts to beautify oneself, while the others, first and foremost the representatives of the church, frowned upon this notion. This feature represents a show?case of the advice and recipes for beautification from two medical collections created in the late Middle Ages. These are the Byzantine medical treatise (dating from 11th to 14th century) and the collection of Serbian medieval medicine, the so-called Hodoch Code (dating from the end of the 14th or beginning of the 15th century). The treatise is focusing more on the practical advice than theoretical knowledge, and its greatest part is dedicated to pharmacology. Hodoch Code (Hodoski zbornik) is in fact a therapeutic collection, and it consists of diverse medical texts. These collections contain the advice how to make one?s face white, hair black or blond, but most certainly rich in volume, as well as recipes for treating facial lines, warts, freckles, cracked lips or bad breath.


2021 ◽  
Vol 25 (4) ◽  
pp. 352-365
Author(s):  
Evgeny I. Zelenev ◽  
Milana Iliushina

This article is devoted to the study of the development of the theory and practice of jihad during the rule of the Circassian sultans in Egypt and Syria (1382–1517). The purpose of the study is to trace the development of key aspects of jihad, to identify features of its perception in the Mamluk state. An essential feature of the theory of jihad in the Mamluk period is the interpretation of jihad as farḍ al-ʿayn (the individual duty of every Muslim). While studying the theory of jihad, the authors rely on a holistic and balanced approach justified in the papers of M. Bonner and D. Cook and their interpretation of the concept of jihad, which has a centuries-old history of development and a sophisticated, multi-layered set of meanings. Another methodological basis of the present paper was the concept of minimalism and maximalism, developed by Yusef Waghid. The source base for the study of jihad theory is the works of Ibn al-Nahhas (d. 1411), a prominent philosopher of the Mamluk era. The interpretation of jihad as an individual duty of every Muslim, substantiated by Ibn al-Nahhas, was the foundation of the volunteer movement that developed in Egypt and Syria in the 15th century. The doctrine of jihad where the concepts of justice (al-‘adl) and truth (al-ḥaqq) play a key role, was used by the Mamluks and then by the Ottomans as a powerful ideological tool to manipulate the minds of Muslims. The relevance of the study is that the findings are not only true for the Middle Ages but are directly related to the present.


Author(s):  
Pavlo Nechytaylo ◽  
◽  
Olena Onohda ◽  
◽  
◽  
...  

The paper analyses ceramics and buildings remains of the second half 13th – first half 15th centuries, coming from excavations in Kamianets-Podilskyi. It aims to introduce materials into scientific circulation, to compare the collection with synchronous objects from adjacent territories, to trace interactions in the material culture development in late medieval towns. Ceramics of the Golden Horde and the Grand Duchy of Lithuania times began to be systematically researched relatively recently in Ukraine. Thus, the materials from Kamianets-Podilskyi contribute to deepening our knowledge of less-known periods in the history of Ukraine and Eastern Europe. Materials analyzed were obtained during rescue archaeological research on the Polish Market square in Kamianets. These were fragmented parts of underground and aboveground building structures, as well as a collection of various household items. Building materials were mostly local clays and loam, less often wood and stone were used. A set of clay ‘roll’ blocks set in one of the pits allows us to assume similarity with the Golden Horde building technologies. Finds of coins and Crimean polychrome bowls fragments also indicate the complex emerged during the Golden Horde period. However, certain groups of pottery and coins of European minting define the complex upper date within the first half 15th century. Diverse ceramic types range from the complex is an interesting local typological phenomenon. It reflects mutual influences of the pottery traditions development both in time and space. After processing artefacts collection, the main groups of pottery were identified according to technological features. Some of them are rooted in the local ancient Rus’ traditions, others were formed under the influence of Western trends, while samples of a ‘specific’ group were common for almost the entire territory of modern Ukraine during Late Middle Ages. Pots collection was preliminary systematized up to 5 most common types selection, based on rim profiles. Many of them have a wide range of analogies, locally from Kamianets, as well as from the Western Ukraine, in Poland, Moldova and Romania. In addition to pots, the collection includes other types of kitchen and tableware, such as makitras, lids, jars and other single samples of ceramics. The typological diversity correlates with the multi-layered processes which took place in Kamianets-Podilskyi life during the Golden Horde and the Lithuanian periods. Materials from the complex, as well as other finds from synchronous objects within the city, deepen our understanding of the city’s development large-scale picture, which, however, requires further research.


2020 ◽  
Vol 66 (6) ◽  
pp. 583-588
Author(s):  
Maxson Lifigao ◽  
Titus Nasi ◽  
Carol Titiulu ◽  
Steven Lumasa ◽  
Trevor Duke

Abstract Introduction Congenital syphilis remains a significant cause of newborn mortality and long-term neurodevelopmental problems in some low- and middle-income countries. This study was done in Honiara, Solomon Islands to determine the incidence of babies born to mothers with a positive venereal disease research laboratory (VDRL) test and a positive Treponema pallidum haemagglutination assay (TPHA); to determine the VDRL status of newborns and features of congenital syphilis; and to estimate the proportion of stillbirths associated with syphilis. Methodology All neonates born to VDRL-positive mothers, including stillbirths were included between April and July 2019. Neonates were examined, investigated and treated. Results Among 1534 consecutive births, 1469 were live births and 65 (4.2%) were stillbirths. One hundred and forty-three neonates were born to VDRL-positive mothers: 130 (90.1%) were live infants and 13 (8.9%) stillbirths. Of the 130 VDRL-exposed live-born infants, 72 (55%) had reactive VDRL and a positive TPHA and 7 (9.7%) had clinical signs of congenital syphilis. Five of the infants with clinical signs of syphilis infection had a 4-fold higher VDRL titre than their mother. Four infants of VDRL-positive mothers died during admission, all of whom had clinical signs of syphilis. Ninety percent of affected infants were born to mothers who were not treated or only partially treated during pregnancy. Conclusions In this study, 1:210 live-born babies had clinical and serological evidence of congenital syphilis, and evidence of Treponema infection was found disproportionately in stillbirths. In a setting where Treponema infections are common, an empirical approach to prevention may be needed.


1991 ◽  
Vol 69 (3) ◽  
pp. 906-906
Author(s):  
Thomas J. Young

An analysis of secondary data yielded no significant ecological correlations for venereal disease rates and aggression management indices based on suicide and homicide rates for the 11 US Indian Health Services areas. This outcome does not cross-culturally replicate research on Field's aggression management hypothesis.


2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Leibovici Vera ◽  
Donchin Milka ◽  
Strauss-Liviatan Nurith ◽  
Shinar Eilat

Data of 1,290,222 volunteer blood donors, in a 5-year period, was analyzed for prevalence and incidence of syphilis. Subsequent testing of donations positive in Treponema pallidum hemagglutination assay included Venereal Disease Research Laboratory and fluorescent Treponemal antibody absorption. Stepwise logistic regression model was used to identify positive syphilis serology. Prevalence of syphilis was 47 : 100,000, similar in men and women and increased significantly with age (P<0.001). Native Israelis had the lowest prevalence rate of syphilis (21 : 100,000), while a significantly higher prevalence was found among immigrants from Africa, Eastern Europe, and South America (odds ratios of 19.0, 10.8, and 7.3, resp., P<0.001 for each). About 33.2% of the seropositive donors had evidence of recent infection, and 66.8% had past infections. Incidence rate reached 8 : 100,000 person-years. Coinfection with HIV, HCV, and HBV was calculated as 8%, 1.88%, and 0.37% for positive donations, respectively. The data support the need to continue screening blood donors in Israel for syphilis and employ preventive measures to populations at risk, in order to improve public health, blood safety, and quality. A subsequent study to assess blood donors’ knowledge, attitude, and behavior is planned. In times of global migration this information may be useful to blood services worldwide.


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