scholarly journals Transcutaneous Treatment with Vetdrop® Sustains the Adjacent Cartilage in a Microfracturing Joint Defect Model in Sheep

2013 ◽  
Vol 7 (1) ◽  
pp. 57-66 ◽  
Author(s):  
M Sidler ◽  
N Fouché ◽  
I Meth ◽  
F von Hahn ◽  
B von Rechenberg ◽  
...  
Keyword(s):  
Cartilage Defect ◽  
Femoral Condyle ◽  
Cartilage Damage ◽  
Recovery Period ◽  
Scoring Systems ◽  
Defect Model ◽  
Medial Condyle ◽  
Stifle Joint ◽  
The Right ◽  
Adjacent Cartilage

The significance of the adjacent cartilage in cartilage defect healing is not yet completely understood. Furthermore, it is unknown if the adjacent cartilage can somehow be influenced into responding after cartilage damage. The present study was undertaken to investigate whether the adjacent cartilage can be better sustained after microfracturing in a cartilage defect model in the stifle joint of sheep using a transcutaneous treatment concept (Vetdrop®). Carprofen and chito-oligosaccharids were added either as single components or as a mixture to a vehicle suspension consisting of a herbal carrier oil in a water-in-oil phase. This mixture was administered onto the skin with the aid of a specific applicator during 6 weeks in 28 sheep, allocated into 6 different groups, that underwent microfracturing surgery either on the left or the right medial femoral condyle. Two groups served as control and were either treated intravenously or sham treated with oxygen only. Sheep were sacrificed and their medial condyle histologically evaluated qualitatively and semi-quantitatively according to 4 different scoring systems (Mankin, ICRS, Little and O’Driscoll). The adjacent cartilage of animals of group 4 treated transcutaneously with vehicle, chito-oligosaccharids and carprofen had better histological scores compared to all the other groups (Mankin 3.3±0.8, ICRS 15.7±0.7, Little 9.0±1.4). Complete defect filling was absent from the transcutaneous treatment groups. The experiment suggests that the adjacent cartilage is susceptible to treatment and that the combination of vehicle, chitooligosaccharids and carprofen may sustain the adjacent cartilage during the recovery period.

scholarly journals The incidence of medial plica in the knees operated on because of reasons other than the medial plica alone and the cartilage damages caused by it

2017 ◽  
Vol 5 (2_suppl2) ◽  
pp. 2325967117S0004
Author(s):  
Hasan Bombaci ◽  
Suavi Aydoğmuş ◽  
Tolga Keçeci ◽  
Çağdaş Deniz Gündüz
Keyword(s):  
English Literature ◽  
Femoral Condyle ◽  
Cartilage Damage ◽  
Medial Femoral Condyle ◽  
Meniscus Tear ◽  
Type I ◽  
Medial Condyle ◽  
Medial Side ◽  
Medial Plica ◽  
Flexion Extension

Introduction: The aim of this study is to analyse the incidence of medial plica (MP) and the damage which has been caused on the medial femoral condyle in the 700 knee of 651 patients who were operated on because of the complaints resulting from intra-articular pathologies unrelated to the MP in particular. Patients and Methods: Medial plicas were detected in the 65 of 700 knees operated on consecutively because of the complaint of pain or catching in the knee. The mean age of 34 male and 28 female patients was 46 (range; 16-82). In 25 knees the lesions were in the right, 34 patients in the left side and in three patients, bilateral. The MP was classified according to the Sakakibara classification, the lesion caused by the MP on the medial femoral condyle, according to the Outerbridge classification. All medial plicas were excised arthroscopically. Results: Medial plicas were classified as type B in eight knees, type C in 52 and type D in five according to the Sakakibara classification. The cartilage lesion related to the MP were classified as type I in 12 knees, type II in 20 and type III in 24 according to the Outerbridge classification. There were no lesions present in nine knees. Discussion and Conclusion: Although the incidence of MP is much higher, the incidence of “MP syndrome” has been reported as 3.8% to 5.5% in the English literature. In the present study, we found that the incidence of MP was 9.28% associated with the rate of 86% type I-III cartilage damage related to the MP itself. Although the symptoms of MP are not specific, there may be some tenderness between the medial condyle and inferior-medial edge of patella. Furthermore a thickened cord-like plica can be palpated at the medial side of the patella, with crepitus or popping sensation during flexion –extension movement of the knee. If the patients suffer from meniscus tear or chondromalasia which affects at least two compartments of the knee, the symptoms of MP cannot be apparent primarily. These findings show that MP is quite significantly associated with other intra-articular pathologies in the knee. However, the common symptoms of MP with the long lasting pathologies in the knee (i.e chondromalasia unrelated to MP) can prevent early diagnosis which would prevent irreversible chondral pathologies developing at a later stage.

scholarly journals An investigation of the effects of melatonin administration on biochemical parameters in rats with experimental cartilage damage

2021 ◽  
Vol 8 (4) ◽  
pp. 203-207
Author(s):  
Kadri Yıldız ◽  
Veysel Tahiroğlu ◽  
Fatih Boy ◽  
Seher Koç ◽  
Vahit Yıldız ◽  
...  
Keyword(s):  
Femoral Condyle ◽  
Cartilage Damage ◽  
Antioxidant Properties ◽  
Sprague Dawley ◽  
Biochemical Tests ◽  
Group I ◽  
Turnover Markers ◽  
Group 2 ◽  
The Right ◽  
Group 1

Objective:  This study was intended to show the effects of melatonin (MEL) in the treatment of cartilage damage in a rat model as a novel field of application. Materials and Methods: Male Sprague Dawley rats aged 3-4 months were assigned into four groups of six rats each. Group I represented the sham group. In groups 2, 3, and 4, the right knee medial meniscus was surgically destabilized. MEL was administered to groups 3 and 4 twice a week at dosages of 0.4 μg/ml and 4 μg/ml, respectively. The application continued for four weeks. Histological examinations, imaging studies [computed tomography and magnetic resonance imaging], and biochemical tests [cartilage and bone turnover markers (COMP and CTX-I)] were performed. Results: The application of MEL initiated regeneration in the damaged areas. However, cartilage repair was not observed in areas with experimental cartilage damage without MEL application. MEL-treated rats had higher T2 scores compared to Group 1 in the median femoral condyle at the 12th week (p<0.05). Serum COMP and CTX-I levels at 12 weeks were significantly higher in Group 2 compared to Group 1 (p<0.05). Serum COMP and CTX-I levels at 12 weeks were lower in groups 3 and 4, but were also significantly higher than in Group 1 (p<0.05). Conclusion: We recommend MEL therapy for diseases related to cartilage damage. MEL seems to exert its therapeutic effect on cartilage damage through its antioxidant properties.

Isolated Lateral Meniscal Tear in the Dog

1988 ◽  
Vol 01 (03/04) ◽  
pp. 152-154
Author(s):  
S. Johnson ◽  
D. Hulse
Keyword(s):  
External Rotation ◽  
Femoral Condyle ◽  
Meniscal Tear ◽  
Lateral Meniscus ◽  
Surgical Excision ◽  
Human Beings ◽  
Stifle Joint ◽  
Microscopic Pathology ◽  
Bucket Handle Tear ◽  
Bucket Handle

degenerative changes of the involved stifle joint associated with a “bucket handle” tear of the caudal body of the lateral meniscus. Surgical excision of the torn section of meniscus was beneficial in the first patient but this patient had persistant difficulty with the leg after exercise. Gross and microscopic pathology of the involved stifle in the second patient showed the meniscal lesion to be associated with severe cartilage fibrillation of the overlying lateral femoral condyle. As in human beings, the mechanism of injury may have been placement of the foot during vigorous external rotation of the femur with the stifle flexed. Extension of the limb from this position could have resulted in an isolated tear of the lateral meniscus.

scholarly journals Comparative Morphological Studies of the Stifle Menisci in Donkeys, Goats and Dogs

2019 ◽  
Vol 36 (02) ◽  
pp. 072-084 ◽  
Author(s):  
Mohamed M.A. Abumandour ◽  
Naglaa Fathi Bassuoni ◽  
Samir El-Gendy ◽  
Ashraf Karkoura ◽  
Raafat El-Bakary
Keyword(s):  
Computed Tomography ◽  
Cross Sections ◽  
Medial Meniscus ◽  
Lateral Meniscus ◽  
Current Work ◽  
Medial Condyle ◽  
Morphological Studies ◽  
Stifle Joint ◽  
Meniscofemoral Ligament ◽  
Anatomical Information

AbstractThe present work aims to provide more anatomical information on the stifle joint of the investigated species using computed tomography with gross anatomical cross-sections. The current work analyzed the stifle joint of the pelvic limbs of 12 adult donkeys, goats and dogs of both genders. The medial condyle of the femur was larger than the lateral one in the donkey, while it was smaller and lower than the lateral one in the goat and in the dog. The unsuitable femoral and tibial condyles were adapted by the presence of menisci. In the donkey, the medial meniscus was crescentic in shape, but it was semicircular in the goat, while in the dog, the medial and lateral menisci were C-shaped. In the donkey, the medial meniscus was larger than the lateral one, but in the goat and in the dog, the lateral meniscus was the largest, and more concave and thicker. The lateral meniscus was semicircular in the donkey, but it was shaped like an elongated kidney in the goat. In the goat and in the dog, the central border of two menisci was thin, concave and notched centrally. The meniscal ligaments included cranial and caudal ligaments of the medial and lateral menisci, and meniscofemoral ligament of the lateral meniscus. In the dog, the cranial ligament of the medial meniscus was absent, and the medial meniscus had no bony attachment to the tibia but it attached to the transverse intermeniscal ligament, which connected the cranial horn of the medial meniscus with the cranial ligament of the lateral meniscus. The meniscofemoral ligament connected the caudal pole of the lateral meniscus with the intercondyloid fossa of the femur.

scholarly journals Arthroscopic Articular Cartilage Scores of the Canine Stifle Joint with Naturally Occurring Cranial Cruciate Ligament Disease

2020 ◽  
Author(s):  
Kimberly A. Agnello ◽  
Kei Hayashi ◽  
Dorothy Cimino Brown
Keyword(s):  
Articular Cartilage ◽  
Cruciate Ligament ◽  
Cartilage Damage ◽  
Meniscal Tear ◽  
Trochlear Groove ◽  
Cranial Cruciate Ligament ◽  
Stifle Joint ◽  
Naturally Occurring ◽  
Medial Meniscal Tear ◽  
Severity Scores

Abstract Objective This study aimed to evaluate frequency, location and severity of cartilage pathology in dogs with naturally occurring cranial cruciate ligament (CCL) disease. Study Design Stifle arthroscopic video recordings (n = 120) were reviewed. A modified Outerbridge classification system (MOCS) (0–4) was used to score cartilage at 10 locations in the femorotibial (medial and lateral femoral condyles and tibial plateaus) and patellofemoral compartments (proximal, middle and distal locations of the patella and femoral trochlear groove) of the stifle joint. Synovial pathology was scored and the presence of a medial meniscal tear was recorded. A Kruskal–Wallis test was used to evaluate association of location and synovitis with cartilage score; and presence of meniscal tear with cartilage and synovitis scores. Bonferroni correction was utilized and p < 0.05 was considered significant. Results Cartilage pathology and synovitis were identified in all joints. Overall cartilage severity scores were low (median MOCS 1). The median MOCS of the proximal trochlear groove (2) was significantly higher than all other locations evaluated. Higher synovitis scores were significantly associated with higher cartilage severity scores and a medial meniscal tear had no association with cartilage severity scores or synovitis. Conclusion Arthroscopic articular cartilage lesions are common in dogs with CCL disease at the time of surgical intervention, although the severity of cartilage damage is mild. The proximal trochlear groove of the femur had the most severe cartilage score in the stifle joint.

scholarly journals Dangguijihwang-tang and Dangguijakyak-san Prevent Menopausal Symptoms and Dangguijihwang-tang Prevents Articular Cartilage Deterioration in Ovariectomized Obese Rats with Monoiodoacetate-Induced Osteoarthritis

2017 ◽  
Vol 2017 ◽  
pp. 1-15
Author(s):  
Hye Won Lee ◽  
Byung-Seob Ko ◽  
Suna Kang ◽  
Jin Ah Ryuk ◽  
Min Joo Kim ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Articular Cartilage ◽  
Normal Control ◽  
Inflammatory Diseases ◽  
Cartilage Damage ◽  
Positive Control ◽  
Postmenopausal Symptoms ◽  
Ovx Rats ◽  
Control Versus ◽  
The Right

We investigated whether dangguijakyak-san (DJY) and dangguijihwang-tang (DJH), oriental medicines traditionally used for inflammatory diseases, could prevent and/or delay the progression of postmenopausal symptoms and osteoarthritis in osteoarthritis-induced estrogen-deficient rats. Treated ovariectomized (OVX) rats consumed either 1% DJY or 1% DJH in the diets. Positive-control rats were given 30 μg/kg bw 17β-estradiol and control rats were given 1% fat as were the normal-control rats. All rats received high-fat diets for 8 weeks. At the 9th week, OVX rats received articular injections of monoiodoacetate (MIA) or saline (normal control) into the right knee. At 3 weeks after MIA injection, DJY reduced visceral-fat mass and improved glucose metabolism by reducing insulin resistance, whereas DJH increased BMD and decreased insulin resistance. DJH improved weight distribution in the right knee and maximum running velocity on a treadmill at days 14 and 21 as much as those of the positive control. TNF-α, IL-1β, and IL-6 levels in articular cartilage were much higher in the control than the positive control, whereas both DJY and DJH reduced the levels to those of the positive control. The histological analysis assessed articular cartilage damage near the tidemark and proteoglycan loss in the control versus the positive control; DJY and DJH prevented this damage and proteoglycan loss. In conclusion, DJY may provide an effective treatment for improving glucose tolerance, and DJH may be appropriate for preventing osteoarthritis.

Canine Synovial Sarcoma of the Stifle Joint with Pulmonary and Liver Metastases

2021 ◽  
Vol 38 ◽  
pp. 6-12
Author(s):  
R.J. Samson ◽  
F.H. Mpagike ◽  
A.K. Felix ◽  
A.B. Matondo ◽  
M. Makungu
Keyword(s):  
Soft Tissue ◽  
Lung Metastases ◽  
Synovial Cell ◽  
Proximal Region ◽  
Radiographic Examination ◽  
Tissue Samples ◽  
Stifle Joint ◽  
Mongrel Dog ◽  
Biopsy Examination ◽  
The Right

A seven-year-old female mongrel dog was presented at the Sokoine University of Agriculture Teaching Animal Hospital for second opinion regarding a progressive swelling of the right hind limb of two months duration. Clinical examination revealed a loss of body condition, tachypnea and tachycardia, a painful immobile solid mass of 20 cm x 14 cm x 10 cm located on the right stifle joint, leucocytosis, and anaemia. Radiographic examination of the joint revealed marked soft tissue swelling with amorphous areas of mineralization and complete destruction of the proximal tibia. Smooth and solid periosteal reaction was seen around the tibia and fibula with a Codman’s triangle. Multiple nodules and a mass with soft tissue opacity were seen in the lung fields. Post-mortem examination revealed separation of tibia and fibula, softening of the proximal parts of the tibia, and complete integration of the proximal region of the two bones and articular tissues into the surrounding muscular tissues. Multifocal nodular lesions of variable sizes were mostly found in the lungs and partly in the liver. Histologically, predominantly oval and round cells with variable nuclear sizes and moderate mitoses were observed in tissue samples from the joint, lungs and the liver although some parts of the lung metastases showed both round and spindle shaped tumor cells. Clinical profile is suggestive of aggressive biphasic (spindle and epithelial) type of synovial cell sarcoma with lung and liver metastasis. Early radiographic and biopsy examination of persistent musculoskeletal nodules is recommended for early diagnosis and interventions.

scholarly journals Particulated Juvenile Articular Cartilage (PJAC) Allograft for Treatment of Lateral Femoral Condyle defect in High-Performance Athletes

2018 ◽  
Vol 6 (6_suppl3) ◽  
pp. 2325967118S0005 ◽  
Author(s):  
Gabriella Bucci ◽  
Michael Begg ◽  
Kevin Pillifant ◽  
Steven B Singleton
Keyword(s):  
Articular Cartilage ◽  
Cartilage Defect ◽  
High Performance ◽  
Femoral Condyle ◽  
Cartilage Lesion ◽  
Lateral Femoral Condyle ◽  
High Grade ◽  
Chondral Defect ◽  
Short Term ◽  
High Level

Background: A relatively new technology for the treatment of high grade articular cartilage lesions is the implantation of particulated articular cartilage obtained from a juvenile allograft donor (PJAC).1-2 Previous studies have reported the ability of juvenile chondrocytes to migrate from cartilage explants after being secured in a cartilage defect.3 There is little in the literature to use as a reference with respect to the use of PJAC for high grade articular cartilage lesion of the lateral femoral condyle after a failure of treatment with a microfracture in the high level athlete. Objective: The aim of this report is to describe the technique of PJAC transplantation for the treatment of chondral lesions of the lateral femoral condyle and to report the short term outcomes in the high performance athlete. Methods: We present a case report of two patients who were treated in our clinic in December 2014. Case 1: 16 year old female Division 1 university soccer player, who one year prior to our index surgery underwent microfractures of a symptomatic lateral femoral condyle articular cartilage lesion without relief. Cae 2: 29 year old male professional tennis player (case 2) with a recurrent, symptomatic chondral defect on the lateral femoral condyle. The player had undergone multiple arthroscopic procedures on the same knee following an injury sustained while playing in the Australian Open, including a surgery 8 months prior to our index operation that had included lateral meniscal tear repair and microfractures. PJAC procedure consists of a minimal debridement and chondroplasty, performed arthroscopically. For these central lateral femoral condyle lesions, a mini-arthrotomy is created along the lateral parapatellar longitudinal axis over a length of about 3 cm. With the chondral defect localized and prepared, a thin fresh layer of fibrin glue is then applied. The PJAC graft is equally distributed in the defect with space in between the fragments so as not over-fill the defect. Then, a new fibrin glue layer is placed to cover the graft. The overall construct remains just below the level of the normal articular surface. The knee is cycled through the range of motion to ensure that the tissue construct is stable. We present images of the cartilage defect after debridement and the allograft implantation procedure. In addition we will submit an instructional video performed on a knee specimen. Results: Outcomes measured were: IKDC, Lysholm, and Tegner knee scores together with arc of motion of the joint. After 28 months follow up, patients had gained complete range of motion and significantly decreased pain. Improvement for each outcome measure used is reported. Conclusions: PJAC transplantation offers pain relief and improved short term outcomes in high level performance athletes. Both of our patients are back to practicing their sport with notable improvement in symptoms. No complications have been noted. Long-term data is not yet available. References: Am J Farr J, Tabet SK, Margerrison E, Cole BJ. Clinical, Radiographic, and Histological Outcomes After Cartilage Repair With Particulated Juvenile Articular Cartilage: A 2-Year Prospective Study. Sports Med. 2014 Jun;42(6):1417-25. Saltzman BM, Lin J, Lee S. Particulated Juvenile Articular Cartilage Allograft Transplantation for Osteochondral Talar Lesions. Cartilage. 2017 Jan;8(1):61-72. Arshi A, Wang D, Jones KJ. Combined Particulated Juvenile Cartilage Allograft Transplantation and Medial Patellofemoral Ligament Reconstruction for Symptomatic Chondral Defects in the Setting of Recurrent Patellar Instability. Arthrosc Tech. 2016 Oct 10;5(5)

scholarly journals Case Report of a Medial Femoral Condyle Fracture in a Unicompartmental Oxford Knee Replacement Surgery

2019 ◽  
Vol 2 (1) ◽  
Keyword(s):  
Femoral Condyle ◽  
Intraoperative Complications ◽  
Weight Bearing ◽  
Full Range ◽  
Postoperative Rehabilitation ◽  
Medial Condyle ◽  
Case Presentation ◽  
Replacement Surgery ◽  
Stable Osteosynthesis ◽  
Condyle Fracture

Introduction: The unicompartmental Oxford prosthesis has been used as a goodalternative for medial unicompartmental osteoarthritis because it is associated with earlyrehabilitation and a low rate of intraoperative complications. This case describes a rarecomplication during the procedure. Case Presentation: We present an intraoperative fracture of the medial condyle in a 70-year-old woman that was treated with 6.5 mm cannulated screws with a compressiontechnique. The patient remained in a non-weight bearing protocol for 6 weeks andreached a full range of mobility at 3 months. Complete radiological consolidation and agood functional outcome were observed. Conclusion: Intraoperative fractures benefit from a stable osteosynthesis that allows freerange of mobility and does not delay postoperative rehabilitation.

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