The Curcumin and Gingerol Combination as an Immune Regulator and Anti-Inflammatory Agent of SARS-CoV Infection According to a Nutrigenomic Approach: A Mini-Review

2021 ◽  
Vol 11 ◽  
Author(s):  
Ketut Agus Adrianta ◽  
I Gede Bayu Somantara
Keyword(s):  
Healing Process ◽  
Relevant Information ◽  
Synergistic Activity ◽  
Literature Study ◽  
Necrosis Factor Alpha ◽  
Inflammatory Agent ◽  
Qualitative Descriptive ◽  
Anti Inflammatory ◽  
Endogenous Antioxidant ◽  
Online Library

Introduction: The COVID-19 pathophysiology caused by SARS-Cov-2 is closely related to immunoregulation and process of inflammation. There are therapeutic targets in both, which are ideal for the healing process of infected patients. Phytonutrients are closely related to nutrigenomics. Curcumin and gingerol are two types of phytonutrients that have been studied, researched, and developed as therapeutic agents for diseases. Objective: This study aimed to examine the potential of curcumin and gingerol as immune regulators and anti-inflammatory agents in SARS-CoV-2 infections using a nutrigenomic approach. Methods: This article uses the literature study method. Relevant information was gathered from scientific engines and databases (Google Scholar, Elsevier, Science Direct, Scopus, Wiley Online Library, PubMed) published 2010-2021, the data were analyzed by deductive qualitative descriptive technique. Result and Discussion: Curcumin in turmeric and gingerol in ginger has the potential to be used as a therapy for COVID-19 as it could be an immune regulator and anti-inflammatory agent for SARS-CoV-2 infection. Curcumin and gingerol can act as primary and secondary antioxidants that can activate endogenous antioxidant enzymes, regulate cell signaling related to immunity such as interferons, nuclear factor-kappa beta, nitric oxide, and tumor necrosis factor-alpha, as well as stimulate anti-inflammatory and pro-inflammatory cytokine homeostasis, especially interleukins (IL-1β, IL-6, IL-17, IL-8). In silico, these two compounds were also proven to have potential as SARS-CoV-2 antivirals by acting as viral protease inhibitors. Conlclusion: The combination of curcumin and gingerol showed synergistic activity with increasing antioxidant and anti-inflammatory capacities. Thus, it has great potential for use in COVID-19 therapy.

scholarly journals Synthesis of N,N′-bis(1,5-dimethyl-2-phenyl-1,2-dihydro-3-oxopyrazol-4-yl) sebacamide that ameliorate osteoarthritis symptoms and improve bone marrow matrix structure and cartilage alterations induced by monoiodoacetate in the rat model: “Suggested potent anti-inflammatory agent against COVID-19”

2020 ◽  
pp. 096032712094577
Author(s):  
MS Refat ◽  
RZ Hamza ◽  
AMA Adam ◽  
HA Saad ◽  
AA Gobouri ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Male Rats ◽  
Albino Rats ◽  
The Novel ◽  
Gene Expressions ◽  
Electron Microscopic ◽  
Necrosis Factor Alpha ◽  
Blood Indices ◽  
Inflammatory Agent ◽  
Anti Inflammatory

To assess the chondroprotective effect and influence of N, N′-bis(1,5-dimethyl-2-phenyl-1,2-dihydro-3-oxopyrazol-4-yl) sebacamide (dpdo) that was synthesized through the reaction of phenazone with sebacoyl chloride and screened for its biological activity especially as anti-arthritic and anti-inflammatory agent in a monoiodoacetate (MA)-induced experimental osteoarthritis (OA) model. Thirty male albino rats weighing “190–200 g” were divided randomly into three groups (10 each): control, MA-induced OA, and MA-induced OA + dpdo. In MA-induced OA rat, the tumor necrosis factor alpha, interleukin 6, C-reactive protein, rheumatoid factors, reactive oxygen species, as well as all the mitochondrial markers such as mitochondria membrane potential, swelling mitochondria, cytochrome c oxidase (complex IV), and serum oxidative/antioxidant status (malondialdehyde level and activities of myeloperoxidase and xanthine oxidase) are elevated. Also, the activity of succinate dehydrogenase (complex II), levels of ATP, the level of glutathione (GSH), and thiol were markedly diminished in the MA-induced OA group compared to the normal control rats. These findings showed that mitochondrial function is associated with OA pathophysiological alterations and high gene expressions of (IL-6, TNF-a, and IL-1b) and suggests a promising use of dpdo as potential ameliorative agents in the animal model of OA and could act as anti-inflammatory agent in case of severe infection with COVID-19. It is clearly appeared in improving the bone cortex and bone marrow in the treated group with the novel compound in histological and transmission electron microscopic sections which is a very important issue today in fighting severe infections that have significant effects on the blood indices and declining of blood corpuscles like COVID-19, in addition to declining the genotoxicity and inflammation induced by MA in male rats. The novel synthesized compound was highly effective in improving all the above mentioned parameters.

scholarly journals In Vitro Evaluation of Antioxidant, Anti-Inflammatory, Antimicrobial and Wound Healing Potential of Thymus Sipyleus Boiss. Subsp. Rosulans (Borbas) Jalas

Molecules ◽  
2019 ◽  
Vol 24 (18) ◽  
pp. 3353 ◽  
Author(s):  
Oya Ustuner ◽  
Ceren Anlas ◽  
Tulay Bakirel ◽  
Fulya Ustun-Alkan ◽  
Belgi Diren Sigirci ◽  
...  
Keyword(s):  
Wound Healing ◽  
Healing Process ◽  
Folk Medicine ◽  
Traditional Use ◽  
Necrosis Factor Alpha ◽  
Treatment Protocols ◽  
Fibroblast Migration ◽  
Anti Inflammatory ◽  
Treatment Of Wounds

Thymus sipyleus Boiss. subsp. rosulans (Borbas) Jalas (TS) is a commonly used plant in the treatment of various complaints, including skin wounds in Turkish folk medicine. Despite the widespread traditional use of TS, there is not any scientific report confirming the effectiveness of this plant on the healing process. This research aimed to investigate the effects of different extracts obtained from TS on biological events during wound healing, on a cellular basis. In this context, proliferative activities of the extracts, as well as the effects on wound closure and hydroxyproline synthesis, were determined. In addition to wound healing properties, the antioxidant, antibacterial and anti-inflammatory activities of the extracts were evaluated. Decoction (D) and infusion (I) extracts contained the highest amount of phenolic content and showed the most potent activity against DPPH radical. All extracts exhibited complete protection against the damage induced by hydrogen peroxide (H2O2) by increasing cell viability compared to only H2O2-treated groups, both in co-treatment and pre-treatment protocols. None of the extracts exhibited cytotoxic activity, and most of the extracts from the TS stimulated fibroblast proliferation and migration. All TS extracts exert anti-inflammatory activity by suppressing the overproduction of tumor necrosis factor-alpha (TNF-α) and nitric oxide (NO). The most pronounced activity on hydroxyproline synthesis was observed in D extract. In summary, it was observed that TS extracts can promote the healing process by enhancing fibroblast migration, proliferation and collagen synthesis as well as suppressing pro-inflammatory cytokines. The obtained data in this work support the traditional use of TS as a valuable plant-based compound for the treatment of wounds.

scholarly journals Pengaruh Pemberian Madu terhadap Perbaikan Kerusakan Mukosa Gaster dan Penyembuhan Luka pada Penderita Ulkus Peptikum

2021 ◽  
Vol 3 (1) ◽  
pp. 61-67
Author(s):  
Clarisa Rahmah
Keyword(s):  
Wound Healing ◽  
Helicobacter Pylori ◽  
Peptic Ulcer ◽  
Gastric Mucosa ◽  
Healing Process ◽  
Gastric Ulcers ◽  
Wound Healing Process ◽  
Peptic Ulcers ◽  
Literature Study ◽  
Anti Inflammatory

Background: Peptic ulcer is one of the diseases that many people experience in digestive tract disorders. Peptic ulcers occur due to excessive secretion of gastric acid (HCl) and pepsin by the gastric mucosa. Objectives: This discussion aims to determine the gastroprotector effect of honey on peptic ulcer healing. Methods: The method used is literature study from national and international journals by summarizing the discussion presented in the article. Discussion: The incidence of gastric ulcers commonly occurs due to because of Helicobacter pylori infection with increased mortality in older people with the use of Anti-Inflammatory Steroids (NSAIDs). Treatment and prevention of disease using traditional medicine that is widely reused, one of which is honey. Honey contains more than 200 compounds that are useful in the wound healing process such as anti-inflammatory, antibacterial, antioxidant, tissue stimulation, retaining moisture, and healing wound healing activities. Conclusion: Honey has a gastroprotective effect on the irritated stomach until the ulcer acts as an antibiotic, balancing gastric pH, and as an inducer of epithelialization of the gastric mucosa. Keywords: gastric, honey, mucosal repair, peptic ulcer, wound healing   Latar Belakang: Ulkus peptikum merupakan salah satu penyakit yang banyak dialami masyarakat dalam gangguan saluran pencernaan. Ulkus peptikum terjadi karena sekresi asam lambung (HCl) dan pepsin berlebih oleh mukosa lambung. Tujuan: Pembahasan ini bertujuan untuk mengetahui efek gastroprotektor pada madu terhadap penyembuhan ulkus peptikum. Metode: Metode yang digunakan studi literatur dari jurnal nasional dan internasional dengan merangkum pembahasan yang disajikan dalam artikel. Pembahasan: Insidensi tukak lambung banyak terjadi karena adanya infeksi Helicobacter pylori yang angka mortalitasnya meningkat pada orang tua dengan penggunaan Obat Anti Inflamasi Steroid (OAINS). Pengobatan dan pencegahan penyakit dengan obat tradisional/ herbal banyak digunakan kembali, salah satunya madu. Madu mengandung lebih dari 200 senyawa yang bermanfaat dalam proses penyembuhan luka seperti aktivitas antiinflamasi, antibakterial, antioksidan, stimulasi pengangkatan jaringan, mempertahankan kelembapan, dan mempercepat penyembuhan luka. Kesimpulan: Madu memiliki efek gastroprotektor pada mukosa gaster yang mengalami iritasi hingga ulkus berperan sebagai antibiotik, penyeimbang pH gaster, dan penginduksi epitelisasi mukosa gaster. Kata Kunci: gaster, madu, penyembuhan luka, perbaikan mukosa, ulkus peptikum

scholarly journals Macroalgae Sargassum cristaefolium Extract Inhibits Proinflammatory Cytokine Expression in BALB/C Mice

Scientifica ◽  
2020 ◽  
Vol 2020 ◽  
pp. 1-10
Author(s):  
Eka Sunarwidhi Prasedya ◽  
Ni Wayan Riyani Martyasari ◽  
Angga Susmana Abidin ◽  
Sonia Ardilla Pebriani ◽  
Bq Tri Khairina Ilhami ◽  
...  
Keyword(s):  
Uv Radiation ◽  
Proinflammatory Cytokine ◽  
Healing Process ◽  
Potential Mechanism ◽  
Skin Damage ◽  
Brown Macroalgae ◽  
Inflammatory Agent ◽  
Anti Inflammatory ◽  
Skin Healing ◽  
Skin Damages

Ultraviolet radiation (UVR) which could induce skin damage and skin disease is a growing concern due to the increase in global warming. Brown macroalgae Sargassum cristaefolium has been recognized to exhibit UV protective activities. However, the mechanism of its photoprotective activity remains unclear. The purpose of this study is to investigate the potential mechanism of S. cristaefolium’s photoprotective activity against UV radiation. Phytochemical analyses revealed valuable bioactive compounds in SCE, such as fucoxanthin which is widely known as an anti-inflammatory carotenoid. Treatment with SCE before UV-A radiation show reduced levels of wrinkles and desquamation. Interestingly, SCE treatment induces the skin healing process after UV radiation. SCE effectively inhibited proinflammatory TNF-α and IL-6 expression while increasing IL-10 production in the BALB/c mice skin. Current results suggest that SCE potentially protects the skin by attenuation of inflammatory cytokines. In addition, SCE demonstrates promising antibacterial activity (MIC = 1.302 µg/mL) against Staphylococcus aureus. Overall, SCE could be a source of an effective anti-inflammatory agent protecting against UV irradiation-induced skin damages.

Reduction of paw edema and liver oxidative stress in carrageenan-induced acute inflammation by Lobaria pulmonaria and Parmelia caperata, lichen species, in mice

2019 ◽  
pp. 1-9
Author(s):  
Samira Salem ◽  
Essaid Leghouchi ◽  
Rachid Soulimani ◽  
Jaouad Bouayed
Keyword(s):  
Time Course ◽  
Acute Inflammation ◽  
Lichen Species ◽  
Paw Edema ◽  
Sod Activity ◽  
Edema Formation ◽  
Lobaria Pulmonaria ◽  
Anti Inflammatory ◽  
Endogenous Antioxidant ◽  
Inflammatory Effect

Abstract. Paw edema volume reduction is a useful marker in determining the anti-inflammatory effect of drugs and plant extracts in carrageenan-induced acute inflammation. In this study, the anti-inflammatory effect of Lobaria pulmonaria (LP) and Parmelia caperata (PC), two lichen species, was examined in carrageenan-induced mouse paw edema test. Compared to the controls in carrageenan-induced inflammation (n = 5/group), our results showed that pretreatment by single oral doses with PC extract (50–500 mg/kg) gives better results than LP extract (50–500 mg/kg) in terms of anti-edematous activity, as after 4 h of carrageenan subplantar injection, paw edema formation was inhibited at 82–99% by PC while at 35–49% by LP. The higher anti-inflammatory effect of PC, at all doses, was also observed on the time-course of carrageenan-induced paw edema, displaying profile closely similar to that obtained with diclofenac (25 mg/kg), an anti-inflammatory drug reference (all p < 0.001). Both LP and PC, at all doses, significantly ameliorated liver catalase (CAT) activity (all p < 0.05). However, superoxide dismutase (SOD) activity, glutathione peroxidase (GPx) activity and glutathione (GSH) levels were found increased in liver of PC- compared to LP-carrageenan-injected mice. Our findings demonstrated on one hand higher preventive effects of PC compared to LP in a mouse carrageenan-induced inflammatory model and suggested, on the other hand, that anti-inflammatory effects elicited by the two lichens were closely associated with the amelioration in the endogenous antioxidant status of liver.

MOTIF YANG BERPENGARUH PADA PROSES KEJIWAAN TOKOH SAM DALAM NOVEL SEBENING SYAHADAT KARYA DIVA SR

2020 ◽  
Vol 8 (2) ◽  
pp. 10
Author(s):  
Dandy Ashghor Dawudi ◽  
Kamidjan Kamidjan ◽  
Agus Sulton
Keyword(s):  
Research Method ◽  
Descriptive Analysis ◽  
Research Process ◽  
Cultural Factors ◽  
Qualitative Approach ◽  
Literature Study ◽  
Love Story ◽  
True Value ◽  
Analysis Technique ◽  
Qualitative Descriptive

This research takes the object of Sebening Syahadat by Diva SR, this work is a novel that tells the story of the journey ofa teenager named Sam who is in the process ofsearching for identity. The journey is filled with interesting twits and turns embelissed with a love story that is very suitable if consumed by the younger generation who are learning to find identit. This study aims to reveal the value motives that led Sam’s character in finding his identity, which expected to be a material for reflection for readers, especially young people who are in the process of discovering his identity, the scope of the problem in this study is to reveal the value motives that affect the character’s psyche. Sam is told to have a rascal character.The research method used in this study took a descriptive qualitative approach, data colletion used was a literature study technique with stages of reading, note taking, coding for futher analysis. The analysis technique used is qualitative descriptive analysis technique.The result of the research in this research process indicate that the mental process of Sam’s character influenced by several factors, including: a. Motives in cultural factors (Situasional Factors), b. The motive for love begins with admiration for the attitude of someone who is full of noble values of character, c. The motive of curiosity and fulfillment of his needs for true value.

ANALISIS WACANA PADA BERITA NONTON FILM SAKINAH, MAHASISWA UIN YOGYAKARTA BERI PUJIAN (ANALISIS MIKROSTRUKTURAL)

2019 ◽  
Vol 7 (4) ◽  
pp. 57
Author(s):  
Resdianto Permata Raharjo ◽  
Maranita Anjarsari
Keyword(s):  
Data Analysis ◽  
Online News ◽  
Analysis Method ◽  
Literature Study ◽  
Lexical Cohesion ◽  
News Discourse ◽  
Qualitative Descriptive ◽  
Descriptive Approach ◽  
Method Analysis ◽  
Descriptive Method

This study aims to describe 1) the form of cohesion contained in the news Watching Sakinah Movies, UIN Yogyakarta Give Praise Students and 2) describing the forms of coherence contained in the news Watching Sakinah Film, Students of UIN Yogyakarta Give Praise. The subjects used in this study were news of watching Sakinah film, UIN Yogyakarta students giving praise, and the objects used were sentences containing grammatical cohesion, a form of lexical cohesion. The approach used in this study is a qualitative descriptive approach. The data in this study are sentences in the news of Watching Sakinah Movies, This student is a method of literature study. While the method of data analysis in this study is descriptive method analysis method, the method used to analyze and describe cohesion markers and analyze markers of coherence. Test The results of the study show that in the news of watching Sakinah films, UIN Yogyakarta Beri Pujian students have varied markers of cohesion and coherence in the Tebuireng Online news discourse. Cohesion markers were found to reference (3), substitution (1), ellipsis (2), conjunction (3), collocation (1), and markers of coherence found cause-effect relationships (2), relationship coherence suggestions — goals (1), coherence temporal relations (1), and coherence of causal relationships (1).

Kebijakan Badan Narkotika Nasional Dalam Penanggulangan Narkoba Wilayah Perbatasan

2020 ◽  
Vol 3 (1) ◽  
pp. 20-31
Author(s):  
Novana Veronica Julenta Kareth ◽  
Reni Shintasari
Keyword(s):  
Central Government ◽  
Descriptive Analysis ◽  
Study Data ◽  
Eastern Region ◽  
Analysis Model ◽  
Literature Study ◽  
Qualitative Descriptive ◽  
Multi Stakeholder ◽  
Collection Methods

This paper aims to determine the policies implemented by the Papua National Narcotics Agency against drug trafficking. This article is a qualitative descriptive study. Data collection methods through interviews and literature study. Data analysis using descriptive analysis model. The results showed that the role of BNN Papua is very central in the eastern region and the Indonesian border. The policies that have been planned by BNN with multi-stakeholder have been implemented, but the new modes adopted by the international network vary. The drug subscription policy cannot be carried out by one institution only, it needs to be supported by other government agencies and the community. The need for a serious role for the regional and central government in both preventive efforts and subscription programs in synergy with the Papua Provincial BNN.

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