Teratogenic Potential of Garbha Chintamani Rasa in Wistar Albino Rats with focus on physical and behaviour changes.

2017 ◽  
Vol 2 (1) ◽  
Author(s):  
Prathviraj Kumar Puranik ◽  
VNK Usha ◽  
B . Ravishankar ◽  
Mundugaru Ravi
Keyword(s):  
Behavioral Pattern ◽  
Albino Rats ◽  
Test Drug ◽  
Pregnant Rats ◽  
Intellectual Quotient ◽  
Stage Of Development ◽  
Behavioral Abnormalities ◽  
Teratogenic Potential ◽  
Wistar Albino Rats ◽  
Behaviour Changes

Teratogens are the substances that may produce physical or functional defects in the human embryo or after the pregnant woman exposed to the substance. Exposure to the teratogenic drugs affects the foetus or embryo in a variety of ways, such as the duration of exposure, the amount of teratogenic substance, and the stage of development the embryo or foetus is in during the exposure. Teratogens may affect the embryo or foetus causing physical malformations, problems in the behavioural or emotional development of the child, and decreased intellectual quotient (IQ) in the child. The present study was carried out to assess the teratogenic potential of Garbhachintamani Rasa in Wistar albino rats based on physical and behaviroal abnormalities. The experiment was designed in such a way that the conformed pregnant rats were selected and administered with Garbhachintamani Rasa for 21 consecutive days. The delivered pups were assessed for teratogenicity based on the physical and behavioural parameter in a set of behaviroal tests such as open field test, rota rod and swimming test at different developing periods. The results showed that, there was significant physical and behavioural alteration in the test drug administered at higher dose level as compared to normal control. Thus it can be concluded that the test drug GCR at therapeutic dose showed well tolerated and nearly normal behavioral pattern, whereas at higher dose it can cause behavioral abnormalities in pups.

scholarly journals Teratogenic Potential of Solenstemma Argel Extract in Wistar Albino Rats

2021 ◽  
Author(s):  
Nazik M.E. Mustafa ◽  
Nafisa A. Osman ◽  
Shahenaz Satti ◽  
Ahmed A.Gameel ◽  
Tarig M. El-hadiyah
Keyword(s):  
Herbal Medicine ◽  
Fetal Development ◽  
Treated Group ◽  
Control Group ◽  
Albino Rats ◽  
P Value ◽  
Pregnant Rats ◽  
Histopathological Findings ◽  
Teratogenic Potential ◽  
Wistar Albino Rats

Abstract Background: The majority of people in Africa receive their basic healthcare through herbal treatments. Herbal medicine may negatively impact fetal development irreparably. Methods: This study examined teratogenic potential of Solenstemma argel extract in pregnant rats. pregnant rats were treated with Solenstemma argel from 7th to 16th day of gestation. Dosage used was 500g/kg, intraperitoneal.Results: Solenstemma argel extract treated group showed fetal abnormalities appeared as body clots, limbs abnormalities and Resorption of fetuses that appears in 25% of the fetuses (P-value = 0.01) which is significantly differ from control group. furthermore, Histopathological findings of liver sections from fetuses of Solenstemma argel - treated mothers showed loose liver texture and hepatocyte hemorrhage.Conclusions: In this study we explore the teratogenic potential of S. argel extract during the organogenesis period in pregnant rats.

scholarly journals Teratogenic Potential of Solenstemma Argel Extract in Wistar Albino Rats

2021 ◽  
Author(s):  
Nazik M.E. Mustafa ◽  
Shahenaz Satti ◽  
Nafisa A. Osman ◽  
Ahmed A.Gameel ◽  
Tarig M. El-hadiyah
Keyword(s):  
Fetal Development ◽  
Treated Group ◽  
Control Group ◽  
Albino Rats ◽  
P Value ◽  
Teratogenic Effects ◽  
Pregnant Rats ◽  
Liver Histopathology ◽  
Teratogenic Potential ◽  
Wistar Albino Rats

Abstract The majority of people in Africa receive their basic health care through herbal treatments. Herbal medicine may negatively impact fetal development irreparably. This study examined the teratogenic potential of Solenstemma argel extract in pregnant rats. Pregnant rats were treated with Solenstemma argel from 7th to 16th day of gestation. The dosage used was 250 mg/kg, intraperitoneal.Solenstemma argel extract treated group showed fetal abnormalities appeared as body hemorrhage, limbs abnormalities and resorption of fetuses. These appears in 25% of the fetuses (P-value = 0.01) which is significantly differed from control group. Furthermore, histopathological findings of liver sections from fetuses of Solenstemma argel - treated mothers showed loose liver texture and hepatocytes hemorrhage.In this study, we conclude that the use Solenstemma argel extract during the organogenesis period in pregnant rats has the potential to cause teratogenic effects, as well as abnormalities in liver histopathology.

scholarly journals Teratogenic Potential of Solenstemma argel Extract in Wistar Albino Rats

2022 ◽  
Author(s):  
Nazik M.E. Mustafa ◽  
Shahenaz Satti ◽  
Nafisa A. Osman ◽  
Ahmed A.Gameel ◽  
Tarig M. El-hadiyah
Keyword(s):  
Fetal Development ◽  
Treated Group ◽  
Control Group ◽  
Albino Rats ◽  
P Value ◽  
Teratogenic Effects ◽  
Pregnant Rats ◽  
Liver Histopathology ◽  
Teratogenic Potential ◽  
Wistar Albino Rats

Abstract The majority of people in Africa receive their basic health care through herbal treatments. Herbal medicine may negatively impact fetal development irreparably. This study examined the teratogenic potential of Solenstemma argel extract in pregnant rats. Pregnant rats were treated with Solenstemma argel from 7th to 16th day of gestation. The dosage used was 250 mg/kg, intraperitoneal.Solenstemma argel extract treated group showed fetal abnormalities appeared as body hemorrhage, limbs abnormalities and resorption of fetuses. These appears in 25% of the fetuses (P-value = 0.01) which is significantly differed from control group. Furthermore, histopathological findings of liver sections from fetuses of Solenstemma argel - treated mothers showed loose liver texture and hepatocytes hemorrhage.In this study, we conclude that the use Solenstemma argel extract during the organogenesis period in pregnant rats has the potential to cause teratogenic effects, as well as abnormalities in liver histopathology.

scholarly journals Screening of anticonvulsant effect of carvedilol on electrically induced convulsions in Wistar albino rats

2020 ◽  
Vol 9 (12) ◽  
pp. 1803
Author(s):  
Biacin Babu ◽  
Madhavrao Chavan
Keyword(s):  
Albino Rats ◽  
High Dose ◽  
Anticonvulsant Effect ◽  
Low Doses ◽  
Test Drug ◽  
Group Iii ◽  
Group I ◽  
Significant Difference ◽  
Group Ii ◽  
Wistar Albino Rats

Background: Epilepsy is one of the major central nervous system disorders. The parent study aimed to screen the anticonvulsant effect of carvedilol on electrically induced convulsions in Wistar albino rats.Methods: This study was done in Wistar albino rats. A total of 30 rats were divided into 6 groups each of six rats. group-I (0.9% normal saline), group-II diphenylhydantoin (10 mg/kg/BW/ip), group-III carvedilol (1mg/kg/BW/PO), group-IV carvedilol (2 mg/kg/BW/PO) and group-V carvedilol (4 mg/kg/BW/PO). All the groups were administered drugs and subjected to electric shock. Scores of seizures and percentage of protection were recorded to compare between the groups. One was ANOVA (post hoc) followed by Dunnet t test applied to find the statistically significant between the groups.Results: Group-I showed significant difference compared to other groups. Group-II showed significant difference with group-III and IV not with V. High dose of test drug and standard drug showed similar results in percentage of seizures prevention. Control and low doses of test drugs showed significant difference compared to standard and high dose of test drug in seizures prevention.Conclusions: High of carvedilol showed significant seizures prevention compared to low doses and control group.

scholarly journals An Experimental Study to Evaluate the Anti-Diarrheal Activity of Bhuvaneshwara Rasa in Wistar Albino Rats

2021 ◽  
pp. 27-35
Author(s):  
Simi Jose ◽  
Chaitra L.V
Keyword(s):  
Experimental Study ◽  
Castor Oil ◽  
Raw Materials ◽  
Life Time ◽  
Drug Group ◽  
Albino Rats ◽  
Test Drug ◽  
Wistar Albino Rats ◽  
Important Disease

Atisara (Diarrhea) is most commonly encountered disease of the present era, due to unhealthy and irregular habits. Atisara (Diarrhea) finds a place as important disease in individual’s life as everyone suffers from it at least once in life time. Bhuvaneshwara rasa is a unique herbo-mineral formulation explained in Bhaishajya ratnavali indicated for all kinds of diarrhea cases. Bhuvaneshwara rasa is a potent formulation having Saindhava, Triphala, Yamani, Bilva peshika and Gruhadhooma. Materials and methods: Raw materials were screened and collected and the formulation selected for the present study Bhuvaneshwara rasa was prepared accordingly. Anti-diarrheal activity of Bhuvaneshwara rasa was evaluated experimentally in albino rats. Experimental study was conducted in 3 groups of animals for anti-diarrheal study each. Anti-diarrheal study was done by castor oil induced diarrhoea and castor oil induced enter-pooling method. Bhuvaneshwara rasa (test drug) and Loperamide are effective in controlling diarrheal episodes. Bhuvaneshwara rasa has shown significant Anti-diarrheal activity in both Castor oil -induced diarrhea and castor oil induced enteropooling, test drug effective than control. Result: Bhuvaneshwara rasa was prepared according to SOP. Test drug group have shown effect experimentally. Conclusion: Bhuvaneshwara rasa is a good anti-diarrheal drug. It can be administered in all types of Atisara.

scholarly journals Effect of Amomum subulatum seeds against cypermethrin induced haematological changes in wistar albino rats

2019 ◽  
Vol 8 (3) ◽  
pp. 604
Author(s):  
Goutham Sagarkatte Puttanna ◽  
Purushotham K. ◽  
Swarnalatha Nayak ◽  
Eesha B. Rao ◽  
Ravi Mundugaru
Keyword(s):  
Body Weight ◽  
Normal Control ◽  
Protective Role ◽  
Control Group ◽  
Albino Rats ◽  
Test Drug ◽  
Group Iii ◽  
Group I ◽  
Amomum Subulatum ◽  
Wistar Albino Rats

Background: Cypermethrin is a well know agricultural pesticide used in the developing countries. It is associated with significant toxic potential on human health. Hence the present study was aimed to evaluate the protective role of Amomum subulatum against cypermethrin induced haematalogical changes in Wistar albino rats.Methods: The albino rats were divided into five different groups of six rats each. Group I considered as normal control, group II cypermethrin control (25mg/kg body weight p.o.), group III only test drug and group IV and V administered with cypermethrin 25mg/kg body weight along test drug 1.08 and 2.16mg/kg body weight for 28 consecutive days. At the end of 28th day blood was withdrawn and total haematalogical parameters were estimated.Results: In the cypermethrin control there was significant reduction in the WBC, Platelet, MCHC and considerable reduction in the haemoglobulin concentration in comparison to normal control. The test drug administered at both dose levels was significantly reversed the cypermethrin induced changes in haematalogical parameters.Conclusions: Authors can conclude that the Amomum subulatum has potency to reverse the cypermethrin induced haematalogical changes.

scholarly journals AN EXPERIMENTAL EVALUATION OF RASA PANCHAKA (ATTRIBUTES) OF FOLK MEDICINAL PLANT Andrographis Macrobotrys Nees

2020 ◽  
Vol 8 (8) ◽  
pp. 4116-4124
Author(s):  
Ranjitha S ◽  
Chandrakanth Bhat ◽  
Sudhakar Bhat ◽  
Reju krishnan
Keyword(s):  
Experimental Study ◽  
Medicinal Plants ◽  
Direct Perception ◽  
Albino Rats ◽  
Test Drug ◽  
Endothermic Reaction ◽  
Liver Disorders ◽  
Whole Plant ◽  
Animal Experimental Study ◽  
Wistar Albino Rats

Background and Objective: Folk medicinal plants are densely found in India which needs to be thorough-ly studied and documented. Andrographis Macrobotrys (Nees) is an erect, stout herb of Acanthaceae fami-ly is used in the treatment of snake bite, diarrhea, muscle pain, fever, jaundice, liver disorders and skin dis-ease by the tribes of Kerala. According to the principles of Ayurveda, basis for use of drug is by analysing its Rasapanchaka (attributes) namely rasa (taste), guna (qualities), vipaka (taste after digestion), virya (po-tency), and prabhava (special action). Hence assessment of Rasapanchaka is necessary for thorough knowledge of the drug. Aim of the present study is to evaluate the Rasa, Guna, Virya, Vipaka and prabha-va of Andrographis Macrobotrys Nees. Methods: Rasa of whole plant was assessed by direct perception by administering test drug to 25 volun-teers. Virya was assessed by exothermic and endothermic reaction of the drug with water in different con-centrations. Vipaka, guna and prabhava were determined through animal experimental study by adminis-tering drug to 12 Wistar Albino rats. Result and Conclusion: The assessment of study on rasapanchaka reveals that test drug possess Tiktha (bitter) rasa, Kashaya (astringent) anurasa, laghu (light), ruksha (dry), ushna (hot) guna, katu (pungent) vipaka, sheetha (cold) virya, pachana (digestive), lekhana (scraping) karma (action).

scholarly journals AN EXPERIMENTAL EVALUATION OF Andrographis macrobotrys Nees., A FOLK MEDICINAL PLANT FOR ANALGESIC ACTION IN WISTAR ALBINO RATS AND SWISS ALBINO MICE- IN VIVO STUDY

2021 ◽  
Vol 9 (8) ◽  
pp. 1688-1697
Author(s):  
Ranjitha S ◽  
Chandrakanth Bhat
Keyword(s):  
Medicinal Plant ◽  
Research Work ◽  
Albino Rats ◽  
Test Drug ◽  
Analgesic Action ◽  
Swiss Albino Mice ◽  
Wide Range ◽  
Albino Mice ◽  
Wistar Albino Rats

Background and objective: In India Medicinal plants have a wide range of uses in folk medical practice. An- drographis macrobotrys Nees. belongs to Acanthaceae family is found in South India and Srilanka. It is in folk use by tribes in Kerala to treat muscle pain, snakebite, fever, and jaundice. The present research work aims to evaluate test drugs for their analgesic action. Methods: The detailed review of the test drug and disease Pain has been carried out. An animal experimental study has been carried out to assess the analgesic activity of the drug by acetic acid- induced writhing movement in Swiss albino mice and Eddy’s hot plate method in Wistar albino rats. Results and conclusion: The test drug showed analgesic action with Swarasa of leaves and Kashaya of the whole plant. The drug was found to have both peripheral and central analgesic action. Keywords: Andrographis macrobotrys Nees., Acanthaceae, folk medicinal plant, Analgesic action

scholarly journals AN EXPERIMENTAL STUDY TO EVALUATE THE HEPATOPROTECTIVE ACTIVITY OF NILITANDULIYADI LEHA IN PARACETAMOL INDUCED HEPATOTOXICITY IN WISTAR ALBINO RATS

2021 ◽  
Vol 10 (5) ◽  
pp. 127-130
Author(s):  
Sreekala Vijayan ◽  
Jugal Kishore
Keyword(s):  
Biochemical Parameters ◽  
Wistar Rats ◽  
Hepatoprotective Activity ◽  
Albino Rats ◽  
Test Drug ◽  
Protective Activity ◽  
Standard Drug ◽  
Liver And Kidney ◽  
Paracetamol Toxicity ◽  
Wistar Albino Rats

Background: Paracetamol toxicity is currently the single most important cause for acute liver failure and is associated with significant number of deaths. Nilitanduliyadi leha is one among the formulation explained in the context of Vishahara yogas (anti-poisonous formulations) in the text Vishavaidya Jyotsnika. Objectives: To experimentally evaluate the hepatoprotective activity of nilitanduliyadi leha in paracetamol induced hepatotoxicity in Wistar albino rats. Methods: Albino Wistar rats of either sex weighing 200 – 250, g were selected and divided into four groups of six animals in each group (n = 6). Treatment was given for 7 days. Blood was drawn and sent for tests and important organs like liver and kidney were dissected out, cleaned to remove extraneous tissues, blotted to remove blood stain and weighed. A piece of liver tissue was preserved in 10% formalin for histopathological processing. Results: The formulation has helped in balancing the biochemical parameters studied almost as efficiently as the standard drug. In the antioxidant study also, the drug has given good results and shows even slightly more effective than the standard drug. The histopathology study also reveals mild protection and regeneration of tissues by the effect of test drug. Conclusion: This present study proves that the formulation is having a comparable hepato protective activity with that of silymarin.

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