Effect of E-cigarette in Harm Reduction among the Adolescents - A Protocol for a Systemic Review (Preprint)
BACKGROUND E-cigarettes present an opportunity to increase the tobacco cessation rates, and thereby suppress the largest cause of global death significantly. Though E-cigarettes are perceived as less harmful than conventional cigarettes still their effectiveness as a tobacco cessation tool, their difference with other prescribed tobacco cessation methods and their long term effects are yet to be synthesized precisely. OBJECTIVE The aim of this review is to provide evidence of existing literature in case of harm reduction by e-cigarettes among adolescent. METHODS To explore the available evidence on the effect of electronic cigarettes in harm reduction among the adolescents, we followed the Standard method of Cochrane for conducting a systematic review. Total 13 bibliographic and impact evaluation database will be searched using a comprehensive search strategy. RCTs and quasi experimental studies on e-cigarettes usability which has been published scientific journals will be included. Timeframe for searching relevant articles for the review were limited between January 2003 and June 2018. The intervention provided to the adult population (population aged 19 years and above), adolescents with pregnancy and adolescents having an other diseased condition will be excluded. Any trial, which is ongoing, published protocol of trials, traditional reviews and systematic reviews will be excluded. Letter to editor, editorial comments and conference proceedings were excluded as well. Articles published only in English language will be included. RESULTS Narrative synthesis of included articles will be provided, including the quality assessment using standard tools. Pooled estimation will be provided regarding harm reduction and smoking cessation where applicable. CONCLUSIONS Not applicable CLINICALTRIAL PROSPERO registration of the systematic review is CRD42018106691