scholarly journals New genetically determined risk factors of diabetic retinopathy in type 2 diabetes mellitus: final report

2021 ◽  
Vol 9 (3) ◽  
pp. 28-33
Author(s):  
S.Yu. Mogilevskyy ◽  
A.S. Hudz ◽  
Yu.O. Panchenko ◽  
O.V. Bushuyeva ◽  
G.E. Zakharevych
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Diabetic Retinopathy ◽  
Diabetes Mellitus Type 2 ◽  
Diabetes Mellitus Type ◽  
Patients With Diabetes ◽  
Genetically Determined

Background. According to the International Diabetes Federation, the number of people with diabetes mellitus is going to increase from 366 to 552 million by 2030. More than 1.5 million patients with diabetes are registered in Ukraine, of which 84–95 % have type 2 diabetes. Diabetic retinopathy (DR) is one of the common diabetes complications, being one of the leading causes of blindness and low vision, in particular in people of occupational age. Metabolic disorders, including activation of the polyol pathway of glucose utilization, play an important role in the pathogenesis of DR, with aldose reductase playing a key role, the activity of which is associated with the polymorphism of its gene, AKR1B1. The study of new meta­bolic and genetic mechanisms for the development and progression of DR in type 2 diabetes mellitus in patients from the Ukrainian population is an actual task of modern ophthalmology. Purpose: to investigate and generalize new genetically determined risk factors for diabetic retinopathy in type 2 diabetes mellitus. Materials and methods. The study involved 409 participants, who were divided into four groups: 1 — comparison cohort (98 people without diabetes mellitus type 2); 2 — 76 patients (stage I DR, without fundus chan­ges); 3 — 64 individuals with non-proliferative DR; 4 — 64 patients with proliferative DR; control group for genetic researches included 107 ophthalmologically healthy individuals. All patients underwent blood sampling for molecular genetic research by puncture of the ulnar vein and aspiration of 2.5 ml of blood through a 23G 5.0 ml disposable syringe (Hemoplast, Etalon+, Ukraine), followed by a release into a 3.0 ml container (Vacuette K3E K3EDTA, Greiner Bio-One, Austria). Distribution of polymorphic alleles and genotypes of rs759853 and rs9640883 aldose reductase gene (AKR1B1) in patients with non-proliferative DR, proliferative DR and in the control group and their association with disease and effects on the occurrence, mechanisms of development and progression of DR were studied. Based on the conducted researches, a model of DR development prognosis was developed by construction of multiple regression with sufficient reliability of degree of influence of independent variables on a calculated indicator. Results. As a result of our research, we identified new genetically determined risk factors for the development and progression of the different stages of DR in patients with diabetes mellitus type 2, namely the role of polymorphic alleles and genotypes rs759853 and rs9640883 of the AKR1B1 gene. The deve­loped logistic regression models found that the risk of DR incidence is five times lower in carriers of the G/G and G/A genotypes compared to carriers of the A/A genotype rs759853 polymorphism (p < 0.001). It was found that the risk is twice as high (p = 0.01) for carriers of the G/G genotype rs9640883 compared to the A/A + G/A genotypes. The risk of developing proliferative DR is 3.3 times lower in carriers of the G/G genotype and 2.5 times lower in carriers of the G/A genotype compared to carriers of the A/A genotype rs759853. Conclusions. Therefore, on the basis of our clinical, ophthalmological, molecular genetic and statistical studies we have identified new risk factors for the development and progression of different stages of DR in patients with diabetes mellitus type 2. Mathematical models of development and progression of different stages of DR in patients with diabetes type 2 were built.

scholarly journals Risk factors associated with diabetic retinopathy in patients with diabetes mellitus type 2

2010 ◽  
Vol 3 (1) ◽  
Author(s):  
Irini P Chatziralli ◽  
Theodoros N Sergentanis ◽  
Petros Keryttopoulos ◽  
Nikolaos Vatkalis ◽  
Antonis Agorastos ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Diabetic Retinopathy ◽  
Diabetes Mellitus Type 2 ◽  
Diabetes Mellitus Type ◽  
Factors Associated ◽  
Patients With Diabetes

KADAR KALSIFEDIOL SEBAGAI PREDIKTOR DERAJAT KEPARAHAN RETINOPATI DIABETIK PADA PASIEN DENGAN DIABETES MELLITUS TIPE 2

2021 ◽  
Vol 8 (3) ◽  
pp. 211-224
Author(s):  
Gilbert Sterling Octavius ◽  
Alvita Suci Edgina ◽  
Stefany Tanto ◽  
Werlison Tobing
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Diabetic Retinopathy ◽  
Diabetes Mellitus Type 2 ◽  
Case Control ◽  
Diabetes Mellitus Type ◽  
Cross Sectional ◽  
Prevalence Of Diabetes Mellitus

Pendahuluan    : Terdapat peningkatan prevalensi pasien diabetes mellitus (DM) dan morbiditasnya, termasuk retinopati diabetik. Retinopati diabetik adalah penyebab paling sering dari kasus baru kebutaan di antara orang dewasa berusia 20-74 tahun yang akan mempengaruhi produktivitas kelompok usia ini jika dibiarkan atau tidak diobati. Tujuan : Mengevaluasi kemungkinan tingkat kalsifediol sebagai prediktor keparahan retinopati diabetik pada pasien dengan diabetes mellitus tipe 2. Metode : Kami mencari di PubMed, Kemajuan Oftalmologi, Laporan Ilmiah dan Ilmu Pengetahuan Langsung menggunakan istilah “25(OH)D3 Level”, “Diabetic Retinopathy”, “Prevalence of Diabetes Mellitus”, “Type 2 Diabetes Mellitus”, dan “Predictor” dalam berbagai kombinasi dan menemukan 7 studi yang digunakan dalam ulasan ini. Hasil                : Kami menemukan 4 literatur yang menyatakan bahwa ada hubungan positif antara level 25 (OH) D3 sebagai prediktor untuk keparahan retinopati diabetik sementara ada 3 literatur yang menyatakan sebaliknya. Enam literatur menggunakan desain cross sectional sedangkan satu dilakukan dengan menggunakan case control. Tingkat pemotongan 25(OH)D3 pada pasien dengan masing-masing 18,9-24,3 ng/ml, 17,4-21,7 ng/ml, dan 14,7-21,1 ng/ml. Kesimpulan      : Sementara penggunaan 25(OH)D3 sebagai prediktor tingkat keparahan retinopati diabetik masih tidak meyakinkan, hubungan proporsional terbalik terlihat antara kedua variabel.

Literature Review: Pemanfaatan Media terhadap Kepatuhan Diet Penderita Diabetes Mellitus Type 2

2021 ◽  
Vol 13 (2) ◽  
pp. 107-112
Author(s):  
Sarah Grasya Elisabeth Pasaribu ◽  
Ratih Kurniasari
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Diabetes Mellitus Type 2 ◽  
Communicable Disease ◽  
Diabetes Mellitus Type ◽  
Patients With Diabetes ◽  
Apparent Reason ◽  
Sugar Levels

Diabetes Mellitus Type 2 is a chronic non-communicable disease characterized by an increase in blood sugar levels. Typical symptoms of Type 2 Diabetes Mellitus consist of polyuria, polydipsia, polyphagia and weight loss for no apparent reason. Diabetes Mellitus cannot be cured but its severity can be controlled by adopting a good lifestyle such as taking medication regularly, doing physical activity and adhering to a recommended diet such as the 3J diet. One way to increase the compliance of the 3J diet in people with Diabetes Mellitus Type 2 can be done by providing education through both print and audio-visual media. The aim was to determine the level of adherence of the 3J diet to the adherence of the 3J diet. The author collects data or sources related to a particular topic that can be obtained from various sources such as journals, books, the internet, and other libraries. Based on 4 reviewed journals, it was found that people with Type 2 Diabetes Mellitus have the potential to increase knowledge and compliance of patients with Diabetes Mellitus Type 2 to the 3J diet. The use of media, either print media or through applications that can increase the knowledge of Type 2 Diabetes Mellitus sufferers, is very well given and educated to patients with Type 2 Diabetes Mellitus. ABSTRAK Diabetes Mellitus Type 2 merupakan salah satu Penyakit Tidak Menular yang bersifat kronik ditandai dengan peningkatan kadar gula dalam darah. Gejala khas Diabetes Mellitus Tipe 2 terdiri dari poliuria, polidipsia, polifagia dan berat badan menurun tanpa sebab yang jelas. Diabetes Mellitus tidak dapat disembuhkan tetapi tingkat keparahannya dapat dikendalikan dengan menerapkan pola hidup yang baik seperti mengonsumsi obat – obatan secara teratur, melakukan aktifitas fisik dan mematuhi pola diet yang disarankan seperti diet 3J. Salah satu cara untuk meningkatkan kepatuhan diet 3J pada penderita Diabetes Mellitus Type 2 dapat dilakukan dengan memberikan edukasi melalui media baik media cetak maupun melalui media aplikasi. Adapun tujuannya untuk mengetahui tingkat kepatuhan diet 3J terhadap kepatuhan diet 3J.  Penulis mengumpulkan data atau sumber yang berhubunga pada sebuah topik tertentu yang bisa didapat dari berbagai sumber seperti jurnal, buku, internet, dan pustaka lain. Berdasarkan 4 jurnal yang di review, didapatkan hasil bahwa penderita Diabetes Mellitus type 2 memiliki potensi untuk meningkatkan pengetahuan dan kepatuhan pasien penderita Diabetes Mellitus Type 2 terhadap diet 3J. Penggunaan media baik itu media cetak atau melalui aplikasi yang dapat menambah pengetahuan penderita Diabetes Mellitus Type 2 sangat baik diberikan dan diedukasi kepada pasien penderita Diabetes Mellitus Tipe 2.

Prevalence of Toenail Onychomycosis in Patients with Type 2 Diabetes Mellitus and Evaluation of Risk Factors

2011 ◽  
Vol 101 (1) ◽  
pp. 49-54 ◽  
Author(s):  
Aynur Gulcan ◽  
Erim Gulcan ◽  
Sukru Oksuz ◽  
Idris Sahin ◽  
Demet Kaya
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Fasting Blood Glucose ◽  
Diabetic Patients ◽  
Essential Components ◽  
Patients With Diabetes ◽  
Epidemiologic Risk

Background: We sought to determine the frequency of toenail onychomycosis in diabetic patients, to identify the causative agents, and to evaluate the epidemiologic risk factors. Methods: Data regarding patients’ diabetic characteristics were recorded by the attending internal medicine clinician. Clinical examinations of patients’ toenails were performed by a dermatologist, and specimens were collected from the nails to establish the onycomycotic abnormality. All of the specimens were analyzed by direct microscopy and culture. Results: Of 321 patients with type 2 diabetes mellitus, clinical onychomycosis was diagnosed in 162; 41 of those diagnoses were confirmed mycologically. Of the isolated fungi, 23 were yeasts and 18 were dermatophytes. Significant correlations were found between the frequency of onychomycosis and retinopathy, neuropathy, obesity, family history, and duration of diabetes. However, no correlation was found with sex, age, educational level, occupation, area of residence, levels of hemoglobin A1c and fasting blood glucose, and nephropathy. The most frequently isolated agents from clinical specimens were yeasts. Conclusions: Long-term control of glycemia to prevent chronic complications and obesity and to promote education about the importance of foot and nail care should be essential components in preventing onychomycosis and its potential complications, such as secondary foot lesions, in patients with diabetes mellitus. (J Am Podiatr Med Assoc 101(1): 49–54, 2011)

scholarly journals Association between obesity and depression in patients with diabetes mellitus type 2; a study protocol

F1000Research ◽  
2015 ◽  
Vol 4 ◽  
pp. 7 ◽  
Author(s):  
Eduardo De la Cruz-Cano ◽  
Carlos Alfonso Tovilla-Zarate ◽  
Emilio Reyes-Ramos ◽  
Thelma Beatriz Gonzalez-Castro ◽  
Isela Juarez-Castro ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Diabetes Mellitus Type 2 ◽  
Cross Sectional Study ◽  
Diabetes Mellitus Type ◽  
Sectional Study ◽  
Cross Sectional ◽  
The World ◽  
Patients With Diabetes

Background: Diabetes mellitus and depression are highly prevalent conditions throughout the world and have significant impact on health outcomes. It has been estimated that diabetes mellitus type 2 affects about 246 million people in the world; nevertheless, incidence varies among countries. There is evidence that depression is associated with a poor metabolic control in patients with type 2 diabetes mellitus that present other health problems (such as hypertension and obesity). The aim of this study protocol is to determine if obesity increases the risk for depression in patient with diabetes type 2.Methods: The analysis will be reported following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA).The studies suitable for inclusion will be assessed by the Newcastle-Ottawa Scale (NOS) to determine their methodological quality. To identify the studies of interest, we will search on PubMed and EBSCO databases. We will use the following keyword combinations: "Diabetes Mellitus type 2 AND obesity AND depression", "depression AND Diabetes Mellitus type 2", "Diabetes Mellitus type 2 AND body mass index cross sectional study", "depression AND obesity cross-sectional study". Causes for exclusion will be publications that studied patients diagnosed with diabetes mellitus type 1; articles that focused on the treatment and complications of diabetes mellitus type 2; publications that have studied other clinical or psychiatric conditions (for instance, seizure disorder or history of schizophrenia, bipolar disorder, psychotic symptoms or dementia).Conclusion: The results of this study will form the basis for a better understanding of the association between obesity and depression in patients with diabetes mellitus type 2, and will allow development of prediction tools and better interventions. It is evident that several modifiable and non-modifiable risk factors play an important role in the pathogenesis of diabetes among population. Currently, evidence for the deleterious effects of diabetes mellitus type 2 are based on cross-sectional or other observational designs. Therefore, this study will have important implications for future research and public health guidance.

scholarly journals Microalbuminuria as an independent risk factor for heart failure in the elderly patients with type 2 diabetes mellitus

2020 ◽  
Vol 49 (2) ◽  
Author(s):  
Enisa Karić ◽  
Zumreta Kušljugić ◽  
Enisa Ramić ◽  
Olivera Batić- Mujanović ◽  
Amila Bajraktarević ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Heart Failure ◽  
Type 2 Diabetes ◽  
Risk Factor ◽  
Diabetes Mellitus Type 2 ◽  
Independent Risk Factor ◽  
The Elderly ◽  
Diabetes Mellitus Type ◽  
Patients With Diabetes

Introduction:The study evaluated of microalbuminuria as a predictor of heart failure in patients with diabetes mellitus type 2.Materials and methods:The prospective study conducted in a period of time from 01-Feb-2007 to 01-Feb-2010.The study included 100 patients with type 2 diabetes, who had diabetes longer than 5 years. All subjects (average age 66 ± 10 years, 33% male, 67% female) were tested for the presence of microalbuminuria, and 50 patients had microalbuminuria. The second group comprised 50 patients without of microalbuminuria with diabetes mellitus type 2.Results:In the patients with microalbuminuria and diabetes mellitus were found 22% of heart failure and 6% in the second group. Average time to the occurance of heart failure in the first group was 32,5 months, in the second group was 35,3 months.Conclusions:The results show that microalbuminuria is an independent risk factor for heart failure in patients with diabetes mellitus type 2 and microalbuminuria. Patients without microalbuminuria had 3,7 less likely to development heart failure compared to patients with microalbuminuria and diabetes mellitus.

scholarly journals Vascular endothelial growth factor (VEGF)-related polymorphisms rs10738760 and rs6921438 are not risk factors for proliferative diabetic retinopathy (PDR) in patients with type 2 diabetes mellitus (T2DM)

2019 ◽  
Vol 19 (1) ◽  
pp. 94-100 ◽  
Author(s):  
Jana Sajovic ◽  
Ines Cilenšek ◽  
Sara Mankoč ◽  
Špela Tajnšek ◽  
Tanja Kunej ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Type 2 Diabetes ◽  
Vascular Endothelial Growth Factor ◽  
Type 2 Diabetes Mellitus ◽  
Diabetic Retinopathy ◽  
Diabetic Patients ◽  
Vascular Endothelial ◽  
Endothelial Growth Factor

Vascular endothelial growth factor (VEGF) is an important regulator of angiogenesis and has been investigated as a candidate gene in a number of conditions, including diabetes and its microvascular complications (e.g., retinopathy and nephropathy). Several VEGF-related polymorphisms have been shown to contribute to nearly half of the variability in circulating VEGF levels in healthy individuals. Our aim was to assess the association between VEGF-related rs10738760 and rs6921438 polymorphisms and proliferative diabetic retinopathy (PDR) in Slovenian patients with type 2 diabetes mellitus (T2DM). We also investigated the effect of these polymorphisms on VEGF receptor 2 (VEGFR-2) expression in fibrovascular membranes (FVMs) from patients with PDR. This case-control study enrolled 505 unrelated patients with T2DM: 143 diabetic patients with PDR as a study group, and 362 patients with T2DM of >10 years duration and with no clinical signs of PDR as a control group. Patient clinical and laboratory data were obtained from their medical records. rs10738760 and rs6921438 polymorphisms were genotyped using TaqMan SNP Genotyping assay. VEGFR-2 expression was assessed by immunohistochemistry in 20 FVMs from patients with PDR, and numerical areal density of VEGFR-2-positive cells was calculated. The occurrence of PDR was 1.7 times higher in diabetic patients carrying GA genotype of rs6921438 compared to patients with GG genotype, with a borderline statistical significance (OR = 1.7, 95% CI = 1.00 – 2.86, p = 0.05). In addition, A allele of rs6921438 was associated with increased VEGFR-2 expression in FVMs from PDR patients. However, we observed no association between AA genotype of rs6921438 nor between rs10738760 variants and PDR, indicating that the two polymorphisms are not genetic risk factors for PDR.

Sign in / Sign up

Export Citation Format

Share Document