scholarly journals PHYTOCHEMICAL SCREENING OF ARTOCARPUS HIRSUTUS AND ITS ANTIMICROBIAL POTENTIAL

2017 ◽  
Vol 10 (6) ◽  
pp. 298 ◽  
Author(s):  
Shanmugapriya K ◽  
Akanya S ◽  
Anderson Clinton B ◽  
Berril Nanzy S ◽  
Prakash Pr ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Antioxidant Activity ◽  
Phytochemical Screening ◽  
Bacterial Strains ◽  
Zone Of Inhibition ◽  
Fruit Extract ◽  
Aspergillus Tamarii ◽  
Plant Materials ◽  
Bioactive Phytochemicals ◽  
Phytochemical Components

Objective: In the present study, the effort was aimed to evaluate the phytochemical components, antioxidant activity, and antimicrobial activity of Artocarpus hirsutus fruit and leaf. Methods: Each plant materials were extracted with two suitable solvents such as acetone and ethanol. Then, the extracts were tested for the presence of active phytoconstituents and antimicrobial activity. Then, it was subjected to antimicrobial activity against fungal and bacterial strains. Results: The present study suggested that the selected plant extracts of A. hirsutus exhibit major phytoconstituents, such as alkaloids, glycosides, terpenoids, phenols, and saponins. Furthermore, the results showed that acetone fruit extract of A. hirsutus and ethanolic fruit extract of A. hirsutus exhibited significant antimicrobial activity with a maximum zone of inhibition against Staphylococcus aureus and Aspergillus tamarii. Conclusion: The present study also exhibited remarkable antimicrobial activity against all the test microorganisms due to the presence of major bioactive phytochemicals

scholarly journals Phytochemical Screening and Antimicrobial Activity from Sonneratia caseolaris Fruit Extract

2019 ◽  
Vol 967 ◽  
pp. 28-33
Author(s):  
Pagarra Halifah ◽  
Hartati ◽  
Rachmawaty ◽  
Hala Yusminah ◽  
A. Rahman Roshanida
Keyword(s):  
Staphylococcus Aureus ◽  
Antimicrobial Activity ◽  
Antioxidant Activity ◽  
Candida Albicans ◽  
Ethyl Acetate ◽  
Scavenging Activity ◽  
Phytochemical Screening ◽  
Fruit Extract ◽  
Mangrove Plant ◽  
Sonneratia Caseolaris

A study out to investigate the phytochemical screening and antimicrobial activity of Sonneratia caseolaris fruit, a mangrove plant from Maros Regency, South Sulawesi, Indonesia. The Sonneratia caseolaris extract was prepared by two different solvent: ethyl acetate and ethanol 70%. We tested the extract of Sonneratia caseolaris for antioxidant activity using 1,1-diphenyl-2-picrylhydrazyl (DPPH). The phytochemicals were extracted separately with ethyl acetate and ethanol 70% by maceration. The evaluation of antibacterial activity for different solvent with different concentration of Sonneratia caseolaris fruit was measurements of inhibitory power are measured by measuring the diameter of the clear zone formed. In phytochemical test Sonneratia caseolaris fruits extracted by ethyl acetate solvent confirmed the presence of flavanoids, saponin, tannin and phenolic and extracted by ethanol 70% solvent confirmed the presence of alkaloid, saponin and phenolic. The antioxidant activity as indicated by 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging activity of the Sonneratia caseolaris fruits extract from the species was found to be quite appreciable. The antioxidant scavenging activity of Sonneratia caseolaris fruit extract by ethyl acetate solvent was 0.38% and by ethanol solvent was 0.08%. Antimicrobial activity of Sonnerati caseolaris fruits ethyl acetate extract obtained significant was from P<0.05 of Escherechia.coli and Candida albicans but not significant of Staphylococcus aureus. The Sonneratia caseolaris extracted by ethanol 70% solvents was highly promising among Escherichia coli, Staphylococcus aureus and Candida albicans with level of significance was from P <0.05. The study suggests Sonneratia caseolaris fruits as a potential source of bioactive compounds with stable antioxidative and antimicrobial properties and can be used as natural antimicrobial/antioxidative agents in clinical, pharmaceutical and food processing industries.

DESIGN, SYNTHESIS, AND CHARACTERIZATION OF THE SOME NOVEL 2‐AMINO-PYRIDINE‐3‐ CARBONITRILE AND 2‐AMINO-4H-PYRAN‐3‐CARBONITRILE DERIVATIVES AGAINST ANTIMICROBIAL ACTIVITY AND ANTIOXIDANT ACTIVITY

2020 ◽  
pp. 125-134
Author(s):  
SURENDRA BABU LAGU ◽  
RAJENDRA PRASAD YEJELLA
Keyword(s):  
Antimicrobial Activity ◽  
Antioxidant Activity ◽  
Antimicrobial Activities ◽  
Docking Studies ◽  
Synthesis And Characterization ◽  
Zone Of Inhibition ◽  
Design Synthesis ◽  
Instrumental Methods ◽  
Objective Investigation

Objective: Investigation, the series of newer 2‐amino-pyridine‐3‐carbonitrile and 2‐amino-4H-pyran‐3‐carbonitrile derivative were synthesized and evaluated antimicrobial activities and antioxidant activity. Methods: Novel synthesized chalcones were further condensation to give 2-amino-3-cyanopyridine and 2-amino-3-cyanopyrans in the presence of malononitrile, pyridine, and ammonia acetate. The product is characterized by conventional and instrumental methods. Pyridine and 4-H-Pyran and their analogs occupy prime position due to their diverse applications. Results: The compounds A3C and B3C exhibited marked zone of inhibition with 30.02±0.02 mm and 29.06±0.01 mm, respectively. Docking studies suggested possible interactions with dihydrofolic reductase 4 with 9.15 and −9.67 kcal/mol, respectively. The IC50 30.28±0.01 exhibited A3C by 2,2-diphenylpicrylhydrazyl methods which is better among the series. The 2-amino-3-cyanopyridine derivatives were found good activity than 2-amino-3-cyanopyrane derivative. Among all synthesized compounds few having potent activity and some are near to the standard. Conclusion: Antimicrobial activity and antioxidant of the newly synthesized pyrans and pyridines derivatives will definitely inspire future researchers for the preparation of new analogs.

scholarly journals Phytochemical screening and in vitro antibacterial, antifungal, antioxidant and antitumor activities of the red propolis Alagoas

2019 ◽  
Vol 79 (3) ◽  
pp. 452-459 ◽  
Author(s):  
F. R. G. Silva ◽  
T. M. S. Matias ◽  
L. I. O. Souza ◽  
T. J. Matos-Rocha ◽  
S. A. Fonseca ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Antioxidant Activity ◽  
Phenolic Compounds ◽  
Gallic Acid ◽  
Bioactive Metabolites ◽  
Diffusion Method ◽  
Total Phenolic ◽  
Phytochemical Screening ◽  
Dpph Method

Abstract The study aimed to evaluate the antimicrobial activity, antioxidant, toxicity and phytochemical screening of the Red Propolis Alagoas. Antimicrobial activity was evaluated by disk diffusion method. Determination of antioxidant activity was performed using the DPPH assay (1.1-diphenyl-2-picrylhydrazyl), FTC (ferric thiocyanate) and determination of phenolic compounds by Follin method. Toxicity was performed by the method of Artemia salina and cytotoxicity by MTT method. The phytochemical screening for the detection of allelochemicals was performed. The ethanol extract of propolis of Alagoas showed significant results for antimicrobial activity, and inhibitory activity for Staphylococcus aureus and Candida krusei. The antioxidant activity of the FTC method was 80% to 108.3% hydrogen peroxide kidnapping, the DPPH method showed an EC50 3.97 mg/mL, the content of total phenolic compounds was determined by calibration curve gallic acid, resulting from 0.0005 mg/100 g of gallic acid equivalent. The extract was non-toxic by A. salina method. The propolis extract showed high activity with a higher percentage than 75% inhibition of tumor cells OVCAR-8, SF-295 and HCT116. Chemical constituents were observed as flavonones, xanthones, flavonols, and Chalcones Auronas, Catechins and leucoanthocyanidins. It is concluded that the extract can be tested is considered a potential source of bioactive metabolites.

scholarly journals Antimicrobial Activity of Coriander sativum

2021 ◽  
pp. 74-81
Author(s):  
Samina Amin Qurban Ali ◽  
Arif Malik
Keyword(s):  
Antimicrobial Activity ◽  
Antioxidant Activity ◽  
Essential Oils ◽  
Aspergillus Flavus ◽  
Food Additives ◽  
Inhibition Zone ◽  
Microbial Pathogens ◽  
Bacterial Strains ◽  
High Concentration ◽  
Natural Oils

The increasing rate of drug-repellent pathogens and poisonousness of existing antiseptic compounds has strained attention toward activity of antimicrobial products which are natural. Main purpose of this research was to assess antimicrobial activity of seeds and leaves of Coriandrum sativum’s essential oil, antioxidant, antimicrobial activity and chemical composition of Coriandrum sativum’s ethanol extracts and essential oils. Numerous approaches were used in reviewing the antioxidant activity such as, p-anisidine test – malonaldhyde, DPPH and peroxide value. Antimicrobial activity of the extracts towards six microbial strains; two bacterial strains (Salmonella typhi and Staphylococcus aureus), one yeast (Candida tropicals) and three fungal strains (Aspergillus flavus, Mucor sp and Emericella nidulans) was assessed by determination of inhibition zone and count of bacteria, yeast and spares of fungus. The antimicrobial mechanisms found in these essential oils have been explained on the basis of their content in natural compounds such as carvacrol, thymol, p-cymene and c-terpinene, among others. Although these two essential oils have received much attention, scientists working in the fields of biomedicine and food science are paying increasing attention to a wider variety of aromatic natural oils in an effort to identify original and natural applications for the inhibition of microbial pathogens. In conclusion, utilization of coriander or their components as food additives will increase the antioxidant and the antimicrobial potential of the food which prevent food deterioration and improve the shelf-life of food beside its nutritional value. The results revealed that the leaves extracts have high levels of phenolics than the seeds extract. Concerning antioxidant activity, significant decreases (p>0.001) were observed in peroxide, P- anisidine and TBA values as compared to control oil. On the other hand, scavenging activity % of the four extracts on DPPH radical were higher than that of butylated hydroxyl toluene (BHT) especially with high concentration (1000 μg/ ml). Regarding antimicrobial activity, the results showed that the extract of coriander seeds has the highest reduction percent in growth of all the examined microorganisms. The result also revealed that Mucor sp was resistant to the action of parsley extracts while Aspergillus flavus has the highest resistance against coriander extracts.

scholarly journals A Comparative Study of Antimicrobial Activity of Ethanolic Extract of Tecoma stans and Abutilon indicum Leaves: An In vitro Study

2021 ◽  
pp. 609-615
Author(s):  
M. Binigha ◽  
R. Gayatri Devi ◽  
J. Selavaraj ◽  
A. Jothi Priya
Keyword(s):  
Antimicrobial Activity ◽  
Agar Plate ◽  
Ethanolic Extract ◽  
Flowering Plant ◽  
Diffusion Method ◽  
Bacterial Strains ◽  
Zone Of Inhibition ◽  
The Family ◽  
Abutilon Indicum

Tecoma stans is a flowering plant belonging to the family Bignoniaceae. It is the floral emblem of the Bahamas. Abutilon indicum belongs to the family Malvaceae. It is also called Indian Mallow. Tecoma stans and Abutilon indicumhave antimicrobial activity and can be used in producing antibiotics. There is an urgent need to produce new antibiotics as there is an increase in the development of pathogen resistant drugs. The aim of this study was to compare the antimicrobial activity of ethanolic extract of Tecoma stansand Abutilonindicum leaves. E.faecalis bacteria were maintained in nutrient agar slopes. The powder of the two herbs, were subjected to extraction by Soxhlet extractor and was concentrated to dry residue by Agar well diffusion method. The nutrient broth was inoculated with bacterial strains. The culture was adjusted to 0.5McFarland turbidity standard. Lawn culture was done in Muller-Hinton agar plate and then the plates were dried. A 6 mm diameter well is bored for different concentrations. The extracts were introduced into the well and allowed to stand for 24 hrs. The antibacterial activity was determined by measuring the zone of inhibition. The present finding on the antimicrobial potential of Abutilon indicum and Tecoma stands showed that the two plants have growth inhibitory activity against oral pathogen E. faecalis. Abutilon indicum has a zone of inhibition greater than Tecoma stans. Abutilon indicum exhibited better activity compared to Tecoma stans.

scholarly journals Phytochemical Screening and Antimicrobial Activity Of Asparagus Racemosus Willd. and Asparagus Curillus Buch.-Ham. Ex Roxb

2018 ◽  
Vol 29 ◽  
pp. 91-102
Author(s):  
Rose Shrestha ◽  
Astha Shakya ◽  
Krishna Kumar Shrestha
Keyword(s):  
Antimicrobial Activity ◽  
Aqueous Extract ◽  
Ethanolic Extract ◽  
Salmonella Typhi ◽  
Diffusion Method ◽  
Asparagus Racemosus ◽  
Alcoholic Extract ◽  
Phytochemical Screening ◽  
Zone Of Inhibition ◽  
Different Strains

Asparagus racemosus Willd. is an important medicinal plant of tropical and subtropical regions of Nepal and India. Its medicinal usage has been reported in the Indian and British Pharmacopoeias and in traditional systems of medicine such as Ayurveda, Unani, and Siddha. Asparagus curillus Buch-Ham.ex Roxb. is also one of the species found in higher altitude of Nepal. Its roots are used as substitute for A. racemosus. Phytochemical investigation was done for these two species of Nepalese Asparagus as per Methodology for Analysis of Vegetable Drugs by I. Ciulei.1982. Phytochemical screening revealed the presence of coumarin, flavonoid, catecholic tannin, reducing compound in alcoholic extract of A. racemosus while its aqueous extract revealed polyuronoid, reducing compound, polyoses, saponin, gallic tannin, catecholic tannin, etc. Similarly, alcoholic extract of A. curillus revealed catecholic tannin, reducing compound and aqueous extract revealed polyuronoid polyoses, saponin, gallic tannin as main phytochemical compounds. Comparative antimicrobial activity of ethanolic extract of these two species has been evaluated using Kirby-Bauer Agar well diffusion method. The extracts were screened for their antimicrobial activity on nine different strains of human pathogenic microorganisms such as Escherichia coli, Salmonella typhi, Bacillus subtilis, Pseudomonas aeruginosa, Staphylococcus aureus, Klebsiella pneumoniae, Enterococcus faecalies, Saccharomyces cerevisiae and Candida albicans. Among them A. racemosus has shown selected antimicrobial effects against B. subtilis, E. coli, E. faecalis, S. cerevisiae and C. albicans with zone of inhibition of 25 mm in an average. While A. curillus showed effects on S. cerevisiae and C. albicans only with zone of inhibition about12 mm.J. Nat. Hist. Mus. Vol. 29, 2015, Page: 91-102 

scholarly journals Phytochemical Analysis, Antioxidant Activity, Antimicrobial Activity, and Cytotoxicity of Chaptalia nutans Leaves

2020 ◽  
Vol 2020 ◽  
pp. 1-15
Author(s):  
Letiele Bruck de Souza ◽  
Amanda Leitão Gindri ◽  
Thainara de Andrade Fortes ◽  
Thais Felli Kubiça ◽  
Jefferson Enderle ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Antioxidant Activity ◽  
Clinical Isolate ◽  
Condensed Tannins ◽  
Total Phenolic ◽  
Phytochemical Analysis ◽  
Phytochemical Screening ◽  
Phytochemical Study ◽  
Carbonyl Protein ◽  
Crude Leaf Extract

Context. Chaptalia nutans (L.) Pol. (family: Asteraceae) is widely used in traditional medicine as laxative and anticough medications and especially in the traumatisms, wounds, and hemorrhages in topical preparations. Objective. This work was to evaluate the chemical constitution of the hydromethanolic (30/70 methanol-water) macerating extract obtained from the leaves of C. nutans, as well as to study the antioxidant, antimicrobial, cytotoxic, and genotoxic activity of the species. Materials and methods. Phytochemical screening, antioxidant activity (total phenolic, total flavonoid, condensed tannins content, DPPH radical, and FRAP), antibacterial activity (P. aeruginosa, B. cereus, E. epidermidis, E. coli, S. aureus, E. faecalis, P. mirabilis, Candida glabrata (clinical isolate), Candida tropicalis (clinical isolate), C. krusei (clinical isolate), and C. albicans (clinical isolate)), and oxidative stress parameters (TBARS, carbonyl protein, and DCFH) were analyzed according to the literature. Toxicity of C. nutans was evaluated using an alternative method, D. melanogaster, as well as a locomotor assay. Results. The phytochemical screening test of methanolic leaves extract revealed the presence of alkaloids, coumarins, quaternary bases, phenolics, flavonoids, tannins, and free steroids. A quantitative phytochemical study indicated the total phenol (30.17 ± 1.44 mg/g), flavonoid (21.64 ± 0.66 mg/g), and condensed tannins (9.58 ± 0.99 mg/g). DPPH (345.41 ± 5.35 μg/mL) and FRAP (379.98 ± 39.25 μM FeSO4/mg sample) show to extract of C. nutans leaves an intermediate value, indicating moderate antioxidant activity of the extract. Antibacterial results revealed only a positive result (antimicrobial activity) for the hexane fraction which significantly inhibited the microorganisms E. epidermidis, C. tropicalis, C. glabrata, and C. krusei at a concentration of 1000 μg/mL. TBARS, carbonyl protein, and DCFH demonstrate that the extract has the ability to protect the cell from protein and lipid damage, as well as the inhibition of oxygen-derived radicals at the three concentrations tested: 0.1, 1, and 10 mg/mL. Regarding the toxicity of C. nutans extract against D. melanogaster, it was found that until the concentration of 15 mg/mL, the extract showed no toxicity and that the LC50 obtained was 24 mg/mL. Results show that the C. nutans extract leaves used to prevent PQ damage were effective in reducing flies’ mortality and improving locomotor capacity. Conclusion. Our studies demonstrated for the first time that C. nutans crude leaf extract has high antioxidant capacity both in vitro and in vivo through different analysis techniques. These results make it possible to infer future applications in the pharmacological area, evidenced by the low toxicity observed in D. melanogatser, as well as the ability to neutralize different sources of RONS.

scholarly journals Antimicrobial Activity of Crinum defixum Ker - Gawler Leaves

2015 ◽  
Vol 46 ◽  
pp. 8-15
Author(s):  
A. Elaiyaraja ◽  
G. Chandramohan ◽  
J. Mariajancyrani
Keyword(s):  
Escherichia Coli ◽  
Antimicrobial Activity ◽  
Leaf Extract ◽  
Phytochemical Screening ◽  
Zone Of Inhibition ◽  
Indigenous Medicine ◽  
Leaf Extracts ◽  
Mean Diameter ◽  
Different Types ◽  
Body Ache

Crinum defixum Ker - Gawler is a bulbous herb which has widely used in indigenous medicine for many diseases; mainly leaf and bulb extracts are of medicinal importance. Leaf extract is used as a treatment for pimples, body-ache, dropsy, carbuncle, paronychia, leprosy, fever and diarrhoea. The bulbs are crushed and applied on to piles and itching. The present study to determine the possible phytochemicals and antimicrobial activity of various leaf extracts of Crinum defixum Ker - Gawler plant. The phytochemical screening demonstrated the presence different types compound like flavonoids, tannins, phenolic compounds, saponins and glycosides. The ethanol, methanol and crude extracts of Crinum defixum Ker - Gawler showed significant antibacterial activity against Escherichia coli, Staphylococcus aureus, pseudomonas aeruginosa, proteus vulgaris and antifungal activity against Candida albicans, Aspergillus flavus when compare to different concentrations (μg/mL). The antimicrobial potential of test compounds was determined on the basis of mean diameter of zone of inhibition around the disk in millimetres. Thus, the present findings revealed the medicinal potential of Crinum defixum Ker - Gawler to develop a drug against various human ailments.

scholarly journals Production of Antiseptic Tablet Aloe Vera Soap

2020 ◽  
Vol 5 (8) ◽  
pp. 612-615
Author(s):  
Muhammad Sulaiman Rahama ◽  
Abubakar Sani
Keyword(s):  
Staphylococcus Aureus ◽  
Antimicrobial Activity ◽  
Research Work ◽  
Aloe Vera ◽  
Reducing Sugar ◽  
Phytochemical Screening ◽  
Zone Of Inhibition ◽  
E Coli ◽  
Commercial Soap ◽  
Phytochemical Constituents

This research work aimed at investigating some phytochemical constituents present in aloe vera based antiseptic soap and its activity against some selected microorganisms. The soap was produced using hot process and the antimicrobial activity was performed against Staphylococcus aureus, Escherichia Coli and Candida albicans using the method of agar well diffusion. The produced soap exhibited highest zone of inhibition on Staphylococcus aureus with 8.6 mm, 10.1 mm, 13.8 mm and 15.1 mm at 25 mg/mL, 50 mg/mL, 100 mg/mL and 200 mg/mL respectively, no inhibition was observed on E. Coli while the C. albicans was slightly inhibited by the soap by 7.6 mm, 9.0 mm, 13.2 mm at 50 mg/mL, 100 mg/mL, 200mg/mL respectively. The phytochemical screening conducted confirmed the presence of tannins, saponins, reducing sugar and flavonoid in the plant extract. The results of the investigations clearly indicated that aloe vera based soap had possessed antimicrobial activity against the tested microorganisms due to the presence of the confirmned phytoconstituents. Likewise pH, formability, and antimicrobial activity of the produced soap were comparable with the commercial soap.

scholarly journals Phytochemical screening and antibacterial effect of root extract of Boerhaavia diffusa L. (Family Nyctaginaceae)

2013 ◽  
Vol 5 (1) ◽  
pp. 221-225 ◽  
Author(s):  
Deepti Malhotra ◽  
Amir Khan ◽  
Fouzia Ishaq
Keyword(s):  
Antimicrobial Activity ◽  
Antibacterial Effect ◽  
Phytochemical Analysis ◽  
Root Extract ◽  
Bacterial Strains ◽  
Zone Of Inhibition ◽  
Analysis And Evaluation ◽  
Root Extracts ◽  
The Family ◽  
Boerhaavia Diffusa

Boerhaavia diffusa belonging to the family of the Nyctaginaceae is mainly a diffused perennial herbaceous creeping weed of India. The present study deals with the investigation of phytochemical analysis and evaluation of the antimicrobial activity of the aqueous and methanolic extract of the roots of Boerhaavia diffusa. The result revealed the presence of alkaloid, glycoside, saponins, flavonoids, polysaccharides, steroid and tannin in both the root extracts. B. diffusa root extract possesses antimicrobial activity as the zone of inhibition was observed for both gram positive as well as gram negative bacterial strains.

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