scholarly journals TO EVALUATE THE ANTI-ATHEROSCLEROTIC POTENTIAL OF QUERCETIN IN ALLOXANINDUCED DIABETIC RATS FED WITH HIGH-FAT DIET

2018 ◽  
Vol 11 (3) ◽  
pp. 379
Author(s):  
Biplav S ◽  
Sindhura G ◽  
Shivalinge Gowda K P
Keyword(s):  
Body Weight ◽  
Lipid Profile ◽  
High Fat Diet ◽  
Density Lipoprotein ◽  
Diabetic Rats ◽  
Group Iv ◽  
Lipoprotein Cholesterol ◽  
Histopathological Study ◽  
High Fat ◽  
Group Iii

 Objective: The main aim of the present study is concerned with the evaluation of anti-atherosclerotic potential of quercetin in alloxan-induced diabetic rats fed with high-fat diet (HFD).Methods: Atherosclerosis (AS) is the major cause for many of the cardiovascular disease, and it is accelerated in the presence of diabetes mellitus and causes profound alterations in the lipid profile. The method used for the induction of AS was using HFD for 60 days. In this study, rats were divided into four groups (n=6). Group I served as normal control, Group II alloxan (120 mg/kg b.w i.p)-treated diabetic rats, Group III received quercetin (50 mg/ kg b.w p.o), and Group IV received atorvastatin (10 mg/kg b.w p.o) along with alloxan (120 mg/kg b.w i.p) on the 1st day of the days of the study period. AS was induced in Group II, Group III, and Group IV rats by feeding them with HFD from the 1st day to 60th day. The body weight, feed intake was measured daily. The blood was withdrawn from retro-orbital plexus, and the serum was used for the estimation of lipid profile (total cholesterol [TC], triglycerides [TGs], low-density lipoprotein cholesterol [LDL-C], very LDL-C [VLDL-C], and high-density lipoprotein cholesterol [HDL-C]). After scarification under overdose of ketamine, the histopathological study of aorta was carried out.Results: The results showed that the quercetin-treated rats showed a decrease in body weight gain, decreased levels of TC, TGs, LDL-C, and VLDL-C, and increased levels of HDL-C were observed in Group III rats when compared to alloxan-induced diabetic rats fed with HFD (Group III). The histopathological study of aorta showed no development of plaques and of foam cells.Conclusion: From this study, it can be calculated that quercetin has anti-atherosclerotic activity as it significantly altered overall lipid profile in diabetic rats fed with HFD. This activity may be attributed to its antioxidant, inhibition of HMG-CoA reductase activity of quercetin.

Lactobacillus rhamnosus NCDC17 ameliorates type-2 diabetes by improving gut function, oxidative stress and inflammation in high-fat-diet fed and streptozotocintreated rats

2017 ◽  
Vol 8 (2) ◽  
pp. 243-255 ◽  
Author(s):  
S. Singh ◽  
R.K. Sharma ◽  
S. Malhotra ◽  
R. Pothuraju ◽  
U.K. Shandilya
Keyword(s):  
Oxidative Stress ◽  
Type 2 Diabetes ◽  
High Fat Diet ◽  
Lactobacillus Rhamnosus ◽  
Density Lipoprotein ◽  
Diabetic Rats ◽  
Lipoprotein Cholesterol ◽  
High Fat ◽  
Epididymal Fat

Restoration of dysbiosed gut microbiota through probiotic may have profound effect on type 2 diabetes. In the present study, rats were fed high fat diet (HFD) for 3 weeks and injected with low dose streptozotocin to induce type 2 diabetes. Diabetic rats were then fed Lactobacillus rhamnosus NCDC 17 and L. rhamnosus GG with HFD for six weeks. L. rhamnosus NCDC 17 improved oral glucose tolerance test, biochemical parameters (fasting blood glucose, plasma insulin, glycosylated haemoglobin, free fatty acids, triglycerides, total cholesterol, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol), oxidative stress (thiobarbituric acid reactive substance and activities of catalase, superoxide dismutase and glutathione peroxidase in blood and liver), bifidobacteria and lactobacilli in cecum, expression of glucagon like peptide-1 producing genes in cecum, and adiponection in epididymal fat, while decreased propionate proportions (%) in caecum, and expression of tumour necrosis factor-α and interlukin-6 in epididymal fat of diabetic rats as compared to diabetes control group. These findings offered a base for the use of L. rhamnosus NCDC 17 for the improvement and early treatment of type 2 diabetes.

scholarly journals Antihyperglycemic and antihyperlipidemic effects of low-molecular-weight carrageenan in rats

2018 ◽  
Vol 13 (1) ◽  
pp. 379-384 ◽  
Author(s):  
Xia Qiu ◽  
Wenwen Zhong
Keyword(s):  
Molecular Weight ◽  
Body Weight ◽  
Blood Glucose ◽  
High Fat Diet ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Postprandial Blood Glucose ◽  
Control Group ◽  
Low Molecular Weight ◽  
High Fat

AbstractThis study investigated the antihyperglycemic and antihyperlipidemic effects of low-molecular-weight carrageenan (LC) on rats fed a high-fat diet. Wistar rats were divided into five groups: normal control group (NC), high-fat diet control group (HC), carrageenan-treated control group (CC), 1% LC group (1% LC), and 3% LC-groups (3% LC). Body weight, food intake, fecal weight, blood glucose, and serum lipid levels were measured. After 30 days, body weight significantly decreased in the LC-treated groups than in the HC group. Moreover, in the LC-treated groups, postprandial blood glucose, total cholesterol, triglyceride, and low-density lipoprotein cholesterol (LDL-C) levels decreased, whereas high-density lipoprotein cholesterol (HDL-C) levels increased. From this study, our data suggest that LC has antihyperglycemic and hypolipidemic effects when compared to carrageenan, likely related to its increased absorption due to its lower molecular weight.

scholarly journals Effect of Antioxidant-rich Nutraceuticals in the Management of High Fat Diet-induced Obesity in Albino Rats

2021 ◽  
pp. 9-18
Author(s):  
Jude Nwaogu ◽  
Ibrahim Babangida Abubakar ◽  
Chizoba Maria Udeze ◽  
Ukperoro Uyoyo Jeremiah
Keyword(s):  
Body Weight ◽  
High Fat Diet ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Albino Rats ◽  
Standard Group ◽  
High Fat ◽  
Apple Cider ◽  
Diet Induced Obesity ◽  
Significant Difference

Background: Obesity, a metabolic disorder caused by an imbalance in energy intake and energy expenditure, is a major risk factor for chronic diseases such as type 2 diabetes, hypertension, cardiovascular heart diseases (CHD) and some types of cancer. This research was designed to investigate the effect of antioxidant rich- nutraceuticals in the management of high fat diet-induced obesity in rats. Method: Induction of obesity was achieved by feeding rats with a formulated high fat diet (HFD) for ten (10) weeks. Rats were subsequently group administered 250mg/kg body weight and 500mg/kg body weight of the nutraceutical respectively while apple cider vinegar of 5ml/kg body weight was administered to the standard group.        Result: Supplementation showed significant (P<0.05) decrease in the glucose, total cholesterol, triglyceride, low density lipoprotein- cholesterol, malondialdehyde and increased in high density lipoprotein-cholesterol and antioxidant status as compared with untreated high fat diet groups. However, there was no significant difference between supplementation of 500mg/kg and the standard group treated with 5ml/kg of Apple cider vinegar. Conclusion: Antioxidant rich nutraceuticals could provide a protective effect against oxidative stress in obesity and remedy complications associated with obesity by reversing the damage to near normal.

scholarly journals The Effect of Vitamin E Supplementation on the Histopathological Changes of The Hearts Mice Given High Fat Diet

2007 ◽  
Vol 1 (1) ◽  
Author(s):  
Razali Daud
Keyword(s):  
Body Weight ◽  
Vitamin E ◽  
High Fat Diet ◽  
Group Iv ◽  
Histopathological Changes ◽  
High Fat ◽  
Group V ◽  
Group Iii ◽  
Ad Libitum ◽  
Vitamin E Supplementation

The aim of this study was to determine the protective effect of vitamin E on mice heart. Twentyfivemalemiceweighing±40gattheageof3monthswereused.Themicewereadaptedforaweekandfedbasaldiet.Themicewerefednormaldietascontrol(group1),highfat+50IUVitaminE(groupII);highfat + 100 IU Vitamin E (group III) high fat + 200 IU Vitamin E (group IV); high fat + 400 IUVitamin E (Group V). Diet was given about 10% body weight, water was given ad libitum every day. After 3 months, all animal were then killed. The hearts were collected for routine histopathologicalexamination. The result indicate that lesions in the heart consist of swollen eosinophilic hyalinization ofcytoplasm, vacuolization, and necrosis myocardium (cardiomiopathy) in all mice receiving high fat dietwith less than 400 IU Vitamin E.Keywords: high fat diet, vitamin E, cardiovascular diseases 

High fat worsens olanzapine induced metabolic abnormalities in rats

2020 ◽  
Vol 122 (10) ◽  
pp. 3065-3075
Author(s):  
Sahara Juita Jamaluddin ◽  
Kiran C. Nilugal ◽  
Nagaraj M. Kulkarni ◽  
Santosh Fattepur ◽  
Ibrahim Abdullah ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Lipid Profile ◽  
High Fat Diet ◽  
Density Lipoprotein ◽  
Diet Group ◽  
Normal Diet ◽  
Metabolic Abnormalities ◽  
High Fat ◽  
Content Type ◽  
Group Iii

PurposeOlanzapine is widely prescribed in the treatment of schizophrenia and various psychiatric illnesses. Schizophrenia patients have been reported to eat a diet that contain higher in fat and lower in fiber. High dietary fat intake can predispose to the development of metabolic abnormalities and exacerbate hepatic changes. The aim of the paper is to investigate the effect of olanzapine and high fat diet on blood glucose, lipid profile and the liver in rats.Design/methodology/approachTwenty-four healthy male Sprague Dawley rats were divided into following groups: group I was given normal diet, group II was given high fat diet, group III was given high fat diet and olanzapine (5 mg/kg/day intraperitoneally twice daily) and group IV was given normal diet and olanzapine (at same dose). After 30 days, the blood samples were collected to assess levels of blood glucose and total lipid profile. Also, liver specimens were processed for histological study by using light microscope.FindingsGroup III showed significant increase in weight, blood glucose (p < 0.05), total cholesterol (p < 0.05), low-density lipoprotein-cholesterol (p < 0.05) and decrease in high-density lipoprotein-cholesterol (p < 0.05) when compared to group II. While group III revealed several histological changes including, dilatation and congestion of central veins and blood sinusoids as well some hepatocytes appeared damaged and were replaced by inflammatory cellular infiltrate.Originality/valueThese results suggest that olanzapine and high fat diet greatly increased the blood glucose, total cholesterol, LDL-C and considerable decreased HDL-C as well as mild inflammatory changes

scholarly journals ANTI-OBESITY EFFECTS OF PULICARIA JAUBERTII E. GAMAL-ELDIN IN HIGH FAT DIET-INDUCED RATS

2020 ◽  
Author(s):  
Noor Kaokabah ◽  
Adana Al-Qubati ◽  
Ghanya Al-Naqeb
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Peer Review ◽  
High Fat Diet ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Control Group ◽  
Potential Candidate ◽  
High Fat ◽  
Traditional Use

Background: Pulicaria jaubertii E. Gamal-Eldin is a traditional medicine and flavoring used in Yemen where a large number of people depend on herbal plants to treat their ailments. This study was conducted to determine and compare the effects of Pulicaria jaubertii leaves and flowers aqueous extract (PJAE) and Pulicaria jaubertii leaves and flowers in powder form mixed with diet (PJPD) on obesity induced rats by high-fat diet (HFD). Methods: Obesity was experimentally induced in male Sprague Dawley rats by feeding them a high-fat diet for 6 weeks. The rats were divided into 3 groups, the HFD control group, whereas the rats fed HFD only and the PJAE group where the rats fed HFD + PJAE and PJPD where the rats fed HFD + PJPD. PJAE was administrated by gavage at 1g/kg body weight and the activity of PJPD was determined as oral administration at 10% of the diet.  Food intake and gain weight were taken once a week and blood samples were obtained at the end of the experiment for lipid profile analysis, glucose level and toxicity parameter including liver and kidney functions parameters. Results: The results indicated a significant decrease in the percentage of weight gain and in the PJPD group at the fifth and sixth weeks of treatment compared to the HFD control rats. Also, there was a significant decrease in the level of blood triglycerides in the PJPD compared to the HFD group. Where no significant change was observed in the percentage of weight gain and triglyceride level in the PJAE group compared to the HFD control rats. Also, there was no significant changes in all the tested parameters including, total cholesterol, high-density lipoprotein cholesterol and low-density lipoprotein cholesterol, liver enzymes and creatinine and urea levels. Conclusion: The results obtained from this study showed that the leaves and flowers of Pulicaria jaubertii mixed with HFD had an anti-obesity effect in rats fed with HFD, and the anti-obesity effects of PJ could be attributed to the phytochemicals present. Therefore, the current study scientifically confirms the traditional use of PJ as a potential candidate for body weight loss. Peer Review History: Received: 7 September 2020; Revised: 11 October; Accepted: 25 October, Available online: 15 November 2020 UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency. Received file Average Peer review marks at initial stage: 5.5/10 Average Peer review marks at publication stage: 7.0/10 Reviewer(s) detail: Prof. Dr. Hassan A.H. Al-Shamahy, Sana'a University, Yemen, [email protected] Dr. Gulam Mohammed Husain, National Research Institute of Unani Medicine for Skin Disorders, Hyderabad, India, [email protected] Comments of reviewer(s): Similar Articles: ASSESSMENT OF THE RISK OF TYPE 2 DIABETES AMONG HEALTHY WITHOUT DIABETES IN SUDAN USING THE FINDRISC TOOL

scholarly journals Effect of Soybean and Soybean Koji on Obesity and Dyslipidemia in Rats Fed a High-Fat Diet: A Comparative Study

2021 ◽  
Vol 18 (11) ◽  
pp. 6032
Author(s):  
Sihoon Park ◽  
Jae-Joon Lee ◽  
Hye-Won Shin ◽  
Sunyoon Jung ◽  
Jung-Heun Ha
Keyword(s):  
Adipose Tissue ◽  
White Adipose Tissue ◽  
High Fat Diet ◽  
Unsaturated Fatty Acids ◽  
Density Lipoprotein ◽  
Serum Triglyceride ◽  
Lipoprotein Cholesterol ◽  
Health Concern ◽  
High Fat ◽  
Cholesterol Levels

Soybean koji refers to steamed soybeans inoculated with microbial species. Soybean fermentation improves the health benefits of soybeans. Obesity is a serious health concern owing to its increasing incidence rate and high association with other metabolic diseases. Therefore, we investigated the effects of soybean and soybean koji on high-fat diet-induced obesity in rats. Five-week-old male Sprague-Dawley rats were randomly divided into four groups (n = 8/group) as follows: (1) regular diet (RD), (2) high-fat diet (HFD), (3) HFD + steamed soybean (HFD+SS), and (4) HFD + soybean koji (HFD+SK). SK contained more free amino acids and unsaturated fatty acids than SS. In a rat model of obesity, SK consumption significantly alleviated the increase in weight of white adipose tissue and mRNA expression of lipogenic genes, whereas SS consumption did not. Both SS and SK reduced serum triglyceride, total cholesterol, and low-density lipoprotein cholesterol levels, and increased high-density lipoprotein cholesterol levels. SS and SK also inhibited lipid accumulation in the liver and white adipose tissue and reduced adipocyte size. Although both SS and SK could alleviate HFD-induced dyslipidemia, SK has better anti-obesity effects than SS by regulating lipogenesis. Overall, SK is an excellent functional food that may prevent obesity.

scholarly journals Regulatory Efficacy of Spirulina platensis Protease Hydrolyzate on Lipid Metabolism and Gut Microbiota in High-Fat Diet-Fed Rats

2018 ◽  
Vol 19 (12) ◽  
pp. 4023 ◽  
Author(s):  
Pengpeng Hua ◽  
Zhiying Yu ◽  
Yu Xiong ◽  
Bin Liu ◽  
Lina Zhao
Keyword(s):  
Lipid Metabolism ◽  
Gut Microbiota ◽  
High Fat Diet ◽  
Spirulina Platensis ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Public Health Issue ◽  
Peroxisome Proliferator ◽  
Hypolipidemic Effect ◽  
High Fat

Lipid metabolism disorder (LMD) is a public health issue. Spirulina platensis is a widely used natural weight-reducing agent and Spirulina platensis is a kind of protein source. In the present study, we aimed to evaluate the effect of Spirulina platensis protease hydrolyzate (SPPH) on the lipid metabolism and gut microbiota in high-fat diet (HFD)-fed rats. Our study showed that SPPH decreased the levels of triglyceride (TG), total cholesterol (TC), low-density-lipoprotein cholesterol (LDL-c), alanine transaminase (ALT), and aspartate transaminase (AST), but increased the level of high-density-lipoprotein cholesterol (HDL-c) in serum and liver. Moreover, SPPH had a hypolipidemic effect as indicated by the down-regulation of sterol regulatory element-binding transcription factor-1c (SREBP-1c), acetyl CoA carboxylase (ACC), SREBP-1c, and peroxisome proliferator-activated receptor-γ (PPARγ) and the up-regulation of adenosine 5’-monophosphate (AMP)-activated protein kinase (AMPK) and peroxisome proliferator-activated receptorα (PPARα) at the mRNA level in liver. SPPH treatment enriched the abundance of beneficial bacteria. In conclusion, our study showed that SPPH might be produce glucose metabolic benefits in rats with diet-induced LMD. The mechanisms underlying the beneficial effects of SPPH on the metabolism remain to be further investigated. Collectively, the above-mentioned findings illustrate that Spirulina platensis peptides have the potential to ameliorate lipid metabolic disorders, and our data provides evidence that SPPH might be used as an adjuvant therapy and functional food in obese and diabetic individuals.

scholarly journals Anti-Obesity Effect of Diphlorethohydroxycarmalol Isolated from Brown Alga Ishige okamurae in High-Fat Diet-Induced Obese Mice

Marine Drugs ◽  
2019 ◽  
Vol 17 (11) ◽  
pp. 637 ◽  
Author(s):  
Yuling Ding ◽  
Lei Wang ◽  
SeungTae Im ◽  
Ouibo Hwang ◽  
Hyun-Soo Kim ◽  
...  
Keyword(s):  
High Fat Diet ◽  
Body Weight Gain ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Epididymal Adipose Tissue ◽  
High Fat ◽  
Expression Levels ◽  
Ishige Okamurae

Diphlorethohydroxycarmalol (DPHC) is one of the most abundant bioactive compounds in Ishige okamurae. The previous study suggested that DPHC possesses strong in vitro anti-obesity activity in 3T3-L1 cells. However, the in vivo anti-obesity effect of DPHC has not been determined. The current study explored the effect of DPHC on high-fat diet (HFD)-induced obesity in C57BL/6J mice. The results indicated that oral administration of DPHC (25 and 50 mg/kg/day for six weeks) significantly and dose-dependently reduced HFD-induced adiposity and body weight gain. DPHC not only decreased the levels of triglyceride, low-density lipoprotein cholesterol, leptin, and aspartate transaminase but also increased the level of high-density lipoprotein cholesterol in the serum of HFD mice. In addition, DPHC significantly reduced hepatic lipid accumulation by reduction of expression levels of the critical enzymes for lipogenesis including SREBP-1c, FABP4, and FAS. Furthermore, DPHC remarkably reduced the adipocyte size, as well as decreased the expression levels of key adipogenic-specific proteins and lipogenic enzymes including PPARγ, C/EBPα, SREBP-1c, FABP4, and FAS, which regulate the lipid metabolism in the epididymal adipose tissue (EAT). Further studies demonstrated that DPHC significantly stimulated the phosphorylation of adenosine monophosphate-activated protein kinase (AMPK) and acetyl-CoA carboxylase (ACC) in both liver and EAT. These results demonstrated that DPHC effectively prevented HFD-induced obesity and suggested that DPHC could be used as a potential therapeutic agent for attenuating obesity and obesity-related diseases.

scholarly journals Melatonin Improves Fatty Liver Syndrome by Inhibiting the Lipogenesis Pathway in Hamsters with High-Fat Diet-Induced Hyperlipidemia

Nutrients ◽  
2019 ◽  
Vol 11 (4) ◽  
pp. 748 ◽  
Author(s):  
Tzu-Hsuan Ou ◽  
Yu-Tang Tung ◽  
Ting-Hsuan Yang ◽  
Yi-Wen Chien
Keyword(s):  
High Fat Diet ◽  
Fatty Acid Synthase ◽  
Plasma Cholesterol ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Lipogenic Enzymes ◽  
High Fat ◽  
Syrian Hamsters ◽  
Hepatic Lipid

The aim of this study was to investigate the effect of melatonin on hepatic lipid metabolism in hamsters with high-fat diet (HFD)-induced dyslipidemia. Male Syrian hamsters were kept on either a chow control (C) or HFD for four weeks. After four weeks, animals fed the HFD were further randomly assigned to four groups: high-fat only (P), melatonin low-dosage (L), medium-dosage (M), and high-dosage (H) groups. The L, M, and H groups, respectively, received 10, 20, and 50 mg/kg/day of a melatonin solution, while the P and C groups received the ethanol vehicle. After eight weeks of the intervention, results showed that a low dose of melatonin significantly reduced HFD-induced hepatic cholesterol and triglycerides; decreased plasma cholesterol, triglycerides, and low-density lipoprotein cholesterol; and increased plasma high-density lipoprotein cholesterol (p < 0.05). In addition, melatonin markedly decreased activities of the hepatic lipogenic enzymes, acetyl-CoA carboxylase (ACC) and fatty acid synthase (FAS) (p < 0.05), and elevated the relative hepatic carnitine palmitoyltransferase-1α expression in hamsters with HFD-induced hyperlipidemia. Consequently, melatonin reduced activities of the hepatic lipogenic enzymes, ACC and FAS. In summary, chronic melatonin administration improved HFD-induced dyslipidemia and hepatic lipid accumulation in Syrian hamsters with HFD-induced dyslipidemia, which might have occurred through inhibiting the lipogenesis pathway.

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