scholarly journals A COMPARATIVE STUDY OF ANTI-NOCICEPTIVE ACTIVITY OF CURCUMA LONGA LINN. WITH THAT OF IBUPROFEN IN EXPERIMENTAL ANIMALS

2020 ◽  
pp. 51-53
Author(s):  
SWOPNA PHUKAN ◽  
SAHELI DAS
Keyword(s):  
Analgesic Activity ◽  
Curcuma Longa ◽  
Tail Flick ◽  
Experimental Animals ◽  
Medical College ◽  
High Doses ◽  
Student’S T ◽  
Analgesic Activities ◽  
Mean Reaction Time ◽  
Student’S T Test

Objective: The aim of the study is to evaluate and compare the analgesic activities of Curcuma longa Linn. in the experimental animals. Methods: The present study was conducted in the Department of Pharmacology, Gauhati Medical College and Hospital, after getting approval from the Institutional Animal Ethics Committee (No MC/68F/2009/MAR-19/02). Healthy rodents weighing between 150 and 200 g were selected and randomly divided into five groups, each group consisting of six animals. Tail-flick analgesiometer was used to assess the analgesic activity of C. longa Linn. and ibuprofen in the experimental animals. Appropriate statistical analyses like Student’s t-test were used to analyze the data. Results: The mean reaction time (s) was prolonged on gradually increasing the dose of C. longa Linn. from 200 to 400 mg/kg. At 400 mg/kg dose C. longa Linn. produced similar analgesic activity as compared to ibuprofen (30 mg/kg). Conclusion: From the study, it can be concluded that curcumin has the capacity to attenuate pain, and when administered in high doses, may produce similar activity as other conventional NSAID’s.

scholarly journals Evaluation of analgesic activity of turmeric (Curcuma longa Linn.) in Wister rats

2017 ◽  
Vol 6 (3) ◽  
pp. 568 ◽  
Author(s):  
Sangita Jogdand ◽  
Jagruti Bhattacharjee
Keyword(s):  
Analgesic Activity ◽  
Normal Saline ◽  
Curcuma Longa ◽  
Ethanolic Extract ◽  
Albino Rats ◽  
Time Intervals ◽  
Hot Plate ◽  
Hot Plate Test ◽  
Analgesic Activities

Background: NSAIDs like Aspirin etc. are randomly used for mild to severe types of pain but long-term and injudicious use of NSAIDs lead to a number of side effects. The present study is designed for exploring the analgesic potential of Curcuma longa Linn (Turmeric) in albino rats, which may widen the therapeutic horizon for the said agent.Methods: Ethanolic extract of Curcuma longa in the doses 100, 200 and 400mg/kg is given orally to 6 Wister rats against a control of normal saline and a standard using Aspirin (300mg/kg) and the animals were subjected to Eddy’s hot plate test at different time intervals i.e., 30, 60, 90 and 120 minutes after administration of the drugs and the parameters were noted.Results: The analgesic activity of Curcuma longa showed significant (p<0.05) increase in mean basal reaction time in Hot plate method when compared to the control (Normal saline). As the dose of the ethanolic extract of Curcuma longa was gradually increased from 100, 200 and 400mg/kg respectively, the analgesic activity significantly increased (<0.05). Effect of curcuma longa at a dose of 400mg/kg is found to be comparable with Aspirin.Conclusions: The results of this study suggest that turmeric (Curcuma longa) has significant analgesic activities in rats. 

Anti-Inflammatory, Antipyretic and Analgesic Potential of Zilla spinosa in Animal Model

2019 ◽  
Author(s):  
Riaz Ullah ◽  
Abdelaaty A Shahat ◽  
Ali S Alqahtani ◽  
Omer Mohammed Almarfad ◽  
Mohammad Sayer M Alharbi ◽  
...  
Keyword(s):  
Analgesic Activity ◽  
Tail Flick ◽  
Chloroform Fraction ◽  
Test Model ◽  
Hot Plate Test ◽  
Tail Flick Test ◽  
Antipyretic Activity ◽  
Rat Paw Edema ◽  
Anti Inflammatory ◽  
Analgesic Activities

The anti-inflammatory, antipyretic and analgesic activities of two concentrations (250 and 500 mg/kg) of the chloroform and butanol fractions of Zilla spinosa were determined. The carrageenan-induced rat paw edema assay was exercised for assessing the anti-inflammatory activity in rats, yeast-induced hyperthermia was utilized to assess the antipyretic activity in mice and the analgesic activity was measured by three different methods (hot-plate test model in mice, tail flick test in mice and acetic acid-induced writhing in mice). The antioxidant activity was studied by using the DPPH assay. The chloroform fraction of the methanol extract of Z. spinosa (ZSC) demonstrated the maximum inhibition of inflammation (50% at 500 mg/kg; 44% at 250 mg/kg). The chloroform fraction showed significant antipyretic activities (p andlt; 0.001 at 500 mg/kg) after 60 and 120 min of administration. ZSC also exhibited significant analgesic activity (p andlt;0.001). The butanol fraction (ZSB) was inactive in all the biological screening assays.

scholarly journals Cytotoxicity, analgesic and anthelmintic studies of the different plant parts of Saraca indica Linn. (Family: Caesalpiniaceae)

2016 ◽  
Vol 2 (11) ◽  
pp. 278
Author(s):  
Most. Nazma Parvin
Keyword(s):  
Cytotoxic Activity ◽  
Analgesic Activity ◽  
Leaf Extract ◽  
Methanol Extract ◽  
Anthelmintic Activity ◽  
Bark Extract ◽  
Tail Flick ◽  
Standard Drug ◽  
Vincristine Sulphate ◽  
Analgesic Activities

<p class="abstract"><strong>Background: </strong><em>Saraca indica</em> or <em>Saraca asoca</em> belonging to the family Caesalpiniaceae. It<em> </em>is popularly known as Ashoka, is the most ancient tree of Bangladesh. This versatile plant has anti-cancer, anti-menorrhagic, anti-oxytocic, anti-microbial activity and has extended uses in ayurveda, unani and homeopathy. The present study attempts to investigate the cytotoxic and analgesic activities of the methanol extract of bark and the anthelmintic activity of the leaf extract of <em>Saraca indica</em>.</p><p class="abstract"><strong>Methods:</strong> The cytotoxic activity of the methanol extract of the bark was performed by brine shrimp lethality bioassay and analgesic potential of the bark extract was evaluated using both acetic acid induced writhing test and tail-flick tests to understand the central analgesic activity using Swiss Albino mice as experimental animal. Anthelmintic activity of the leaf extract was performed by observing the time of paralysis and the time of death of earthworms, <em>Pheretima posthuma</em>.  </p><p class="abstract"><strong>Results:</strong> The methanol extract of the bark showed moderate cytotoxic activity when compared with the standard drug vincristine sulphate. The results of analgesic activities suggested that the methanol extract of the bark possess significant analgesic activity in mice, which is comparable to the standard drug, diclofenac-Na. The fresh juice extract of the leaf of <em>S. indica </em>showed potent anthelmintic activity when compared with standard drug, albendazole.</p><p><strong>Conclusions:</strong> Our present study, demonstrates the cytotoxic, analgesic and anthelmintic, properties of <em>Saraca</em> <em>indica</em>, which validate its use in traditional medicine.</p>

Report on Antidiabetic, Diuretic and Analgesic Activities of Methanolic Extract of Leaves of Strychnos colubrina L.an Endangered Medicinal Plant

2019 ◽  
Vol 10 (01) ◽  
Author(s):  
Indira Priyadarsini A. ◽  
S K M Basha2 ◽  
Chakrapani I S ◽  
Nagalakshmi Devamma M
Keyword(s):  
Blood Glucose ◽  
Medicinal Plant ◽  
Analgesic Activity ◽  
Methanolic Extract ◽  
Tail Flick ◽  
Methanolic Extracts ◽  
Endangered Medicinal Plant ◽  
Sugar Levels ◽  
Analgesic Activities ◽  
Dose Dependent

Strychnos colubrina L. belongs to family Loganiaceae was known as snake wood tree.The methanolic extracts from Strychnos colubrina L. leave collected from different provinces in Penchalakona of Nellore district were prepared by decoction and maceration with methanol and evaluated for their antidiabetic, diuretic and analgesic activities. Methanolic extracts from Strychnos colubrina L. leaves (SCM) were evaluated for anti diabetic effect in Streptozocin (STZ) induced diabetes in rats. The blood sugar levels were analysed as indices of diabetes. 200 mg/kg b.w. of the extract showed a greater reduction in blood glucose level which was comparable to glibenclamide. To find out diuretic efficacy, SCM of leaves were administered to experimental rats orally at doses of 100 and 200 mg/kg and compared with Furosemide (20 mg/kg,o.p) as the standard. The rats treated with SCM of leaves in a dose of 200 mg/kg shown near similar urine output and electrolytes excretion when compared to the respective control. The analgesic activity of SCM of leaves is estimated using tail flick in mice. Results demonstrated that SCM of leaves exhibited a potent dose-dependent analgesic activity in all tested models for analgesia. This report could be used for medicinal and pharmaceutical exploration in the future.

scholarly journals Effects of green tea on glycemic status in female metabolic syndrome patients

2020 ◽  
Vol 15 (2) ◽  
pp. 85-90
Author(s):  
Sabira Tabassum ◽  
Qazi Shamima Akhter
Keyword(s):  
Metabolic Syndrome ◽  
Green Tea ◽  
T Test ◽  
Control Group ◽  
Study Group ◽  
Ethical Aspect ◽  
Glycemic Status ◽  
Medical College ◽  
Student’S T ◽  
Student’S T Test

Background: According to International Diabetic Federation, around 20-25% of world adult population have the clinical features of metabolic syndrome (MetS). Different organizations recommend to modify lifestyle and dietary habit as primary intervention. Green tea has several pharmacological effects on metabolic diseases including MetS. Objective: To evaluate the effects of green tea consumption on two glycemic variables in women with MetS. Method: This interventional study was conducted in the Department of Physiology, Dhaka Medical College from January 2016 to December 2016. After fulfilling the ethical aspect, a total number of 42 female patients with MetS aged 40 to 50 years were selected from the outpatient department of Endocrinology, Dhaka Medical College Hospital. Participants were randomly assigned in study group (n=22) and control group (n=20). Study group consumed green tea for 12 weeks and the control group did not consume green tea. In both groups fasting serum glucose (FSG) and glycosylated hemoglobin (HbA1c) were measured by glucose oxidase (GOD/ PAP) method and modified high performance liquid chromatography (HPLC) method respectively 2 times (before and after 12 weeks). Data were analyzed by paired Student’s ‘t’ test and unpaired Student’s ‘t’ test. Results: After 12 weeks of intervention, FSG & HbA1c significantly (p<0.001) decreased in the study group than those of their baseline value and these values were also significantly (p<0.05) lower in comparison to those of control group. Conclusions: Regular consumption of green tea may improve glycemic status in patients with metabolic syndrome. J Bangladesh Soc Physiol. 2020, December; 15(2): 85-90

scholarly journals AN AN STUDY OF ANALGESIC ACTIVITY OF HAFFNER’S TAIL CLIP METHOD ON ALBINO WISTAR RATS OF SOME POLYHERBAL FORMULATION

2019 ◽  
pp. 142-144
Author(s):  
LOKENDRA SINGH
Keyword(s):  
Analgesic Activity ◽  
Side Effect ◽  
Analgesic Effect ◽  
Design Method ◽  
Curcuma Longa ◽  
Albino Rats ◽  
Tail Flick ◽  
Herbal Drugs ◽  
Tail Flick Test ◽  
Tail Clip

Objective: Herbal drugs are more beneficial better than aspirin because this is an herb so no side effect this drug and it is easy to collect or use to as herbal drugs. Words are inadequate to describe the motivation for my work given to my beloved guide. I would like to add special thanks to my guide Gauravbilwal, for their guidance, support, and encouragement. Purpose (Hypothesis): The main purpose of this article pays to attention for herbal drugs because they are naturally old effective drugs. As well as, Ayurveda treatment is very older effective technique. Design/Method: Haffner gave to this technique of determining analgesic are around in 1929. Procedure: This technique according to tail if clipped with any object and tightly or will be compression generation of pain in the tail as well as mice starting to bite that portion of its tail, and could evaluate and recorded the response how much it bites tail quickly or in potential. Using this simple yet important marvel, we may apply the drug to be evaluated and record the response whether it bites tail quickly or in potential. If given drugs have analgesic likely, then rat will not bite its tail so frequently. Mice that do not show any response within 15 s will reject from the experiment. Results: The found in analgesic activity of additional compounds test to significant on tail flick test than acetic acid-induced test and thus it appears that the test compounds inhibit predominantly the peripheral pain mechanism. The results of the study indicate that the extracts of polyherbal plants of analgesic activity by reducing the abdominal constriction significantly and may supposed to have a possible role in inhibition of cyclooxygenase in the prostaglandin pathways (p****<0.0001, ***0.0001, *0.05). Conclusion: The present study showed the significant analgesic effect of both aqueous and alcoholic at 400 mg/kg doses in albino rats, we reported for the 1st time analgesic effect of different plants (Curcuma longa, Colchicaceae, Colocynthis, Withania somnifera, and Achyranthes aspera) in Haffner’s tail clip models. Aspirin has each uncoated effervescent tablet content are acetylsalicylic acid I.P. 325 mg. Finally summarized in this article represent a most effective results of herbal drugs equalized allopathic drugs without any other side effect. Hence, this is very usefully combination of Ayurveda drugs.

scholarly journals Assessment of analgesic and anti-inflammatory potential of ethanolic extract of Gossypium arboreum leaves in experimental animals

2019 ◽  
Author(s):  
Sharad Patange ◽  
Vijay Navghare ◽  
Prashant Zagade ◽  
Akshay Kendre ◽  
Swarp Jadhav ◽  
...  
Keyword(s):  
Cotton Plant ◽  
Analgesic Activity ◽  
Ethanolic Extract ◽  
Tail Flick ◽  
Gossypium Arboreum ◽  
Paw Edema ◽  
Experimental Animals ◽  
Rat Paw Edema ◽  
Anti Inflammatory ◽  
Rat Paw

Background and objectives: Gossypium arboreum commonly known as cotton plant, this variety of cotton plant available throughout India. Cotton plant was used traditionally for the treatment of infection, diarrhea and other inflammatory conditions. The aim of present study is to evaluate analgesic and anti-inflammatory activity of Gossypium arboreum leaves extract on experimental animals. Materials and Methods: The ethanolic extract of Gossypium arboreum leaves (EEGA) was subjected to assess its antioxidant potential using DPPH radical scavenging assay; further anti-inflammatory and analgesic activity was assessed by using carrageenan-induced rat paw edema and tail flick test respectively in experimental animals. Results: It was observed that free radicals were scavenged by the EEGA in a concentration dependent manner. The Ethanolic extract showed maximum 72% scavenging activities at 200 g/ml concentration. The ethanol extract exhibited significant analgesic activity in the tail-flick model (?&lt;0.01) by increasing the reaction time of the mice to 8.9 sec at 180min after treatment in comparison to control (3.4 sec). The EEGA (100, 200 and 400 mg/kg, p.o.) showed dose-dependent, inhibition of carrageenan-induced rat paw edema from 30 min onwards (P&lt;0.01), Conclusions: Present study revealed that the ethanolic extract of Gossypium arboreum displayed prominent analgesic and anti-inflammatory activity in experimental animals owing to its antioxidant property.

scholarly journals Serum Electrolyte Profile of Children Less Than Five Years of Age Admitted with Pneumonia in a Tertiary Care Hospital

2019 ◽  
Vol 31 (2) ◽  
pp. 59-62
Author(s):  
Abu Hena Mostafa Kamal ◽  
Sharmin Afrozy ◽  
Marjina Khatun ◽  
Mst Shaheen Nawrozy ◽  
Most Merina Akhter
Keyword(s):  
Hospital Stay ◽  
Tertiary Care ◽  
Distribution Patterns ◽  
Care Hospital ◽  
Medical College ◽  
Efficient Test ◽  
Hospital Stays ◽  
Delayed Recovery ◽  
Student’S T ◽  
Student’S T Test

The study was done to observe whether there is any association of pneumonia with hyponatraemia, as well as to have a view to the patients’ hospital-stay in this regard. This study was conducted from July 2009 to September 2011 at the Department of Biochemistry of Shaheed Ziaur Rahman Medical College (SZMC), Bogra. Total 35 cases, 1 month to 5 years of age, who suffered from pneumonia, were included in this study. Their serum Na+, K+& Cl- levels were measured and their hospital stays in days were recorded for the comparison between normonatraemics and hyponatraemics. The distribution patterns were described as percentage of total. In addition, Student’s ‘t’ test and Pearson’s correlation co-efficient test were also used. Among 35 cases, 22 (63%) cases were male and 13 (37%) cases were female; 14 (40%) cases were hyponatraemic and 21 (60%) cases were normonatraemic. Mean (±SD) of age was 19.6 (±15.2) months. For all the cases, there was a positive correlation of serum Cl– with serum Na+ levels (p<0.001); but no correlation was observed between serum K+& Na+ levels (P>0.10). Hospital stay of hyponatraemic cases was higher than the normonatraemic cases (P<0.05). Children with pneumonia may develop hyponatraemia, which if not managed in due time, may lead to delayed recovery from illness. TAJ 2018; 31(2): 59-62

scholarly journals Dose-dependent analgesic activity of mexiletine on thermally induced pain in rats

2018 ◽  
Vol 8 (1) ◽  
pp. 90
Author(s):  
Aravind Patil ◽  
Vijaya Chandra Reddy Konda
Keyword(s):  
Analgesic Activity ◽  
Standard Dose ◽  
Emotional Experience ◽  
Drug Repurposing ◽  
Tail Flick ◽  
Channel Blockers ◽  
Significant Difference ◽  
Analgesic Activities ◽  
Dose Dependent ◽  
Higher Doses

Background: Pain is an unpleasant sensory and emotional experience associated with actual or potential tissue damage or described in terms of such damage. In spite of many advances in pain research, we are unable to deal in an effective way. The cost for new drug development is increasing day by day. Drug repurposing is an approach to look for new use in drugs that are already approved for other indications. Mexiletine is a sodium channel blockers that is being approved for treatment of arrhythmias. It is being tried in treatment of various painful conditions. The present study is to evaluate the dose-dependent analgesic activity of mexiletine with ibuprofen.Methods: The analgesic activity of mexiletine was compared at doses of 15mg/kg, 30mg/kg and 45mg/kg with the standard dose of ibuprofen at 10mg/kg in male Wistar rats in thermal model of tail flick analgesiometer.Results: At lower doses (15mg/kg) of mexiletine, analgesic activity of ibuprofen was significantly higher. At higher doses (30 mg/kg and 45 mg/kg) of mexiletine, it was observed that there is no significant difference between the analgesic activities of both drugs.Conclusions: Mexiletine demonstrated a dose-dependent analgesic activity. There was no statistically significant difference between the analgesic activities of higher doses of mexiletine when compared to ibuprofen.

scholarly journals Phytochemical Investigation and Analgesic Activity of Stem Bark Extract of Sapindus trifoliatus Linn

2021 ◽  
pp. 398-407
Author(s):  
B. Sangeetha ◽  
Ronald Fernandes ◽  
K. Adarsha Govinda ◽  
K. Vijay Bhaskar
Keyword(s):  
Acetic Acid ◽  
Analgesic Activity ◽  
Lethal Dose ◽  
Ethanolic Extract ◽  
Stem Bark ◽  
Bark Extract ◽  
Tail Flick ◽  
Experimental Animals ◽  
Stem Bark Extract ◽  
Phytochemical Studies

Aims: The study is designed to isolate and charecterize the phytoconstituents, and screen for the analgesic activity of stem bark extracts of Sapindus trifoliatus Linn. Methodology: The cleaned, dried and powdered stem barks of Sapindus trifoliatus were subjected to extraction by maceration process. The concentrated ethanolic extract of stem bark on was further subjected to preliminary phytochemical studies.  The fractionated extracts were then packed into column chromatography for the isolation of phytoconstituents and they were characterized by IR, 1HNMR, 13CNMR and mass spectroscopy.Acute toxicity was performed to establish the lethal dose of the extract and In vivo analgesic activity was performed by tail flick and acetic acid induced writhing methods in experimental animals. Results: Preliminary phytochemical studies showed the presence of steroids, terpenoids, flavonoids, saponins and carbohydrates. Isolation of extracts led to give compounds like saponin glycoside, a steroid and triterpenoids. The extract was found to be safe up to 2000 mg kg bodyweight. Analgesic activity was found significant at level P = 05 when compared with control by tail flick and acetic acid induced writhing models in experimental animals. Conclusion: From ethanolic extract isolated a saponin glycoside,from petroleum ether stigmasterol and triterpenoids ursolic acid. The presence of saponin glycoside, triterpenoids, steroids might be responsible for the analgesic activity of the stem bark extract of Sapindus trifoliatus Linn.

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