THE EFFICACY OF COVID-19 VACCINE AND THE CHALLENGE IN IMPLEMENTING MASS VACCINATION IN INDONESIA

Novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has caused more than 2,38 million deaths and more than 108 million cases confirmed in one year of the pandemic are massive upheavals in social life and economy in the international world. An effective vaccine is needed to prevent further morbidity and mortality. This research aims to identify the challenge in implementing mass vaccination in Indonesia which is related to the efficacy of the COVID-19 vaccine. We retrieve sources from relevant and published articles in Google Scholar, Pubmed, DOAJ and Science Direct of articles up to January 2021. The keywords used for gathering information were listed below. Vaccine efficacy is defined as the proportional reduction of a disease case in a group of vaccinated participants compared with unvaccinated participants. The study of vaccine efficacy is a cohort study that is an important vaccine trial method in the field. It is conducted randomly on a large scale by using a control-placebo. During the trials, the country which used the vaccine needs to maintain and observe the vaccine epidemiology. A trial roadmap is expected to identify the condition of the area epidemiologically. Vaccine efficacy is essential to be observed before implementing the vaccine in society. However, intensive socialization about the advantage of vaccines is mainly needed to prevent irrelevant information in social media about mass vaccination.

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COVID-19 Pandemic’s precautionary measures had hit the reset button of the quality of life at different aspects

The Journal of Infection in Developing Countries ◽

10.3855/jidc.12943 ◽

2020 ◽

Vol 14 (08) ◽

pp. 812-816

Author(s):

Huda H Alsayedahmed

Keyword(s):

Quality Of Life ◽

Social Life ◽

Large Scale ◽

Occupational Safety ◽

Health Administration ◽

Protective Measures ◽

Precautionary Measures ◽

Novel Coronavirus ◽

The Impact

COVID-19 is a novel coronavirus that emerged in Wuhan-China during the last quarter in 2019 and caused an infectious respiratory disease pandemic. The strategy of “Attack and Defend” was attempted to mitigate COVID-19 crisis worldwide. A list of precautionary measures were set by healthcare professional experts to protect public from infection, social physical distancing measures being the most efficient. On the other hand, Occupational Safety and Health Administration (OSHA) has established protective guidelines for healthcare workers to guarantee a healthy workplace and safe environment. The physical distancing measures have obviously reshaped the relationship between family members leading to better quality of family life. Meanwhile, travel suspension also led to slightly higher health standards with less air pollution, lower traffic induced stress levels and subsequently a greener footprint. Herein, we intend to highlight the impact of COVID-19 pandemic protective measures on family connections, as well as on environmental health. Moreover, we aimed at pointing out the effect on Saudi Arabian cultural and humanitarian behavior in dealing with the pandemic under the governance care of the custodian of the two holy mosques; King Salman Al-Saud. In fact, a combination of restrictive and protective measures is the most efficient to curb COVID-19 spread. In addition to improving the quality of social life, this pandemic revealed a healthier climate, which will certainly be visible on a large scale. Certainly, all together with solidarity we will be able to restrain COVID-19 pandemic and have a better quality of life.

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Reporting and interpreting the numerical results of a vaccine trial: a practical guide for students and health care professionals

Journal of Analytical & Pharmaceutical Research ◽

10.15406/japlr.2021.10.00370 ◽

2021 ◽

Vol 10 (2) ◽

pp. 93-96

Author(s):

Andrea Manfrin ◽

Miland Joshi

Keyword(s):

Health Care ◽

Health Care Professionals ◽

Vaccine Efficacy ◽

Vaccine Trial ◽

Numerical Results ◽

Practical Guide ◽

Global Health Care ◽

One Year ◽

Definition Of ◽

Simple Definition

In one year, the COVID pandemic has changed the world. Universities, pharmaceutical companies, and many other organisations worldwide worked effortlessly to develop vaccines to ease the socioeconomic burden of the disease and improve global health care. Nowadays, vaccine efficacy is a very popular term; but do we know what it means and how to calculate it? This article provides information on reporting and interpreting the numerical results of a vaccine trial. It aims to be a practical guide for students and health care professionals. It gives a simple definition of the common terminology, the vaccine efficacy, how to calculate it, and how the confidence interval can be found (though formulae for the latter are not given here). Additionally, it provides two simple examples (A, B), including the formulae for calculating the vaccine efficacy explaining the differences of vaccine efficacy between the two examples simply and pragmatically.

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HIV population-level adaptation can rapidly diminish the impact of a partially effective vaccine

10.1101/110783 ◽

2017 ◽

Cited By ~ 1

Author(s):

Joshua T. Herbeck ◽

Kathryn Peebles ◽

Paul T. Edlefsen ◽

Morgane Rolland ◽

James T. Murphy ◽

...

Keyword(s):

Vaccination Coverage ◽

Vaccine Efficacy ◽

Vaccine Development ◽

Vaccine Trial ◽

Development Program ◽

Population Level ◽

Hiv Vaccine ◽

Effective Vaccine ◽

Vaccination Programs ◽

The Impact

AbstractDevelopment of an HIV vaccine is essential to ending the HIV/AIDS pandemic. However, vaccines can result in the emergence and spread of vaccine-resistant strains. Indeed, analyses of breakthrough infections in the HIV vaccine trial RV144 identified HIV genotypes with differential rates of transmission in vaccine and placebo recipients. We hypothesized that, for HIV vaccination programs based on partially effective vaccines similar to RV144, HIV adaptation will diminish the expected vaccine impact. Using two HIV epidemic models, we simulated large-scale vaccination programs and, critically, included HIV strain diversity with respect to the vaccine response. We show here that rapid population-level viral adaptation can lead to decreased overall vaccine efficacy and substantially fewer infections averted by vaccination, when comparing scenarios with and without viral evolution (depending on vaccination coverage, vaccine efficacy against the sensitive allele, and the initial resistant allele frequency). Translating this to the epidemic in South Africa, a scenario with 70% vaccination coverage may result in 250,000 new infections within 10 years of vaccine rollout that are due solely to HIV adaptation, all else being equal. These findings suggest that approaches to HIV vaccine development, program implementation, and epidemic modeling may require attention to viral evolutionary responses to vaccination.

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Critical Insight into the Attributes of Emerging Novel Coronavirus (COVID-19) in India and Across the World

Coronaviruses ◽

10.2174/2666796701999200623172631 ◽

2020 ◽

Vol 1 (1) ◽

pp. 49-56

Author(s):

Gaurav M. Doshi ◽

Hemen S. Ved ◽

Ami P. Thakkar

Keyword(s):

Review Article ◽

World Health ◽

Effective Vaccine ◽

Human Contact ◽

The World ◽

Critical Insight ◽

Novel Coronavirus ◽

Health Organization ◽

Insight Into ◽

Old Drugs

The World Health Organization (WHO) has recently announced the spread of novel coronavirus (nCoV) globally and has declared it a pandemic. The probable source of transmission of the virus, which is from animal to human and human to human contact, has been established. As per the statistics reported by the WHO on 11th April 2020, data has shown that more than sixteen lakh confirmed cases have been identified globally. The reported cases related to nCoV in India have been rising substantially. The review article discusses the characteristics of nCoV in detail with the probability of potentially effective old drugs that may inhibit the virus. The research may further emphasize and draw the attention of the world towards the development of an effective vaccine as well as alternative therapies. Moreover, the article will help to bridge the gap between the new researchers since it’s the current thrust area of research.

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Insectivorous songbirds as early indicators of future defoliation by spruce budworm

Landscape Ecology ◽

10.1007/s10980-021-01300-z ◽

2021 ◽

Author(s):

Marion Germain ◽

Daniel Kneeshaw ◽

Louis De Grandpré ◽

Mélanie Desrochers ◽

Patrick M. A. James ◽

...

Keyword(s):

Large Scale ◽

Spatial Scales ◽

Spruce Budworm ◽

Detection Methods ◽

Maximum Probability ◽

Point Count ◽

Probability Of Presence ◽

Time Lagged ◽

One Year ◽

Local Sampling

Abstract Context Although the spatiotemporal dynamics of spruce budworm outbreaks have been intensively studied, forecasting outbreaks remains challenging. During outbreaks, budworm-linked warblers (Tennessee, Cape May, and bay-breasted warbler) show a strong positive response to increases in spruce budworm, but little is known about the relative timing of these responses. Objectives We hypothesized that these warblers could be used as sentinels of future defoliation of budworm host trees. We examined the timing and magnitude of the relationships between defoliation by spruce budworm and changes in the probability of presence of warblers to determine whether they responded to budworm infestation before local defoliation being observed by standard detection methods. Methods We modelled this relationship using large-scale point count surveys of songbirds and maps of cumulative time-lagged defoliation over multiple spatial scales (2–30 km radius around sampling points) in Quebec, Canada. Results All three warbler species responded positively to defoliation at each spatial scale considered, but the timing of their response differed. Maximum probability of presence of Tennessee and Cape May warbler coincided with observations of local defoliation, or provided a one year warning, making them of little use to guide early interventions. In contrast, the probability of presence of bay-breasted warbler consistently increased 3–4 years before defoliation was detectable. Conclusions Early detection is a critical step in the management of spruce budworm outbreaks and rapid increases in the probability of presence of bay-breasted warbler could be used to identify future epicenters and target ground-based local sampling of spruce budworm.

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COVID-19 in conflict border regions: a case of South Kordofan, Sudan

Conflict and Health ◽

10.1186/s13031-021-00370-9 ◽

2021 ◽

Vol 15 (1) ◽

Author(s):

Quraish Sserwanja ◽

Mohammed Bashir Adam ◽

Joseph Kawuki ◽

Emmanuel Olal

Keyword(s):

Case Fatality ◽

Mechanical Ventilators ◽

Governmental Organizations ◽

Non Governmental Organizations ◽

Bed Capacity ◽

Displaced People ◽

Set Up ◽

One Year ◽

Novel Coronavirus ◽

South Kordofan

AbstractThe novel coronavirus disease (COVID-19) was first reported in Sudan on 13 March 2020. Since then, Sudan has experienced one of the highest rates of COVID-19 spread and fatalities in Africa. One year later, as per 22 March 2021, Sudan had registered 29,661 confirmed cases and 2,028 deaths with a case fatality rate (CFR) of 6.8 %. By 12 December 2020, of the 18 states in Sudan, South Kordofan had the fifth highest CFR of 17.4 %, only surpassed by the other conflict affected North (57.5 %), Central (50.0 %) and East (31.8 %) Darfur States. By late March 2021, just three months from December 2020, the number of cases in South Kordofan increased by 100 %, but with a significant decline in the CFR from 17.4 to 8.5 %. South Kordofan is home to over 200,000 poor and displaced people from years of destructive civil unrests. To date, several localities such as the Nubba mountains region remain under rebel control and are not accessible. South Kordofan State Ministry of Health in collaboration with the federal government and non-governmental organizations set up four isolation centres with 40 total bed capacity, but with only two mechanical ventilators and no testing centre. There is still need for further multi-sectoral coalition and equitable allocation of resources to strengthen the health systems of rural and conflict affected regions. This article aims at providing insight into the current state of COVID-19 in South Kordofan amidst the second wave to address the dearth of COVID-19 information in rural and conflict affected regions.

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Multi-Objective Optimization of Integrated Civilian-Military Scheduling of Medical Supplies for Epidemic Prevention and Control

Healthcare ◽

10.3390/healthcare9020126 ◽

2021 ◽

Vol 9 (2) ◽

pp. 126

Author(s):

Hai-Feng Ling ◽

Zheng-Lian Su ◽

Xun-Lin Jiang ◽

Yu-Jun Zheng

Keyword(s):

Prevention And Control ◽

Large Scale ◽

Medical Services ◽

The Novel ◽

Multi Objective ◽

Medical Supplies ◽

Problem Instances ◽

Novel Coronavirus ◽

And Control ◽

Minimum Ratio

In a large-scale epidemic, such as the novel coronavirus pneumonia (COVID-19), there is huge demand for a variety of medical supplies, such as medical masks, ventilators, and sickbeds. Resources from civilian medical services are often not sufficient for fully satisfying all of these demands. Resources from military medical services, which are normally reserved for military use, can be an effective supplement to these demands. In this paper, we formulate a problem of integrated civilian-military scheduling of medical supplies for epidemic prevention and control, the aim of which is to simultaneously maximize the overall satisfaction rate of the medical supplies and minimize the total scheduling cost, while keeping a minimum ratio of medical supplies reservation for military use. We propose a multi-objective water wave optimization (WWO) algorithm in order to efficiently solve this problem. Computational results on a set of problem instances constructed based on real COVID-19 data demonstrate the effectiveness of the proposed method.

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SARS-CoV-2 vaccines strategies: a comprehensive review of phase 3 candidates

npj Vaccines ◽

10.1038/s41541-021-00292-w ◽

2021 ◽

Vol 6 (1) ◽

Cited By ~ 3

Author(s):

Nikolaos C. Kyriakidis ◽

Andrés López-Cortés ◽

Eduardo Vásconez González ◽

Alejandra Barreto Grimaldos ◽

Esteban Ortiz Prado

Keyword(s):

Neutralizing Antibodies ◽

Large Scale ◽

Vaccine Development ◽

Rna Virus ◽

Protein S ◽

Effective Vaccine ◽

Phase 3 ◽

Vaccine Candidates ◽

Advantages And Disadvantages ◽

The World

AbstractThe new SARS-CoV-2 virus is an RNA virus that belongs to the Coronaviridae family and causes COVID-19 disease. The newly sequenced virus appears to originate in China and rapidly spread throughout the world, becoming a pandemic that, until January 5th, 2021, has caused more than 1,866,000 deaths. Hence, laboratories worldwide are developing an effective vaccine against this disease, which will be essential to reduce morbidity and mortality. Currently, there more than 64 vaccine candidates, most of them aiming to induce neutralizing antibodies against the spike protein (S). These antibodies will prevent uptake through the human ACE-2 receptor, thereby limiting viral entrance. Different vaccine platforms are being used for vaccine development, each one presenting several advantages and disadvantages. Thus far, thirteen vaccine candidates are being tested in Phase 3 clinical trials; therefore, it is closer to receiving approval or authorization for large-scale immunizations.

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The Sense of Smell and Aging: What We Have Learned From Population Studies

Innovation in Aging ◽

10.1093/geroni/igaa057.2947 ◽

2020 ◽

Vol 4 (Supplement_1) ◽

pp. 810-811

Author(s):

Jayant Pinto

Keyword(s):

Mental Health ◽

Older Adults ◽

Social Life ◽

Large Scale ◽

Population Studies ◽

Vital Role ◽

Sensory Function ◽

Physical And Mental Health ◽

Sense Of Smell ◽

Health Aging

Abstract Decline of the sense of smell with age causes a marked impact on older adults, markedly reducing quality of life. Olfactory dysfunction impairs nutrition, decreases the ability to experience pleasure, and results in depression, among other burdens. Large-scale population studies have identified impaired olfaction as a key heath indicator that predicts the development of decreased physical and mental health, reduced physical activity, weight loss, mild cognitive impairment and dementia, and mortality itself. These data have been generated via analyses of data from several aging cohorts, including the National Social Life, Health, and Aging Project (NSHAP); the Beaver Dam cohort; the Atherosclerosis Risk in Communities project; the Rush Memory and Aging Project; the Health, Aging, and Body Composition project; the Washington Heights/Inwood Columbia Aging Project; among others. In this presentation, we will review the close connection between olfaction, health, aging, including discussion of insights from these studies. We will also discuss emerging data from NSHAP on the effects of sensory function on cognition, mental health, and social interaction, which demonstrate that sensory function plays a vital role in the lives of older adults. Part of a symposium sponsored by Sensory Health Interest Group.

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Intention to Be Vaccinated for COVID-19 among Italian Nurses during the Pandemic

Vaccines ◽

10.3390/vaccines9050500 ◽

2021 ◽

Vol 9 (5) ◽

pp. 500

Author(s):

Marco Trabucco Aurilio ◽

Francesco Saverio Mennini ◽

Simone Gazzillo ◽

Laura Massini ◽

Matteo Bolcato ◽

...

Keyword(s):

Vaccine Efficacy ◽

Online Survey ◽

Vaccine Development ◽

Vaccine Coverage ◽

World Health ◽

Vaccine Hesitancy ◽

Effective Vaccine ◽

Online Questionnaire ◽

Cross Sectional ◽

Female Sex

Background: While the COVID-19 pandemic has spread globally, health systems are overwhelmed by both direct and indirect mortality from other treatable conditions. COVID-19 vaccination was crucial to preventing and eliminating the disease, so vaccine development for COVID-19 was fast-tracked worldwide. Despite the fact that vaccination is commonly recognized as the most effective approach, according to the World Health Organization (WHO), vaccine hesitancy is a global health issue. Methods: We conducted a cross-sectional online survey of nurses in four different regions in Italy between 20 and 28 December 2020 to obtain data on the acceptance of the upcoming COVID-19 vaccination in order to plan specific interventions to increase the rate of vaccine coverage. Results: A total of 531 out of the 5000 nurses invited completed the online questionnaire. Most of the nurses enrolled in the study (73.4%) were female. Among the nurses, 91.5% intended to accept vaccination, whereas 2.3% were opposed and 6.2% were undecided. Female sex and confidence in vaccine efficacy represent the main predictors of vaccine intention among the study population using a logistic regression model, while other factors including vaccine safety concerns (side effects) were non-significant. Conclusions: Despite the availability of a safe and effective vaccine, intention to be vaccinated was suboptimal among nurses in our sample. We also found a significant number of people undecided as to whether to accept the vaccine. Contrary to expectations, concerns about the safety of the vaccine were not found to affect the acceptance rate; nurses’ perception of vaccine efficacy and female sex were the main influencing factors on attitudes toward vaccination in our sample. Since the success of the COVID-19 immunization plan depends on the uptake rate, these findings are of great interest for public health policies. Interventions aimed at increasing employee awareness of vaccination efficacy should be promoted among nurses in order to increase the number of vaccinated people.

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