scholarly journals COMPARISON OF TREATMENT OUTCOME OF ANTIHYPERTENSIVE DRUGS IN THE MANAGEMENT OF PREGNANCY INDUCED HYPERTENSION

2017 ◽  
Vol 9 (3) ◽  
pp. 287
Author(s):  
Sivakumar Velusamy
Keyword(s):  
Blood Pressure ◽  
Treatment Outcome ◽  
Pregnancy Outcome ◽  
Prospective Observational Study ◽  
Antihypertensive Drugs ◽  
Drug Group ◽  
Pregnancy Induced Hypertension ◽  
Significant Difference ◽  
Specialty Hospital ◽  
Induced Hypertension

This study was aimed to find out the differences in the pregnancy outcome of PIH women treated with the antihypertensive drugs methyldopa and nifedipine. The prospective observational study was conducted in a multi specialty hospital at Coimbatore with 161 PIH diagnosed women. Women were categorised into the no-drug group, methyldopa group, nifedipine group and methyldopa with nifedipine group. All the women were monitored from diagnosis to delivery. The maternal and neonatal data were collected and analysed. The drugs were significantly controlled the blood pressure (BP) from base to end (P<0.001). There was no significant difference in the reduction of BP between the drugs. Cesarean delivery (>90%) and preterm delivery were high across all the groups. No significant difference was seen between these groups. The AGA (Average for gestational age) babies were significantly higher with a no-drug group (83%) and lower with nifedipine group (40%). Two women were reported with HELLP syndrome in methyldopa with nifedipine group. No significant difference was found in terms of pregnancy outcome between these groups except for eclampsia and AGA. Eclampsia was affected more with 14% in methyldopa with nifedipine group. We found similar outcomes; there were no significant changes between methyldopa, nifedipine, and the no-drug treatment. The antihypertensive drugs nifedipine and methyldopa both were significantly reduced the BP. The maternal and neonatal complications were similar between these two drugs. No beneficial effect can be identified one over another.

Outcome of Labetalol and Methyldopa as Oral Antihypertensive Agent in the Treatment of Pregnancy Induced Hypertension

Mediscope ◽  
2021 ◽  
Vol 8 (1) ◽  
pp. 19-26
Author(s):  
Kakali Rani Ghosh ◽  
Shamima Akhter ◽  
Adhir Kumar Das ◽  
Naznin Naher ◽  
Suma Rani Paul ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Side Effects ◽  
Antihypertensive Drugs ◽  
Treated Group ◽  
Mean Blood Pressure ◽  
Pregnancy Induced Hypertension ◽  
Mortality And Morbidity ◽  
Induced Hypertension ◽  
Group A ◽  
Group B

Background: In a developing country like Bangladesh pregnancy induced hypertension is an important medical problem and a major cause of maternal and perinatal mortality and morbidity. Antihypertensive drugs are often used to lower blood pressure and also help in reducing maternal and fetal complications. Objective: To compare the efficacy and safety of labetalol and methyldopa in management of pregnancy induced hypertension. Methods: A total of 100 patients having newly onset hypertension during pregnancy were taken and divided randomly into two groups. Group A was given labetalol and group B methyldopa. In both groupsmean blood pressure was measured on 1stday as pretreatment and at 48th hour and 8th day as post-treatment measurement, total dose of each drug require per day and side effects were recorded.Reduction in blood pressure, doseand side effects were compared. Results: Labetalol treated group of patients showed significant fall in mean blood pressure from 1st day to 48th hour and 1st day to 8th day.In patients treated with labetalol mean blood pressure on 1st day was 123.9 ± 17.11 mmHg and was controlled to 100.03 ± 6.38 mmHg on 48th hour and 94.13 ± 4.3 mmHg on day 8, while in methyldopa treated group on 1st day was 121.23 ± 13.597 mmHg which was reduced to 105.8 ± 6.53 mmHg on 48th hour and 97.96 ± 4.11 mmHg on day 8.The mean drug dosage required to control BP in group A was 380 ± 259.5 mg and in group B was 1540 ± 503.45 mg. Group A had less side effects. Conclusion: Labetalol is safe more efficacious and quicker control of blood pressure withless maternal adverse effects and thus advantageous over methyldopa. Mediscope Vol. 8, No. 1: January 2021, Page 19-26

scholarly journals Co-Relation of Ocular Fundus Changes and Pregnancy Induced Hypertension and Its Foetal Outcomes

2021 ◽  
pp. 219-228
Author(s):  
Mohmed Kandeel ◽  
Hoda El-Sobky ◽  
Ahmed Shalah ◽  
Essam A. Amin
Keyword(s):  
Blood Pressure ◽  
Neonatal Death ◽  
Pregnancy Induced Hypertension ◽  
Slit Lamp ◽  
Ocular Fundus ◽  
Follow Up Study ◽  
Significant Difference ◽  
Induced Hypertension ◽  
Grade Ii

Background: Pregnancy-Induced Hypertension (PIH) is a stigmatizing condition in obstetrics and a significant cause of maternal and neonatal death. It is a kind of pregnancy-related hypertension that develops after 20th week of pregnancy with no presence of other reasons of high blood pressure. Objectives: To study the relation between grades of ocular fundus changes& degree of features severity of pregnancy induced hypertension and its maternal and foetal outcomes. Subjects and Methods: This is a prospective observational follow up study, the research lasted about 16 months and included 121 pregnant women diagnosed with PIH. Ocular examinations were performed using a direct ophthalmoscope, a slit lamp and grades of retinopathy were recorded and linked to the severity of PIH and its consequences. The data were analyzed statistically. Results: Results of the study revealed that most of the patients 62% had no abnormal fundus changes while 29.8% of the patients were grade I retinopathy and 7.4% of the patients were grade II retinopathy & There was significant difference between grades of retinopathy and degree of features of severity of PIH & some of its important maternal & foetal outcomes. Conclusion: Grades of ocular fundus alterations are associated with the severity of PIH's characteristics and are predictive of maternal and fetal comorbidity.

Serum Uric Acid Level as a Predictive Biomarker of Gestational Hypertension Severity; A Prospective Observational Case-Control Study

2020 ◽  
Vol 15 (3) ◽  
pp. 227-239 ◽  
Author(s):  
Hader I. Sakr ◽  
Akef A. Khowailed ◽  
Reham S. Al-Fakharany ◽  
Dina S. Abdel-Fattah ◽  
Ahmed A. Taha
Keyword(s):  
Blood Pressure ◽  
Pregnant Women ◽  
Case Control Study ◽  
Serum Urate ◽  
Interleukin 1Β ◽  
Pregnancy Induced Hypertension ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Induced Hypertension ◽  
Control Study

Background: Pre-eclampsia poses a significant potential risk of hypertensive disorders during pregnancy, a leading cause of maternal deaths. Hyperuricemia is associated with adverse effects on endothelial function, normal cellular metabolism, and platelet aggregation and adhesion. This study was designed to compare serum urate levels in normotensive pregnant women to those with pregnancy-induced hypertension, and to evaluate its value as a potential predictive marker of hypertension severity during pregnancy. Methods: A prospective, observational, case-control study conducted on 100 pregnant women in their third trimester. Pregnant women were classified into two groups (n=50) according to arterial blood pressure measurements: group I had normal blood pressure, and group II had a blood pressure of ≥ 140/90, which was further subdivided according to hypertension severity into IIa (pregnancy- induced hypertension, IIb (mild pre-eclampsia), and IIc (severe pre-eclampsia). Blood samples were obtained on admission. Serum urate, high sensitive C-reactive protein, and interleukin-1β levels, and lipid profile were compared among the groups. Results: A significant increase in the mean values of serum urate, C-reactive protein, and interleukin- 1β levels was detected in gestational hypertensives. In addition, there was a positive correlation between serum urate levels and C-reactive protein and interleukin-1β, as well as between serum urate levels and hypertension severity. Conclusion: Hyperuricemia and increased C-reactive protein and interleukin-1β serum levels correlate with the severity of pregnancy-induced hypertension, and these biomarkers may play a role in the pathogenesis of pre-eclampsia. Serum urate measurement is sensitive, reliable markers that correlate well with the severity of hypertension in pregnant females with pre-eclampsia.

Incidence of Pregnancy Induced Hypertensive Women and its Associated Factors

2021 ◽  
Vol 15 (12) ◽  
pp. 3307-3309
Author(s):  
Samia Saifullah ◽  
Maryam Shoaib ◽  
Muhammad Sohail Tareen ◽  
Nosheen Sikander Baloch
Keyword(s):  
Blood Pressure ◽  
Family History ◽  
Pregnant Women ◽  
Cross Sectional Study ◽  
Mean Value ◽  
Renal Diseases ◽  
Pregnancy Induced Hypertension ◽  
Cross Sectional ◽  
Induced Hypertension ◽  
Keywords Pregnancy

Background: Pregnancy induced hypertension is a fetal disease resulting into morbidity and mortality of female as well as its neonate. Objective: To find the incidence of pregnancy induced hypertension in Pakistani women. Study Design: Cross sectional study Place and Duration of the Study: Department of Obstetrics & Gynaecology, Sandeman Provincial Hospital, Quetta from 1st March 2019 to 31st March 2021. Methodology: Seven hundred and twenty eight females were identified with pregnancy induced hypertension from all the pregnant women attending the outdoor were enrolled. Each female was checked for their protein urea as well as systolic and diastolic blood pressure according to standard operating protocol. Socio-demographic, clinical and family history were documented. Results: Among all pregnant women, 150 were identified as pregnancy induced hypertensive with a 20.6% incidence of pregnancy induced hypertension. The mean value systolic blood pressure value was 144.3±5.2 and of diastolic as 83.1±5.2 in pregnancy induced hypertension women. Conclusion: Family history, obesity and renal diseases are the main factors associated with pregnancy induced hypertension with an incidence of 20.6% among pregnant women. Keywords: Pregnancy induced hypertension, Body mass index, Pregnant women, Hypertension

scholarly journals Roll-over test in primigravidae attending a public primary care service

1997 ◽  
Vol 115 (5) ◽  
pp. 1533-1536
Author(s):  
Luiz Francisco Marcopito
Keyword(s):  
Blood Pressure ◽  
Primary Care ◽  
Roc Curve ◽  
Operating Characteristic ◽  
Care Setting ◽  
Care Service ◽  
Primary Care Service ◽  
Pregnancy Induced Hypertension ◽  
Predictive Values ◽  
Induced Hypertension

OBJECTIVE:To determine the roll-over test (ROT) performance in predicting pregnancy-induced hypertension (PIH) in primigravidae aged 15-29 years in a public primary care service. METHOD: Prospective cohort study enrolling 369 consecutive and initially normotensive primigravidae. The ROT was applied within 28-32 weeks of pregnancy. PIH was defined as diastolic blood pressure (DBP) 90 mm Hg or systolic blood pressure (SBP) 140 mm Hg, or a rise in DBP 15 mm Hg or a rise in SBP 30 mm Hg. The ROT prognostic properties were calculated, and a receiver operating characteristic (ROC) curve was constructed. RESULTS: For the 20 mm Hg cutoff point, sensitivity was 20% and specificity was 93%. Positive and negative predictive values were, respectively, 23% and 92%, for a PIH cumulative incidence of 9.5%. With other cutoff points, the ROC curve showed a poor discriminatory value of the test. CONCLUSION: The ROT was not useful for predicting PIH in a primary prenatal care setting.

scholarly journals A Blood Pressure Lowering Effect Only through Complex Korean Medical Treatment, without Antihypertensive Drugs, for Patients with Stress Induced Hypertension - A Case Report

2021 ◽  
Vol 42 (5) ◽  
pp. 808-819
Author(s):  
Ji-hyun Lee ◽  
Min-yeong Roh ◽  
Seok-yeong Yoon ◽  
Hyung-sun Jun ◽  
Yang-hee Han ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Medical Treatment ◽  
Antihypertensive Drugs ◽  
Blood Pressure Lowering Effect ◽  
Hypertensive Patients ◽  
Pittsburg Sleep Quality Index ◽  
Induced Hypertension ◽  
Pressure Lowering ◽  
Pressure Symptom

Objectives: This study considered the effectiveness of integrative Korean medical treatment for stress-induced hypertensive patients without the use of conventional medication.Methods: A 62-year-old female with stress-induced hypertension (HTN) was hospitalized for 33 days. Her pattern identification was ascendant hyperactivity of liver yang (Ganyangsanghang)-type HTN. Herbal medicine and acupuncture were used for the treatment: Cheonggansoyo-san for 33 days and Chunwangbosim-dan for 15 days, together with acupuncture for 20 minutes twice a day. Blood pressure was checked daily during hospitalization with a digital sphygmomanometer in the brachial artery.Results: After 33 days of treatment, blood pressure decreased. The Handicap Inventory (DHI) scale and Pittsburg Sleep Quality Index (PSQI) scores both decreased. The patient also reported fewer complaints. A five-month follow-up after discharge, with no further treatment, confirmed stable blood pressure. Symptom improvements continued with no significant side effects.Conclusions: This study indicates that Korean medical treatment is effective for stress-induced hypertensive patients.

scholarly journals A prospective observational study to analyse the relationship between fundus changes in pregnancy induced hypertension with visual impairment and its reversibility

2021 ◽  
Vol 10 (11) ◽  
pp. 4272
Author(s):  
Vinitha Dharmalingam ◽  
R. Kala
Keyword(s):  
Observational Study ◽  
Visual Impairment ◽  
Prospective Observational Study ◽  
Hypertensive Retinopathy ◽  
Pregnancy Induced Hypertension ◽  
Choroidal Ischemia ◽  
Induced Hypertension ◽  
Changes In Pregnancy ◽  
The Relationship ◽  
In Pregnancy

Background: Irreversible visual impairment and morbidity are associated with pregnancy induced hypertension. It causes pathological changes in vascularity of placenta, kidney and brain along with two major pathological types of changes in fundus namely arteriolar vasospasm and permeability changes in vascular endothelium. The aim of our study was to analyse the relationship between fundus changes in pregnancy induced hypertension with visual impairment and its reversibility.Methods: A prospective observational study done on pregnant women with any grade of pregnancy induced hypertension with recent visual impairment from 24 completed weeks of pregnancy.Results: Out of 75 patients with PIH, all the patients had varying degree of fundus changes in one or both eyes. In 150 eyes of the 75 patients, 86 (57.30%) eyes had isolated arteriolar vasospasm, 14 (9.33%) had grade III hypertensive retinopathy, 4 (2.66%) had grade IV hypertensive retinopathy, 30 (20%) had macular oedema, 4 (2.66%) had central serous chorioretinopathy, 2 (1.33%) had vascular occlusion, 2 (2.66%) eyes had normal fundus with cortical blindness, 2 (2.66%) had exudative retinal detachment, 6 (4%) eyes had normal fundus with changes in the other eye.Conclusions: Out of 75 patients, 7 (9.3%) patients had irreversible loss of vision, 3 (42.85%) due to arteriolar vasospasm, and 4 (57.15%) due to choroidal ischemia. Among the 4 patients with choroidal ischemia, 3 (75%) were in the group of eclampsia and 1 (25%) in gestational hypertension.

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