Effects of major lifestyle factors on breast cancer risk: impact of weight, nutrition, physical activity, alcohol and tobacco

Breast cancer (BC) is the most commonly diagnosed cancer and second most common cause of cancer death in US women. Family history and genetics are well-known BC risk factors, but they only account for 15–20% of BC cases. Therefore, in addition to family history, healthcare providers must consider a woman’s modifiable and nonmodifiable personal risk factors that are associated with an increase in BC risk. The World Cancer Research Fund/American Institute for Cancer Research estimate that 30% of BC cases in the US are preventable. Lifestyle education is imperative given the magnitude of BC occurrence. Evidence supports prevention as an effective, long-term strategy for reducing risk. Healthcare providers are key stakeholders in empowering patients to adopt a healthy lifestyle for primary BC prevention. In this paper, we review the available evidence on modifiable BC risk including weight management, nutrition, physical activity, alcohol and tobacco use and provide strategies to counsel patients on lifestyle modifications.

Download Full-text

Breast cancer and some epidemiological factors: a hospital based study

Journal of Dhaka Medical College ◽

10.3329/jdmc.v22i1.15628 ◽

2013 ◽

Vol 22 (1) ◽

pp. 61-66 ◽

Cited By ~ 3

Author(s):

Suraiya Jabeen ◽

Musarrat Haque ◽

Md Johirul Islam ◽

Mohammad Zaid Hossain ◽

Atiya Begum ◽

...

Keyword(s):

Breast Cancer ◽

Risk Factors ◽

Cancer Research ◽

Family History ◽

Breast Feeding ◽

Positive Family History ◽

Induced Abortion ◽

Early Age ◽

Medical College ◽

History Of

Objective: The aim of this study was to determine risk factors associated with breast cancer in the National Institute of Cancer Research and Hospital, Dhaka, Bangladesh. Methodology: A case control study was conducted from July 2009 to June 2010, on 262 biopsy proven cases of breast cancer from National Institute of Cancer Research and Hospital and 262 matched controls of acute diseases from Dhaka Medical College Hospital. Religion, residential status and age (±2 years) were matched. Statistical analysis was carried out using conditional logistic regression, odds ratios, chi-square and t- test with SPSS software (V-17). Results: Multivariate analysis showed that higher education (OR=1.72), personal income (OR=5.71), history of induced abortion (OR= 20.62), history of breast feeding (OR= 7.91), OCP users (OR= 1.47), current smokers (OR=6.78), personal history of breast disease (OR=10.99), family history of breast cancer (OR=3.85) and family history of other cancer (OR=2.21) were risk factors for breast cancer. Furthermore, having menarche at an early age (OR=0.35), giving birth to an early age (OR= 0.35), early menopause (OR= 0.22), longer duration of breast feeding (OR=0.30), parity of 2 and more (OR=0.29) and regular physical activity (OR=0.58) were shown to be protective factors. Conclusion: Physical inactivity, being menopause, positive family history of breast cancer and history of induced abortion were found important risk factors. Longer duration of breast feeding should be encouraged for its protective effect. Study revealed that the women who have one or more of the above risk factors should be given special attention for breast cancer prevention DOI: http://dx.doi.org/10.3329/jdmc.v22i1.15628 J Dhaka Medical College, Vol. 22, No. 1, April, 2013, Page 61-66

Download Full-text

FAKTOR YANG BERHUBUNGAN DENGAN KEJADIAN TEKANAN DARAH TINGGI PADA USIA PRODUKTIF DI KELURAHAN PILANGBANGO

Jurnal Kesmas (Kesehatan Masyarakat) Khatulistiwa ◽

10.29406/jkmk.v7i4.2197 ◽

2020 ◽

Vol 7 (4) ◽

pp. 178

Author(s):

Agnes Candra Febrianita ◽

Avicena Sakufa Marsanti ◽

Retno Widiarini

Keyword(s):

Physical Activity ◽

Risk Factors ◽

Blood Pressure ◽

Family History ◽

High Blood Pressure ◽

Healthy Lifestyle ◽

Communicable Disease ◽

Chi Square ◽

Chi Square Test ◽

Non Communicable Disease

ABSTRAK Tekanan darah tinggi merupakan salah satu penyakit tidak menular yang menjadi penyebab kematian global dan diperkirakan telah meyebabkan 9,4 juta kematian. Prevalensi penyakit tekanan darah tinggi di Indonesia sering meningkat. Pada tahun 2018 prevalensi penyakit tekanan darah tinggi di Indonesia sebesar 34,1%. Tujuan penelitian ini adalah untuk membuktikan faktor-faktor risiko yang berpengaruh terhadap kejadian tekanan darah tinggi pada usia produktif dan mengukur besarnya pengaruh faktor risiko. Metode penelitian ini dengan menggunakan metode Case Control dengan jumlah sampel dalam penelitian ini adalah 102 orang dengan 51 kasus dan 51 kontrol. Data penelitian diperoleh melalui kuesioner dan observasi. Analisis data menggunakan uji Chi-Square. Hasil penelitian menunjukkan ada hubungan antara jenis kelamin (OR 3,484; 95% CI 1,522-7,972) riwayat keluarga (OR 9,840 ; 95% CI 3,934-24,616), indeks massa tubuh (OR 3,380; 95% CI 1,447-7,897), dan aktivitas fisik OR 3,720 ; 95% CI 1,632-8,479) dengan kejadian tekanan darah tinggi pada usia produktif di Kelurahan Pilangbango. Dari hasil penelitian tersebut faktor yang menjadi penyebab tekanan darah tinggi pada usia produktif di Kelurahan Pilangbango yaitu jenis kelamin, IMT, aktivitas fisik dan riwayat keluarga. Berdasarkan faktor risiko tersebut, diharapkan masyarakat usia produktif yang berada di kelurahan Pilangbango menerapakan gaya hidup sehat dan rutin memeriksakan tekanan darah ke fasilitas terdekat.ABSTRACTHigh blood pressure is a non-communicable disease that causes global death and is estimated to have caused 9.4 million deaths. The prevalence of high blood pressure in Indonesia often increases. In 2018 the prevalence of high blood pressure in Indonesia is 34.1%. The purpose of this study is to prove the risk factors that influence the incidence of high blood pressure in the productive age and measure the magnitude of the influence of risk factors. The type of this research is using Case Conrol method with the number of samples in this study were 102 people with 51 cases and 51 controls. Research data was obtained through questionnaires and observations. Data analysis used Chi-Square test. The results showed that there was a relationship between gender (OR 3,484; 95% CI 1,522-7,972) family history (OR 9,840; 95% CI 3,934-24,616), body mass index (OR) OR 3,380; 95% CI 1,447-7,897), and physical activity OR 3,720; 95% CI 1,632-8,479) with the incidence of high blood pressure in the productive age in Pilangbango Village. From the results of the study, the factors that cause high blood pressure at productive age in Pilangbango Village are gender, BMI, physical activity and family history. From this risk factors, it is expect that people in Pilangbango Village adopt a healthy lifestyle and routinely check their blood pressure to the nearest facility.Kata Kunci: Tekanan Darah tinggi, Usia Produktif, Kelurahan Pilangbango

Download Full-text

Life style effects on hypertension and obesity in adolescents

International Journal of Contemporary Pediatrics ◽

10.18203/2349-3291.ijcp20200113 ◽

2020 ◽

Vol 7 (2) ◽

pp. 377

Author(s):

Sonia Bhatt ◽

Shehraz Firoz

Keyword(s):

Physical Activity ◽

Risk Factors ◽

Family History ◽

Fast Food ◽

Positive Family History ◽

Age Group ◽

Lifestyle Modifications ◽

Dietary Practices ◽

History Of ◽

Associated Risk Factors

Background: Studies based on effects of lifestyle on hypertension and obesity in adolescent age group are lacking in India. The present study was conducted to evaluate the prevalence of lifestyle associated risk factors in school going adolescents of Kendriya Vidyalaya in district Firozabad and their effects on hypertension and obesity.Methods: The study was carried out among 200 students of classes 9th and 11th in the age group of 13 to 17 years. Students were given a pre-designed questionnaire and feedback was taken about dietary practices and physical activity along with family history of hypertension and obesity. Height, weight, waist circumference, hip circumference, blood pressure was measured in all children. Effects of lifestyle associated risk factors were determined on obesity and hypertension.Results: The study documents that inappropriate dietary practices (fast food consumption, low fruit intake) and less physical activity were strongly associated with high prevalence of obesity and hypertension in the adolescents. The study also showed that adolescents with positive family history of obesity and/or hypertension are also at higher risk. There was a positive correlation between high BMI and hypertension.Conclusions: School based interventions are required to educate the adolescent children about lifestyle modifications to reduce the morbidity associated with non-communicable diseases.

Download Full-text

Physical Activity and Postmenopausal Breast Cancer

Methods of Information in Medicine ◽

10.3414/me9239 ◽

2009 ◽

Vol 48 (05) ◽

pp. 444-450 ◽

Cited By ~ 5

Author(s):

M. E. Schmidt ◽

J. Chang-Claude ◽

T. Slanger ◽

N. Obi ◽

D. Flesch-Janys ◽

...

Keyword(s):

Breast Cancer ◽

Physical Activity ◽

Risk Factors ◽

Family History ◽

Breast Cancer Risk ◽

Cancer Risk ◽

Postmenopausal Breast Cancer ◽

Breast Diseases ◽

Inverse Association ◽

Hormone Receptor Positive

Summary Objectives: Epidemiological evidence suggests an inverse association between physical activity (PA) and postmenopausal breast cancer risk. Breast cancer is a heterogeneous disease, influenced by reproductive factors, lifestyle pattern, and predispositions. We investigated whether these risk factors modify the effect of PA on breast cancer risk. Methods: We analyzed data from 2004 hormone-receptor-positive postmenopausal breast cancer cases and 6569 controls from the population-based MARIE study conducted 2002–2005 in Germany. Interaction was statistically tested using adjusted unconditional logistic regression models. Results: The inverse association between leisure-time PA and risk of postmenopausal hormone-receptor-positive breast cancer was not heterogeneous by family history of breast cancer or by hormone therapy. PA showed a significant interaction with benign breast diseases (p = 0.023) and with breastfeeding (p = 0.045) but not with parity (p = 0.94), with clear risk reductions only for women who ever had breastfed or who ever had a benign breast disease (among ever breastfed: odds ratio = 0.63; 95% confidence interval = (0.52, 0.77), highest vs. lowest PA quartile). Interaction with BMI was weak (p = 0.053). Conclusions: Breastfeeding and benign breast diseases modified the effect of PA on postmenopausal breast cancer risk. If other studies find similar modifications, increasing knowledge about these risk factors may contribute to a better understanding of the mode of action of PA on breast cancer risk. For women who are at higher risk for breast cancer due to family history or due to hormone therapy use, it is encouraging that they might lower their risk by being physically active.

Download Full-text

Risk factors for cardiovascular complications in patients with left breast cancer in daily clinical practice

HERALD of North-Western State Medical University named after I I Mechnikov ◽

10.17816/mechnikov202012263-70 ◽

2020 ◽

Vol 12 (2) ◽

pp. 63-70

Author(s):

Elena G. Poroshina ◽

Irina V. Vologdina ◽

Razifa M. Zhabina ◽

Andrey A. Stanzhevsky ◽

Larisa A. Krasilnikova

Keyword(s):

Breast Cancer ◽

Physical Activity ◽

Risk Factors ◽

Elderly Patients ◽

Healthy Lifestyle ◽

The Elderly ◽

Cardiovascular Complications ◽

Left Breast ◽

Middle Aged ◽

Aged Patients

Purpose. Detection of adherence to a healthy lifestyle (HLS) and evaluation of behavioral risk factors for cardiovascular complications (CVC), including psychosocial, in patients with left breast cancer at the stage of chemoradiotherapy in daily clinical practice. Materials and methods. The patients were hospitalized for 3D conformal radiation therapy on the bed of the left breast with a total radiation dose (TRD) of 39 Gy (equivalent to 48 Gy of conventional fractionation). All the patients had a Madden mastectomy at the previous stages followed by doxorubicin therapy at a cumulative dose not exceeding 360 mg/m2. Determination of all components of a healthy lifestyle was carried out according to the data of interviewing the participants. The risk category of cardiovascular complications was assessed according to the SCORE scale. Additional characteristics including psychosocial factors were assessed. The examination included ECG and echocardiography. Results. At the initial examination, 58% of middle-aged patients and 74% of elderly patients showed comorbidity, while 18% of middle-aged patients and 29% of elderly patients had multiple comorbidities. Low adherence to healthy lifestyle in the patients was primarily associated with low physical activity due to the existing pain syndrome caused by both the tumor process itself and the surgical intervention. Physical activity in both groups was significantly lower than in the general population. High risk of CVC was significantly more common in the elderly patients. Systolic and diastolic dysfunction as a manifestation of cardiotoxicity after the previous stage of doxorubicin therapy were detected in middle-aged patients in 35.7% of the cases, in the elderly patients in 56.5% of the cases (HR 0.643, 95% CI 0.470-0.880). Psychosocial factors such as acute chronic stress and family problems were the most common. All the examined patients showed moderate reactive anxiety. The elderly patients showed a high level of personal anxiety. Conclusions. The obtained data suggest that in breast cancer patients, low adherence to HLS is primarily associated with low physical activity and unhealthy diet and to a much lesser extent smoking, which is of great importance in the formation of a healthy lifestyle in these patients in the future. In elderly patients, the study significantly more often identified risk factors such as obesity, high blood pressure, hypercholesterolemia and hyperglycemia. These patients revealed increased level of personal anxiety. This highlights the need for an expanded study of not only the main but also additional risk factors.

Download Full-text

Hygienic characteristics of the cosmetologists' lifestyle

Russian Journal of Occupational Health and Industrial Ecology ◽

10.31089/1026-9428-2020-60-12-958-963 ◽

2020 ◽

Vol 60 (12) ◽

pp. 958-963

Author(s):

Natalia I. Latyshevskaya ◽

Tatyana L. Yatsyshena ◽

Elena L. Shestopalova ◽

Irina Yu. Krainova

Keyword(s):

Physical Activity ◽

Risk Factors ◽

Information And Communication Technologies ◽

Health Risks ◽

Healthy Lifestyle ◽

Personal Hygiene ◽

Risk Category ◽

Essential Components ◽

Group A ◽

Group B

Modern trends in the deterioration of health and the growth of non-communicable diseases among the adult working-age population, including medical workers, actualize the importance of a healthy lifestyle for maintaining health and professional longevity. There were almost no studies related to cosmetologists' experienced group as representatives of aesthetic medicine. There is no scientific evidence on behavioral risks of this group. It justifies the relevance of this study. The study aims to analyze the essential components of the cosmetologists' lifestyle depending on age and the argumentation of priority behavioral health risk factors for preventive and recreational work justification. Sixty women (practicing cosmetologists in Volgograd at the age of 28-39 years (group A) and 40-53 (group B)) took part in the study. Lifestyle assessment included a modified questionnaire. The questionnaire consists of 5 blocks (block 1 - nutrition; 2 - physical activity, including hardening and active rest; 3 - daily regimen; 4 - personal hygiene; 5 - bad habits). It allows the analysis of the adherence to a healthy lifestyle based on the provision of quantitative data. Statistical data processing was carried out using the Excel package. The authors identified the essential and statistically significant differences in the cosmetologists' lifestyle depending on age. The respondents of group B demonstrated hygienically rational indicators in all blocks of the lifestyle more often. They had a more formed adherence to a healthy lifestyle: 504 answers in the category "insignificant risk" of respondents in group B versus 354 in group A. Distribution of answers in the "high risk" category: 119 responses in group B and 185 in group A. The lifestyle of 46.7% of the respondents in group B refers to a healthy lifestyle. 3.3% of the group B respondents have an anxious lifestyle, 50% have health risks. 10% of Group A respondents' lifestyle refers to a healthy lifestyle. 13.3% of Group A respondents' lifestyle refers to an anxious lifestyle; 76.7% of this group have health risks. There was almost no complex hygienic research profession of medical cosmetologists. Cosmetologists of the older age group (40-53 years old) are more conscious of maintaining a hygienically rational lifestyle. The most significant defects among cosmetologists aged 28-39 years are low physical activity, nutritional defects, insufficient duration of night rest, and excessive use of information and communication technologies for rest, accompanied by manifestations of neurotization and signs of pronounced fatigue. The obtained results argue the need to develop and implement informational and educational measures to prevent risk behavior patterns, taking into account the age of cosmetologists and the priority of the identified behavioral risk factors.

Download Full-text

Modifiable and Non-Modifiable Risk Factors for Atherothrombotic Ischemic Stroke among Subjects in the Malmö Diet and Cancer Study

Nutrients ◽

10.3390/nu13061952 ◽

2021 ◽

Vol 13 (6) ◽

pp. 1952

Author(s):

Anna Johansson ◽

Isabel Drake ◽

Gunnar Engström ◽

Stefan Acosta

Keyword(s):

Physical Activity ◽

Risk Factors ◽

Body Mass Index ◽

Ischemic Stroke ◽

Family History ◽

Diet Quality ◽

Alcohol Intake ◽

Modifiable Risk Factors ◽

History Of ◽

Diet And Cancer

Risk factors for ischemic stroke is suggested to differ by etiologic subtypes. The purpose of this study was to examine the associations between modifiable and non-modifiable risk factors and atherothrombotic stroke (i.e., excluding cardioembolic stroke), and to examine if the potential benefit of modifiable lifestyle factors differs among subjects with and without predisposing comorbidities. After a median follow-up of 21.2 years, 2339 individuals were diagnosed with atherothrombotic stroke out of 26,547 study participants from the Malmö Diet and Cancer study. Using multivariable Cox regression, we examined non-modifiable (demographics and family history of stroke), semi-modifiable comorbidities (hypertension, dyslipidemia, diabetes mellitus and atherosclerotic disease), and modifiable (smoking, body mass index, diet quality, physical activity, and alcohol intake) risk factors in relation to atherothrombotic stroke. Higher age, male gender, family history of stroke, and low educational level increased the risk of atherothrombotic stroke as did predisposing comorbidities. Non-smoking (hazard ratio (HR) = 0.62, 95% confidence interval (CI) 0.56–0.68), high diet quality (HR = 0.83, 95% CI 0.72–0.97) and high leisure-time physical activity (HR = 0.89, 95% CI 0.80–0.98) decreased the risk of atherothrombotic ischemic stroke independent of established risk factors, with non-significant associations with body mass index and alcohol intake. The effect of the lifestyle factors was independent of predisposing comorbidities at baseline. The adverse effects of several cardiovascular risk factors were confirmed in this study of atherothrombotic stroke. Smoking cessation, improving diet quality and increasing physical activity level is likely to lower risk of atherothrombotic stroke in the general population as well as in patient groups at high risk.

Download Full-text

Differing Contributions of Classical Risk Factors to Type 2 Diabetes in Multi-Ethnic Malaysian Populations

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph15122813 ◽

2018 ◽

Vol 15 (12) ◽

pp. 2813

Author(s):

Noraidatulakma Abdullah ◽

Nor Abdul Murad ◽

John Attia ◽

Christopher Oldmeadow ◽

Mohd Kamaruddin ◽

...

Keyword(s):

Physical Activity ◽

Risk Factors ◽

Type 2 Diabetes ◽

Family History ◽

Characteristic Curve ◽

Lifestyle Factors ◽

Predictive Utility ◽

Family History Of Diabetes ◽

History Of

The prevalence of type 2 diabetes is escalating rapidly in Asian countries, with the rapid increase likely attributable to a combination of genetic and lifestyle factors. Recent research suggests that common genetic risk variants contribute minimally to the rapidly rising prevalence. Rather, recent changes in dietary patterns and physical activity may be more important. This nested case-control study assessed the association and predictive utility of type 2 diabetes lifestyle risk factors in participants from Malaysia, an understudied Asian population with comparatively high disease prevalence. The study sample comprised 4077 participants from The Malaysian Cohort project and included sub-samples from the three major ancestral groups: Malay (n = 1323), Chinese (n = 1344) and Indian (n = 1410). Association of lifestyle factors with type 2 diabetes was assessed within and across ancestral groups using logistic regression. Predictive utility was quantified and compared between groups using the Area Under the Receiver-Operating Characteristic Curve (AUC). In predictive models including age, gender, waist-to-hip ratio, physical activity, location, family history of diabetes and average sleep duration, the AUC ranged from 0.76 to 0.85 across groups and was significantly higher in Chinese than Malays or Indians, likely reflecting anthropometric differences. This study suggests that obesity, advancing age, a family history of diabetes and living in a rural area are important drivers of the escalating prevalence of type 2 diabetes in Malaysia.

Download Full-text