Per- and polyfluoroalkyl substances, epigenetic age and DNA methylation: a cross-sectional study of firefighters

Epigenomics ◽  
2021 ◽  
Author(s):  
Jaclyn M Goodrich ◽  
Miriam M Calkins ◽  
Alberto J Caban-Martinez ◽  
Todd Stueckle ◽  
Casey Grant ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Cross Sectional Study ◽  
Serum Concentrations ◽  
Sectional Study ◽  
Cross Sectional ◽  
Toxicity Biomarkers ◽  
Epigenetic Age ◽  
Polyfluoroalkyl Substances ◽  
Blood Leukocyte ◽  
Epic Array

Background: Per- and polyfluoroalkyl substances (PFASs) are persistent chemicals that firefighters encounter. Epigenetic modifications, including DNA methylation, could serve as PFASs toxicity biomarkers. Methods: With a sample size of 197 firefighters, we quantified the serum concentrations of nine PFASs, blood leukocyte DNA methylation and epigenetic age indicators via the EPIC array. We examined the associations between PFASs with epigenetic age, site- and region-specific DNA methylation, adjusting for confounders. Results: Perfluorohexane sulfonate, perfluorooctanoate (PFOA) and the sum of branched isomers of perfluorooctane sulfonate (Sm-PFOS) were associated with accelerated epigenetic age. Branched PFOA, linear PFOS, perfluorononanoate, perfluorodecanoate and perfluoroundecanoate were associated with differentially methylated loci and regions. Conclusion: PFASs concentrations are associated with accelerated epigenetic age and locus-specific DNA methylation. The implications for PFASs toxicity merit further investigation.

scholarly journals The Relationship between Body Mass Index, Obesity, and LINE-1 Methylation: A Cross-Sectional Study on Women from Southern Italy

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Andrea Maugeri ◽  
Martina Barchitta ◽  
Roberta Magnano San Lio ◽  
Giuliana Favara ◽  
Claudia La Mastra ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Dna Methylation ◽  
Body Mass ◽  
Methylation Level ◽  
Molecular Mechanisms ◽  
Smoking Status ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
The Relationship

Uncovering the relationship between body mass index (BMI) and DNA methylation could be useful to understand molecular mechanisms underpinning the effects of obesity. Here, we presented a cross-sectional study, aiming to evaluate the association of BMI and obesity with long interspersed nuclear elements (LINE-1) methylation, among 488 women from Catania, Italy. LINE-1 methylation was assessed in leukocyte DNA by pyrosequencing. We found a negative association between BMI and LINE-1 methylation level in both the unadjusted and adjusted linear regression models. Accordingly, obese women exhibited lower LINE-1 methylation level than their normal weight counterpart. This association was confirmed after adjusting for the effect of age, educational level, employment status, marital status, parity, menopause, and smoking status. Our findings were in line with previous evidence and encouraged further research to investigate the potential role of DNA methylation markers in the management of obesity.

scholarly journals Ambient PM exposure and DNA methylation in tumor suppressor genes: a cross-sectional study

2011 ◽  
Vol 8 (1) ◽  
pp. 25 ◽  
Author(s):  
Lifang Hou ◽  
Xiao Zhang ◽  
Letizia Tarantini ◽  
Francesco Nordio ◽  
Matteo Bonzini ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Tumor Suppressor ◽  
Tumor Suppressor Genes ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Suppressor Genes

scholarly journals STAT3 methylation in white blood cells as a novel sensitive biomarker for the toxic effect of low-dose benzene exposure

2016 ◽  
Vol 5 (3) ◽  
pp. 800-807 ◽  
Author(s):  
Di Liu ◽  
Yujiao Chen ◽  
Pengling Sun ◽  
Wenlin Bai ◽  
Ai Gao
Keyword(s):  
Dna Methylation ◽  
Toxic Effect ◽  
Health Effects ◽  
Blood Cells ◽  
Low Dose ◽  
White Blood Cells ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Benzene Exposure

A cross-sectional study was conducted in a sample of 571 workers to explore the toxic effect and early sensitive biomarker of the health effects of low-dose benzene exposure (LDBE), as well as the correlation between DNA methylation and the toxic effect of LDBE.

scholarly journals A cross-sectional study of global DNA methylation and risk of colorectal adenoma

BMC Cancer ◽  
2014 ◽  
Vol 14 (1) ◽  
Author(s):  
Will D King ◽  
Janet E Ashbury ◽  
Sherryl A Taylor ◽  
M Yat Tse ◽  
Stephen C Pang ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Colorectal Adenoma ◽  
Cross Sectional Study ◽  
Global Dna Methylation ◽  
Sectional Study ◽  
Cross Sectional

scholarly journals The Correlation between the Indonesian Version of Montreal Cognitive Assessment and Homocysteine Levels in Bataknese Male with Schizophrenia in Prof. DR. M. Ildrem Psychiatric Hospital Medan

2021 ◽  
Vol 9 (T3) ◽  
pp. 135-137
Author(s):  
Yoseva Hotnauli ◽  
Bahagia Loebis ◽  
Muhammad Surya Husada ◽  
Nazli Mahdinasari Nasution ◽  
Elmeida Effendy
Keyword(s):  
Dna Methylation ◽  
Cognitive Assessment ◽  
Homocysteine Level ◽  
Cross Sectional Study ◽  
Cellular Level ◽  
Montreal Cognitive Assessment ◽  
Sectional Study ◽  
Cross Sectional ◽  
Maximum Score ◽  
Minimum Score

BACKGROUND: The pathogenesis of schizophrenia and its mechanism is not convinced. Several studies indicate that schizophrenia pathogenesis can be related to changes at the cellular level. The studies show homocysteine in people with schizophrenia was significantly increased, abnormal homocysteine metabolism can lead to DNA methylation. AIM: This study aimed to establish the correlation between the Indonesian Montreal Cognitive Assessment Version (MoCA-Ina) scores and homocysteine levels in males with Bataknese schizophrenia. METHODS: This study is a numerical correlative analytic study with an approach to cross-sectional study; by evaluating the correlation between the MoCA-Ina scores and the level of homocysteine in males with Bataknese schizophrenia. RESULTS: The median of the MoCA-Ina score in the study subjects was 22, with a minimum score of 18 and a maximum score of 26. There was a significant correlation between the MoCA-Ina scores and Homocysteine levels (p = 0.001). CONCLUSION: The interpretation obtained from this study is that the higher Homocysteine level, the lower the MoCA-Ina scores in Bataknese men with schizophrenia is.

Low serum concentrations of 25-hydroxyvitamin D in young adult Japanese women: a cross sectional study

Nutrition ◽  
2001 ◽  
Vol 17 (11-12) ◽  
pp. 921-925 ◽  
Author(s):  
Kazutoshi Nakamura ◽  
Mitsue Nashimoto ◽  
Shigeki Matsuyama ◽  
Masaharu Yamamoto
Keyword(s):  
Young Adult ◽  
Cross Sectional Study ◽  
Japanese Women ◽  
Serum Concentrations ◽  
Sectional Study ◽  
Cross Sectional ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D ◽  
Low Serum
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