scholarly journals The Correlation between the Indonesian Version of Montreal Cognitive Assessment and Homocysteine Levels in Bataknese Male with Schizophrenia in Prof. DR. M. Ildrem Psychiatric Hospital Medan

2021 ◽  
Vol 9 (T3) ◽  
pp. 135-137
Author(s):  
Yoseva Hotnauli ◽  
Bahagia Loebis ◽  
Muhammad Surya Husada ◽  
Nazli Mahdinasari Nasution ◽  
Elmeida Effendy
Keyword(s):  
Dna Methylation ◽  
Cognitive Assessment ◽  
Homocysteine Level ◽  
Cross Sectional Study ◽  
Cellular Level ◽  
Montreal Cognitive Assessment ◽  
Sectional Study ◽  
Cross Sectional ◽  
Maximum Score ◽  
Minimum Score

BACKGROUND: The pathogenesis of schizophrenia and its mechanism is not convinced. Several studies indicate that schizophrenia pathogenesis can be related to changes at the cellular level. The studies show homocysteine in people with schizophrenia was significantly increased, abnormal homocysteine metabolism can lead to DNA methylation. AIM: This study aimed to establish the correlation between the Indonesian Montreal Cognitive Assessment Version (MoCA-Ina) scores and homocysteine levels in males with Bataknese schizophrenia. METHODS: This study is a numerical correlative analytic study with an approach to cross-sectional study; by evaluating the correlation between the MoCA-Ina scores and the level of homocysteine in males with Bataknese schizophrenia. RESULTS: The median of the MoCA-Ina score in the study subjects was 22, with a minimum score of 18 and a maximum score of 26. There was a significant correlation between the MoCA-Ina scores and Homocysteine levels (p = 0.001). CONCLUSION: The interpretation obtained from this study is that the higher Homocysteine level, the lower the MoCA-Ina scores in Bataknese men with schizophrenia is.

scholarly journals SKRINING COGNITIVE IMPAIRMENT PADA PASIEN HIPERTENSI DI BANDUNG

2019 ◽  
Vol 5 (2) ◽  
pp. 114-120
Author(s):  
Irma Darmawati ◽  
Heni Purnama ◽  
Linlin Lindayani
Keyword(s):  
Cognitive Impairment ◽  
White Matter ◽  
Cognitive Assessment ◽  
Cross Sectional Study ◽  
Montreal Cognitive Assessment ◽  
Sectional Study ◽  
Cross Sectional

Hipertensi merupakan salah satu faktor resiko tertinggi untuk gangguan fungsi kognitif. Studi sebelumnya melaporkan bahwa terjadi peningkatan white matter lession pada pasien hipertensi. Akan tetapi, penelitian tentang deteksi dini gangguan fungsi kognitif pada pasien hipertensi di Indonesia masih terbatas. Tujuan dari penelitian ini adalah mengidentifikasi gangguan fungsi kognitif pada pasien dengan hipertensi. Jenis penelitian yanga akan digunakan adalah cross-sectional study. Peserta dalam penelitian adalah seseorang berusia lebih dari 18 tahun yang didiagnosa hipertensi, tidak ada riwayat penyakit yang berhubungan dengan fungsi kognitif seperti stroke, epilepsy atau riwayat bedah otak. Fungsi Kognitif diukur dengan menggunakan The Montreal Cognitive Assessment (MoCA). Sebanyak 120 pasien dengan hipertensi berhasil direkrut dalam penelitian ini. Sebanyak 68.9% mengalami gangguan fungsi kognitif dengan nilai rata-rata paling rendah adalah dalam kemampuan mengingat angka, huruf, pengurangan, dan orientasi. Deteksi dini gangguan kognitif pada pasien hipertensi harus dilakukan secara rutin di klinik ataupun pusat pelayanan kesehatan primer lainnnya.

Evaluation of a Telephone Version for the Montreal Cognitive Assessment: Establishing a Cutoff for Normative Data From a Cross-Sectional Study

2021 ◽  
pp. 089198872110026
Author(s):  
Sivan Klil-Drori ◽  
Natalie Phillips ◽  
Alita Fernandez ◽  
Shelley Solomon ◽  
Adi J. Klil-Drori ◽  
...  
Keyword(s):  
Cognitive Assessment ◽  
Cross Sectional Study ◽  
Montreal Cognitive Assessment ◽  
Cutoff Score ◽  
Cognitive Screening ◽  
Cross Sectional ◽  
A Prospective Study ◽  
Sectional Analysis ◽  
State Examination ◽  
Normal Cognition

Objective: Compare a telephone version and full version of the Montreal Cognitive Assessment (MoCA). Methods: Cross-sectional analysis of a prospective study. A 20-point telephone version of MoCA (Tele-MoCA) was compared to the Full-MoCA and Mini Mental State Examination. Results: Total of 140 participants enrolled. Mean scores for language were significantly lower with Tele-MoCA than with Full-MoCA (P = .003). Mean Tele-MoCA scores were significantly higher for participants with over 12 years of education (P < .001). Cutoff score of 17 for the Tele-MoCA yielded good specificity (82.2%) and negative predictive value (84.4%), while sensitivity was low (18.2%). Conclusions: Remote screening of cognition with a 20-point Tele-MoCA is as specific for defining normal cognition as the Full-MoCA. This study shows that telephone evaluation is adequate for virtual cognitive screening. Our sample did not allow accurate assessment of sensitivity for Tele-MoCA in detecting MCI or dementia. Further studies with representative populations are needed to establish sensitivity.

scholarly journals The Relationship between Body Mass Index, Obesity, and LINE-1 Methylation: A Cross-Sectional Study on Women from Southern Italy

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Andrea Maugeri ◽  
Martina Barchitta ◽  
Roberta Magnano San Lio ◽  
Giuliana Favara ◽  
Claudia La Mastra ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Dna Methylation ◽  
Body Mass ◽  
Methylation Level ◽  
Molecular Mechanisms ◽  
Smoking Status ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
The Relationship

Uncovering the relationship between body mass index (BMI) and DNA methylation could be useful to understand molecular mechanisms underpinning the effects of obesity. Here, we presented a cross-sectional study, aiming to evaluate the association of BMI and obesity with long interspersed nuclear elements (LINE-1) methylation, among 488 women from Catania, Italy. LINE-1 methylation was assessed in leukocyte DNA by pyrosequencing. We found a negative association between BMI and LINE-1 methylation level in both the unadjusted and adjusted linear regression models. Accordingly, obese women exhibited lower LINE-1 methylation level than their normal weight counterpart. This association was confirmed after adjusting for the effect of age, educational level, employment status, marital status, parity, menopause, and smoking status. Our findings were in line with previous evidence and encouraged further research to investigate the potential role of DNA methylation markers in the management of obesity.

Per- and polyfluoroalkyl substances, epigenetic age and DNA methylation: a cross-sectional study of firefighters

Epigenomics ◽  
2021 ◽  
Author(s):  
Jaclyn M Goodrich ◽  
Miriam M Calkins ◽  
Alberto J Caban-Martinez ◽  
Todd Stueckle ◽  
Casey Grant ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Cross Sectional Study ◽  
Serum Concentrations ◽  
Sectional Study ◽  
Cross Sectional ◽  
Toxicity Biomarkers ◽  
Epigenetic Age ◽  
Polyfluoroalkyl Substances ◽  
Blood Leukocyte ◽  
Epic Array

Background: Per- and polyfluoroalkyl substances (PFASs) are persistent chemicals that firefighters encounter. Epigenetic modifications, including DNA methylation, could serve as PFASs toxicity biomarkers. Methods: With a sample size of 197 firefighters, we quantified the serum concentrations of nine PFASs, blood leukocyte DNA methylation and epigenetic age indicators via the EPIC array. We examined the associations between PFASs with epigenetic age, site- and region-specific DNA methylation, adjusting for confounders. Results: Perfluorohexane sulfonate, perfluorooctanoate (PFOA) and the sum of branched isomers of perfluorooctane sulfonate (Sm-PFOS) were associated with accelerated epigenetic age. Branched PFOA, linear PFOS, perfluorononanoate, perfluorodecanoate and perfluoroundecanoate were associated with differentially methylated loci and regions. Conclusion: PFASs concentrations are associated with accelerated epigenetic age and locus-specific DNA methylation. The implications for PFASs toxicity merit further investigation.

scholarly journals Ambient PM exposure and DNA methylation in tumor suppressor genes: a cross-sectional study

2011 ◽  
Vol 8 (1) ◽  
pp. 25 ◽  
Author(s):  
Lifang Hou ◽  
Xiao Zhang ◽  
Letizia Tarantini ◽  
Francesco Nordio ◽  
Matteo Bonzini ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Tumor Suppressor ◽  
Tumor Suppressor Genes ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Suppressor Genes

scholarly journals STAT3 methylation in white blood cells as a novel sensitive biomarker for the toxic effect of low-dose benzene exposure

2016 ◽  
Vol 5 (3) ◽  
pp. 800-807 ◽  
Author(s):  
Di Liu ◽  
Yujiao Chen ◽  
Pengling Sun ◽  
Wenlin Bai ◽  
Ai Gao
Keyword(s):  
Dna Methylation ◽  
Toxic Effect ◽  
Health Effects ◽  
Blood Cells ◽  
Low Dose ◽  
White Blood Cells ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Benzene Exposure

A cross-sectional study was conducted in a sample of 571 workers to explore the toxic effect and early sensitive biomarker of the health effects of low-dose benzene exposure (LDBE), as well as the correlation between DNA methylation and the toxic effect of LDBE.

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