Thirty-day mortality rates after immunotherapy initiation

Immunotherapy ◽  
2021 ◽  
Author(s):  
Osman Sütcüoğlu ◽  
Ayşegül İlhan ◽  
Seher Yıldız Tacar ◽  
Deniz Can Güven ◽  
Gökhan Uçar ◽  
...  
Keyword(s):  
Side Effects ◽  
Cause Of Death ◽  
Patient Population ◽  
Palliative Therapy ◽  
Mortality Rates ◽  
Thromboembolic Events ◽  
Tertiary Referral ◽  
Common Cause ◽  
Referral Hospitals ◽  
Line Of Therapy

Background: The aim of this study was to determine the cause of death in patients who died within 30 days after the first dose of immunotherapy. Methods: The data of 1432 patients treated with immunotherapy in six tertiary referral hospitals were retrospectively analyzed. Results: It was determined that 34 (2%) of the patients died within 30 days after the first dose of immunotherapy. Death occurred in all patients who received palliative therapy, and most patients (88%) received immunotherapy as second- or subsequent-line of therapy. The most common cause of death was disease progression and thromboembolic events. Conclusion: Preliminary results of the current study might give some clues to define the patient population in whom the fatal side effects of immunotherapy might be encountered.

scholarly journals Causes of sudden death - autopsy review in a tertiary referral center

2020 ◽  
Vol 6 (8) ◽  
pp. 481-485
Author(s):  
Dr. S.M. Choukimath ◽  
◽  
Dr. Megha M. Naik ◽  
Keyword(s):  
Sudden Death ◽  
Cause Of Death ◽  
Urban Population ◽  
World Health ◽  
Tertiary Referral ◽  
Common Cause ◽  
Tertiary Referral Center ◽  
Male Preponderance ◽  
Health Organization ◽  
Respiratory Causes

Background: The incidence of sudden death has been increasing steadily all over the worldparticularly in the urban population for the last 5 years. World health organization [WHO] hasdefined sudden death as “Death within 24 hrs from the onset of symptoms”. It can be defined asdeaths that are sudden, unexpected, clinically unexplained, or otherwise obscure even though thereneed to be no unnatural element in their causation. Materials and methods: Complete analysisand review of all autopsy/post-mortem specimens received in the Department of Pathology, KIMS,Hubballi between September 2017 to June 2019 done to find out the cause of death. Results:During the study period, a total of 153 cases of sudden death were received, age ranged from 6months to 72 years, with male preponderance. The cause of death were, 67 cases - cardiac causes[43.7%], 15 cases- respiratory causes [9.8%], 7 cases of sepsis [4.5%], 6 cases of Miliary TB[3.9%], CNS- 5 cases [3.2%], Hepatobiliary [2.6%], Renal- 2 cases [1.3%], Gastrointestinal 2cases [1.3%] Malignancy – 1 case [0.65%], Inconclusive 44 - cases [ 28.7%]. Conclusion: Thisstudy concludes that sudden death can occur at any age with the most common cause being cardiacdiseases and few among these are preventable. Therefore, creating awareness about the risk factorsand prevention of disease progression can reduce the incidence of sudden deaths.

Epidemiology of ischaemic heart disease

2021 ◽  
pp. 9-10
Author(s):  
Nick Townsend
Keyword(s):  
Developing Countries ◽  
Heart Disease ◽  
Ischaemic Heart Disease ◽  
Cause Of Death ◽  
Mortality Rates ◽  
High Income ◽  
Common Cause ◽  
Mortality And Morbidity

Ischaemic heart disease (IHD) is the most common cause of death globally. However, the worldwide burden from IHD comes not only from the deaths attributable to it, but also from the disability it causes in those who survive with it. Both mortality and morbidity from IHD is greater in men than women, with large inequalities also existing between countries and global regions. This is particularly noticeable when comparing countries of different income classifications, with more than three-quarters of all IHD deaths occurring in developing countries and the lowest age-standardized mortality rates for IHD found in high-income countries.

scholarly journals Determining the Cause of Death Among Drug Addicts in Residential Rehab Campuses in Tehran

2021 ◽  
Vol 11 (4) ◽  
pp. 33606-33606
Author(s):  
Shahram Jahanmanesh ◽  
◽  
Sareh Farhadi ◽  
Fares Najari ◽  
◽  
...  
Keyword(s):  
Side Effects ◽  
Pulmonary Edema ◽  
Cause Of Death ◽  
Causes Of Death ◽  
Pulmonary Hemorrhage ◽  
Mortality Rates ◽  
Drug Addicts ◽  
Drug Side Effects ◽  
Cross Sectional ◽  
Tissue Samples

Background: Determining the cause of death among drug addicts in Residential Rehab Campuses (RRCs) is of paramount importance, since it may prevent and reduce morbidity and mortality rates. Therefore, the present study was done to investigate the cause of death among drug addicts in RRCs in Kahrizak Dissection Hall, Tehran Province, Iran, from September 2011 to September 2019. Methods: In this descriptive cross-sectional study, a total number of 166 drug addicts, who had died in the RRCs located in Tehran, Iran were examined, and the findings were analyzed using the SPSS v. 26. Moreover, the Chi-square test was utilized to compare the results. Results: In this study, the most important causes of death, were infections, drug side effects, Myocardial Infarction (MI), and drowning, respectively. The highest frequency of death had occurred in the 31-40-year-old age group and was mostly observed in unmarried individuals. The most common causes of death were infection among the single and divorced ones and were MI for married cases. Toxicological results were generally negative in 60.84% of the cases. Also, 86.74% of the cases were non-pathological with regard to the brain tissue samples and 65.66% of the individuals had no pathological cardiac lesions. Besides, the most common microscopic findings of the lungs were associated with pulmonary edema. In the trauma group and also drug side effects and drowning groups, the most frequent pathological findings were pulmonary hemorrhage and pulmonary edema, respectively. As a whole, 69.87% of the deaths had occurred in the RRCs and 55.42% of them were assumed natural in terms of mode of occurrence. Conclusion: The majority of the deaths in the RRCs should not have occurred if the given centers were authorized and the illegal centers were closed. Moreover, these centers should have proper management with the presence of resident physicians and trained medical staff as well as necessary medical equipment, proper nutrition, no access to drugs and other illicit substances, along with adherence to hygienic principles to minimize mortality rates among the drug addicts living in the RRCs.

Energy-Sensing Pathways in Ischemia: The Counterbalance Between AMPK and mTORC

2020 ◽  
Vol 25 (45) ◽  
pp. 4763-4770
Author(s):  
Angel Cespedes ◽  
Mario Villa ◽  
Irene Benito-Cuesta ◽  
Maria J. Perez-Alvarez ◽  
Lara Ordoñez ◽  
...  
Keyword(s):  
Blood Flow ◽  
Ischemic Stroke ◽  
Middle Cerebral Artery ◽  
Cause Of Death ◽  
Artery Occlusion ◽  
Brain Pathology ◽  
Common Cause ◽  
Specific Analysis ◽  
Energy Sensing ◽  
Cerebral Artery Occlusion

: Stroke is an important cause of death and disability, and it is the second leading cause of death worldwide. In humans, middle cerebral artery occlusion (MCAO) is the most common cause of ischemic stroke. The damage occurs due to the lack of nutrients and oxygen contributed by the blood flow. : The present review aims to analyze to what extent the lack of each of the elements of the system leads to damage and which mechanisms are unaffected by this deficiency. We believe that the specific analysis of the effect of lack of each component could lead to the emergence of new therapeutic targets for this important brain pathology.

scholarly journals Mortality Associated with Idiopathic Pulmonary Fibrosis in Northeastern Italy, 2008–2020: A Multiple Cause of Death Analysis

2021 ◽  
Vol 18 (14) ◽  
pp. 7249
Author(s):  
Alessandro Marcon ◽  
Elena Schievano ◽  
Ugo Fedeli
Keyword(s):  
Idiopathic Pulmonary Fibrosis ◽  
Pulmonary Fibrosis ◽  
Cause Of Death ◽  
Age Groups ◽  
Mortality Rates ◽  
Annual Percent Change ◽  
Northeastern Italy ◽  
Mortality Ratio ◽  
The Impact ◽  
Related Mortality

Mortality from idiopathic pulmonary fibrosis (IPF) is increasing in most European countries, but there are no data for Italy. We analysed the registry data from a region in northeastern Italy to assess the trends in IPF-related mortality during 2008–2019, to compare results of underlying vs. multiple cause of death analyses, and to describe the impact of the COVID-19 epidemic in 2020. We identified IPF (ICD-10 code J84.1) among the causes of death registered in 557,932 certificates in the Veneto region. We assessed time trends in annual age-standardized mortality rates by gender and age (40–74, 75–84, and ≥85 years). IPF was the underlying cause of 1310 deaths in the 2251 certificates mentioning IPF. For all age groups combined, the age-standardized mortality rate from IPF identified as the underlying cause of death was close to the European median (males and females: 3.1 and 1.3 per 100,000/year, respectively). During 2008–2019, mortality rates increased in men aged ≥85 years (annual percent change of 6.5%, 95% CI: 2.0, 11.2%), but not among women or for the younger age groups. A 72% excess of IPF-related deaths was registered in March–April 2020 (mortality ratio 1.72, 95% CI: 1.29, 2.24). IPF mortality was increasing among older men in northeastern Italy. The burden of IPF was heavier than assessed by routine statistics, since less than two out of three IPF-related deaths were directly attributed to this condition. COVID-19 was accompanied by a remarkable increase in IPF-related mortality.

scholarly journals Monitoring progress with national and subnational health goals by integrating verbal autopsy and medically certified cause of death data

2021 ◽  
Vol 6 (5) ◽  
pp. e005387
Author(s):  
Tim Adair ◽  
Sonja Firth ◽  
Tint Pa Pa Phyo ◽  
Khin Sandar Bo ◽  
Alan D Lopez
Keyword(s):  
Cause Of Death ◽  
Verbal Autopsy ◽  
Integration Method ◽  
Mortality Rates ◽  
Vital Statistics ◽  
Death Registration ◽  
Chronic Respiratory Diseases ◽  
Health Goals ◽  
Specific Mortality ◽  
Four Causes

IntroductionThe measurement of progress towards many Sustainable Development Goals (SDG) and other health goals requires accurate and timely all-cause and cause of death (COD) data. However, existing guidance to countries to calculate these indicators is inadequate for populations with incomplete death registration and poor-quality COD data. We introduce a replicable method to estimate national and subnational cause-specific mortality rates (and hence many such indicators) where death registration is incomplete by integrating data from Medical Certificates of Cause of Death (MCCOD) for hospital deaths with routine verbal autopsy (VA) for community deaths.MethodsThe integration method calculates population-level cause-specific mortality fractions (CSMFs) from the CSMFs of MCCODs and VAs weighted by estimated deaths in hospitals and the community. Estimated deaths are calculated by applying the empirical completeness method to incomplete death registration/reporting. The resultant cause-specific mortality rates are used to estimate SDG Indicator 23: mortality between ages 30 and 70 years from cardiovascular diseases, cancers, chronic respiratory diseases and diabetes. We demonstrate the method using nationally representative data in Myanmar, comprising over 42 000 VAs and 7600 MCCODs.ResultsIn Myanmar in 2019, 89% of deaths were estimated to occur in the community. VAs comprised an estimated 70% of community deaths. Both the proportion of deaths in the community and CSMFs for the four causes increased with older age. We estimated that the probability of dying from any of the four causes between 30 and 70 years was 0.265 for men and 0.216 for women. This indicator is 50% higher if based on CSMFs from the integration of data sources than on MCCOD data from hospitals.ConclusionThis integration method facilitates country authorities to use their data to monitor progress with national and subnational health goals, rather than rely on estimates made by external organisations. The method is particularly relevant given the increasing application of routine VA in country Civil Registration and Vital Statistics systems.

scholarly journals Cardioinformatics: the nexus of bioinformatics and precision cardiology

2019 ◽  
Author(s):  
Bohdan B Khomtchouk ◽  
Diem-Trang Tran ◽  
Kasra A Vand ◽  
Matthew Might ◽  
Or Gozani ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Cancer Research ◽  
Computational Biology ◽  
Cause Of Death ◽  
Cancer Mortality ◽  
Unmet Need ◽  
Mortality Rates ◽  
Cardiovascular Medicine ◽  
Biology Research

Abstract Cardiovascular disease (CVD) is the leading cause of death worldwide, causing over 17 million deaths per year, which outpaces global cancer mortality rates. Despite these sobering statistics, most bioinformatics and computational biology research and funding to date has been concentrated predominantly on cancer research, with a relatively modest footprint in CVD. In this paper, we review the existing literary landscape and critically assess the unmet need to further develop an emerging field at the multidisciplinary interface of bioinformatics and precision cardiovascular medicine, which we refer to as ‘cardioinformatics’.

scholarly journals Mortality Rates and Cause of Death Among Former Prison Inmates in North Carolina

2017 ◽  
Vol 78 (4) ◽  
pp. 223-229
Author(s):  
Mark Jones ◽  
Gregory D. Kearney ◽  
Xiaohui Xu ◽  
Tammy Norwood ◽  
Scott K. Proescholdbell
Keyword(s):  
North Carolina ◽  
Cause Of Death ◽  
Mortality Rates ◽  
Prison Inmates

scholarly journals Suicide prevention in low- and middle-income countries: part perceptions, partial solutions

2017 ◽  
Vol 211 (5) ◽  
pp. 264-265 ◽  
Author(s):  
K. S. Jacob
Keyword(s):  
Public Health ◽  
Suicide Prevention ◽  
Cause Of Death ◽  
Population Based ◽  
Personal Distress ◽  
Public Health Perspective ◽  
Middle Income ◽  
Common Cause ◽  
Middle Income Countries ◽  
Low And Middle Income

SummarySuicide, a common cause of death in many low- and middle-income countries, has often been viewed through a medical/psychiatric lens. Such perspectives medicalise social and personal distress and suggest individual and medication-based treatments. This editorial argues for the need to examine suicide from a public health perspective and suggests the need for population-based social and economic interventions.

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