Association of Body Mass Index with Serum Vitamin D and PSA Levels among Sudanese Prostate Cancer Patients

Background: Prostate cancer is the second most common cancer in men worldwide and the second leading cause of cancer deaths in men in the United States. Obesity has been consistently associated with lower 25-hydroxyvitamin D (25(OH)D) concentrations. Objectives: This cross-sectional study aimed to evaluate the serum vitamin D and PSA levels in Sudanese Obese and Non-Obese prostate cancer (PCa) attending the National Cancer Institute. Patients and Methods: Eighty six prostate cancer patients were included in this study, they were identified by clinical examination, histopathology and prostate-specific antigen (PSA). The mean age of them was 71.78 ± 8.04 years. Serum Vitamin D and PSA were measured by Electrochemiluminescence (ECL) immunoassay reactions using (Cobase411, serial No: 0868-16, manufactured by Hitachi high technologies corporation, Tokyo-Japan) the Elecsys reagents kit (Roche – Germany) Results: The means of serum vitamin D levels of among obese was 35.5 ± 15.4 ng/dL and 38.4 ± 16.2 ng/dL among non-obese group with non-significant differences(P=0.505). No signiﬁcant association was observed between PSA levels and obese and non-obese (P=0.351). Vitamin D levels non-significantly negative correlated with BMI (r = -0.031, P = 0.778) and PSA (r = -0.062, P = 0.569), but there was insignificantly Positive correlated between PSA and vitamin D level (r = 0.151, P = 0.164). Conclusion: insignificant differences between vitamin D and serum PSA with BMI, Oral supplementation is recommended for individuals with low level of vitamin D. Keywords: Prostate cancer, Body mass index, Vitamin D, PSA, Sudanese.

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Body Mass Index, Vitamin D, and Type 2 Diabetes: A Systematic Review and Meta-Analysis

Nutrients ◽

10.3390/nu10091182 ◽

2018 ◽

Vol 10 (9) ◽

pp. 1182 ◽

Cited By ~ 21

Author(s):

Shamaila Rafiq ◽

Per Jeppesen

Keyword(s):

Systematic Review ◽

Body Mass Index ◽

Vitamin D ◽

Body Mass ◽

Observational Studies ◽

Meta Analysis ◽

Serum Vitamin ◽

Vitamin D Supplementation ◽

Serum Vitamin D ◽

Vitamin D Levels

The deficiency of vitamin D is prevalent all over the world. Studies have shown that vitamin D may play an important role in the development of obesity. The current study was conducted to quantitatively evaluate the association between serum 25-(OH) vitamin D levels and the risk of obesity in both diabetic and non-diabetic subjects. A systematic review and meta-analysis of observational studies was carried out for that purpose. We searched the Medline, PubMed, and Embase databases throughout all of March 2018. A total of fifty five observational studies for both diabetic and non-diabetic subjects were finally included in the meta-analysis. The data were analyzed by comprehensive meta-analysis software version 3 and the random effects model was used to analyze the data. The meta-analysis showed an overall inverse relationship between serum vitamin D status and body mass index (BMI) in studies of both diabetic (r = −0.173, 95% = −0.241 to −0.103, p = 0.000) and non-diabetic (r = −0.152, 95% = −0.187 to −0.116, p = 0.000) subjects. The evidence of publication bias was not found in this meta-analysis. In conclusion, the deficiency of vitamin D is associated with an increased level of BMI in the studies of both diabetic and non-diabetic subjects. Reliable evidence from well-designed future randomized controlled trials is required to confirm the findings from observational studies and to find out the potential regulatory effects of vitamin D supplementation to lower BMI.

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Serum vitamin D levels and body mass index in children with vernal keratoconjunctivitis

Beyoglu Eye Journal ◽

10.14744/bej.2020.75047 ◽

2020 ◽

Author(s):

GÖNÜL KARATAS DURUSOY

Keyword(s):

Body Mass Index ◽

Vitamin D ◽

Body Mass ◽

Serum Vitamin ◽

Vernal Keratoconjunctivitis ◽

Serum Vitamin D ◽

Vitamin D Levels

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Body mass index and serum vitamin D levels in Cuban, African, and Haitian Americans with type 2 diabetes (1029.7)

The FASEB Journal ◽

10.1096/fasebj.28.1_supplement.1029.7 ◽

2014 ◽

Vol 28 (S1) ◽

Author(s):

Fatma Huffman ◽

Karol Feijao ◽

Lemia Shaban ◽

Gustavo Zarini ◽

Sahar Ajabshir ◽

...

Keyword(s):

Type 2 Diabetes ◽

Body Mass Index ◽

Vitamin D ◽

Body Mass ◽

Serum Vitamin ◽

Serum Vitamin D ◽

Vitamin D Levels ◽

Haitian Americans

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Association between vitamin D deficiency and prostate cancer: Prospective case-control study

Journal of Clinical Urology ◽

10.1177/2051415821993606 ◽

2021 ◽

pp. 205141582199360

Author(s):

Ghanshyam Kumawat ◽

Vijay Chaudhary ◽

Anurag Garg ◽

Nishkarsh Mehta ◽

Gagan Talwar ◽

...

Keyword(s):

Prostate Cancer ◽

Vitamin D ◽

Vitamin D Deficiency ◽

Case Control Study ◽

Serum Vitamin ◽

P Value ◽

Serum Vitamin D ◽

Severe Vitamin ◽

Vitamin D Levels ◽

Control Study

Objective: We aimed to find out the association of low serum vitamin D levels with the incidence of prostate cancer through a prospective case-control study. Material and methods: This study was carried out in the tertiary care hospital (India). All newly diagnosed patients of prostate cancer and age-matched controls were included. Serum vitamin D levels were measured in all of them. Vitamin D status (ng/mL) was classified as severe deficiency <10, moderate deficiency 10–<30, normal 30–100, and toxicity >100. Normality of the data was tested by the Kolmogorov–Smirnov test, statistical analysis was done with Statistical Package for the Social Sciences version 26.0, p-value of <0.05 was considered significant. Results: In our study, 320 cases and 320 controls were included. The mean vitamin D levels in cases and controls were 15.71 ± 6.5 (ng/mL) and 17.63 ± 4.54 (ng/mL), respectively, ( p-Value <0.01). Patients with severe vitamin D deficiency (73.58%) had a Gleason score ⩾8 on biopsy and 79.24% of them had a serum prostate specific antigen (PSA) level >20 ng/mL. Conclusion: We had concluded that there was no significant association between vitamin D deficiency and increased risk of prostate cancer, although patients with higher-grade prostate cancer and with higher PSA level had severe vitamin D deficiency. Level of evidence: Not applicable for this multicentre audit.

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AACE2021-A-1101: Association of Body Mass Index and Serum Vitamin D Level Among Patients Attending a Tertiary Care Hospital in Bangladesh

Endocrine Practice ◽

10.1016/j.eprac.2021.11.021 ◽

2021 ◽

Vol 27 (12) ◽

pp. S21

Author(s):

Nazma Akter

Keyword(s):

Body Mass Index ◽

Vitamin D ◽

Body Mass ◽

Tertiary Care Hospital ◽

Tertiary Care ◽

Serum Vitamin ◽

Care Hospital ◽

Serum Vitamin D

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Associations Between Serum Vitamin D and Adverse Pathology in Men Undergoing Radical Prostatectomy

Journal of Clinical Oncology ◽

10.1200/jco.2015.65.1463 ◽

2016 ◽

Vol 34 (12) ◽

pp. 1345-1349 ◽

Cited By ~ 22

Author(s):

Yaw A. Nyame ◽

Adam B. Murphy ◽

Diana K. Bowen ◽

Gregory Jordan ◽

Ken Batai ◽

...

Keyword(s):

Prostate Cancer ◽

Vitamin D ◽

Radical Prostatectomy ◽

Univariate Analysis ◽

Serum Vitamin ◽

Serum Vitamin D ◽

Cancer Aggressiveness ◽

Increased Risk ◽

Vitamin D Levels ◽

The Relationship

Purpose Lower serum vitamin D levels have been associated with an increased risk of aggressive prostate cancer. Among men with localized prostate cancer, especially with low- or intermediate-risk disease, vitamin D may serve as an important biomarker of disease aggression. The aim of this study was to assess the relationship between adverse pathology at the time of radical prostatectomy and serum 25-hydroxyvitamin D (25-OH D) levels. Methods This cross-sectional study was carried out from 2009 to 2014, nested within a large epidemiologic study of 1,760 healthy controls and men undergoing prostate cancer screening. In total, 190 men underwent radical prostatectomy in the cohort. Adverse pathology was defined as the presence of primary Gleason 4 or any Gleason 5 disease, or extraprostatic extension. Descriptive and multivariate analyses were performed to assess the relationship between 25-OH D and adverse pathology at the time of prostatectomy. Results Eighty-seven men (45.8%) in this cohort demonstrated adverse pathology at radical prostatectomy. The median age in the cohort was 64.0 years (interquartile range, 59.0 to 67.0). On univariate analysis, men with adverse pathology at radical prostatectomy demonstrated lower median serum 25-OH D (22.7 v 27.0 ng/mL, P = .007) compared with their counterparts. On multivariate analysis, controlling for age, serum prostate specific antigen, and abnormal digital rectal examination, serum 25-OH D less than 30 ng/mL was associated with increased odds of adverse pathology (odds ratio, 2.64; 95% CI, 1.25 to 5.59; P = .01). Conclusion Insufficiency/deficiency of serum 25-OH D is associated with increased odds of adverse pathology in men with localized disease undergoing radical prostatectomy. Serum 25-OH D may serve as a useful biomarker in prostate cancer aggressiveness, which deserves continued study.

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The Role of the Serum 25-OH Vitamin D Level in Detecting Prostate Cancer in Men with Elevated Prostate-Specific Antigen Levels

10.21203/rs.3.rs-1206468/v1 ◽

2022 ◽

Author(s):

Min Hyuk Kim ◽

Sangjun Yoo ◽

Min Soo Choo ◽

Min Chul Cho ◽

Hwancheol Son ◽

...

Keyword(s):

Prostate Cancer ◽

Vitamin D ◽

Cancer Diagnosis ◽

Prostate Biopsy ◽

Serum Vitamin ◽

Study Cohort ◽

Prostate Cancer Diagnosis ◽

Serum Vitamin D ◽

Vitamin D Levels ◽

Clinically Significant

Abstract We aimed to determine whether vitamin D levels before prostate biopsy have diagnostic value for clinically significant prostate cancer. The study cohort included patients who underwent prostate biopsy. A total of 224 patients were enrolled in our study, and serum vitamin D levels were measured from February 2016 to December 2019 in routine laboratory tests. To determine the relationship between vitamin D levels and the aggressiveness of prostate cancer, we used multivariate analysis. Based on the histopathological results, the serum vitamin D level was marginally lower in the group with higher positive cores and pT3 or higher, and the serum vitamin D level was significantly lower in the large tumor volume group. In the univariate analysis, the prostate cancer diagnosis rate was associated with low vitamin D levels. In clinically significant prostate cancer diagnosis, low vitamin D levels were found in the univariate (odds ratio [OR], 0.955; P<0.001) and multivariate (OR, 0.944; P=0.027) analyses. In conclusion, we found that the incidence of prostate cancer tends to increase as the vitamin D level is lower in the Asian population, and this is particularly helpful in diagnosing clinically significant prostate cancer.

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