scholarly journals Role of Kalmegha (Andrographis paniculata (Burm.F.) Wall. Ex Nees) in treating Vatarakta (Gout)

2018 ◽  
Vol 8 (6) ◽  
pp. 98-101
Author(s):  
Harsh Sehgal ◽  
Bhavna Singh ◽  
Sanandan Thapliyal
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Skin Diseases ◽  
Adult Population ◽  
Gouty Arthritis ◽  
Andrographis Paniculata ◽  
P Value ◽  
Objective Parameter ◽  
Wide Range ◽  
Anti Cancer

Andrographis paniculata (Burm.f.) Wall. Ex. Nees (A. Paniculata), i.e. Kalmegha is a medicinal plant traditionally used for various diseases such as fever, diarrhea, worm infestation, hepatic and skin diseases. Modern studies have also explicitly revealed that A. Paniculata has a wide range of pharmacological effects such as anti-inflammatory, anti-hyperglycemic, anti-diarrhoeal, anti-viral, anti-malarial, hepato-protective, anti-cancer, anti-human immunodeficiency virus (HIV), and also work as an immune stimulator. On the other hand, Gout (Vatarakta) is one common metabolic disorder which affects over 1% of the world’s adult population. Objective: To assess the clinical efficacy of A.Paniculata in Gouty Arthritis. Study Design: A clinical research, prospective in style, wherein a hypothesis, based on the previous studies on the various effects of A. Paniculata, was made; to assess its efficacy in treating Gout. Methodology: Randomly selected patients (n = 31) were administered powder of A. Paniculata, 2 gms thrice daily with water, for 45 days with a follow-up in every 15 days for one month. Assessment of the treatment was based on before treatment (BT) and after treatment (AT) effects of A. Paniculata on the parameters namely; subjective, i.e. the symptoms of Gout and objective, i.e. the levels of Serum Uric Acid. Results: In subjective parameters, Wilcoxon non-parametric test was used. The outcome shows that except the symptom i.e. Pallor (shwetata), in all other symptoms of Gout, p value was either < 0.05 or < 0.01, which is considered to be significant to highly significant. In objective parameter, Z test was used, in which the outcome of p value was < 0.01, which indicates that the effect of A.Paniculata on Serum Uric Acid is highly significant. Keywords: Kalmegha, Andrographis paniculata, Gout, Vatarakta, Serum Uric Acid, Clinical Studies

scholarly journals Clinical Study of Palasha Pushpa (Butea Monosperma (Lam.) Kuntze) in the Management of Vatarakta (Gouty arthritis)

AYUSHDHARA ◽  
2021 ◽  
pp. 3283-3293
Author(s):  
Gandham Neelima ◽  
V.Narasimha ◽  
A.Vijaya Lakshmi
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Gouty Arthritis ◽  
Average Decrease ◽  
Objective Parameter ◽  
Before And After ◽  
The Individual ◽  
Average Serum ◽  
Trial Drug

Objectives: This study was conducted to evaluate the effectiveness of Palashapushpa churna in the Management of Vatarakta (Gouty Arthritis). Materials and Methods: A single blind clinical trial was conducted at Department of Dravyaguna, Dr.B.R.K.R Govt. Ayurvedic Hospital, Erragadda, Hyderabad. 30 patients were selected and trial drug was advocated in a dose of 3 gm Palashapushpa churna twice a day with water as Anupana. Treatment was given for 45 days with the result assessment recorded at every 15 days. Subjective and objective parameters were analyzed before and after the treatment. In subjective parameters Shula, Daha, Shotha, Raga, Sthabdata are taken, while Serum uric acid levels is considered as objective parameter. Results: Out of 30 patients, Sula, Daha, Shotha, Sthabdata was found in all patients, Raga was found in 6 patients, which suggests the severity of condition. After treatment it was observed that Sula is found to be relieved by 93.33% of patients, Daha and Shotha is found to be relieved by 60%, Raga is found to be relieved by20% of patients, Sandhi stabdata is found to be relieved by 80% of patients . It is observed that Sandhi shula and Sandhi sthabdata was got good relief, Sandhi daha and Sandhi shotha was got moderate relief. Sandhi raga was got mild relief. The average serum uric acid levels in the patients of Vatarakta before the treatment is 2.13 after the treatment with administration of Palashapushpa churna orally it was brought down to the average of 1.13. The average decrease in the levels of uric acid with highly significant (P<0.001). Conclusion: Palasha pushpa churna prepared as per the textual standards is highly effective in Vatarakta and showing a way out to the individual suffering from this chronic disease. The study confirmed the effect of trial drug in Vatarakta (Gouty arthritis) in improving the quality of life of patients without any untoward effects.

Management of Gouty Arthritis with special reference to Vatarakta - A Case Report

2017 ◽  
Vol 2 (4) ◽  
Author(s):  
V. Balendu Krishnan ◽  
Prashanth A. S.
Keyword(s):  
Uric Acid ◽  
Case Report ◽  
Serum Uric Acid ◽  
Serum Uric Acid Level ◽  
Gouty Arthritis ◽  
Treatment Protocol ◽  
Joint Inflammation ◽  
High Serum ◽  
Common Disease ◽  
Disease Condition

Gouty Arthritis has now become a common disease condition which we deal in Ayurveda, but a proper treatment protocol is not followed in many cases. The case reported here was as a result of improper diet and lack of exercise which resulted in an increase serum uric acid level and joint inflammation. The treatment was given at IPD level diagnosing it as Gambhira Vatarakta with valid Chikitsa Siddhanta. This case report provides us a guidelines that even a chronic gouty arthritis with a very high serum uric acid can be treated as per Vataraktha Chikitsa Siddhanta in Ayurveda.

scholarly journals Comparative Study of Anti-Gouty Arthritis Effects of Sam-Myo-Whan according to Extraction Solvents

Plants ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 278
Author(s):  
Yun Mi Lee ◽  
Eunjung Son ◽  
Dong-Seon Kim
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Proinflammatory Cytokines ◽  
High Performance ◽  
Weight Bearing ◽  
Gouty Arthritis ◽  
Extraction Solvents ◽  
Main Components ◽  
Factor Α ◽  
Necrosis Factor

Sam-Myo-Whan (SMW) has been used in Korean and Chinese traditional medicine to help treat gout, by reducing swelling and inflammation and relieving pain. This study compared the effects of SMW extracted by using different solvents, water (SMWW) and 30% EtOH (SMWE), in the treatment of gouty arthritis. To this end, we analyzed the main components of SMWW and SMWE, using high-performance liquid chromatography (HPLC). Anti-hyperuricemic activity was evaluated by measuring serum uric acid levels in hyperuricemic rats. The effects of SMWW and SMWE on swelling, pain, and inflammation in gouty arthritis were investigated by measuring affected limb swelling and weight-bearing, as well as by enzyme-linked immunosorbent assays, to assess the levels of proinflammatory cytokines and myeloperoxidase (MPO). In potassium oxonate (PO)-induced hyperuricemic rats, SMWW and SMWE both significantly decreased serum uric acid to similar levels. In monosodium urate (MSU)-induced gouty arthritis mice, SMWE more efficiently decreased paw swelling and attenuated joint pain compare to SMWW. Moreover, SMWE and SMWW suppressed the level of inflammation by downregulating proinflammatory cytokines (interleukin-1β, tumor necrosis factor-α, and interleukin-6) and MPO activity. HPLC analysis further revealed that berberine represented one of the major active ingredients demonstrating the greatest change in concentration between SMWW and SMWE. Our data demonstrate that SMWE retains a more effective therapeutic concentration compared to SMWW, in a mouse model of gouty arthritis.

scholarly journals A STUDY OF SERUM URIC ACID LEVELS IN TYPE 2 DIABETES MELLITUS CASES AND ITS COMPARISON WITH THE SERUM CREATININE LEVELS

2021 ◽  
pp. 20-22
Author(s):  
Shajahan Shajahan ◽  
Koneru Sri Lahari ◽  
P. Kiranmai
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Uric Acid ◽  
Serum Creatinine ◽  
Serum Uric Acid ◽  
Fasting Blood Glucose ◽  
Control Group ◽  
P Value

BACKGROUND:Type 2 Diabetes Mellitus is a major non-communicable disease resulting from insulin resistance and is associated with cardiovascular,neurological and renal complications.Recent studies show association of hyperuricemia and Diabetes Mellitus.Uric acid increases oxidative stress that leads to vascular dysfunction and high intra glomerular pressure leading to renal complications.High serum creatinine is an indicator of renal compromise. OBJECTIVES: To evaluate serum uric acid and serum creatinine levels in type 2 diabetes mellitus patients and to find association between them. METHODOLOGY: The study was conducted in Osmania general hospital. Fifty cases of established Type 2 Diabetes Mellitus formed the study group and 50 normal healthy individuals formed the control group. Serum uric acid, Fasting Blood Glucose (FBS) and serum creatinine were estimated by colorimetric enzymatic methods on Beckman coulter AU5800.Mean values were compared in cases and controls using student t- test.Study group was further studied under 2 subgroups with serum Uric acid < 7 mg/dl and ≥7 mg/dl.In these 2 subgroups the association of Serum uric acid with FBS and creatinine was analysed statistically. RESULTS: Serum uric acid were found high in cases(7.63+/- 3.36)as compared to controls(4.48+/- 1.09) p value < 0.001.Serum creatinine were also high in cases(1.59+/- 1.39 )as compared to controls ( 0.87+/- 0.29) p value <0.005.Study subgroup with serum uric acid ≥7 mg/dl was associated with high creatinine and high fasting blood sugar levels when compared to subgroup with serum uric acid <7 mg/dl. CONCLUSION: Our study showed increased serum uric acid and serum creatinine levels in cases when compared to controls.There was significant association between high serum uric acid and high creatinine levels in cases.Therefore,it is important to measure serum uric acid and serum creatinine levels in diabetics for early detection of renal pathology.

scholarly journals Andrographolide, A Natural Antioxidant: An Update

Antioxidants ◽  
2019 ◽  
Vol 8 (12) ◽  
pp. 571 ◽  
Author(s):  
Eugenie Mussard ◽  
Annabelle Cesaro ◽  
Eric Lespessailles ◽  
Brigitte Legrain ◽  
Sabine Berteina-Raboin ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Herbal Remedy ◽  
Biological Activities ◽  
Lung Infection ◽  
Andrographis Paniculata ◽  
Natural Antioxidant ◽  
Nuclear Factor ◽  
Wide Range ◽  
Anti Cancer ◽  
Antioxidant Mechanisms

Traditionally, Andrographis paniculata has been used as an herbal remedy for lung infection treatments. Its leaves contain a diterpenoid labdane called andrographolide responsible for a wide range of biological activities such as antioxidant, anti-inflammatory, and anti-cancer properties. This manuscript is a brief review of the antioxidant mechanisms and the regulation of the Nrf2 (nuclear factor (erythroid-derived 2)-like 2) signaling pathway by andrographolide.

Association of uric acid with metabolic parameters and obesity

2020 ◽  
Vol 50 (6) ◽  
pp. 1241-1254
Author(s):  
Marjan Mahdavi-Roshan ◽  
Mina Movahedian ◽  
Hamed Kord Varkaneh ◽  
Arsalan Salari ◽  
Melahat Sedanur Macit ◽  
...  
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Communicable Disease ◽  
Adult Population ◽  
Elevated Serum ◽  
Cross Sectional Study ◽  
Metabolic Parameters ◽  
Cross Sectional ◽  
Content Type ◽  
Non Communicable Disease

Purpose Recent studies have shown that hyperuricemia is a predictor of non-communicable disease and an increment of mortality rate. Also, elevated serum uric acid may be associated with obesity in the adult population. This study aims to evaluate the association between serum uric acid levels with metabolic parameters and risk of obesity in the Iranian population. Design/methodology/approach The cross-sectional study was done on 550 participants, who were referred to a hospital for elective angiography in Rasht, Iran; anthropometric indices (waist circumference (WC) and body mass index (BMI)) and hematological factors were measured using the standard approaches. Based to the angiography results, the severity of atherosclerosis was defined. Findings The mean (SD) concentration of serum uric acid for all participants was 5.15 (1.37) mg/dl. Individuals who were at the highest tertile had higher mean (SD) of weight (p = 0.004), creatinine and blood urea nitrogen (p < 0.001) lower fasting blood sugar (FBS) (p = 0.000) and HbA1c (p = 0.016), and they were mostly men compared with those in the lowest tertile. After adjusting for confounders, FBS (ß = –0.145, p = 0.001) and HbA1c (%) (ß = –0.130, p = 0.019) had inverse and weight (ß = 0.156, p = 0.001) had direct association with serum uric acid. After adjustment for additionally potential confounders subjects in the highest tertile of serum uric acid had 92 per cent higher chance of obesity compared with subjects in the lowest tertile (OR 1.92; 95 per cent CI 1.13, 3.23). Originality/value The present study has concluded that increase serum uric acid related to high risk of obesity and low mean of FBS and HbA1c.

scholarly journals A study of angiographic severity in patients with coronary artery disease and hyperuricemia

2015 ◽  
Vol 7 (2) ◽  
pp. 1-4 ◽  
Author(s):  
Subhraprakash Pramanik ◽  
Koushik Mondal ◽  
Arpan Kumar Dey ◽  
Pijush Kanti Mandal ◽  
Shovan Kumar Das ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Uric Acid ◽  
Coronary Artery ◽  
Serum Uric Acid ◽  
Uric Acid Level ◽  
Acid Level ◽  
Serum Uric Acid Level ◽  
P Value ◽  
Gensini Score ◽  
Artery Disease

Backgrounds: Hyperuricemia has not yet been established as cardiovascular risk factor. We aimed to study the angiographic severity in patients with coronary artery disease (CAD) and hyperuricemia.Materials and Methods: In this observational cross-sectional study we measured serum uric acid level in 82 patients of CAD who underwent coronary angiography in catheterisation laboratory of our Institution. Severity of CAD was determined on the basis of Gensini score, number of diseased vessels, critical lesions and total occlusions.Results: The prevalence of hyperuricemia in patients with CAD was 42.68% in our study. Hyperuricemia was associated with higher Gensini score (33.33±10.64 vs. 22.90±6.75, p value <0.001), number of critical lesions (1.03±0.84 vs. 0.63±0.72, p value 0.031), total occlusions (0.67±0.47 vs. 0.37±0.48, p value 0.007) and dyslipidemia (63.6% vs. 30.6%, p value 0.003) more frequently compared to normouricemic patients. And also the higher serum uric acid level was correlated with higher Gensini score (beta 0.418, t 4.430, p value <0.001, 95% CI 0.036 and 0.094) and frequent number of total occlusion (beta 0.338, t 3.589, p value 0.001, 95% CI 0.462 and 1.613).Conclusion: Hyperuricemia was associated with higher Gensini score, frequent total occlusions and critical lesions in patients with Coronary Artery Disease compared to patients with normal uric acid level and also it was significantly correlated with higher Gensini score and frequent total occlusions.Asian Journal of Medical Sciences Vol.7(2) 2015 1-4

scholarly journals Uric acid as a future biomarker in diagnosing metabolic syndrome patients.

2019 ◽  
Vol 26 (11) ◽  
pp. 1911-1915
Author(s):  
Shameela Majeed ◽  
Brig. Rizwan Hashim
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Uric Acid ◽  
Waist Circumference ◽  
Serum Uric Acid ◽  
Serum Triglyceride ◽  
Military Hospital ◽  
P Value ◽  
Model Assessment ◽  
R Value

Objectives: To determine the possible correlation between raised serum uric acid and various components of metabolic syndrome (Waist circumference, serum triglyceride, plasma HDL-C). Study Design: Descriptive case control. Setting: Army Medical College laboratory, Military Hospital, Rawalpindi. Period: One year (November 2014 to October 2015). Material and Methods: Total of 100 subjects were enrolled in this study. WHO criteria were applied for identifying the patients of metabolic syndrome. Fasting plasma glucose, lipid profile and serum uric acid levels were measured by using colorimetric enzymatic method. The formula of Homeostasis Model Assessment-Insulin Resistance (HOMA-IR) was applied to calculate Insulin resistance. Collected data was analyzed by using SPSS- Window version-17 for statistical analysis. Results: Serum uric acid levels were turned out to be high in metabolic syndrome patients (cases= 6.1±1.3mg/dL) when compared with controls (having no symptoms of MetS=3.6±1.2; p<0.001). Uric acid showed a statistically significant positive association with waist circumference (WC=r-value:0.250; p-value:0.000) and serum triglyceride (TG=r-value:0.341; p-value:0.000). Negative correlation had been found between plasma high-density lipoprotein-cholesterol (HDL-C=r-value: -0.173; p-value:<0.01) with uric acid levels. Conclusion: Serum uric acid levels show a significant association with components of metabolic syndrome making it a powerful biomarker of metabolic syndrome and its various cardiometabolic complications.

scholarly journals Study of the serum uric acid level as a prognostic indicator in hypertensive disorders of pregnancy

2021 ◽  
Vol 10 (9) ◽  
pp. 3441
Author(s):  
Smitha Krishnegowda ◽  
G. Nita
Keyword(s):  
Uric Acid ◽  
Disease Severity ◽  
Serum Uric Acid ◽  
Mode Of Delivery ◽  
Prognostic Indicator ◽  
Maternal Serum ◽  
P Value ◽  
Chronic Hypertension ◽  
Hypertensive Disorders Of Pregnancy ◽  
Hypertensive Disorders

Background: Abnormal uric acid levels in patients with preeclampsia and eclampsia affect both maternal and fetal outcome negatively. This study was done to know the alterations in these serum levels in comparison to normal pregnancy and also among various hypertensive disorders of pregnancies.Methods: Maternal serum uric acid levels were compared among cases and controls in relation to disease severity, mode of delivery, maternal outcome.Results: In group A (cases), 10 patients had raised uric acid levels, of which 5 were severe preeclampsia, 3 were eclampsia and 2 cases of chronic hypertension superimposed preeclampsia. P value is 0.001 (highly significant). Also serum uric acid is significantly elevated in hypertensive disorders of pregnancy compared with controls with a P value of 0.001.Conclusions: Significant correlation was observed between maternal serum uric acid, disease severity and maternal outcome. Our study concludes that uric acid can be considered as a sensitive prognostic indicator of severity in hypertensive disorders of pregnancy.

scholarly journals PREGNANCY INDUCED HYPERTENSION;

2018 ◽  
Vol 25 (08) ◽  
pp. 1168-1172
Author(s):  
Uzma Jamil ◽  
Anam Mukhtar ◽  
Shaista Hussain ◽  
Farida Munawar
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Late Pregnancy ◽  
Fetal Distress ◽  
Cross Sectional Study ◽  
Categorical Variables ◽  
P Value ◽  
Age Difference ◽  
Continuous Variables ◽  
Cross Sectional

Objectives: To investigate serum uric as an indicator of fetomaternal complicationsin women with late pregnancy. Study Design: Cross sectional study. Setting: Shalamar Medicaland Dental College Lahore ethical committee. Period: One year from October 2016 to October2017. Methodology: Continuous variables were presented as mean and standard deviationlike age and Serum malonaladehyde concentration; categorical variables were presented asnumbers and percentages like intra uterine growth restriction, Mild to moderate and sever preeclampsia and fetal distress. One way ANOVA, independent sample t test and chi square testwere applied to check significance of results, p value less than or equal to 0.05 was consideredas significant. Results: Overall, 100% (n=400) patients were included in this study. The meanage of the patients was 25.81±4.33 years. The age difference was not statistically significant,in groups (p=0.383). The mean serum uric acid levels of the patients for maturity (weeks)36, 37, 38, 39 and 40 was 247.96±2.52 (nmol/l), 253.95±2.04 (nmol/l), 261.19±3.15 (nmol/l),263.95±2.75 (nmol/l) and 296.19±2.55 (nmol/l) respectively. The differences were statisticallysignificant (p=0.000). Fetal distress, number with rising levels were (n=23) 71.8%, number withno change in levels were (n=3) 9.4% and number with falling levels were (n=6) 18.8%. Thedifferences were statistically significant. (p=0.000). Conclusion: The observations of our studyconcluded that serial increase of serum uric acid from 36th week to 40th week was observedin pregnancy induced hypertion patients, and raised serum level of uric acid had significantrelation with fetomaternal complications. like Fetal distress, preeclampsia, and intrauterinegrowth retardation. So serum uric acid can be used an indicator for fetometernal complicationsin late pregnancy.

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