scholarly journals Andrographolide, A Natural Antioxidant: An Update

Antioxidants ◽  
2019 ◽  
Vol 8 (12) ◽  
pp. 571 ◽  
Author(s):  
Eugenie Mussard ◽  
Annabelle Cesaro ◽  
Eric Lespessailles ◽  
Brigitte Legrain ◽  
Sabine Berteina-Raboin ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Herbal Remedy ◽  
Biological Activities ◽  
Lung Infection ◽  
Andrographis Paniculata ◽  
Natural Antioxidant ◽  
Nuclear Factor ◽  
Wide Range ◽  
Anti Cancer ◽  
Antioxidant Mechanisms

Traditionally, Andrographis paniculata has been used as an herbal remedy for lung infection treatments. Its leaves contain a diterpenoid labdane called andrographolide responsible for a wide range of biological activities such as antioxidant, anti-inflammatory, and anti-cancer properties. This manuscript is a brief review of the antioxidant mechanisms and the regulation of the Nrf2 (nuclear factor (erythroid-derived 2)-like 2) signaling pathway by andrographolide.

scholarly journals Role of Kalmegha (Andrographis paniculata (Burm.F.) Wall. Ex Nees) in treating Vatarakta (Gout)

2018 ◽  
Vol 8 (6) ◽  
pp. 98-101
Author(s):  
Harsh Sehgal ◽  
Bhavna Singh ◽  
Sanandan Thapliyal
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Skin Diseases ◽  
Adult Population ◽  
Gouty Arthritis ◽  
Andrographis Paniculata ◽  
P Value ◽  
Objective Parameter ◽  
Wide Range ◽  
Anti Cancer

Andrographis paniculata (Burm.f.) Wall. Ex. Nees (A. Paniculata), i.e. Kalmegha is a medicinal plant traditionally used for various diseases such as fever, diarrhea, worm infestation, hepatic and skin diseases. Modern studies have also explicitly revealed that A. Paniculata has a wide range of pharmacological effects such as anti-inflammatory, anti-hyperglycemic, anti-diarrhoeal, anti-viral, anti-malarial, hepato-protective, anti-cancer, anti-human immunodeficiency virus (HIV), and also work as an immune stimulator. On the other hand, Gout (Vatarakta) is one common metabolic disorder which affects over 1% of the world’s adult population. Objective: To assess the clinical efficacy of A.Paniculata in Gouty Arthritis. Study Design: A clinical research, prospective in style, wherein a hypothesis, based on the previous studies on the various effects of A. Paniculata, was made; to assess its efficacy in treating Gout. Methodology: Randomly selected patients (n = 31) were administered powder of A. Paniculata, 2 gms thrice daily with water, for 45 days with a follow-up in every 15 days for one month. Assessment of the treatment was based on before treatment (BT) and after treatment (AT) effects of A. Paniculata on the parameters namely; subjective, i.e. the symptoms of Gout and objective, i.e. the levels of Serum Uric Acid. Results: In subjective parameters, Wilcoxon non-parametric test was used. The outcome shows that except the symptom i.e. Pallor (shwetata), in all other symptoms of Gout, p value was either < 0.05 or < 0.01, which is considered to be significant to highly significant. In objective parameter, Z test was used, in which the outcome of p value was < 0.01, which indicates that the effect of A.Paniculata on Serum Uric Acid is highly significant. Keywords: Kalmegha, Andrographis paniculata, Gout, Vatarakta, Serum Uric Acid, Clinical Studies

scholarly journals Enhancing Activity of Pleurotus sajor-caju (Fr.) Sing β-1,3-Glucanoligosaccharide (Ps-GOS) on Proliferation, Differentiation, and Mineralization of MC3T3-E1 Cells through the Involvement of BMP-2/Runx2/MAPK/Wnt/β-Catenin Signaling Pathway

Biomolecules ◽  
2020 ◽  
Vol 10 (2) ◽  
pp. 190
Author(s):  
Thanintorn Yodthong ◽  
Ureporn Kedjarune-Leggat ◽  
Carl Smythe ◽  
Pannawich Sukprasirt ◽  
Aratee Aroonkesorn ◽  
...  
Keyword(s):  
Bone Formation ◽  
Signaling Pathway ◽  
Molecular Mechanisms ◽  
Integration Site ◽  
Biological Activities ◽  
Mitogen Activated Protein Kinase ◽  
Bone Morphogenetic Protein 2 ◽  
World Health ◽  
Wide Range ◽  
Pleurotus Sajor Caju

Osteoporosis is a leading world health problem that results from an imbalance between bone formation and bone resorption. β-glucans has been extensively reported to exhibit a wide range of biological activities, including antiosteoporosis both in vitro and in vivo. However, the molecular mechanisms responsible for β-glucan-mediated bone formation in osteoblasts have not yet been investigated. The oyster mushroom Pleurotus sajor-caju produces abundant amounts of an insoluble β-glucan, which is rendered soluble by enzymatic degradation using Hevea glucanase to generate low-molecular-weight glucanoligosaccharide (Ps-GOS). This study aimed to investigate the osteogenic enhancing activity and underlining molecular mechanism of Ps-GOS on osteoblastogenesis of pre-osteoblastic MC3T3-E1 cells. In this study, it was demonstrated for the first time that low concentrations of Ps-GOS could promote cell proliferation and division after 48 h of treatment. In addition, Ps-GOS upregulated the mRNA and protein expression level of bone morphogenetic protein-2 (BMP-2) and runt-related transcription factor-2 (Runx2), which are both involved in BMP signaling pathway, accompanied by increased alkaline phosphatase (ALP) activity and mineralization. Ps-GOS also upregulated the expression of osteogenesis related genes including ALP, collagen type 1 (COL1), and osteocalcin (OCN). Moreover, our novel findings suggest that Ps-GOS may exert its effects through the mitogen-activated protein kinase (MAPK) and wingless-type MMTV integration site (Wnt)/β-catenin signaling pathways.

Current Pharmaceutical Aspects of Synthetic Quinoline Derivatives

2020 ◽  
Vol 20 ◽  
Author(s):  
Rukhsana Tabassum ◽  
Muhammad Ashfaq ◽  
Hiroyuki Oku
Keyword(s):  
Fungal Infections ◽  
Biological Activities ◽  
Chemical Properties ◽  
New Drugs ◽  
Quinoline Derivatives ◽  
Wide Range ◽  
Anti Cancer ◽  
Anti Fungal ◽  
Physical And Chemical ◽  
And Chemical Properties

Abstract:: Quinoline derivatives are considered as broad spectrum pharmacological compounds that exhibit wide range of biological activities. Integration of quinoline moiety can improve its physical and chemical properties and also pharmacological behavior. Due to its wide range of pharmaceutical applications it is very popular compound to design new drugs for treatment of multiple diseases like cancer, dengue fever, malaria, tuberculosis, fungal infections, AIDS, Alzheimer’s disease and diabetes . In this review our major focus is to pay attention on biological activities of quinoline compounds in treatment of these diseases such as, anti-viral, anti-cancer, anti-malarial, anti-bacterial, anti-fungal, anti-tubercular and anti-diabetic.

Synthesis, Antioxidant and Antitumor Activity of Some Substituted 9-Anilinoacridine and 4-Anilinoquinolines Derivatives

2018 ◽  
Vol 15 (6) ◽  
pp. 846-852 ◽  
Author(s):  
Fatimah A. Agili
Keyword(s):  
Antioxidant Activity ◽  
Antitumor Activity ◽  
Biological Activities ◽  
Radical Scavenging ◽  
Breast Adenocarcinoma ◽  
Liver Carcinoma ◽  
Quinoline Derivatives ◽  
Wide Range ◽  
Anti Cancer ◽  
Radical Scavenging Ability

Background: Acridine and quinoline derivatives have a wide range of biological activities such as antioxidant and antitumor where quinoline derivatives intercalate between base pairs of double-stranded DNA through π-π interactions. Therefore, the development of new compounds with antitumor activity could be an important therapeutic strategy against this metabolic syndrome. Objective: This study was undertaken to synthesize different series of new anilinoacridines and anlinoquinoline with different substituents having biological activity. Materials and Methods: A series of new anilinoacridines and anlinoquinoline with different substituents was prepared by condensation of methyl 3-amino-4-methoxybenzoate hydrochloride with 9- chloroacridine and 4- chloroquinoline to give the target derivatives. Results: New anilinoacridines and anlinoquinoline with different substituents have been synthesized as antioxidant and anti-cancer agents. The structure of the synthesized compounds was confirmed by using spectral methods (FT-IR, 1H-NMR). The antioxidant activity of the synthesized compounds was evaluated by using DPPH radical scavenging ability. Also, the anti-cancer activity was evaluated using lung carcinoma, breast adenocarcinoma and liver carcinoma. The developed compounds 4a, b, 5a,b, 7a,b and 8a,b have shown a potent antioxidant activity. On the other hand, 4a, b, 5a and 7a exhibited the best antitumor activity against both A-549 and MCF7 cancer cells. Conclusion: For the active developed compounds, the most active antioxidant and antitumor one was 4a which registered the highest radical scavenging as well as antitumor activity.

scholarly journals Phytoecdysteroids: Chemical Structure And Biological Activity

2021 ◽  
Author(s):  
Zh.S. Akhmetkarimova ◽  
B.S. Temirgaziev
Keyword(s):  
Herbal Remedy ◽  
Biological Effects ◽  
Food Additives ◽  
Biologically Active ◽  
Biochemical Processes ◽  
Wide Range ◽  
Anti Cancer ◽  
Therapeutic Properties ◽  
Polyhydroxylated Sterols ◽  
The Brain

Owing to the need to develop new medicines and biologically active food additives with adaptogenic effects, phytoecdysteroids – polyhydroxylated sterols-are of great interest. Different types of drugs, extracts and individual compounds, have a wide range of pharmacological effects on several organs, such as the brain, blood, cardiovascular and nervous systems, as well as on various biochemical processes and physiological functions. Extracts and preparations from plants are safe and exhibit additional biological effects (antioxidant, immunomodulatory, anti-cancer, antimicrobial, antiparasitic and antifidant). Data on the chemical, pharmacological, and toxicological characteristics of R. carthamoides demonstrate that this species has beneficial therapeutic properties, and indicate its potential as an effective adaptogenic herbal remedy.

scholarly journals Antibacterial, Antiviral, Antioxidant, and Anticancer Activities of Postbiotics: A review of Mechanisms and Therapeutic Perspectives

2021 ◽  
Vol 12 (2) ◽  
pp. 2629-2645
Keyword(s):  
Human Health ◽  
Fermentation Process ◽  
Biological Activities ◽  
Scientific Evidence ◽  
Food Allergies ◽  
Live Cells ◽  
Anticancer Activities ◽  
Wide Range ◽  
Anti Cancer ◽  
Improve Health

Several scientific evidence has shown the advantageous effects of probiotic-derived metabolites on human health. Postbiotics are a wide range of bioactive compounds derived from probiotics through a fermentation process and/or produced in pure forms in laboratory scales. These compounds have native biological activities that have been extensively studied in recent years. Immunomodulation, antimicrobial, anti-cancer, antioxidant, anti-diabetic, and reduction of food allergies compose the most important biological roles of postbiotics. In terms of safety, it has been confirmed that postbiotics, as potential substitute elements, might be superior to their parent live cells. Also, due to their appropriate economic, technological, and clinical features, they could be employed as favorable apparatuses in the food and drug industry to improve health benefits. This review comprehensively discusses the concept of postbiotics and their characteristics, emphasizing their potential antibacterial, antiviral, antioxidant, and anticancer activities.

scholarly journals Polyphenols in Liubao Tea Can Prevent CCl4-Induced Hepatic Damage in Mice through Its Antioxidant Capacities

Nutrients ◽  
2018 ◽  
Vol 10 (9) ◽  
pp. 1280 ◽  
Author(s):  
Yanni Pan ◽  
Xingyao Long ◽  
Ruokun Yi ◽  
Xin Zhao
Keyword(s):  
B Cells ◽  
Liver Injury ◽  
Cell Damage ◽  
Biological Activities ◽  
Morphological Observation ◽  
Interleukin 12 ◽  
Nuclear Factor ◽  
Messenger Rnas ◽  
Wide Range ◽  
Liver Tissues

The present study investigated the preventive effect of polyphenols in Liubao tea (PLT) on carbon tetrachloride (CCl4)-induced liver injury in mice. The mice were initially treated with PLT, followed by induction of liver injury using 10 mL/kg CCl4. Then liver and serum indices, as well as the expression levels of related messenger RNAs (mRNAs) and proteins in liver tissues were measured. The results showed that PLT reduces the liver quality and indices of mice with liver injury. PLT also downregulates aspartate aminotransferase (AST), alanine aminotransferase (ALT), triglycerides (TGs), and malondialdehyde (MDA), and upregulates superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in the sera of mice with liver injury. PLT also reduces serum levels of interleukin-6 (IL-6), interleukin-12 (IL-12), tumor necrosis factor-α (TNF-α), and interferon-γ (IFN-γ) cytokines in mice with liver injury. Pathological morphological observation also shows that PLT reduces CCl4-induced central venous differentiation of liver tissues and liver cell damage. Furthermore, qPCR and Western blot also confirm that PLT upregulates the mRNA and protein expressions of Gu/Zn-SOD, Mn-SOD, catalase (CAT), GSH-Px, and nuclear factor of κ-light polypeptide gene enhancer in B-cells inhibitor-α (IκB-α) in liver tissues, and downregulates the expression of cyclooxygenase 2 (COX-2) and nuclear factor κ-light-chain-enhancer of activated B cells (NF-κB). Meanwhile, PLT also raised the phosphorylated (p)-NF-κB p65 and cytochrome P450 reductase protein expression in liver injury mice. The components of PLT include gallic acid, catechin, caffeine, epicatechin (EC), epigallocatechin gallate (EGCG), gallocatechin gallate (GCG), and epicatechin gallate (ECG), which possibly have a wide range of biological activities. Thus, PLT imparts preventive effects against CCl4-induced liver injury, which is similar to silymarin.

scholarly journals A Review on Daphnane-Type Diterpenoids and Their Bioactive Studies

Molecules ◽  
2019 ◽  
Vol 24 (9) ◽  
pp. 1842 ◽  
Author(s):  
Yue-Xian Jin ◽  
Lei-Ling Shi ◽  
Da-Peng Zhang ◽  
Hong-Yan Wei ◽  
Yuan Si ◽  
...  
Keyword(s):  
Biological Activities ◽  
Structural Diversity ◽  
Cytotoxic Activities ◽  
Hydroxyl Groups ◽  
Substitution Pattern ◽  
In Vivo Experiments ◽  
Wide Range ◽  
Anti Cancer

Natural daphnane diterpenoids, mainly distributed in plants of the Thymelaeaceae and Euphorbiaceae families, usually include a 5/7/6-tricyclic ring system with poly-hydroxyl groups located at C-3, C-4, C-5, C-9, C-13, C-14, or C-20, while some special types have a characteristic orthoester motif triaxially connectedat C-9, C-13, and C-14. The daphnane-type diterpenoids can be classified into five types: 6-epoxy daphnane diterpenoids, resiniferonoids, genkwanines, 1-alkyldaphnanes and rediocides, based on the oxygen-containing functions at rings B and C, as well as the substitution pattern of ring A. Up to now, nearly 200 daphnane-type diterpenoids have been isolated and elucidated from the Thymelaeaceae and Euphorbiaceae families. In-vitro and in-vivo experiments of these compounds have shown that they possess a wide range of biological activities, including anti-HIV, anti-cancer, anti-leukemic, neurotrophic, pesticidal and cytotoxic effects. A comprehensive account of the structural diversity is given in this review, along with the cytotoxic activities of daphnane-type diterpenoids, up to April 2019.

Research Progress on Ways of Secondary Metabolism in Plants

2012 ◽  
Vol 178-181 ◽  
pp. 1004-1007
Author(s):  
Xiu Bo Liu ◽  
Yan Shu Jia ◽  
Na Li ◽  
He Gong ◽  
Yan He Zhang ◽  
...  
Keyword(s):  
Secondary Metabolites ◽  
Biological Activities ◽  
Natural Habitat ◽  
Chemical Compounds ◽  
Research Progress ◽  
Primary Metabolites ◽  
Isolation And Characterization ◽  
Wide Range ◽  
Anti Cancer

The function of secondary metabolites has been a subject of debate since the first isolation and characterization of these often times structurally complex chemical compounds. By definition, secondary metabolites are naturally produced compounds that are not essential for the survival of the producing organism, as opposed to primary metabolites. Bioassays have revealed a wide range of biological activities, such as cytotoxicity, ichthyotoxicity, antimicrobial and antifeedant activity, antifoulant and anti-cancer activities. However, some of these activities are manifested against organisms that do not represent logical targets, since they would never be encountered by the producing organism in their natural habitat.

Design, Synthesis and Biological Activity Evaluation of Novel N-Acylation Substituted Isatin Derivatives

2013 ◽  
Vol 683 ◽  
pp. 34-37
Author(s):  
Bin Zeng ◽  
Xiao Hua Zhu
Keyword(s):  
Human Cancer ◽  
Biological Activities ◽  
Human Cancer Cell ◽  
Design Synthesis ◽  
Design And Synthesis ◽  
Wide Range ◽  
Anti Cancer ◽  
Endogenous Compound ◽  
Isatin Derivatives ◽  
Cancer Activity

Isatin, an endogenous compound existent in many organisms, shows a wide range of biological activities. In this paper, we like to report the design and synthesis of several isatin derivatives through the acetalization and N-Acylation. Six newly synthesized compounds were characterized on the basis of 1H NMR, and those compounds were determined using two different human cancer cell . Anti-cancer activity showed those compounds IC50＜50 μm.

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