scholarly journals HIV and infertility: neuro-endocrine and metabolic aspects

2021 ◽  
Vol 12 (4) ◽  
pp. 73-80
Author(s):  
O. Ya. Leshchenko ◽  
E. V. Genich ◽  
M. A. Darenskaya ◽  
L. I. Kolesnikova

Objective: to establish a correlation of the main neuroendocrine and metabolic parameters associated with infertility and to provide a prognostic assessment of reproductive disorders in HIV-infected women, stages 4.Materials and methods. Cross-sectional, cohort, clinical and sociological study of fertility of 83 women of reproductive age with HIV, stages 4.Results. The most significant indicators of lipid peroxidation and neuroendocrine regulation systems have been established in patients with HIV infection and reproductive disorders, which will make it possible to predict these disorders in the future. Decreased ovarian reserve, ovarian steroid function, increased pituitary prolactinergic function are associated with a deficiency of a number of antioxidants (retinol, tocopherol, superoxide dismutase) and the development of oxidative stress with a predominant accumulation of intermediate lipid peroxidation products in HIV-infected women with infertility.Conclusion. The pathogenetically substantiated principle of the correction of antioxidant status is the use of a-tocopherol and retinol preparations and the correction of hormonal levels in HIV-infected women with reproductive disorders.

Author(s):  
A.O. Atykanov ◽  
G.U. Asymbekova ◽  
A.A. Masybaeva

The paper presents quantitative indicators of lipid peroxidation (LP) products and antioxidant support network (ASN) in blood plasma in women with various histological forms of endometrial hyperplastic processes (EHPs). The goal of the paper is to assess the state of LP processes and ASN in women of reproductive age with various forms of EHPs. Materials and Methods. The trial enrolled 137 women of reproductive age: 112 women with endometrial hyperplasia (EH) and 25 women with uterine cavity synechia without EH. Conclusion. In case if EH progresses from a simple atypical form to adenocarcinoma, an increase in lipid peroxidation intensity and ASN inhibition is observed. Keywords: women, endometrial hyperplastic processes, endometrial hyperplasia, lipid peroxidation, antioxidant support network. В работе представлены количественные показатели содержания продуктов перекисного окисления липидов (ПОЛ) и системы антиоксидантной защиты (АОЗ) в плазме крови у женщин с различными гистологическими формами гиперпластического процесса эндометрия (ГПЭ). Цель исследования. Оценить состояние процессов ПОЛ и системы АОЗ при развитии различных форм ГПЭ у женщин репродуктивного возраста. Материалы и методы. Объектом исследования явились 137 женщин репродуктивного возраста: 112 женщин с гиперплазией эндометрия (ГЭ) и 25 женщин с синехиями полости матки без ГЭ. Выводы. При прогрессировании ГЭ от простой неатипичной до аденокарциномы происходит нарастание интенсивности липопереокисления и угнетения системы АОЗ. Ключевые слова: женщины, гиперпластические процессы эндометрия, гиперплазия эндометрия, перекисное окисление липидов, система антиоксидантной защиты.


2021 ◽  
pp. 1-10
Author(s):  
James Forty ◽  
Mpho Keetile

Abstract Malaria is a major public health concern in Malawi. This study explored the patterns and correlates of ownership and utilization of ITNs for malaria control among women of reproductive age in Malawi. Data were derived from the multi-stage cross-sectional Malaria Indicator Survey (MIS) conducted in 2017, which followed ITN distribution in 2012 and 2015. Of the 3860 sampled women aged 15–49 years, 88% (3398/3860) and 64% (2473/3860) reported that they owned and utilized ITNs, respectively. Adjusted multivariate logistic regression analysis showed that the odds of ownership of ITNs were significantly low among women with no education (AOR = 0.36, CI = 0.18–0.72), those with primary education (AOR = 0.50, CI = 0.27–0.94) and poor women (AOR = 0.70, CI = 0.51–0.97). Similarly, the odds of utilization of ITNs were significantly low among women with no education, (AOR = 0.40, CI = 0.26–0.63), primary education (AOR = 0.53, CI = 0.36–0.78) and poor women (AOR = 0.70, CI = 0.51–0.97). Furthermore, the odds of utilization of ITNs were significantly low among women living in households without a radio (AOR = 0.79, CI = 0.67–0.93) and those who have not seen or heard a malaria message in the last 6 months (AOR = 0.74, CI = 0.64–0.87). In order to prevent malaria morbidity and mortality among women of reproductive age, especially those from poor households, the Malawi government and relevant stakeholders need to continue the free distribution of ITNs to the poor and encourage social behaviours that promote the ownership and utilization of ITNs.


2020 ◽  
Vol 2020 ◽  
pp. 1-9
Author(s):  
Befikaduwa Zekarias ◽  
Frehiwot Mesfin ◽  
Bezatu Mengiste ◽  
Adane Tesfaye ◽  
Lemma Getacher

Background. Iodine deficiency disorder is a major public health problem in Ethiopia that is more common in women of reproductive age. However, it is not well addressed and there is a lack of information on its prevalence and associated factors in women of reproductive age group. Therefore, the objective of this study was to assess goiter prevalence and associated factors among women of reproductive age in the Demba Gofa woreda, Gamo Gofa Zone, Southwest Ethiopia. Methods. A community-based cross-sectional study was used among 584 randomly selected women in the reproductive age group from February 05 to April 20, 2016. A simple random sampling technique was used to select the study kebeles, and a systematic random sampling technique was used to select the study samples. Data were collected through a pretested questionnaire, and the goiter examination was done clinically for each participant. The collected data were coded and entered into a computer for statistical analysis using EpiData version 3.2 and analyzed using SPSS version 20. Variables with a P value ≤0.25 in bivariate logistic regression analysis were entered into multivariate logistic regression analysis, and finally, variables with a P value <0.05 in multivariate logistic regression were considered significantly associated with the dependent variable. Results. The total goiter rate was 43%, 95% CI = 39.2–46.9. Cassava consumption (AOR: 2.02, 95% CI: 1.03–4), salt wash before use (AOR: 3.14, 95% CI: 1.1–11.3), salt use after >2 months of purchase (AOR: 11, 95% CI: 5–26), family history of goiter (AOR: 4.6, 95% CI: 1.4–15.8), and poor knowledge of iodized salt (AOR: 2.7, 95% CI: 1.4–5.5) were significant factors associated with goiter. Conclusion. Iodine deficiency was found to be severe in women of reproductive age in the study area. This showed that women of reproductive age, especially during pregnancy, are exposed to iodine deficiency and its adverse effects at delivery. Thus, they need urgent supplementation with iodine, improved access to foods rich in iodine, and intake of iodized salt. Additionally, health education should focus on the importance of iodized salt, the proper method of use, and the prevention of iodine deficiency, which are highly recommended to minimize the problem.


2021 ◽  
Vol 10 ◽  
Author(s):  
Melisa A. Muñoz-Ruiz ◽  
Laura I. González-Zapata ◽  
Victoria Abril-Ulloa ◽  
Diego A. Gaitán-Charry

Abstract The present study aimed to assess the associations of the stages of Fe deficiency (Fe deficiency without anaemia (ID) and Fe-deficiency anaemia (IDA)) and anaemia with metabolic syndrome (MetS) in Ecuadorian women. A cross-sectional study was conducted in 5894 women aged 20–59 years, based on data from the 2012 Ecuadorian National Health and Nutrition Survey. The sample was stratified by age. A χ2 test was used to assess the possible associations of ID, IDA and anaemia with MetS. The prevalence ratio (PR) for each stage of Fe deficiency and anaemia was estimated considering women without MetS as a reference. The total prevalence of MetS, ID, IDA and anaemia was 32⋅3 % (se 0⋅6), 6⋅2 % (se 0⋅3), 7⋅1 % (se 0⋅3) and 5⋅0 % (se 0⋅3), respectively. In women aged 20–29, 30–39 and 40–49 years, MetS was associated with a lower prevalence of ID (PR (95 % CI; P-value)): 0⋅17 (0⋅06, 0⋅46; P < 0⋅001), 0⋅69 (0⋅48, 0⋅99; P = 0⋅044) and 0⋅44 (0⋅29, 0⋅67; P < 0⋅001), respectively. In women aged 50–59 years, MetS was associated with IDA and anaemia (PR (95 % CI; P-value)): 0⋅12 (0⋅02, 0⋅96; P = 0⋅026) and 0⋅22 (0⋅07, 0⋅64; P = 0⋅002), respectively. In conclusion, Ecuadorian women of reproductive age with MetS have a lower prevalence of ID compared with those without MetS. Furthermore, the MetS and IDA coexist at the population level. These findings require an analysis from a dietary pattern approach, which could provide key elements for developing public policies that simultaneously address all forms of malnutrition.


2019 ◽  
Vol 1 (1) ◽  
pp. 15-20
Author(s):  
Umme Kulsoom Khattak ◽  
Saima Perwaiz Iqbal ◽  
Ahmed Abdullah ◽  
Ayesha Chowhan

Objective: To determine the prevalence of utilization of family planning methods among married women of reproductive age in a semi urban community of Islamabad. Methodology: A cross-sectional survey was done using two stage sampling, including cluster and consecutive sampling techniques. A proportionate sample from each mohallas of Nurpur Shahan was taken to achieve our sample size. All married women of the reproductive age group (15-45 years) living with their husbands, not diagnosed as a case of infertility and permanent residents of Nurpur Shahan were included. Results: Total of 550 women were included in the study with mean age of 31.64 years. Majority of women 497 (94.7%) were currently married while 322 (59.9 %) were literate. Of all the women, 72 (13.2%) women were currently pregnant and only 62 (11.3%) had a planned pregnancy. Induced abortion was practiced once by 9 (1.8%) women and 21 (4.1%) had done it twice. 394 (72.8%) had knowledge of family planning methods and only 102 (19.5%) women were using family Planning methods currently. Conclusion: Miscellaneous challenges are involved to increase involvement of the women and their families in the use of family planning services. Health education campaigns at community level to increase awareness regarding different family planning methods are highly needed. Government needs to improve the LHWs services to increase the use of family planning methods and combat induced abortions as a method of contraception. Controlling population through sterilization after attaining a large family size should not be the preferred method of family Planning.


2019 ◽  
Author(s):  
Dieudonne Hakizimana ◽  
Marie Paul Nisingizwe ◽  
Jenae Logan ◽  
Rex Wong

Abstract Background Anemia among Women of Reproductive Age (WRA) continues to be among the major public health problems in many developing countries, including Rwanda, where it increased in prevalence between the 2015 and 2010 Rwanda Demographic and Health Survey (RDHS) reports. A thorough understanding of its risk factors is necessary to design better interventions. However, to the best of our knowledge, no study has been conducted in Rwanda on a nationally representative sample to assess factors associated with anemia among WRA. Accordingly, this study was conducted to address such gap. Methods A quantitative, cross-sectional study was conducted using data from the RDHS 2014-2015 report. The study population consisted of 6680 WRA who were tested for anemia during the survey. Anemia was defined as having a hemoglobin level equal to or below 10.9 g/dl for a pregnant woman, and hemoglobin level equal to or below 11.9 g/dl for a non-pregnant woman. Pearson’s chi-squared test and multiple logistic regression were conducted for bivariate and multivariable analysis, respectively. Results The prevalence of anemia among WRA was 19.2% (95% CI: 18.0 - 20.5). Four factors were found to be associated with lower odds of anemia, including being obese (OR: 0.61, 95% CI: 0.40 - 0.91), being in the rich category (OR: 0.74, 95% CI: 0.63 - 0.87), sleeping under a mosquito net (OR: 0.85, 95% CI: 0.74 - 0.98), and using hormonal contraceptives (OR: 0.61, 95% CI: 0.50 - 0.73). Five factors were associated with higher odds of anemia, including being underweight (OR: 1.39, 95% CI: 1.09 - 1.78), using an intrauterine device (OR: 1.98, 95% CI: 1.05 - 3.75), being separated or widowed (OR: 1.35, 95% CI: 1.09 - 1.67), and living in the Southern province (OR: 1.45, 95% CI: 1.11 - 1.89) or in the Eastern province (OR: 1.41, 95% CI: 1.06 - 1.88). Conclusion Anemia continues to pose public health challenges; novel public health interventions should consider geographic variations in anemia risk, seek to improve women’s economic statuses, and strengthen iron supplementation especially for Intrauterine device users. Additionally, given the association between anemia and malaria, interventions to prevent malaria should be enhanced.


PeerJ ◽  
2016 ◽  
Vol 4 ◽  
pp. e1945 ◽  
Author(s):  
Bishwajit Ghose ◽  
Shangfeng Tang ◽  
Sanni Yaya ◽  
Zhanchun Feng

Background:Food insecurity and hidden hunger (micronutrient deficiency) affect about two billion people globally. Household food insecurity (HFI) has been shown to be associated with one or multiple micronutrient (MMN) deficiencies among women and children. Chronic food insecurity leads to various deficiency disorders, among which anemia stands out as the most prevalent one. As a high malnutrition prevalent country, Bangladesh has one of the highest rates of anemia among all Asian countries. In this study, we wanted to investigate for any association exists between HFI and anemia among women of reproductive age in Bangladesh.Methodology:Information about demographics, socioeconomic and anemia status on 5,666 married women ageing between 13 and 40 years were collected from a nationally representative cross-sectional survey Bangladesh Demographic and Health Survey (BDHS 2011). Food security was measured by the Household Food Insecurity Access Scale (HFIAS). Capillary hemoglobin concentration (Hb) measured by HemoCue® was used as the biomarker of anemia. Data were analysed using cross-tabulation, chi-square tests and multiple logistic regression methods.Results:Anemia prevalence was 41.7%. Logistic regression showed statistically significant association with anemia and type of residency (p = 0.459; OR = 0.953, 95%CI = 0.840–1.082), wealth status (Poorest: p < 0.001; OR = 1.369, 95%CI = 1.176–1.594; and average: p = 0.030; 95%CI = 1.017–1.398), educational attainment (p < 0.001; OR = 1.276, 95%CI = 1.132–1.439) and household food insecurity (p < 0.001; 95%CI = 1.348–1.830). Women who reported food insecurity were about 1.6 times more likely to suffer from anemia compared to their food secure counterparts.Conclusion:HFI is a significant predictor of anemia among women of reproductive age in Bangladesh. Programs targeting HFI could prove beneficial for anemia reduction strategies. Gender aspects of food and nutrition insecurity should be taken into consideration in designing national anemia prevention frameworks.


2018 ◽  
Vol 25 (02) ◽  
pp. 237-241
Author(s):  
Shabana Rafiq ◽  
Razia Bibi ◽  
Samina Ashraf

Objectives: To determine the frequency of ovarian malignancy in women ofreproductive age presenting with ovarian mass and to determine frequency of factors leadingto ovarian malignancy. Study Design: Cross sectional study. Setting: Department of Obstetrics& Gynaecology, Lady Wallington Hospital, Lahore. Period with Dates: From 05.11.11 to26.06.12. Results: The result of our study reveals majority of the patients between 21-30 yearsi.e. 45.88%(n=39), common age was 24.21+3.76 years, 43.53%(n=37) were nulliparous (inmajority), while frequency of ovarian malignancy in women of reproductive age presenting withovarian mass was recorded in 14.11%(n=12) while frequency of factors leading to ovarianmalignancy was 91.67%(n=11) patients were nulliparous while family history of ovarianmalignancy was in 8.33%(n=1) patients. Conclusions: The frequency of ovarian malignancy ishigher among reproductive age females with increased risk of nulliparity.


Author(s):  
Arshiya Sultana ◽  
Khaleequr Rahman

Abstract Objectives Amenorrhoea in women of reproductive age may be an indication of an undiagnosed and chronic condition. The concept of temperament is a fundamental component of health preservation and diagnosis of various disease conditions including amenorrhoea in Unani medicine. Dystemperament is the commonest cause of various diseases. Therefore, general body temperament and uterine dystemperament in amenorrhoea was determined. Methods A prospective, single-centre, cross-sectional observational study from June to November 2019 was conducted in 80 patients of reproductive age with amenorrhoea ≥60 days. Validated questionnaire for the assessment of women’s general body temperament and clinical features of uterine dystemperament was used. The data were analysed by appropriate statistical analysis. Results The age of patients with amenorrhoea ranged from 14 to 50 years. The most prevalent general body temperament was cold (57.5%) and wet (60%). Cold and wet general temperament was more common at the age of 21–30 years (30 and 36.25%), 60–90 days of amenorrhoea (33.75 and 32.5%) and body mass index (BMI) ≥25 kg/m2 (47.5 and 50%). The most prevalent uterine dystemperament was cold and dry (95%). A significant correlation between general temperament with age, amenorrhoea and BMI >23 kg/m2 was noted. Moreover, the cold temperament of the body had a significant correlation with cold uterine temperament (r=0.864, p<0.001). Conclusions This study corroborated the claim of Unani scholars that cold and wet general and uterine temperament is more common in amenorrhoea and obesity. However, amenorrhoea can also occur in normal and other temperaments.


2021 ◽  
Vol 2 (4) ◽  
pp. 13-16
Author(s):  
M. M Asatova ◽  
◽  
S. M. Safoeva

PCOS occupies a leading place in the population of women with clinical manifestations of excessive androgen secretion and is detected in 72.1-82% of cases, while among women with anovulatory infertility-in 55-91% of cases (Lizneva D. (2016). The criteria, prevalence and phenotypes of PCOS. Fertil.Steril., 106 (1), 6-15). The article discusses the results of a study conducted based on the City Perinatal Center of Tashkent to study the frequency and nature of reproductive disorders in women with symptoms of hyperandrogenism. The study involved women of reproductive age with various menstrual disorders and infertility. The analysis of anamnestic, subjective and objective, clinical and laboratory data of patients was carried out


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