scholarly journals ANALISIS QSAR SENYAWA TURUNAN MEISOINDIGO SEBAGAI ANTIKANKER PAYUDARA

2019 ◽  
Vol 1 (1) ◽  
pp. 1-5
Author(s):  
Agus Dwi Ananto
Keyword(s):  
Mathematical Model ◽  
Statistical Analysis ◽  
Research Method ◽  
Semiempirical Method ◽  
Quantitative Structure ◽  
Multilinear Regression ◽  
Pm3 Method ◽  
Calculation Data ◽  
Selection Of ◽  
Semiempirical Pm3 Method

Quantitative Structure and Relationship (QSAR) of meisoindigo derivative compounds was successfully carried out. The purpose of this study was to find out the best model of meisoindigo derivative compounds as breast anticancer. The research method of this research using the semiempirical PM3 method. The semiempirical method of PM3 was chosen as a better method because it has model results that more represent physicochemical aspects. The selection of the best mathematical model is done by multilinear regression statistical analysis of the calculation data obtained. The results of this study formulate model 5 as the best model with a formula Log 1/IC50 = 44.316 + (-0.0000282*Eis.at) + (-0.257*µ) + (-0.054*LogP) + (0.014*EH) + (-7.241*qC6) + (-1.734*qC9) + (25.711*qO10) + (7.309*qN11) + (94.825*qC13) + (58.794*qO14) + (5.866*qC15)

scholarly journals QSAR treatment of meisoindigo derivatives as a potentbreast anticancer agent

2019 ◽  
Vol 2 (2) ◽  
pp. 114 ◽  
Author(s):  
Evie Kama Lestari ◽  
Agus Dwi Ananto ◽  
Maulida Septiyana ◽  
Saprizal Hadisaputra
Keyword(s):  
Anticancer Activity ◽  
Anticancer Agent ◽  
Qsar Model ◽  
Quantitative Structure Activity Relationship ◽  
Quantitative Structure ◽  
Multilinear Regression ◽  
Qsar Analysis ◽  
Pm3 Method ◽  
Structure Activity ◽  
Semiempirical Pm3 Method

A quantitative structure-activity relationship (QSAR) analysis of meisoindigo derivatives as a breast anticancer has been carried out. This study aimed to obtain the best QSAR model in order to design new meisoindigo based compounds with best anticancer activity. The semiempirical PM3 method was used for descriptor calculation. The best QSAR model was built using multilinear regression (MLR) with enter method. It was found that there were 19 new meisoindigo derivativeswith better predictive a potent anticancer agent. The best compound was (E)-2-(1-((3-ethylisoxazol-5-yl)methyl)-2-oxoindolin-3-ylidene)-N-(4-methoxyphenyl)acetamide with the value of IC505.31144 x10-15 (μM).

scholarly journals QSAR Modeling of Compounds Derived from 1,2,3-Triazolopiperidine as DPP-4 Enzyme Inhibitors Using Semiempirical AM1

2020 ◽  
Vol 5 (1) ◽  
pp. 70
Author(s):  
Anjar Purba Asmara ◽  
Reni Silvia Nasution ◽  
Rosi Minarty
Keyword(s):  
Regression Analysis ◽  
Statistical Analysis ◽  
Chemical Shift ◽  
Correlation Coefficient ◽  
Enzyme Inhibitors ◽  
Semiempirical Method ◽  
3D Modelling ◽  
Multilinear Regression ◽  
Qsar Modeling ◽  
Multilinear Regression Analysis

<p>This study aims to model the derived compounds of 1,2,3-triazolopiperidine using sem­iempirical method AM1 and determine the further derivation with the better IC<sub>50</sub> values against DPP-4 enzyme theoretically. This research employed ChemDraw Pro 12 software for for 2D struc­tural drawing, Hyperchem 8.0 for 3D modelling, and MLR statistical analysis for modeling QSAR equations. The semiempirical method was likely to be the appropriate platform to apply because the correlation coefficient of H<sup>1 </sup>NMR chemical shift between theoretical and actual value is rela­tively close, 0.8891. The multilinear regression analysis produced 4 equation models where the best one is equation 4 as detailed below:” IC<sub>50</sub>   = 875,5116 + (-7400,27*qH35) + (-0,00133* Eat.is) + (-3230,72* qN23) + (3,30277* µ)” n = 25; r<sup>2</sup> = 0,594; <em>Adjusted r<sup>2</sup></em>= 0,486; PRESS = 1,2× 10<sup>4</sup><sup>. </sup>Finally, the theoretically promising substituent was -CN possessing IC<sub>50</sub> value = 1.61 nM. </p>

Pengaruh Kecerdasan Emosional Dan Kecerdasan Spiritual Pada Kepuasan Kerja Yang Berdampak Terhadap Kinerja Karyawan PT. Madu Baru Bantul, Yogyakarta

2018 ◽  
Vol 26 (1) ◽  
pp. 13-29
Author(s):  
Erlangga Arya Mandala ◽  
Faresti Nurdiana Dihan
Keyword(s):  
Job Satisfaction ◽  
Emotional Intelligence ◽  
Statistical Analysis ◽  
Significant Influence ◽  
Significant Relationship ◽  
Research Method ◽  
Quantitative Method ◽  
Employee Performance ◽  
Spiritual Intelligence ◽  
Employee Job Satisfaction

The Emotional intelligence, spiritual intelligence and job satisfaction to be part of the factors that influence performance. The purpose of this study was to determine the effect of emotional intelligence and spiritual intelligence on the performance through job satisfaction as an intervening variable partially and simultaneously. This study also aimed to determine the effect of emotional intelligence and spiritual intelligence on the performance through job satisfaction as an intervening variable directly and indirectly. This study was conducted to 77 respondents employees of PT. Madu Baru, Yogyakarta. The research method used is quantitative method uses statistical analysis and descriptive. The results of this study are (1) there is a significant effect of emotional intelligence on employee job satisfaction. (2) there is a significant influence of spiritual intelligence on employee job satisfaction. (3) There is a significant relationship between emotional intelligence and spiritual intelligence on job satisfaction. (4) There is a significant relationship between emotional intelligence on employee performance. (5) There is a significant relationship between spiritual intelligence on employee performance. (6) There is a significant relationship between emotional intelligence and spiritual intelligence on employee performance. (7) There is a significant relationship between job satisfaction on employee performance. (8) There is an indirect effect of emotional intelligence on the performance of employees through job satisfaction. (9) There is the indirect influence of spiritual intelligence on the performance of employees through job satisfaction. Keywords: emotional intelligence, spiritual intelligence, job satisfaction and employee performance

Pola Bimbingan Orang Tua Asuh dalam Menumbuhkan Kecerdasan Emosional Remaja

2019 ◽  
Vol 7 (3) ◽  
pp. 311-330
Author(s):  
Iva Faridha Azahro ◽  
Nanih Machendrawaty ◽  
Hajir Tajiri
Keyword(s):  
Emotional Intelligence ◽  
Foster Care ◽  
Research Method ◽  
Foster Parents ◽  
Data Gathering ◽  
Qualitative Approach ◽  
Research Results ◽  
Descriptive Research ◽  
Selection Of

Tujuan dari peneliti ini yaitu untuk mengetahui (1) karakteristik kecerdasan emosional remaja di RPSAA Ciumbuleuit Bandung; (2) pola bimbingan orang tua asuh dalam menumbuhkan kecerdasan emosional remaja di RPSAA Ciumbuleuit Bandung; (3) hasil pola bimbingan orang tua asuh dalam menumbuhkan kecerdasan emosional remaja di RPSAA Ciumbuleuit Bandung. Penelitian ini menggunakan pendekatan kualitatif dengan metode penelitian deskriptif, pemilihan subjek dan informan dengan cara acak dan teknik pengumpulan datanya melalui observasi, dokumentasi dan wawancara terhadap enam orang anak asuh dan tiga orang tua asuh. Hasil penelitian yang diperoleh peneliti menyimpulkan bahwa anak sebelum memperoleh pengasuhan dari orang tua asuh di RPSAA memiliki karakteristik kecerdasan emosional rendah. Pola pengasuhan yang diterapkan di RPSAA kepada anak asuh adalah pola asuh demokratis. Sedangkan hasil pengasuhan dalam menumbuhkan kecerdasan emosional remaja di RPSAA Ciumbuleuit Bandung menyimpulkan bahwa anak asuh usia remaja telah memiliki kecerdasan emosional yang cukup baik, yaitu terlihat dari bagaimana cara mereka mampu mengendalikan segala perasaan yang pada dirinya, meskipun ada remaja yang belum sepenuhnya memenuhi aspek kecerdasan emosional.   The goal of these researchers is to figure out (1) characteristics of the emotional intelligence of teenagers in RPSAA Ciumbuleuit Bandung; (2) foster parents guidance pattern in fostering emotional intelligence RPSAA Ciumbuleuit Bandung in adolescents; (3) results foster parents guidance pattern in fostering emotional intelligence RPSAA Ciumbuleuit Bandung in teens. This research used the qualitative approach with descriptive research method, the selection of subjects and informants by means of random and data gathering techniques through observation, interview and documentation against six people and three foster care parents foster care. The research results obtained by researchers concluded that child before obtaining care of foster parents in RPSAA has the characteristic of low emotional intelligence. Parenting patterns are applied in the RPSAA to foster care parenting is democratic. While parenting results in fostering emotional intelligence RPSAA Ciumbuleuit Bandung teenager in concluding that foster care teens have had a pretty good emotional intelligence, that is visible from how they are able to control all the feelings on him, even though there are teenagers who do not yet fully meet aspects of emotional intelligence.

DIFFERENTIAL EQUATIONS FOR TRAIN STARTING WITH ELASTIC CONNECTIONS

2021 ◽  
Vol 2 ◽  
pp. 18-26
Author(s):  
I.P. POPOV
Keyword(s):  
Mathematical Model ◽  
Differential Equations ◽  
Friction Force ◽  
Static Friction ◽  
Longitudinal Vibrations ◽  
Maximum Tension ◽  
Inert Mass ◽  
The Moment ◽  
Elastic Couplings ◽  
Selection Of

The starting mode for the train is the most difficult. An effective method of pulling is the selection of coupling clearances. In this case, the cars are set in motion sequentially and the inert mass, as well as the static friction force immediately at the moment of starting, are minimal. This method has two significant drawbacks - a small fixed value of the gaps in the couplings and the shock nature of the impulse transfer. These disadvantages can be avoided by using elastically deformable couplings. The aim of this work is to construct a mathematical model of "easy" starting of a train with elastic couplings. The softening of the train start-off mode is essentially due to the replacement of the simultaneous start-off of the sections with alternate ones. To exclude longitudinal vibrations of the composition, after reaching the maximum tension of the coupling, the possibility of its harmonic compression should be mechanically blocked.

scholarly journals Three Evidence Based Methods to Compensate for a Lack of Subject Background when Ordering Chemistry Monographs

2008 ◽  
Vol 3 (3) ◽  
pp. 3
Author(s):  
Robert A. Wright
Keyword(s):  
Statistical Analysis ◽  
Statistical Significance ◽  
Evidence Base ◽  
Circulation Rate ◽  
Evidence Based ◽  
Practical Application ◽  
Present Evidence ◽  
Library System ◽  
Over Time ◽  
Selection Of

Objective – The aim of this article is to present evidence based methods for the selection of chemistry monographs, particularly for librarians lacking a background in chemistry. These methods will be described in detail, their practical application illustrated, and their efficacy tested by analyzing circulation data. Methods – Two hundred and ninety-five chemistry monographs were selected between 2005 and 2007 using rigorously-applied evidence based methods involving the Library's integrated library system (ILS), Google, and SciFinder Scholar. The average circulation rate of this group of monographs was compared to the average circulation rate of 254 chemistry monographs selected between 2002 and 2004 when the methods were not used or were in an incomplete state of development. Results – Circulations/month were on average 9% greater in the cohort of monographs selected with the rigorously-applied evidence based methods. Further statistical analysis, however, finds that this result can not be attributed to the different application of these methods. Conclusion – The methods discussed in this article appear to provide an evidence base for the selection of chemistry monographs, but their application does not change circulation rates in a statistically significant way. Further research is needed to determine if this lack of statistical significance is real or a product of the organic development and application of these methods over time, making definitive comparisons difficult.

A Study on Statistical Analysis of Si-Wafer Polishing Process for the Optimum Polishing Condition

2008 ◽  
Vol 389-390 ◽  
pp. 493-497 ◽  
Author(s):  
Sung Chul Hwang ◽  
Jong Koo Won ◽  
Jung Taik Lee ◽  
Eun Sang Lee
Keyword(s):  
Surface Roughness ◽  
Statistical Analysis ◽  
Process Parameters ◽  
Wafer Surface ◽  
Wafer Polishing ◽  
Ultra Precision ◽  
Important Processing ◽  
The Many ◽  
Selection Of ◽  
Si Wafer

As the level of Si-wafer surface directly affects device line-width capability, process latitude, yield, and throughput in fabrication of microchips, it needs to have ultra precision surface and flatness. Polishing is one of the important processing having influence on the surface roughness in manufacturing of Si-wafers. The surface roughness in wafer polishing is mainly affected by the many process parameters. For decreasing the surface roughness, the control of polishing parameters is very important. In this paper, the optimum condition selection of ultra precision wafer polishing and the effect of polishing parameters on the surface roughness were evaluated by the statistical analysis of the process parameters.

scholarly journals Effective Strategies on Learning Arabic for Children

ALSINATUNA ◽  
2018 ◽  
Vol 4 (1) ◽  
pp. 68
Author(s):  
SOKIP
Keyword(s):  
Foreign Language ◽  
Language Learning ◽  
Learning Strategies ◽  
Research Method ◽  
Learning Strategy ◽  
Existing Problems ◽  
Effective Strategies ◽  
Library Research ◽  
Literary Sources ◽  
Selection Of

Arabic learning can take place at various ages of either children, adolescents or adults. Learning Arabic is something needed for especially Muslim because it is important in Muslim life. This paper will explain about the Arabic learning strategy for children. This is important to discuss because children need special strategies in learning for their ages. In collecting information, the writer uses library research method, which is done by comparing several literary sources, especially those that are the main source of discussion to discuss about the existing problems. Then, as the result, language learning is a help to determine how, and how well, learners learn a foreign language. There are many variations on learning strategy. Arabic learning strategies for children include playing, singing, telling stories, projects, demonstration, and conversation. By using the suitable and fun strategy, children can develop their potential well and effectively. The selection of learning strategies depends on children’s ages and characteristics.  

scholarly journals PENERAPAN METODE BERMAIN PERAN MAKRO TERHADAP KEMAMPUAN BERBICARA

Instruksional ◽  
2019 ◽  
Vol 1 (1) ◽  
pp. 9
Author(s):  
Nirwana Nirwana
Keyword(s):  
Statistical Analysis ◽  
Role Playing ◽  
Wilcoxon Test ◽  
Control Group ◽  
Observation Data ◽  
Group Data ◽  
Before And After ◽  
Group B ◽  
Nonparametric Statistical ◽  
Selection Of

Effect of  role playing macro methods on children's speaking ability in group B in Nurul Rohmah Bekasi. This research is motivated by the lack of ability to speak children. This is because the method used in the learning process is more likely to use conventional methods. The selection of methods to role playing macro so that children can be motivated and interested in learning and can stimulate the ability to speak children. The population in this study were all children of group B in kindergarten Nurul Rohmah while the study sample was B3 group 11 children for the experimental group and B1 group 11 children for the control group. Data collection techniques through test techniques, and observation. Data analysis techniques used were descriptive statistical analysis and nonparametric statistical analysis. Based on the results of the Wilcoxon test calculation, the calculated T value is 66 and T table 11 then the results obtained T count (66)> T table (11) H1 is accepted and Ho is rejected means that there is an effect of role playing macro  methods on children's speaking ability. Whereas the calculated Z value obtained is 2.93 and 1.645 table Z then the result of Z arithmetic (2.93)> Z table (1.645) H1 is accepted and Ho is rejected which means that there is an effect of role playing macro method on children's speaking ability. These results indicate that there is a change in the value of the child's speaking ability before and after getting learning based on the role playing macro method.

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