scholarly journals DRY-POWDER OF CHITOSAN-COATED LIPID-CORE NANOCAPSULES CONTAINING DAPSONE: DEVELOPMENT, LASER DIFFRACTION CHARACTERIZATION AND ANALYTICAL QUANTIFICATION

2019 ◽  
Vol 3 (1) ◽  
pp. 10-15
Author(s):  
Rodrigo Cé ◽  
Denise Soledade Jornada ◽  
João Guilherme Barreto De Marchi ◽  
Silvia Stanisçuaski Guterres ◽  
Adriana Raffin Pohlmann
Keyword(s):  
Spray Drying ◽  
High Performance ◽  
Aqueous Dispersion ◽  
Analytical Techniques ◽  
Drying Process ◽  
Dry Powders ◽  
Lipid Core ◽  
Drug Molecules ◽  
Analytical Quantification ◽  
The Stability

Analytical techniques are critical for ensuring physical and chemical stability of a drug both for assessing the stability of drug molecules and for quantifying and identifying the drug content in products. We proposed the development of dry-powders of lipid-core nanocapsules containing dapsone and coated with chitosan, as well as, the analytical quantification of dapsone in dry-powders with 1% and 2% (m/v) of leucine by high-performance liquid chromatography (HPLC). Size is the most relevant physicochemical property of nanoparticulated drug delivery systems. In this context, our results demonstrated that during the powders redispersion in water, could be observed that the mean particle diameters (DAP-LNC-CS-L1 and DAP-LNC-CS-L2) decreased with redispersion times increase. The spray-drying of the lipid-core nanocapsule formulations showed yields ranging from 58 ± 1.0 % (DAP-LNC-CS-L1) to 61 ± 1.5 % (DAP-LNC-CS-L2) indicating an efficient drying process. In this context, the analytical quantifications of dapsone in the dry powders of nanocapsules by HPLC showed that the dapsone content ranged from 92 ± 1.4% (DAP-LNC-CS-L2) to 95 ± 0.8% (DAP-LNC-CS-L1). Can be concluded that spray-drying process of DAP-LNC-CS-L1 and DAP-LNC-CS-L2 formulations showed an efficient aqueous dispersion of nanocapsule powders and the analytical quantification of dapsone in spray-dryed powders were higher than 90%.

Effect of thermal and shear stresses in the spray drying process on the stability of siRNA dry powders

2019 ◽  
Vol 566 ◽  
pp. 32-39 ◽  
Author(s):  
Jingya Wu ◽  
Lan Wu ◽  
Feng Wan ◽  
Jukka Rantanen ◽  
Dongmei Cun ◽  
...  
Keyword(s):  
Spray Drying ◽  
Shear Stresses ◽  
Drying Process ◽  
Dry Powders ◽  
The Stability

scholarly journals Quantification of Unknown Nanoscale Biomolecules Using the Average-Weight-Difference Method

2019 ◽  
Vol 9 (1) ◽  
pp. 130 ◽  
Author(s):  
Kyungwoo Lee ◽  
Yonghyun Choi ◽  
Kyobum Kim ◽  
Hyung-Jun Koo ◽  
Jonghoon Choi
Keyword(s):  
Difference Method ◽  
High Performance ◽  
Drug Delivery Systems ◽  
Reliable Method ◽  
Analytical Techniques ◽  
Drug Analysis ◽  
Average Weight ◽  
Weight Difference ◽  
Drug Molecules ◽  
Set Up

In order to quantify the amount of drug molecules in drug delivery systems, analytical techniques such as high-performance liquid chromatography are used due to their accuracy and reliability. However, the instruments required for such techniques are expensive and not available in all laboratories. Therefore, in this study, we introduce a method that can be a relatively inexpensive and easy to perform drug analysis in almost any laboratory set-up. We have devised the “average-weight-difference method” within the limits of existing spectral analyses. By employing this method, we quantitatively analyzed the amount of isoniazid or doxorubicin molecules loaded onto β-glucan nanoparticles. This proved to be a relatively simple and reliable method and can be used to estimate the amount of nanoscale biomolecules before their analysis through expensive equipment in an environment where the instruments are not readily available.

scholarly journals The effect of excipients on the stability and aerosol performance of salmon calcitonin dry powder inhalers prepared via the spray freeze drying process

2016 ◽  
Vol 66 (2) ◽  
pp. 207-218 ◽  
Author(s):  
Narges Poursina ◽  
Alireza Vatanara ◽  
Mohammad Reza Rouini ◽  
Kambiz Gilani ◽  
Abdolhossein Rouholamini Najafabadi
Keyword(s):  
Salmon Calcitonin ◽  
Freeze Drying ◽  
Tween 80 ◽  
Drying Process ◽  
Dry Powders ◽  
Aerosol Performance ◽  
Inhalation Delivery ◽  
Spray Freeze Drying ◽  
The Stability ◽  
Structurally Stable

Abstract Spray freeze drying was developed to produce dry powders suitable for applications such as inhalation delivery. In the current study, the spray freeze drying technique was employed to produce inhalable salmon calcitonin microparticles. Effects of the carrier type, concentration of hydroxyl propyl-β-cyclodextrin and the presence of Tween 80 on the chemical and structural stability, as well as on the aerosol performance of the particles were investigated. The results indicated that hydroxyl propyl-β-cyclodextrin had the most important effect on the chemical stability of the powder and strongly increased its stability by increasing its concentration in the formulation. Chemically stable formulations (over 90 % recovery) were selected for further examinations. Fluorescence spectroscopy and circular dichroism suggested that the formulations were structurally stable. Aerosol performance showed that the Tween-free powders produced higher fine particle fraction values than the formulations containing Tween (53.7 vs. 41.92 % for trehalose content and 52.85 vs. 43.06 % for maltose content).

scholarly journals Retention capacity of maltodextrin antioxidants in cranberry juice by spray drying process

2019 ◽  
pp. 12-20
Author(s):  
María Zenaida Saavedra-Leos ◽  
Macrina Beatriz Silva-Cázares ◽  
María Cruz del Rocío Terrones-Gurrola ◽  
Cynthia Lizeth González-Trevizo
Keyword(s):  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
Spray Drying ◽  
Air Temperature ◽  
High Performance ◽  
Drying Process ◽  
Cranberry Juice ◽  
Retention Capacity ◽  
Drying Temperature ◽  
Dextrose Equivalent

A group of four maltodextrins with different degrees of dextrose equivalent (DE) was used as carriers for the spray drying of cranberry juice, with the objective of evaluating the effect of drying temperature, DE grade and concentration of maltodextrin on the performance of cranberry juice powder and the ability to retain antioxidants. For this purpose, the conditions of the spray drying process were: inlet air temperature: 170-210° C, maltodextrin type (Mc, M10, M20 and M40) and maltodextrin concentration: 10-30% w/w. The different powders obtained from the spray drying process were analyzed by high performance liquid chromatography (HPLC) for the quantification of antioxidants (resveratrol and quercetin). The analysis of the data was carried out from a design of D-Optimal experiments. The results of the analysis showed that the highest yield of cranberry juice powder is achieved by using 30% w/w of M10 at a drying temperature of 193 °C. Such conditions allowed a retention of antioxidants in the powder of 20% and 30% of resveratrol and quercetin, respectively.

Ultrasmall Sn nanodots embedded inside N-doped carbon microcages as high-performance lithium and sodium ion battery anodes

2017 ◽  
Vol 5 (18) ◽  
pp. 8334-8342 ◽  
Author(s):  
Hangjun Ying ◽  
Shunlong Zhang ◽  
Zhen Meng ◽  
Zixu Sun ◽  
Wei-Qiang Han
Keyword(s):  
Electrochemical Performance ◽  
Spray Drying ◽  
High Performance ◽  
Sodium Ion ◽  
Sodium Ion Battery ◽  
Drying Process ◽  
Excellent Electrochemical Performance

Sn/N-doped carbon microcage composites (Sn/NMCs) are synthesized through a simple spray drying process and these composites exhibit excellent electrochemical performance in both LIBs and SIBs.

scholarly journals Stabilizing effect of chitosan-poly vinyl alcohol complex on simvastatin loaded nanoformulation

2019 ◽  
Vol 10 (3) ◽  
pp. 2265-2279
Author(s):  
Irisappan Sarathchandiran ◽  
Nandakumar Selvasudha ◽  
Kailasam Koumaravelou ◽  
Kandasamy Ruckmani
Keyword(s):  
High Performance ◽  
Freezing Temperature ◽  
Simulation Method ◽  
Stability Study ◽  
Poly Vinyl Alcohol ◽  
Forced Degradation ◽  
Stability Studies ◽  
Drug Molecules ◽  
Accelerated Stability ◽  
The Stability

Biopolymers are attractive new and general means of presenting more stable drug delivery system. This is accomplished by encapsulation of polymers to respective drug molecules which offer formation of bonds between them.  In this work, chitosan-coated simvastatin nanoformulation was formulated using a method named solvent evaporation technique, and various stability studies were performed. The steadiness of preparation was evaluated by accelerated stability method and forced degradation method. High-performance thin-layer chromatography (HPTLC) was utilized to detect the degradant present in formulation after subjecting it in different stress condition. Simulated annealing process for the prediction of nanoformulation stability was also performed. The accelerated stability study was performed at three altered temperature conditions, (i.e.) accelerated temperature (40 ± 2 °C/75 ± 5% RH), room temperature (25 ± 2 °C/60%) ± 5% RH, and freezing temperature (4°C) and change in drug content, solubility, % cumulative drug release, moisture content and molecular weight were calculated. Standard sample and nanoformulation were exposed to different stress conditions (thermal, base, acid, and light). Finally, the percentage of decomposition was calculated by HPTLC method. All stability studies, along with the simulation method, represented the stability of simvastatin in nanoformulation.  Establishment of adequate shelf life also was achieved. This work evidenced the extensive stability offered by chitosan polymers to the prodrug simvastatin. Also, give insight when the problem of poor stability of drug molecules limits its practical applicability.

Lipid Core Peptide System for Gene, Drug, and Vaccine Delivery

2009 ◽  
Vol 62 (9) ◽  
pp. 956 ◽  
Author(s):  
Wei Zhong ◽  
Mariusz Skwarczynski ◽  
Istvan Toth
Keyword(s):  
Group A Streptococcus ◽  
Biologically Active ◽  
Cell Permeability ◽  
Vast Number ◽  
Lipid Core ◽  
Drug Molecules ◽  
Efficient Delivery ◽  
Group A ◽  
Core Peptide ◽  
The Stability

A vast number of biologically active compounds await efficient delivery to become therapeutic agents. Lipidation has been demonstrated to be a convenient and useful approach to improve the stability and transport across biological membranes of potential drug molecules. The lipid core peptide (LCP) system has emerged as a promising lipidation tool because of its versatile features. This review discusses the progress in the development of the LCP system to improve cell permeability of nucleotides, physicochemical properties of potential drugs, and vaccine immunogenicity. Emphasis was put on the application of the LCP system to deliver antigens for the prevention of group A streptococcus infection, novel techniques of conjugation of target molecules to the LCP, and new alterations of the LCP system itself.

Dietary Vitamin and Stability of Oral Anticoagulation: Proposal of a Diet with Constant Vitamin K1 Content

1997 ◽  
Vol 77 (03) ◽  
pp. 504-509 ◽  
Author(s):  
Sarah L Booth ◽  
Jacqueline M Charnley ◽  
James A Sadowski ◽  
Edward Saltzman ◽  
Edwin G Bovill ◽  
...  
Keyword(s):  
Dietary Intake ◽  
Vitamin K ◽  
High Performance ◽  
Case Reports ◽  
Food Composition ◽  
Dietary Guidelines ◽  
Dietary Vitamin ◽  
Vitamin K1 ◽  
The Stability ◽  
The Impact

SummaryCase reports cited in Medline or Biological Abstracts (1966-1996) were reviewed to evaluate the impact of vitamin K1 dietary intake on the stability of anticoagulant control in patients using coumarin derivatives. Reported nutrient-drug interactions cannot always be explained by the vitamin K1 content of the food items. However, metabolic data indicate that a consistent dietary intake of vitamin K is important to attain a daily equilibrium in vitamin K status. We report a diet that provides a stable intake of vitamin K1, equivalent to the current U.S. Recommended Dietary Allowance, using food composition data derived from high-performance liquid chromatography. Inconsistencies in the published literature indicate that prospective clinical studies should be undertaken to clarify the putative dietary vitamin K1-coumarin interaction. The dietary guidelines reported here may be used in such studies.

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