scholarly journals The New Markers of Ventricular Dispersion in Patients with Acute Poisoning with TCAs: Tp-e Interval and Tp-e/QTc Ratio

2020 ◽  
Keyword(s):  
Heart Rate ◽  
Ventricular Arrhythmias ◽  
Tricyclic Antidepressants ◽  
Acute Poisoning ◽  
Study Data ◽  
Control Group ◽  
Qtc Interval ◽  
Healthy Individuals ◽  
Gender Characteristics ◽  
And Gender

Introduction: Purpose of this study was to investigate the changes in Tp-e/QTc rates and Tp-e intervals in patients poisoned with tricyclic antidepressants. Methods: 187 patients who were poisoned with tricyclic antidepressants and admitted to our emergency department were included in this study. Control group consisted of 187 healthy individuals with similar age and gender characteristics. All patients underwent 12-lead electrocardiograms (ECG). In addition to QTc measurement, Tp-e/QTc ratios and Tp-e interval were measured in the ECG. Study data were divided two groups as patients and healthy controls. Results: It was found that the QTc interval, Tp-e interval, and Tp-e/QTc ratio were significantly higher in the patient group compared to control group. The analysis demonstrated that QTc interval; Tp-e interval and Tp-e/QTc ratio were independently associated with heart rate. Conclusion: In poisoning with TCAs, the rate of QTc interval, Tp-e/QTc and Tp-e interval has increased and is independently associated with the heart rate in these patients. This may be the precursor of possible fatal ventricular arrhythmias in tricyclic antidepressants.

scholarly journals Biosignals to Detect the Imbalance of Explicit and Implicit Affect in Dementia: A Pilot Study

2019 ◽  
Vol 34 (7-8) ◽  
pp. 457-463
Author(s):  
Doug Hyun Han ◽  
Hyuk Ga ◽  
Sun Mi Kim ◽  
Soyoung Kim ◽  
Joon Seok Chang ◽  
...  
Keyword(s):  
Heart Rate ◽  
High Frequency ◽  
Older Patients ◽  
Emotional Responses ◽  
Control Group ◽  
Positive And Negative Affect ◽  
Fast Wave ◽  
Healthy Individuals ◽  
Implicit Affect ◽  
Implicit And Explicit

Background: We assessed implicit and explicit emotion in older patients with dementia using biosignals. Methods: Fifty patients with dementia and 34 healthy individuals watched 3 videos that aimed to elicit various emotional responses. Electroencephalogram and heart rate variability were recorded. Results: Patients with dementia experienced less fun and more fear than controls. The high frequency (HF) from the baseline in response to funny stimulation as well as HF from neutral to fear stimulation in the dementia group increased further than in the control group. The slow wave (SW)–fast wave (FW) ratio from neutral to funny stimulation in the control group increased further than in the dementia group. The SW-FW from neutral to fear stimulation was further decreased in the dementia group than in the control group. Conclusions: Although patients with dementia were more sensitive to implicit affect, they showed more enhanced imbalance between positive and negative affect in explicit affect assessment.

scholarly journals Distinct effects of over-general autobiographical memory on suicidal ideation among depressed and healthy people

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Wen Jiang ◽  
Guangtao Hu ◽  
Jingxuan Zhang ◽  
Ken Chen ◽  
Dongni Fan ◽  
...  
Keyword(s):  
Risk Factors ◽  
Suicidal Ideation ◽  
Autobiographical Memory ◽  
Childhood Trauma ◽  
Study Data ◽  
Path Model ◽  
Control Group ◽  
Healthy Controls ◽  
Healthy Individuals ◽  
Healthy Control

Abstract Background Childhood trauma and over-general autobiographical memory (OGM) are crucial risk factors of suicide. This study aimed to investigate whether suicidal ideation was predicted by one’s childhood trauma and OGM and the mechanism of OGM underlying suicidal ideation in depression patients and healthy controls. Methods A total of 180 depression patients and 176 matched healthy individuals were recruited in this study. Data were analyzed using descriptive statistics, and Pearson’s correlation coefficient was obtained. Path analysis was conducted to test a meditational model. The multigroup comparison was applied to find differences between groups. Results Significant differences were detected between depression patients and healthy controls with respect to childhood trauma, OGM, suicidal ideation, and suicidal behavior. OGM was positively correlated with both current and worst-point suicidal ideation in the depression group and significantly correlated with worst-point suicidal ideation in the healthy control group. The path model showed that childhood trauma had a direct impact on the current suicidal ideation directly, and an indirect influence through OGM and worst-point suicidal ideation. Multigroup analysis further demonstrated that OGM affected and mediated the current suicidal ideation due to childhood trauma in depression patients, whereas only worst-point suicidal ideation was affected in healthy controls. Conclusions The OGM mediates suicidal ideation in depression patients, but only affects the worst-point suicidal ideation in the healthy controls. As it is one of the major risk factors of suicidal ideation in depression, amelioration of OGM might be an useful method to reduce or prevent suicidal ideation in depression patients.

Antidepressants, autonomic function and mortality in patients with coronary heart disease: data from the Heart and Soul Study

2014 ◽  
Vol 44 (14) ◽  
pp. 2975-2984 ◽  
Author(s):  
F. Zimmermann-Viehoff ◽  
L. K. Kuehl ◽  
H. Danker-Hopfe ◽  
M. A. Whooley ◽  
C. Otte
Keyword(s):  
Heart Rate ◽  
Coronary Heart Disease ◽  
Heart Rate Variability ◽  
Heart Disease ◽  
Selective Serotonin Reuptake Inhibitors ◽  
Tricyclic Antidepressants ◽  
Autonomic Function ◽  
Control Group ◽  
Observational Period ◽  
Lower Heart Rate

BackgroundAntidepressants reduce depressive symptoms in patients with coronary heart disease, but they may be associated with increased mortality. This study aimed to examine whether the use of tricyclic antidepressants (TCA) or selective serotonin reuptake inhibitors (SSRI) is associated with mortality in patients with coronary heart disease, and to determine whether this association is mediated by autonomic function.MethodA total of 956 patients with coronary heart disease were followed for a mean duration of 7.2 years. Autonomic function was assessed as heart rate variability, and plasma and 24-h urinary norepinephrine.ResultsOf 956 patients, 44 (4.6%) used TCA, 89 (9.3%) used SSRI, and 823 (86.1%) did not use antidepressants. At baseline, TCA users exhibited lower heart rate variability and higher norepinephrine levels compared with SSRI users and antidepressant non-users. At the end of the observational period, 52.3% of the TCA users had died compared with 38.2% in the SSRI group and 37.3% in the control group. The adjusted hazard ratio (HR) for TCA use compared with non-use was 1.74 [95% confidence interval (CI) 1.12–2.69, p = 0.01]. Further adjustment for measures of autonomic function reduced the association between TCA use and mortality (HR = 1.27, 95% CI 0.67–2.43, p = 0.47). SSRI use was not associated with mortality (HR = 1.15, 95% CI 0.81–1.64, p = 0.44).ConclusionsThe use of TCA was associated with increased mortality. This association was at least partially mediated by differences in autonomic function. Our findings suggest that TCA should be avoided in patients with coronary heart disease.

scholarly journals Energy expenditure of nordic walking and conventional walking assessed by accelerometer

2014 ◽  
Vol 6 (1) ◽  
Author(s):  
Władysław Mynarski ◽  
Małgorzata Grabara ◽  
Michał Rozpara ◽  
Agnieszka Nawrocka ◽  
Aneta Powerska-Didkowska ◽  
...  
Keyword(s):  
Heart Rate ◽  
Physical Education ◽  
Energy Expenditure ◽  
Study Data ◽  
Exercise Heart Rate ◽  
Men Students ◽  
Nordic Walking ◽  
Warm Up ◽  
And Gender ◽  
Moving Speed

Summary Study aim: the objective was to assess and compare the energy expenditure (EE) and exercise heart rate (EHR) during Nordic Walking (NW), and conventional walking (W) in physical education and tourism/recreation university students. Material and methods: a total of 53 women and 65 men, students at the Academy of Physical Education in Katowice, and Polytechnic in Opole, in Poland, were investigated to assess the EE of Nordic Walking and conventional walking, and to measure the EHR, a uniaxial accelerometer – Caltrac Monitor, and a pulsometer – Polar RS 400 SD were used. After a standard warm-up, the participants (joined group) were marching with poles for 30 minutes, at a speed regulated by the group’s leader, who used footpod’s indications: 5.5–6.5 km/h – in Katowice, and 7.5–8.5 km/h – in Opole. After a break, during which the participants’ heart rate decreased below 100 bpm, the above actions and measurements were repeated, during normal walking. Results: energy expenditure during Nordic Walking (EE NW), expressed in kcals and METs, was in women and in men, at both analyzed speeds, significantly higher (p < 0.05) than during conventional walking (EE W). EHR was higher during NW, compared to W, and the statistically significant differences were revealed both in female’s and male’s groups. Conclusions: our study data have shown that EE and EHR during Nordic Walking, have been significantly higher than during conventional walking, regardless of the moving speed and gender. NW might present a useful modality in prevention of hypokinetic disorders.

Heart rate recovery after maximal exercise is associated with acetylcholine receptor M2 (CHRM2) gene polymorphism

2006 ◽  
Vol 291 (1) ◽  
pp. H459-H466 ◽  
Author(s):  
Arto J. Hautala ◽  
Tuomo Rankinen ◽  
Antti M. Kiviniemi ◽  
Timo H. Mäkikallio ◽  
Heikki V. Huikuri ◽  
...  
Keyword(s):  
Heart Rate ◽  
Endurance Training ◽  
Acetylcholine Receptor ◽  
Maximal Exercise ◽  
Heart Rate Recovery ◽  
Control Group ◽  
Receptor Subtype ◽  
Healthy Individuals ◽  
Chronotropic Response ◽  
Increased Risk

The determinants of heart rate (HR) recovery after exercise are not well known, although attenuated HR recovery is associated with an increased risk of cardiovascular mortality. Because acetylcholine receptor subtype M2 (CHRM2) plays a key role in the cardiac chronotropic response, we tested the hypothesis that, in healthy individuals, the CHRM2 gene polymorphisms might be associated with HR recovery 1 min after the termination of a maximal exercise test, both before and after endurance training. The study population consisted of sedentary men and women ( n = 95, 42 ± 5 yr) assigned to a training ( n = 80) or control group ( n = 15). The study subjects underwent a 2-wk laboratory-controlled endurance training program, which included five 40-min sessions/wk at 70–80% of maximal HR. HR recovery differed between the intron 5 rs324640 genotypes at baseline (C/C, −33 ± 10; C/T, −33 ± 7; and T/T, −40 ± 11 beats/min, P = 0.008). Endurance training further strengthened the association: the less common C/C homozygotes showed 6 and 12 beats/min lower HR recovery than the C/T heterozygotes or the T/T homozygotes ( P = 0.001), respectively. A similar association was found between A/T transversion at the 3′-untranslated region of the CHRM2 gene and HR recovery at baseline ( P = 0.025) and after endurance training ( P = 0.005). These data suggest that DNA sequence variation at the CHRM2 locus is a potential modifier of HR recovery in the sedentary state and after short-term endurance training in healthy individuals.

Effect of age and gender on the QTc-interval in healthy individuals and patients with long-QT syndrome

2018 ◽  
Vol 28 (1) ◽  
pp. 64-75 ◽  
Author(s):  
Arja Suzanne Vink ◽  
Sally-Ann B. Clur ◽  
Arthur A.M. Wilde ◽  
Nico A. Blom
Keyword(s):  
Long Qt Syndrome ◽  
Qtc Interval ◽  
Healthy Individuals ◽  
Long Qt ◽  
Age And Gender ◽  
Qt Syndrome ◽  
And Gender ◽  
Effect Of Age

scholarly journals Evaluation of Ventricular Repolarization Parameters in Patients Admitted to Emergency Department with Electrical Injury

2020 ◽  
Keyword(s):  
Ventricular Arrhythmias ◽  
Troponin I ◽  
Ventricular Repolarization ◽  
Control Group ◽  
Qtc Interval ◽  
Elevated Troponin ◽  
Surface Ecg ◽  
Healthy Control ◽  
The Mean ◽  
Electrocardiogram Ecg

Objective: Prolonged T-peak to T-end (Tp-e), a ventricular repolarization parameter, has been related with ventricular arrhythmias (VAs). Novel electrocardiogram (ECG) parameters of ventricular repolarization have received considerable attention recently. In this study, we sought to investigate ventricular repolarization indexes such as the Tp-e and corrected Tp-e (Tp-ec) intervals, Tp-e/QT, Tp-e/QTc, and Tp-ec/QT ratios in patients with electrical injuries (EIs). Methods: Thirty-six patients diagnosed with EIs and 35 age- and sex-matched healthy control patients were included. Admission ECGs of the EI patients were compared with those of the healthy controls. QT and QTc intervals were measured, and the Tp-e and Tp-ec intervals, Tp-e/QT, Tp-ec/QT, and Tp-e/QTc ratios were then calculated from a 12-lead surface ECG. Results: The QT, Tp-e, Tp-e/QT, Tp-e/QTc, Tp-ec/QT were not significantly different between the control group and the EI group (p > 0.05). However, the mean QTc interval was significantly higher in the EI group compared to the control group (412.81 ± 25.46 vs 396.31 ± 26.47 ms; p:0.009). Furthermore, the Tp-ec and Tp-ec/QT of the EI subgroup with elevated troponin levels significantly differed from those of the EI patients with normal troponin levels (p:0.033 and p:0.016, respectively). Conclusions: This retrospective study indicated that patients with EIs tend to have a prolonged QTc interval. Additionally, Tp-ec and Tp-ec/QT, which reportedly designate the tendency for VAs, were significantly higher in the EI patients with elevated troponin I levels than the EI patients with normal troponin levels, suggesting that patients with myocardial injury may be prone to VAs.

scholarly journals Exercise-induced ventricular arrhythmias: analysis of predictive factors in a population with sleep disorders

2010 ◽  
Vol 8 (1) ◽  
pp. 62-67 ◽  
Author(s):  
Fatima Dumas Cintra ◽  
Marcia Regina Pinho Makdisse ◽  
Wercules Antônio Alves de Oliveira ◽  
Camila Furtado Rizzi ◽  
Francisco Otávio de Oliveira Luiz ◽  
...  
Keyword(s):  
Ventricular Arrhythmia ◽  
Physical Examination ◽  
Sleep Disorders ◽  
Ventricular Arrhythmias ◽  
Control Group ◽  
Sample Collection ◽  
Age And Gender ◽  
Lower Oxygen ◽  
And Gender ◽  
Exercise Induced

ABSTRACT Objective: To assess the prevalence of ventricular arrhythmias induced by exercise in a population with sleep disorders and to analyze the triggering factors. Methods: Patients were consecutively selected from the database of the Sleep Clinic of Universidade Federal de São Paulo. All subjects were submitted to basal polysomnography, blood sample collection, physical examination, 12-lead ECG, spirometry, cardiorespiratory exercise study on a treadmill, and echocardiogram. The Control Group was matched for age and gender. Results: A total of 312 patients were analyzed. Exercise-induced ventricular arrhythmia was observed in 7%. The aortic diameter was larger (3.44 ± 0.30, 3.16 ± 0.36, p = 0.04) and the minimal saturation was lower (92.75 ± 3.05, 95.50 ± 1.73, p=0.01) in the ventricular arrhythmia group when compared to controls, respectively. After correction of the aortic root to body surface, there was only a trend to a larger diameter being associated with the emergence of arrhythmia. Conclusions: Exercise-induced ventricular arrhythmia was observed in 7% of sample and it was associated with lower oxygen saturation during exercise.

scholarly journals Estimation of Nitric Oxide, Malondialdehyde, and Adenosine Deaminase in Serum of Hypertensive Patients and Normotensive Individuals in Erbil City

2019 ◽  
Vol 24 (3) ◽  
pp. 17
Author(s):  
Gulzar I. Ibrahim1 ◽  
Saman M. Abdulkareem2 ◽  
Lutfiya M. Hasan1
Keyword(s):  
Oxidative Stress ◽  
Nitric Oxide ◽  
Serum Level ◽  
Adenosine Deaminase ◽  
Control Group ◽  
Healthy Individuals ◽  
Hypertensive Patients ◽  
And Gender

This study was aimed to estimate nitric oxide (NO), malondialdehyde (MDA), and adenosine deaminase (ADA) in the serum of hypertensive patients. Fifty patients (25 males and 25 females) age 40-70 diagnosed with hypertension involved in the study. Fifty healthy individuals, who had no hypertension in the last year, were identified as the control group. NO, MDA and ADA have performed accordingly. MDA was higher with aging and gender in hypertensive patients. Serum level of MDA was higher in females compared with male due to oxidative stress more in female than a male with aging. ADA was higher among hypertensive with aging, though no significant differences among gender. Serum level of NO was lower with aging with no significant differences among gender.   http://dx.doi.org/10.25130/tjps.24.2019.043

scholarly journals Residual signal auto-correlation to evaluate speech in Parkinson’s disease patients

2006 ◽  
Vol 64 (4) ◽  
pp. 912-915 ◽  
Author(s):  
José Carlos Pereira ◽  
Arthur Oscar Schelp ◽  
Arlindo Neto Montagnoli ◽  
Ana Rita Gatto ◽  
André Augusto Spadotto ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Statistical Difference ◽  
Control Group ◽  
Healthy Individuals ◽  
Age And Gender ◽  
Residual Signal ◽  
Auto Correlation ◽  
Significant Difference ◽  
And Gender

OBJECTIVE: To evaluate the maximum residual signal auto-correlation also known as pitch amplitude (PA) values in patients with Parkinson’s disease (PD) patients. METHOD: The signals of 21 Parkinson’s patients were compared with 15 healthy individuals, divided according age and gender. RESULTS: Statistical difference was seen between groups for PA, 0.39 for controls and 0.25 for PD. Normal value threshold was set as 0.3; (p<0.001). In the Parkinson’s group 80.77%, and in the control group only 12.28%, had a PA<0.3 demonstrating an association between these variables. The dispersion diagram for age and PA for PD individuals showed p=0.01 and r=0.54. There was no significant difference in relation to gender and PA between groups. CONCLUSION: The significant differences in pitch’s amplitude between PD patients and healthy individuals demonstrate the methods specificity. The results showed the need of prospective controlled studies to improve the use and indications of residual signal auto-correlation to evaluate speech in PD patients.

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