scholarly journals Evaluation of Ventricular Repolarization Parameters in Patients Admitted to Emergency Department with Electrical Injury

2020 ◽  
Keyword(s):  
Ventricular Arrhythmias ◽  
Troponin I ◽  
Ventricular Repolarization ◽  
Control Group ◽  
Qtc Interval ◽  
Elevated Troponin ◽  
Surface Ecg ◽  
Healthy Control ◽  
The Mean ◽  
Electrocardiogram Ecg

Objective: Prolonged T-peak to T-end (Tp-e), a ventricular repolarization parameter, has been related with ventricular arrhythmias (VAs). Novel electrocardiogram (ECG) parameters of ventricular repolarization have received considerable attention recently. In this study, we sought to investigate ventricular repolarization indexes such as the Tp-e and corrected Tp-e (Tp-ec) intervals, Tp-e/QT, Tp-e/QTc, and Tp-ec/QT ratios in patients with electrical injuries (EIs). Methods: Thirty-six patients diagnosed with EIs and 35 age- and sex-matched healthy control patients were included. Admission ECGs of the EI patients were compared with those of the healthy controls. QT and QTc intervals were measured, and the Tp-e and Tp-ec intervals, Tp-e/QT, Tp-ec/QT, and Tp-e/QTc ratios were then calculated from a 12-lead surface ECG. Results: The QT, Tp-e, Tp-e/QT, Tp-e/QTc, Tp-ec/QT were not significantly different between the control group and the EI group (p > 0.05). However, the mean QTc interval was significantly higher in the EI group compared to the control group (412.81 ± 25.46 vs 396.31 ± 26.47 ms; p:0.009). Furthermore, the Tp-ec and Tp-ec/QT of the EI subgroup with elevated troponin levels significantly differed from those of the EI patients with normal troponin levels (p:0.033 and p:0.016, respectively). Conclusions: This retrospective study indicated that patients with EIs tend to have a prolonged QTc interval. Additionally, Tp-ec and Tp-ec/QT, which reportedly designate the tendency for VAs, were significantly higher in the EI patients with elevated troponin I levels than the EI patients with normal troponin levels, suggesting that patients with myocardial injury may be prone to VAs.

Ryanodine receptor inhibition prevents ventricular arrhythmia in a murine model of hypokalaemia

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
V.M Robinson ◽  
I Alsalahat ◽  
S Freeman ◽  
H Barajas-Martinez ◽  
C Antzelevitch ◽  
...  
Keyword(s):  
Ventricular Arrhythmia ◽  
Ryanodine Receptor ◽  
Murine Model ◽  
Ventricular Arrhythmias ◽  
Control Group ◽  
Funding Source ◽  
Treatment Groups ◽  
Receptor Inhibition ◽  
Surface Ecg ◽  
The Mean

Abstract Background Hypokalaemia-induced arrhythmia is a major cause of morbidity and mortality, affecting approximately 14% of outpatients and 20% of inpatients. Hypokalaemic inpatients have a mortality 10 times higher than their counterparts. This is due to ventricular arrhythmias initiated by early afterdepolarisations (EADs) and triggered activity. There is no antiarrhythmic drug approved for the prevention of hypokalaemia-induced ventricular arrhythmia. Recent evidence suggests that EADs can arise because of the synchronised release of Ca2+ from the sarcoplasmic reticulum, rather than the reactivation of L-type Ca2+ channels during action potential prolongation. Therefore, ryanodine receptor inhibition should prevent hypokalaemia-induced ventricular arrhythmia. Purpose To test the hypothesis that the ryanodine receptor inhibitors dantrolene and VKII-86 (a carvedilol analogue) are effective in preventing hypokalaemia-induced ventricular arrhythmia. Methods Whole heart Langendorff preparations isolated from C57BL/J6 mice were perfused with Krebs-Henseleit solution containing normal (4mM) or low (2mM) concentrations of [K+]. Surface ECG and subepicardial ventricular action potentials were simultaneously recorded. After establishing that the model reproduces EAD-mediated triggered arrhythmias in low extracellular [K+], hearts in the treatment groups were pre-treated with dantrolene or VKII-86 for 30 minutes prior to being exposed to low extracellular [K+]. The frequency of non-sustained and sustained ventricular arrhythmias occurring during a 30-minute period of exposure to low extracellular [K+] were compared between the treatment groups and controls treated with the solvent DMSO (0.1% v/v) (n=6 in each group). Results The mean number of non-sustained arrhythmias was 29.3±9.6 (Mean±SEM) in the control group, 3.2±1.2 in the dantrolene group and 0 in the VKII-86 group; p<0.05 for both treatments vs. control. The mean number of sustained arrhythmias was 1.7±0.4 in the control group, 0.17±0.17 in the dantrolene group and 0 in the VKII-86 group; p<0.05 for both treatments vs. control. Thus, dantrolene significantly reduced arrhythmia frequency by approximately 90%, whereas VKII-86 prevented all hypokalaemia-induced ventricular arrhythmias. Conclusions These results provide the first demonstration of ryanodine receptor inhibition as an effective treatment for the prevention of ventricular arrhythmia in a murine model of hypokalaemia. This study is consistent with recent studies indicating that intracellular Ca2+ load is an important mechanism underlying the development of EAD-mediated triggered arrythmia. Further studies are needed to determine whether these drugs could be re-purposed as antiarrhythmics in the setting of hypokalemia. Further development of the carvedilol analogue VKII-86 should also be considered. Funding Acknowledgement Type of funding source: Foundation. Main funding source(s): The British Heart Foundation, The Lankenau Institute for Medical Research.

Vitamin D Treatment in Patients with Hashimoto’s Thyroiditis may Decrease the Development of Hypothyroidism

2016 ◽  
Vol 86 (1-2) ◽  
pp. 9-17 ◽  
Author(s):  
Bekir Ucan ◽  
Mustafa Sahin ◽  
Muyesser Sayki Arslan ◽  
Nujen Colak Bozkurt ◽  
Muhammed Kizilgul ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Hashimoto’S Thyroiditis ◽  
Healthy Control Group ◽  
Hashimoto's Thyroiditis ◽  
Control Group ◽  
Endocrine Society ◽  
Thyroid Autoantibody ◽  
Healthy Control ◽  
The Mean

Abstract.The relationship between Hashimoto’s thyroiditis and vitamin D has been demonstrated in several studies. The aim of the present study was to evaluate vitamin D concentrations in patients with Hashimoto’s thyroiditis, the effect of vitamin D therapy on the course of disease, and to determine changes in thyroid autoantibody status and cardiovascular risk after vitamin D therapy. We included 75 patients with Hashimoto’s thyroiditis and 43 healthy individuals. Vitamin D deficiency is defined as a 25-hydroxy vitamin D (25(OH)D3) concentration less than 20ng/mL. Vitamin D deficient patients were given 50.000 units of 25(OH)D3 weekly for eight weeks in accordance with the Endocrine Society guidelines. All evaluations were repeated after 2 months of treatment. Patients with Hashimoto’s thyroiditis had significantly lower vitamin D concentrations compared with the controls (9.37±0.69 ng/mL vs 11.95±1.01 ng/mL, p < 0.05, respectively). Thyroid autoantibodies were significantly decreased by vitamin D replacement treatment in patients with euthyroid Hashimoto’s thyroiditis. Also, HDL cholesterol concentrations improved in the euthyroid Hashimoto group after treatment. The mean free thyroxine (fT4) concentrations were 0.89±0.02 ng/dL in patients with Hashimoto’s thyroiditis and 1.07±0.03 ng/dL in the healthy control group (p < 0.001). The mean thyroid volumes were 7.71±0.44 mL in patients with Hashimoto’s thyroiditis and 5.46±0.63 mL in the healthy control group (p < 0.01). Vitamin D deficiency is frequent in Hashimoto’s thyroiditis and treatment of patients with this condition with Vitamin D may slow down the course of development of hypothyroidism and also decrease cardiovascular risks in these patients. Vitamin D measurement and replacement may be critical in these patients.

scholarly journals Urine CA-2 as a biomarker for diagnosis urinary stone and prediction of its complications

2020 ◽  
Author(s):  
Yuan-jing Leng ◽  
Hai-bin Zhou ◽  
Jiang-ling Fu ◽  
Wen-juan Wang
Keyword(s):  
Healthy Subjects ◽  
Characteristic Curve ◽  
Urinary Stone ◽  
Urinary Stones ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control Group ◽  
Healthy Control ◽  
The Mean ◽  
The Difference ◽  
The Relationship

Abstract PURPOSECarbonic anhydrase-2 (CA-2) plays a role in mineralization and calcification in organism. Strong evidence suggests that CA-2 is associated with urolithiasis. However, the relationship between CA-2 and urinary stone remains unclear. The study aimed to assess the association of urine CA-2 (uCA-2) level and the potential risk of urinary stone.METHODSFrom March 2017 to November 2019, a prospective cohort study was conducted on patients with urinary stones and healthy subjects to determine the pretreatment uCA-2 level detection by Enzyme linked immunosorbent assay (ELISA). The difference of uCA-2 level between patients with urinary stones and healthy subjects was compared. Then comparison between stone patients with complications and without complications was carried out as well as correlation analysis to detect factors associated with biomarker expression.RESULTS118 patients with urinary stones were into urinary stones group and 42 healthy subjects were into healthy control group. The mean pretreatment uCA-2 level was significantly higher in patients with urinary stones group than healthy controls group (P=0.028). Furthermore, The uCA-2 level was positive correlation with urinary stones complications (R=0.379, P=0.000), especially pain complications (R=0.524, P=0.000) and hematuria complications (R=0.374, P=0.000). Receiver operating characteristic curve (ROC) analysis that a uCA-2 level threshold of 10.94 ng/mL had 83.67% sensitivity and 68.12% specificity for predicting urinary stones complications. CONCLUSIONSExcessive uCA-2 excretion is a major risk factor for urinary stone. Our findings suggested that uCA-2 may be used as an unappreciated biomarker for the diagnosis urinary stone in patients and to predict its complications.

scholarly journals Effect of Curcuma longa (Turmeric) on serum creatine kinase-MB and troponin I in isoproterenol induced myocardial infarction in wistar albino rats

2018 ◽  
Vol 13 (2) ◽  
pp. 47-53
Author(s):  
Sharmin Nahar ◽  
Qazi Shamima Akhter
Keyword(s):  
Myocardial Infarction ◽  
Body Weight ◽  
Troponin I ◽  
Curcuma Longa ◽  
Heart Weight ◽  
Control Group ◽  
Albino Rats ◽  
Creatine Kinase Mb ◽  
The Mean ◽  
Wistar Albino Rats

Background: The prevalence of myocardial infarction (MI) is increasing day by day in Bangladesh due to socioeconomic transition. Spices and herbs are important source of remedy for various diseases in human. Curcuma longa suggested to be used as an indigenous medicine for the prevention and treatment of cardiovascular disease. Objective: To observe the effect of Curcuma longa in isoproterenol induced myocardial infarction in Wistar albino rats. Methods: This experimental study was carried out in the Department of Physiology, Dhaka Medical College, Dhaka during 2015. Twenty one Wistar albino male rats, weighing 100 to 150 g (initial body weight); aged 85 to 100 days were selected for the study. After acclimatization for 14 days, the rats were divided into BC (Baseline control group), ISP-TC (Isoproterenol treated control group) and CLP-ISPT (Curcuma longa pretreated and isoproterenol treated group). Each group consisted of 7 rats. After experiment, on the 10th day, final body weight was taken, rats were sacrificed and blood samples were collected from the heart. The heart was removed and weighed. Serum creatine kinase-MB (CK-MB) level was estimated by ELISA method and Troponin I (cTnI) level by AxSYM method. The statistical analysis was done by one way ANOVA and Bonferroni test as applicable. Results: In this study, the mean percent (%) change of body weight (p<0.01), mean serum CK-MB (p<0.001) and cTnI (p<0.001) levels were significantly higher but mean heart weight was non significantly higher in ISP-TC in comparison to those of BC. Again, the mean percent (%) change of body weight (p<0.01), mean heart weight (p<0.01), mean serum CK-MB (p<0.01) and cTnI (p<0.001) levels were significantly lower in CLP-ISPT than those of ISP-TC group. Conclusion: From the results, it can be concluded that Curcuma longa may have cardioprotective effect. J Bangladesh Soc Physiol. 2018, December; 13(2): 47-53

Increased QT and P-wave dispersion during attack-free period in pediatric patients with migraine attacks

2019 ◽  
Vol 29 (4) ◽  
pp. 488-491
Author(s):  
Oyku Tosun ◽  
Elif Karatoprak
Keyword(s):  
Wave Dispersion ◽  
P Wave ◽  
Sympathetic System ◽  
Control Group ◽  
Qtc Interval ◽  
Control Groups ◽  
P Wave Dispersion ◽  
Surface Ecg ◽  
Migraine Group ◽  
And Control

AbstractIntroduction:Migraine is a common neurovascular disease characterised with recurrent attacks by pain-free periods. It has been suggested that both sympathetic and parasympathetic dysfunctions play a role in its pathophysiology.Aim:The aim of our study was to investigate the ECG changes during attack-free period in children with migraine, in terms of QTc interval, QTc, and P-wave dispersion to evaluate the autonomic nervous system disturbance.Methods:Sixty children who were diagnosed with migraine were included as patient group and 50 healthy, age- and body mass index-matched children who were examined for innocent murmur were included as control group. The patients’ routine ECG records were screened from the outpatient clinic files. The durations of P-wave, QT, and QTc intervals and dispersion values and heart rates (beats/minute) were compared between the patient and control groups.Results:P maximum and P dispersion were significantly higher, and P minimum was significantly lower in the migraine group compared with the control group. QT–QTc maximum and QT–QTc dispersion were significantly higher and QT–QTc minimum was significantly lower in the migraine group compared with the control group.Conclusion:According to our findings, although migraine patients were asymptomatic and no arrhythmia was detected in the surface ECG, sympathovagal balance in the sympathetic system, which may be disrupted in favour of the sympathetic system, should continue even in the attack-free period, and we should be careful in terms of serious arrhythmias that may develop in these patients.

scholarly journals C5n 5 55Detection of Some Immunological Parameters in Psoriatic Iraqi Female Patients

2020 ◽  
pp. 2515-2524
Author(s):  
Rehab Morad Khazem ◽  
Shaima R. Ibraheem
Keyword(s):  
Serum Levels ◽  
Interleukin 10 ◽  
Living Condition ◽  
Healthy Control Group ◽  
Control Group ◽  
Immunological Parameters ◽  
Female Patients ◽  
Healthy Control ◽  
The Mean ◽  
Severity Of The Disease

Psoriasis is a common, chronic, immune-mediated skin disease with systemic pro-inflammatory activation.  This study was designed to estimate the level of two cytokines, Interleukin-36 (IL-36) and Interleukin-10 (IL-10), in psoriasis female patients. The study was accomplished on 50 Iraqi patients with psoriasis who were referred to the consulting clinic at Al-Yarmouk Teaching Hospital during the period from November 2018 to March 2019. These patients were diagnosed under the supervision of dermatologists. For the purpose of comparison, the study included 30 healthy women as a healthy control group. The serum levels of cytokines  were measured using the enzyme-linked immunosorbent technique (ELISA).The results of this study showed that the mean age of the female patients was 35.9 ± 1.85 years, whereas the age of the patients with a severity of higher than 30% ranged 15-25 years. Most of the patients were married, in an average living condition, and non-smokers, and their menstrual cycle was continuous. It was also found that 28% of the psoriatic patients had other chronic diseases. The study showed statistically significant differences (p <0.05) in the mean level of IL-36 between the patients and healthy control group, whereas there was no statistical difference in the mean level of IL-10. In conclusion,   the   decrease in the level of IL-36 in the patients might be related to the increase in the severity of the disease.

scholarly journals The New Markers of Ventricular Dispersion in Patients with Acute Poisoning with TCAs: Tp-e Interval and Tp-e/QTc Ratio

2020 ◽  
Keyword(s):  
Heart Rate ◽  
Ventricular Arrhythmias ◽  
Tricyclic Antidepressants ◽  
Acute Poisoning ◽  
Study Data ◽  
Control Group ◽  
Qtc Interval ◽  
Healthy Individuals ◽  
Gender Characteristics ◽  
And Gender

Introduction: Purpose of this study was to investigate the changes in Tp-e/QTc rates and Tp-e intervals in patients poisoned with tricyclic antidepressants. Methods: 187 patients who were poisoned with tricyclic antidepressants and admitted to our emergency department were included in this study. Control group consisted of 187 healthy individuals with similar age and gender characteristics. All patients underwent 12-lead electrocardiograms (ECG). In addition to QTc measurement, Tp-e/QTc ratios and Tp-e interval were measured in the ECG. Study data were divided two groups as patients and healthy controls. Results: It was found that the QTc interval, Tp-e interval, and Tp-e/QTc ratio were significantly higher in the patient group compared to control group. The analysis demonstrated that QTc interval; Tp-e interval and Tp-e/QTc ratio were independently associated with heart rate. Conclusion: In poisoning with TCAs, the rate of QTc interval, Tp-e/QTc and Tp-e interval has increased and is independently associated with the heart rate in these patients. This may be the precursor of possible fatal ventricular arrhythmias in tricyclic antidepressants.

Importance of the FcγRIIa-Arg/His-131 Polymorphism in Heparin-induced Thrombocytopenia Diagnosis

1998 ◽  
Vol 79 (03) ◽  
pp. 523-528 ◽  
Author(s):  
Raphaël Saffroy ◽  
Dominique Lasne ◽  
Gilles Chatellier ◽  
Martine Aiach ◽  
Francine Rendu ◽  
...  
Keyword(s):  
Serotonin Release ◽  
Positive Answer ◽  
Control Group ◽  
Normal Donor ◽  
Heparin Induced Thrombocytopenia ◽  
Weak Association ◽  
Healthy Control ◽  
Release Assay ◽  
The Mean

SummaryHeparin-induced thrombocytopenia (HIT) involves heparin-dependent antibodies which induce platelet activation. In the present study, we searched for a relationship between the polymorphism of the Fc receptor (FcγRIIa) and the development of HIT. In this purpose, all the donors were genotyped for their FcγRIIA and HIT patients were selected on the basis of at least one positive answer by 14C-serotonin release assay (SRA). The frequency distribution of the FcγRIIa polymorphism in the HIT patient group was similar to that observed in the healthy control group. Moreover, a statistical analysis taking into account our results and those of 3 previously published studies, suggested at most only a weak association between HIT and the FcγRIIa-131 polymorphism.Laboratory tests used to diagnose HIT rely on the activation of normal donor platelets but fail to detect every HIT positive patient. We determined the role of FcγRIIa-131 polymorphism on the reactivity of control platelets to HIT plasmas. When control platelet FcγRIIa-131 was of Arg/Arg form, only 47% of the HIT plasmas were positive by SRA, compared to 81% and 74% for His/His or His/Arg forms, respectively. We also compared the level of anti PF4/heparin antibodies in the HIT plasmas with the response obtained by SRA. The mean anti PF4/heparin antibodies level in HIT plasma was significantly lower in negative SRA than in positive tests when using control platelets from FcγRIIa-Arg/Arg131 and heterozygous donors. Thus, the variability of control platelets to respond to HIT plasmas in the SRA test is related to both the FcγRIIa-131 polymorphism, and to the amount of anti PF4/heparin antibodies.

Application of ImageJ software for quantification of Hand Joint Space Narrowing in Patients with Rheumatoid Arthritis

2021 ◽  
Vol 17 ◽  
Author(s):  
Nui Nguyen Minh ◽  
Nga Phi Thi Nguyen ◽  
Chau Nguyen Ngoc ◽  
Tien Tran Duy ◽  
Thong Nguyen Huy ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Joint Space Narrowing ◽  
Joint Space Width ◽  
Joint Space ◽  
Control Group ◽  
Healthy Control ◽  
The Mean ◽  
The Right ◽  
Imagej Software

Background: ImageJ software is used to quantify the joint space width (JSW) of hand and wrist in patients with rheumatoid arthritis (RA) as well as in the healthy control group. Method: Forty-one RA patients and 31 healthy controls are included in this study. All of 72 participants underwent digital radiography of the bilateral hand and wrist, then all the images were opened by ImageJ software to measure the width of wrist and hand joint space (total 2160 joints). Joint space narrowing (JSN) was defined if the width was less than the mean - 2SD of the control group. Result: The mean JSW of all sites of wrist and hand joints of RA patients was significantly reduced as compared to those in the control group (p<0.001). There were 37/41 (90.24%) RA patients who had JSN in at least one joint in hand or wrist. In total, 70.89% of joints on the right and 68.46% of joints on the left wrist and hand had JSN. Conclusion: ImageJ software was simple and convenient , which helps rheumatologists quantify the width of joint space for diagnosis and follow-up in RA patients.

The evaluation of serum N-terminal prohormone brain-type natriuretic peptide, troponin-I, and high-sensitivity C-reactive protein levels in children with congenital heart disease

2014 ◽  
Vol 33 (11) ◽  
pp. 1158-1166 ◽  
Author(s):  
A Uner ◽  
M Doğan ◽  
M Ay ◽  
Ç Acar
Keyword(s):  
Septal Defect ◽  
Troponin I ◽  
High Sensitivity ◽  
Control Group ◽  
Asymptomatic Group ◽  
Reactive Protein ◽  
Significant Difference ◽  
Healthy Control ◽  
Hs Crp ◽  
And Control

Although advanced diagnostic and treatment methods are available, congenital heart disease (CHD) holds an important place among the causes of death within the first year of age. Therefore, several prognostic factors are needed for diagnosis and monitoring of these patients. In this study, which includes 66 CHD patients and 38 healthy control children, serum cardiac troponin-I (cTnI), high-sensitivity C-reactive protein (Hs-CRP), and N-terminal prohormone brain-type natriuretic peptide (NT-proBNP) levels were analyzed for their prognostics values. The patient groups were categorized and then evaluated as cyanotic ( n = 16), acyanotic ( n = 50), symptomatic ( n = 23), asymptomatic ( n = 43), and isolated ventricular septal defect (VSD)-isolated atrial septal defect (ASD) groups. Cyanotic group was statistically compared with acyanotic group, symptomatic group with asymptomatic group, and VSD group with ASD group. Between the cyanotic, acyanotic, and control groups; between symptomatic and asymptomatic groups; and between the VSD and ASD groups, significant difference was not showed for age ( p > 0.05). NT-proBNP was found to be significantly higher in the cyanotic group than acyanotic and control group, in the symptomatic group than asymptomatic group; and in the patient group than healthy control group ( p < 0.05). Between the groups of VSD and ASD, significant difference was not showed ( p > 0.05). The same comparison results for TnI and Hs-CRP were not significant ( p > 0.05). TnI and Hs-CRP were only found significantly higher in the patient group than healthy control group ( p < 0.05). Eventually, we think that NT-proBNP, Hs-CRP, and TnI might be used for clinical management and estimation of outcome of these disorders in the future and these also might be able to modify existing strategies, but much more studies are needed.

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