scholarly journals High-doses vitamin C improves cardiac injury through preventing hyper-inflammatory response in coronavirus disease 2019

2020 ◽  
Author(s):  
Guozhi Xia ◽  
Di Fan ◽  
Chaoran Ma ◽  
Yanru He ◽  
Ming Wang ◽  
...  
Keyword(s):  
Vitamin C ◽  
Inflammatory Response ◽  
Cardiac Injury ◽  
High Doses

scholarly journals High-doses vitamin C improves cardiac injury through attenuating hyperinflammation in COVID-19

2021 ◽  
Author(s):  
Guozhi Xia ◽  
Di Fan ◽  
Chaoran Ma ◽  
Yanru He ◽  
Yaohu Zhu ◽  
...  
Keyword(s):  
Vitamin C ◽  
Critically Ill ◽  
Electronic Medical Records ◽  
Medical Records ◽  
Inflammatory Markers ◽  
Troponin I ◽  
Cardiac Injury ◽  
High Dose ◽  
High Doses ◽  
Intravenous Vitamin

Background: Cardiac injury is common and associated with worse clinical outcomes in COVID-19. Data are lacking whether high-dose intravenous vitamin C (HIVC) could help to improve cardiac injury in the pandemic. Methods: The study included severe and critically ill COVID-19 with cardiac injury. Troponin I and inflammatory markers were collected at admission and 14 days after treatment with HIVC along with symptomatic supportive treatment from the electronic medical records. Results: The patients (n = 113) were categorized into the improved cardiac injury (ICI) group (n = 70) and the non-improved cardiac injury (NICI) group (n = 43). Overall, 51 (45.1%) patients were administrated with HIVC, the percentages of patients with HIVC were higher in the ICI group than those in the NICI group. Logistic regression analysis revealed that HIVC was independently associated with improved cardiac injury. Further analysis showed that inflammatory markers levels significantly decreased at 14 days after treatment with HIVC compared to those without HIVC. Meanwhile, similar results were also observed regarding changes in inflammatory markers levels from baseline to 14 days after treatment with HIVC. Conclusions: HIVC can improve cardiac injury through attenuating hyperinflammation in severe and critically ill patients with COVID-19.

scholarly journals Vitamin C—Sources, Physiological Role, Kinetics, Deficiency, Use, Toxicity, and Determination

Nutrients ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 615
Author(s):  
Martin Doseděl ◽  
Eduard Jirkovský ◽  
Kateřina Macáková ◽  
Lenka Krčmová ◽  
Lenka Javorská ◽  
...  
Keyword(s):  
Ascorbic Acid ◽  
Vitamin C ◽  
Iron Absorption ◽  
Plasma Concentrations ◽  
Physiological Role ◽  
Renal Stones ◽  
Anti Oxidant ◽  
High Doses ◽  
Epigenetic Processes

Vitamin C (L-ascorbic acid) has been known as an antioxidant for most people. However, its physiological role is much larger and encompasses very different processes ranging from facilitation of iron absorption through involvement in hormones and carnitine synthesis for important roles in epigenetic processes. Contrarily, high doses act as a pro-oxidant than an anti-oxidant. This may also be the reason why plasma levels are meticulously regulated on the level of absorption and excretion in the kidney. Interestingly, most cells contain vitamin C in millimolar concentrations, which is much higher than its plasma concentrations, and compared to other vitamins. The role of vitamin C is well demonstrated by miscellaneous symptoms of its absence—scurvy. The only clinically well-documented indication for vitamin C is scurvy. The effects of vitamin C administration on cancer, cardiovascular diseases, and infections are rather minor or even debatable in the general population. Vitamin C is relatively safe, but caution should be given to the administration of high doses, which can cause overt side effects in some susceptible patients (e.g., oxalate renal stones). Lastly, analytical methods for its determination with advantages and pitfalls are also discussed in this review.

scholarly journals Effects of vitamin C supplementation on acute phase Chagas disease in experimentally infected mice with Trypanosoma cruzi QM1 strain

2012 ◽  
Vol 54 (6) ◽  
pp. 319-323 ◽  
Author(s):  
Ricardo Guimarães Marim ◽  
Alex Silva de Gusmão ◽  
Roberto Esteves Pires Castanho ◽  
Rafael Deminice ◽  
Altino Luiz Silva Therezo ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Vitamin C ◽  
Chagas Disease ◽  
Acute Phase ◽  
Immune Reaction ◽  
Parasite Clearance ◽  
Vitamin C Supplementation ◽  
Affected Tissue ◽  
Tissue Changes ◽  
High Doses

The tissue changes that occur in Chagas disease are related to the degree of oxidative stress and antioxidant capacity of affected tissue. Studies with vitamin C supplementation did not develop oxidative damage caused by Chagas disease in the host, but other studies cite the use of peroxiredoxins ascorbate - dependent on T. cruzi to offer protection against immune reaction. Based on these propositions, thirty "Swiss" mice were infected with T. cruzi QM1 strain and treated with two different vitamin C doses in order to study the parasitemia evolution, histopathological changes and lipid peroxidation biomarkers during the acute phase of Chagas disease. The results showed that the parasite clearance was greater in animals fed with vitamin C overdose. There were no significant differences regarding the biomarkers of lipid peroxidation and inflammatory process or the increase of myocardium in animals treated with the recommended dosage. The largest amount of parasite growth towards the end of the acute phase suggests the benefit of high doses of vitamin C for trypomastigotes. The supplementation doesn't influence the production of free radicals or the number of amastigote nests in the acute phase of Chagas disease.

scholarly journals High-dose pyruvate treatment alters skeletal muscle differentiation and expression of inflammation-related genes

2020 ◽  
Author(s):  
Kazuya Hasegawa ◽  
Yuya Yamaguchi ◽  
Yutthana Pengjam
Keyword(s):  
Gene Expression ◽  
Skeletal Muscle ◽  
Inflammatory Response ◽  
Muscle Contraction ◽  
Signaling Pathway ◽  
Receptor Interaction ◽  
High Dose ◽  
Ppi Network ◽  
Acid Therapy ◽  
High Doses

ABSTRACTPyruvic acid therapy is used for various diseases, but the therapeutic effect decreases at high doses. The molecular mechanism of high-dose pyruvate is not well understood. The purpose of this study was to identify the effects of high dose pyruvate addition on skeletal muscle using C2C12. The gene expression profile for the GSE5497 dataset was taken from the Gene Expression Omnibus database. GEO2R was used to identify specifically expressed genes (DEGs). Functional analysis and pathway enrichment analysis of DEG were performed using the DAVID database. The protein-protein interaction (PPI) network was built in the STRING database and visualized using Cytoscape. GO analysis showed that up-regulated DEG was primarily involved in angiogenesis, cell adhesion, and inflammatory response. We also showed that down-regulated DEG is involved in the regulation of muscle contraction, skeletal muscle fiber development. In addition, the upregulated KEGG pathway of DEG included Rheumatoid arthritis, Chemokine signaling pathway, and Cytokine-cytokine receptor interaction. Downregulated DEG included Calcium signaling pathway, hypertrophic cardiomyopathy (HCM), Dilated cardiomyopathy, Neuroactive ligand-receptor interaction, and Cardiac muscle contraction. Further, analysis of two modules selected from the PPI network showed that high-dose pyruvate exposure to C2C12 was primarily associated with muscle contraction, muscle organ morphogenesis, leukocyte chemotaxis, and chemokine activity. In conclusion, High-dose pyruvate treatment of C2C12 was found to be associated with an increased inflammatory response and decreased skeletal muscle formation. However, further studies are still needed to verify the function of these molecules at high doses of pyruvate.

scholarly journals High-dose vitamin C enhances cancer immunotherapy

2020 ◽  
Vol 12 (532) ◽  
pp. eaay8707 ◽  
Author(s):  
Alessandro Magrì ◽  
Giovanni Germano ◽  
Annalisa Lorenzato ◽  
Simona Lamba ◽  
Rosaria Chilà ◽  
...  
Keyword(s):  
Immune System ◽  
Vitamin C ◽  
Clinical Evidence ◽  
High Dose ◽  
Dependent Manner ◽  
Cancer Cell Growth ◽  
Mutational Burden ◽  
Cancer Types ◽  
High Doses ◽  
High Dose Vitamin

Vitamin C (VitC) is known to directly impair cancer cell growth in preclinical models, but there is little clinical evidence on its antitumoral efficacy. In addition, whether and how VitC modulates anticancer immune responses is mostly unknown. Here, we show that a fully competent immune system is required to maximize the antiproliferative effect of VitC in breast, colorectal, melanoma, and pancreatic murine tumors. High-dose VitC modulates infiltration of the tumor microenvironment by cells of the immune system and delays cancer growth in a T cell–dependent manner. VitC not only enhances the cytotoxic activity of adoptively transferred CD8 T cells but also cooperates with immune checkpoint therapy (ICT) in several cancer types. Combination of VitC and ICT can be curative in models of mismatch repair–deficient tumors with high mutational burden. This work provides a rationale for clinical trials combining ICT with high doses of VitC.

High doses vitamin C treatment in severe acute pancreatitis

Pancreatology ◽  
2020 ◽  
Vol 20 ◽  
pp. S64-S65
Author(s):  
S. Chooklin ◽  
S. Chuklin ◽  
G. Shershen
Keyword(s):  
Acute Pancreatitis ◽  
Vitamin C ◽  
Severe Acute Pancreatitis ◽  
High Doses

Antioxidant Status of Patients on Peritoneal Dialysis: Associations with Inflammation and Glycoxidative Stress

2009 ◽  
Vol 29 (1) ◽  
pp. 89-101 ◽  
Author(s):  
Isabella Sundl ◽  
Johannes M. Roob ◽  
Andreas Meinitzer ◽  
Beate Tiran ◽  
Gholamali Khoschsorur ◽  
...  
Keyword(s):  
Peritoneal Dialysis ◽  
Vitamin C ◽  
Interleukin 6 ◽  
Antioxidant Status ◽  
Low Dose ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Chronic Inflammatory Response ◽  
Plasma Ascorbate ◽  
High Doses

Background Patients on peritoneal dialysis (PD) frequently exhibit oxidant–antioxidant imbalance, advanced glycation end-product overload, and subclinical inflammation but the interrelations between these pathophysiological changes have not been fully elucidated. Subjects and Methods To study possible associations, a cross-sectional study of antioxidant status, glycoxidative stress, and inflammation, using HPLC and ELISA methods, was undertaken in 37 PD patients and age- and sex-matched healthy controls. Results Plasma ascorbate concentrations were low in patients not taking at least low-dose vitamin C supplements. In patients taking vitamin C supplements, there was a positive relation between ascorbate and pentosidine concentrations. Vitamin E and carotenoid concentrations were comparable between patients and controls, while lycopene and lutein/zeaxanthin concentrations were lower. Interleukin-6, C-reactive protein (CRP), and pentosidine concentrations were elevated in PD patients. β–Cryptoxanthin, lycopene, and lutein/zeaxanthin concentrations were inversely related to interleukin-6 concentrations. β–Cryptoxanthin concentrations were also inversely related to CRP concentrations. Pentosidine showed a low dialysate-to-plasma ratio, indicating low peritoneal clearance. Pentosidine concentrations increased with duration of PD therapy, while α– and β–carotene concentrations decreased. Malondialdehyde concentrations were elevated compared to controls but remained within the normal range. Retinol concentrations decreased with PD therapy and were inversely related to interleukin-6 and CRP concentrations. Conclusions Low-dose vitamin C supplements and a carotenoid-rich diet should be recommended for PD patients to maintain normal antioxidant status and efficiently counteract the chronic inflammatory response, rather than high doses of vitamin C, which could play a role as a precursor of pentosidine.

scholarly journals A Novel Combination of Vitamin C, Curcumin and Glycyrrhizic Acid Potentially Regulates Immune and Inflammatory Response Associated with Coronavirus Infections: A Perspective from System Biology Analysis

Nutrients ◽  
2020 ◽  
Vol 12 (4) ◽  
pp. 1193 ◽  
Author(s):  
Liang Chen ◽  
Chun Hu ◽  
Molly Hood ◽  
Xue Zhang ◽  
Lu Zhang ◽  
...  
Keyword(s):  
Immune Response ◽  
Vitamin C ◽  
Inflammatory Response ◽  
Signaling Pathways ◽  
System Biology ◽  
Glycyrrhizic Acid ◽  
Inflammatory Responses ◽  
Mapk Signaling ◽  
Gene Target

Novel coronaviruses (CoV) have emerged periodically around the world in recent years. The recurrent spreading of CoVs imposes an ongoing threat to global health and the economy. Since no specific therapy for these CoVs is available, any beneficial approach (including nutritional and dietary approach) is worth investigation. Based on recent advances in nutrients and phytonutrients research, a novel combination of vitamin C, curcumin and glycyrrhizic acid (VCG Plus) was developed that has potential against CoV infection. System biology tools were applied to explore the potential of VCG Plus in modulating targets and pathways relevant to immune and inflammation responses. Gene target acquisition, gene ontology and Kyoto encyclopedia of genes and genomes (KEGG) pathway enrichment were conducted consecutively along with network analysis. The results show that VCG Plus can act on 88 hub targets which are closely connected and associated with immune and inflammatory responses. Specifically, VCG Plus has the potential to regulate innate immune response by acting on NOD-like and Toll-like signaling pathways to promote interferons production, activate and balance T-cells, and regulate the inflammatory response by inhibiting PI3K/AKT, NF-κB and MAPK signaling pathways. All these biological processes and pathways have been well documented in CoV infections studies. Therefore, our findings suggest that VCG Plus may be helpful in regulating immune response to combat CoV infections and inhibit excessive inflammatory responses to prevent the onset of cytokine storm. However, further in vitro and in vivo experiments are warranted to validate the current findings with system biology tools. Our current approach provides a new strategy in predicting formulation rationale when developing new dietary supplements.

scholarly journals Vitamin C as a Modulator of the Response to Cancer Therapy

Molecules ◽  
2019 ◽  
Vol 24 (3) ◽  
pp. 453 ◽  
Author(s):  
Wiktoria Blaszczak ◽  
Wojciech Barczak ◽  
Julia Masternak ◽  
Przemysław Kopczyński ◽  
Anatoly Zhitkovich ◽  
...  
Keyword(s):  
Vitamin C ◽  
Cancer Cells ◽  
Aerobic Glycolysis ◽  
Cell Metabolism ◽  
Experimental Studies ◽  
Reactive Oxygen Species Generation ◽  
Prolyl Hydroxylases ◽  
Beneficial Effects ◽  
Preferential Uptake ◽  
High Doses

Ascorbic acid (vitamin C) has been gaining attention as a potential treatment for human malignancies. Various experimental studies have shown the ability of pharmacological doses of vitamin C alone or in combinations with clinically used drugs to exert beneficial effects in various models of human cancers. Cytotoxicity of high doses of vitamin C in cancer cells appears to be related to excessive reactive oxygen species generation and the resulting suppression of the energy production via glycolysis. A hallmark of cancer cells is a strongly upregulated aerobic glycolysis, which elevates its relative importance as a source of ATP (Adenosine 5′-triphosphate). Aerobic glycolysis is maintained by a highly increased uptake of glucose, which is made possible by the upregulated expression of its transporters, such as GLUT-1, GLUT-3, and GLUT-4. These proteins can also transport the oxidized form of vitamin C, dehydroascorbate, permitting its preferential uptake by cancer cells with the subsequent depletion of critical cellular reducers as a result of ascorbate formation. Ascorbate also has a potential to affect other aspects of cancer cell metabolism due to its ability to promote reduction of iron(III) to iron(II) in numerous cellular metalloenzymes. Among iron-dependent dioxygenases, important targets for stimulation by vitamin C in cancer include prolyl hydroxylases targeting the hypoxia-inducible factors HIF-1/HIF-2 and histone and DNA demethylases. Altered metabolism of cancer cells by vitamin C can be beneficial by itself and promote activity of specific drugs.

Sign in / Sign up

Export Citation Format

Share Document