scholarly journals Can energetic vaccines, based on physics, be the sound options for COVID-19 and other pandemics in the absence of pharmaceutical vaccines?

2020 ◽  
Author(s):  
Savely Yurkovsky
Keyword(s):  
Chronic Diseases ◽  
Viral Infections ◽  
Low Cost ◽  
Scientific Evidence ◽  
Healthcare Personnel ◽  
Antibiotic Resistant ◽  
Practical Advantage ◽  
Energy Field ◽  
Public Health Emergencies ◽  
Uncertain Future

The proposed approach presents substantial scientific evidence based on physics and clinical data to support a clinical trial of an energetic SARS-CoV-2 vaccine. This is particularly imperative in the absence of a pharmaceutical vaccine as well as its uncertain future efficacy and safety, considering the limited time for testing and rapid mutations of the virus. Some of the vaccine trials have already been halted due to volunteers falling ill. Physics and biophysics of the fundamental electromagnetic nature of the living matter, including microbes as well as water, support the imprinting of electromagnetic fields of microbes in water that elicits an immune response. Energetic vaccines can be rapidly mass-produced for both prophylaxis and treatment of the public and healthcare personnel against the original as well as mutated viral strains. These can be prepared through a standard homeopathic process, as well as an energy field imprinting device,* offering a unique potential in versatility, speed, and low cost in mass protection against the current and future public health emergencies. Other viral infections, epidemics, antibiotic-resistant, and vector-borne infections could be similarly addressed. Paradoxically, in spite of a general perception of homeopathy by physicians as the most alien and least scientific, among complementary and alternative medicine (CAM), it is just the opposite. Homeopathy carries formidable scientific support, with the specific proposed homeopathic model being fully in line with physicians’ superior knowledge of infectious diseases and medicine, making its adaptation into their practice intuitive and more effective than in the hands of non-MDs or DOs homeopaths. The practical advantage of the proposed homeopathic model in acute infections versus its oldest one of multisystemic, totality approach, yielding mixed results in chronic diseases, parallels a similar prevailing success of the corresponding conventional modalities in acute versus chronic diseases.

scholarly journals Methods of Respiratory Virus Detection: Advances towards Point-of-Care for Early Intervention

Micromachines ◽  
2021 ◽  
Vol 12 (6) ◽  
pp. 697
Author(s):  
Siming Lu ◽  
Sha Lin ◽  
Hongrui Zhang ◽  
Liguo Liang ◽  
Shien Shen
Keyword(s):  
Viral Load ◽  
Respiratory Virus ◽  
Viral Infections ◽  
Point Of Care ◽  
Human Life ◽  
Low Cost ◽  
Virus Detection ◽  
Frequent Monitoring ◽  
User Friendly ◽  
New Strategies

Respiratory viral infections threaten human life and inflict an enormous healthcare burden worldwide. Frequent monitoring of viral antibodies and viral load can effectively help to control the spread of the virus and make timely interventions. However, current methods for detecting viral load require dedicated personnel and are time-consuming. Additionally, COVID-19 detection is generally relied on an automated PCR analyzer, which is highly instrument-dependent and expensive. As such, emerging technologies in the development of respiratory viral load assays for point-of-care (POC) testing are urgently needed for viral screening. Recent advances in loop-mediated isothermal amplification (LAMP), biosensors, nanotechnology-based paper strips and microfluidics offer new strategies to develop a rapid, low-cost, and user-friendly respiratory viral monitoring platform. In this review, we summarized the traditional methods in respiratory virus detection and present the state-of-art technologies in the monitoring of respiratory virus at POC.

scholarly journals Evidence in Practice of Tissue Healing with Latex Biomembrane: Integrative Review

2019 ◽  
Vol 2019 ◽  
pp. 1-17 ◽  
Author(s):  
Suélia de Siqueira Rodrigues Fleury Rosa ◽  
Mário Fabrício Fleury Rosa ◽  
Marcos Augusto Moutinho Fonseca ◽  
Glécia Virgolino da Silva Luz ◽  
Carlos Federico Domínguez Avila ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Wound Healing ◽  
Chronic Diseases ◽  
Low Cost ◽  
Rubber Tree ◽  
Antimicrobial Effect ◽  
Integrative Review ◽  
Complication Rates ◽  
Biocompatible Material ◽  
Tissue Healing

Wound healing is a perfectly coordinated cascade of cellular, molecular, and biochemical events which interact in tissue reconstitution. Chronic diseases such as pressure ulcers (PU) and diabetes mellitus (DM) are considered risk factors for wound healing. Patients with such diseases often have higher sepsis, infection, and complication rates, since they have revascularization inhibition and low growth factor expression. Thus, latex biomembrane (LBM), a biocompatible material, derived from the latex of the rubber tree (Hevea brasiliensis) appears to create tendencies as an angiogenic-inducing tissue healing agent and as biomaterial, resulting from its structural qualities and its low cost when compared to conventional treatments. Therefore, this work aims at summarizing the results, experiments, and scientific findings that certify or recommend the use of LBM as a new technique to be applied effectively in the treatment of wounds. An integrative review was held in the BIREME, LILACS, Burns, MEDLINE, PubMed, and SciELO databases, from 2000 to 2016, using the following descriptors: “healing,” “diabetes mellitus,” “wounds,” and “latex membrane.” As a result, 600 experiments (out of 612) presented satisfactory results; however, 33% of the cases received explicit recommendations, 11% required more studies on the subjects, and 1% was denied. On the other hand, half of the studies did not expressly endorse its use, despite presenting satisfactory results. The LBM was characterized as a good therapeutic alternative in cases of wounds, including chronic diseases, such as diabetes mellitus and PU, due to its relevant potential for wound healing stimulation, acceleration of cell tissue mending and revascularization, or the reestablishment of angiogenic functions (creation of new blood vessels). The LBM was also confirmed to be safe as a biocompatible material whose structural qualities (elasticity, adaptability, impermeability, and possibility of suture), devoid of toxicity, allowed interaction between tissues and presented no hypersensitivity inducer and no antimicrobial effect.

scholarly journals Novel Neonatal Simulator Provides High-Fidelity Ventilation Training Comparable to Real-Life Newborn Ventilation

Children ◽  
2021 ◽  
Vol 8 (10) ◽  
pp. 940
Author(s):  
Joanna Haynes ◽  
Peder Bjorland ◽  
Øystein Gomo ◽  
Anastasia Ushakova ◽  
Siren Rettedal ◽  
...  
Keyword(s):  
Skill Acquisition ◽  
Low Cost ◽  
Negative Relationship ◽  
Real Life ◽  
Neonatal Resuscitation ◽  
Healthcare Personnel ◽  
Positive Pressure ◽  
High Fidelity ◽  
High Resource ◽  
Clinical Conditions

Face mask ventilation of apnoeic neonates is an essential skill. However, many non-paediatric healthcare personnel (HCP) in high-resource childbirth facilities receive little hands-on real-life practice. Simulation training aims to bridge this gap by enabling skill acquisition and maintenance. Success may rely on how closely a simulator mimics the clinical conditions faced by HCPs during neonatal resuscitation. Using a novel, low-cost, high-fidelity simulator designed to train newborn ventilation skills, we compared objective measures of ventilation derived from the new manikin and from real newborns, both ventilated by the same group of experienced paediatricians. Simulated and clinical ventilation sequences were paired according to similar duration of ventilation required to achieve success. We found consistencies between manikin and neonatal positive pressure ventilation (PPV) in generated peak inflating pressure (PIP), mask leak and comparable expired tidal volume (eVT), but positive end-expiratory pressure (PEEP) was lower in manikin ventilation. Correlations between PIP, eVT and leak followed a consistent pattern for manikin and neonatal PPV, with a negative relationship between eVT and leak being the only significant correlation. Airway obstruction occurred with the same frequency in the manikin and newborns. These findings support the fidelity of the manikin in simulating clinical conditions encountered during real newborn ventilation. Two limitations of the simulator provide focus for further improvements.

scholarly journals Phytochemicals: A Promising Weapon in the Arsenal against Antibiotic-Resistant Bacteria

Antibiotics ◽  
2021 ◽  
Vol 10 (9) ◽  
pp. 1044
Author(s):  
Bahman Khameneh ◽  
N. A. Michael Eskin ◽  
Milad Iranshahy ◽  
Bibi Sedigheh Fazly Bazzaz
Keyword(s):  
Antimicrobial Agents ◽  
Scientific Evidence ◽  
Antimicrobial Activities ◽  
Clinical Aspects ◽  
Resistant Bacteria ◽  
Global Public Health ◽  
Health Issues ◽  
Antibiotic Resistant ◽  
Safe Strategy ◽  
Wide Range

The extensive usage of antibiotics and the rapid emergence of antimicrobial-resistant microbes (AMR) are becoming important global public health issues. Many solutions to these problems have been proposed, including developing alternative compounds with antimicrobial activities, managing existing antimicrobials, and rapidly detecting AMR pathogens. Among all of them, employing alternative compounds such as phytochemicals alone or in combination with other antibacterial agents appears to be both an effective and safe strategy for battling against these pathogens. The present review summarizes the scientific evidence on the biochemical, pharmacological, and clinical aspects of phytochemicals used to treat microbial pathogenesis. A wide range of commercial products are currently available on the market. Their well-documented clinical efficacy suggests that phytomedicines are valuable sources of new types of antimicrobial agents for future use. Innovative approaches and methodologies for identifying plant-derived products effective against AMR are also proposed in this review.

Smart Nanodevices for Point-of-Care Applications

2021 ◽  
Vol 17 ◽  
Author(s):  
Rajasekhar Chokkareddy ◽  
Suvardhan Kanchi ◽  
Inamuddin
Keyword(s):  
Chronic Diseases ◽  
Patient Monitoring ◽  
State Of The Art ◽  
Point Of Care ◽  
Low Cost ◽  
Medical Diagnostics ◽  
Diagnostic Tools ◽  
Current State ◽  
Rural Patients ◽  
Diagnosis Of Diseases

Background: While significant strides have been made to avoid mortality during the treatment of chronic diseases, it is still one of the biggest health-care challenges that have a profound effect on humanity. The development of specific, sensitive, accurate, quick, low-cost, and easy-to-use diagnostic tools is therefore still in urgent demand. Nanodiagnostics is defined as the application of nanotechnology to medical diagnostics that can offer many unique opportunities for more successful and efficient diagnosis and treatment for infectious diseases. Methods: In this review we provide an overview of infectious disease using nanodiagnostics platforms based on nanoparticles, nanodevices for point-of-care (POC) applications. Results: Current state-of-the-art and most promising nanodiagnostics POC technologies, including miniaturized diagnostic tools, nanorobotics and drug delivery systems have been fully examined for the diagnosis of diseases. It also addresses the drawbacks, problems and potential developments of nanodiagnostics in POC applications for chronic diseases. Conclusions: While progress is gaining momentum in this field and many researchers have dedicated their time in developing new smart nanodevices for POC applications for various chronic diseases, the ultimate aim of achieving longterm, reliable and continuous patient monitoring has not yet been achieved. Moreover, the applicability of the manufactured nanodevices to rural patients for on-site diagnosis, cost, and usability are the crucial aspects that require more research, improvements, and potential testing stations. Therefore, more research is needed to develop the demonstrated smart nanodevices and upgrade their applicability to hospitals away from the laboratories.

Probabilistic Evaluation of SMS Messages as Forensic Evidence

2013 ◽  
pp. 138-149
Author(s):  
Shunichi Ishihara
Keyword(s):  
Likelihood Ratio ◽  
Low Cost ◽  
Scientific Evidence ◽  
Short Message ◽  
Likelihood Ratios ◽  
Forensic Evidence ◽  
Probabilistic Evaluation ◽  
Popular Medium ◽  
Log Likelihood ◽  
Message Service

This study is one of the first likelihood ratio-based forensic text comparison studies in forensic authorship analysis. The likelihood-ratio-based evaluation of scientific evidence has started being adopted in many disciplines of forensic evidence comparison sciences, such as DNA, handwriting, fingerprints, footwear, voice recording, etc., and it is largely accepted that this is the way to ensure the maximum accountability and transparency of the process. Due to its convenience and low cost, short message service (SMS) has been a very popular medium of communication for quite some time. Unfortunately, however, SMS messages are sometimes used for reprehensible purposes, e.g., communication between drug dealers and buyers, or in illicit acts such as extortion, fraud, scams, hoaxes, and false reports of terrorist threats. In this study, the author performs a likelihood-ratio-based forensic text comparison of SMS messages focusing on lexical features. The likelihood ratios (LRs) are calculated in Aitken and Lucy’s (2004) multivariate kernel density procedure, and are calibrated. The validity of the system is assessed based on the magnitude of the LRs using the log-likelihood-ratio cost (Cllr). The strength of the derived LRs is graphically presented in Tippett plots. The results of the current study are compared with those of previous studies.

In Inflamation Dietary Inflammatory Index and the Role of Different Diet Types

2020 ◽  
pp. 169-201
Author(s):  
Ramazan Mert Atan ◽  
Uğur Günşen
Keyword(s):  
Chronic Diseases ◽  
Inflammatory Cytokines ◽  
Scientific Evidence ◽  
Inflammatory Biomarkers ◽  
Dietary Inflammatory Index ◽  
Food Groups ◽  
Negative Effects ◽  
Inflammatory Index ◽  
Anti Inflammatory

Inflammation usually occurs as a result of imbalances between pro-inflammatory and anti-inflammatory cytokines. Diet is one of the factors that play a role in their development and prevent them from developing. Therefore, it is important to determine the pro- and anti-inflammatory properties of foods. Diet is an important and modifiable determinant of chronic diseases. There is a lot of scientific evidence to support the fact that foods consumed have positive and negative effects on individuals' health. In addition to being effective whole of diet, it is seen that the food groups contained in the diet affect the inflammatory biomarkers separately. This section provides information about dietary inflammatory index (DII) and diets that are effective on inflammation.

scholarly journals Viral miRNAs as Active Players and Participants in Tumorigenesis

Cancers ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 358 ◽  
Author(s):  
Alessia Gallo ◽  
Vitale Miceli ◽  
Matteo Bulati ◽  
Gioacchin Iannolo ◽  
Flavia Contino ◽  
...  
Keyword(s):  
Viral Infections ◽  
Human Cancer ◽  
Scientific Evidence ◽  
Adaptive Immune System ◽  
Viral Gene Expression ◽  
Viral Gene ◽  
Cellular Mirnas ◽  
Viral Mirnas ◽  
Human Cancers ◽  
Cellular Pathways

The theory that viruses play a role in human cancers is now supported by scientific evidence. In fact, around 12% of human cancers, a leading cause of morbidity and mortality in some regions, are attributed to viral infections. However, the molecular mechanism remains complex to decipher. In recent decades, the uncovering of cellular miRNAs, with their invaluable potential as diagnostic and prognostic biomarkers, has increased the number of studies being conducted regarding human cancer diagnosis. Viruses develop clever mechanisms to succeed in the maintenance of the viral life cycle, and some viruses, especially herpesviruses, encode for miRNA, v-miRNAs. Through this viral miRNA, the viruses are able to manipulate cellular and viral gene expression, driving carcinogenesis and escaping the host innate or adaptive immune system. In this review, we have discussed the main viral miRNAs and virally influenced cellular pathways, and their capability to drive carcinogenesis.

scholarly journals Microbiological Properties of Beejamrit, an Ancient Indian Traditional Knowledge, Uncover a Dynamic Plant-Beneficial Microbial Network

2021 ◽  
Author(s):  
Shibasis Mukherjee ◽  
Suchana Sain ◽  
Md Nasim Ali ◽  
Rupak Goswami ◽  
N Ravisankar ◽  
...  
Keyword(s):  
Plant Growth ◽  
Seed Treatment ◽  
Low Cost ◽  
Scientific Evidence ◽  
Foliar Spray ◽  
Plant Growth Promoting Rhizobacteria ◽  
Cow Dung ◽  
Beneficial Bacteria ◽  
Traditional Practice ◽  
Microbiological Properties

Abstract Beejamrit is an ancient organic formulation commonly used as a seed treatment in organic and natural farming in India. This low-cost input is primarily composed of cow dung, cow urine, and forest soil, which is often supplemented with limestone. In organic agriculture, it is a traditional practice among the farming community to incubate the seeds in Beejamrit prepared overnight before sowing in the field. However, a lack of substantial scientific evidence has been a major limitation to promote this farmers' innovative practice. On the other hand, growing data suggests that cow-based formulations are mostly enriched with microbial sources, including several plant growth-promoting rhizobacteria that are capable of synthesizing plant growth regulators. However, the microbiological properties of Beejamrit and their temporal changes over different periods of decomposition are largely unexplored. In this study, we aim to analyze the decomposition rate of Beejamrit over 7-consecutive days of incubation. This study further elucidates the microbial niche and their dynamics in Beejamrit, including the plant-beneficial bacteria. It was observed that the population of plant-beneficial bacteria such as the free-living nitrogen fixers and the phosphate solubilizers proliferates progressively up to 4-days of incubation. Similarly, the indolic compounds, including indole acetic acid, were enriched to the highest concentration in Beejamrit after 4-days of decomposition. Together, our analyses establish that Beejamrit provides a dynamic, microbe-based metabolic network and acts as a plant growth regulator. In conclusion, this study recommends the Beejamrit preparation after 4-days of incubation in the seed treatment and foliar spray to receive its optimum benefits.

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