scholarly journals C-myc amplification in precancerous lesions of oral cavity and larynx

2003 ◽  
Vol 50 (3) ◽  
pp. 117-119 ◽  
Author(s):  
Tanja Ninkovic ◽  
Nasta Dedovic ◽  
Rade Kosanovic ◽  
Bogomir Dimitrijevic ◽  
Obrad Josipovic ◽  
...  
Keyword(s):  
Malignant Transformation ◽  
Precancerous Lesions ◽  
Premalignant Lesions ◽  
Pathological Changes ◽  
Neck Tumors ◽  
The Status ◽  
Probable Role ◽  
Transformation Potential ◽  
Chronic Laryngitis

Although myc genes are an important family of oncogenes involved in human carcinogenesis, data concerning its role in head and neck tumors are quite limited. Moreover, information regarding precancerous lesions is almost inexisting. In order to better understand mechanisms of progression of premalignant lesions into malignant and the possible role of c-myc amplification, the status of this oncogene was analyzed in two types of pathological changes known to possess malignant transformation potential oral leukoplakia and chronic laryngitis. In the first type of lesions a high percentage of c-myc activation (33%) was observed pointing to a probable role of myc in leukoplakia malignant transformation, while in the other type of lesion there were no signs of myc amplification.

scholarly journals An Update on Precancerous Lesions of Oral Cavity

2018 ◽  
Vol 2 (1) ◽  
pp. 70 ◽  
Author(s):  
Deepak Goyal ◽  
Pardeep Goyal ◽  
Harkanwal Preet Singh ◽  
Chanchal Verma
Keyword(s):  
Head And Neck Cancer ◽  
Survival Rate ◽  
High Risk ◽  
Oral Cancer ◽  
Malignant Transformation ◽  
Death Rate ◽  
Precancerous Lesions ◽  
Correct Diagnosis ◽  
Premalignant Lesions ◽  
Timely Treatment

Oral cancer is the most common head and neck cancer, found in 270,000 patients annually worldwide. Some cancers develop from precancerous lesions; however, there is no definitive clinico pathological factor or biomarker that reliably enables malignant transformation to be predicted in an individual patient. Early detection and early treatment of oral cancer are important for improving the survival rate of patients; prevention of oral cancer will clearly contribute most to decreasing its death rate. So correct diagnosis and timely treatment of premalignant lesions with high risk of malignant transformation may help to prevent malignant transformation.

scholarly journals Role of p53 and Ki-67 immunomarkers in oral premalignant lesions and squamous cell carcinoma: a hospital based study in BPKIHS

2018 ◽  
Vol 8 (2) ◽  
pp. 1330-1336 ◽  
Author(s):  
Mona Dahal ◽  
Smriti Karki ◽  
Paricha Upadhyaya ◽  
Shyam Thapa Chettri ◽  
Mehul Rajesh Jaisani
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Malignant Transformation ◽  
Squamous Cell ◽  
Labelling Index ◽  
Premalignant Lesion ◽  
Premalignant Lesions ◽  
Ki 67

Background: As most of the oral squamous cell carcinoma develop from precursor premalignant lesions, it would be helpful if the malignant transformation is detected early in premalignant state. The objective of the research was to study the role of immunohistochemical expression of p53 and Ki-67 in oral premalignant lesion and squamous cell carcinoma.Materials and Methods: The expression of immunomarkers p53 and Ki67 were studied on formalin fixed paraffin embedded tissue sections from human oral squamous mucosal lesion for duration of 1 year. Results: Of total 36 cases, 80% cases of keratosis without dysplasia showed basal pattern of p53 staining while 47.1% cases of squamous cell carcinoma showed p53 staining in all layers of epithelium. The median p53 Labelling Index of squamous cell carcinoma was more than those of keratosis with and without dysplasia though the result was statistically non-significant. 50.0% cases of keratosis without dysplasia and 83.3% cases of keratosis with dysplasia displayed Ki-67 immunostaining confined to basal and suprabasal layer whereas 94.1% cases of squamous cell carcinoma showed Ki-67 positivity in all layers of epithelium. Median Ki-67 Labelling Index increased from keratosis without dysplasia to keratosis with dysplasia to squamous cell carcinoma, difference being statistically significant. A positive and insignificant correlation was observed between p53 and Ki-67 Labelling Index.Conclusion: Increased expressions of Ki-67 and p53 in oral squamous cell carcinoma compared to premalignant lesion suggest that they may be useful indicator of malignant transformation in dysplastic lesion.

The study of interfacial reactions of nickel thin films on GaAs

1983 ◽  
Vol 41 ◽  
pp. 156-157
Author(s):  
L.J. Chen ◽  
Y.F. Hsieh
Keyword(s):  
Thin Films ◽  
Integrated Circuits ◽  
Interfacial Reactions ◽  
Metal Contacts ◽  
Nickel Thin Films ◽  
Thin Foils ◽  
The Status ◽  
Si Doped ◽  
Electron Microscopes

One measure of the maturity of a device technology is the ease and reliability of applying contact metallurgy. Compared to metal contact of silicon, the status of GaAs metallization is still at its primitive stage. With the advent of GaAs MESFET and integrated circuits, very stringent requirements were placed on their metal contacts. During the past few years, extensive researches have been conducted in the area of Au-Ge-Ni in order to lower contact resistances and improve uniformity. In this paper, we report the results of TEM study of interfacial reactions between Ni and GaAs as part of the attempt to understand the role of nickel in Au-Ge-Ni contact of GaAs.N-type, Si-doped, (001) oriented GaAs wafers, 15 mil in thickness, were grown by gradient-freeze method. Nickel thin films, 300Å in thickness, were e-gun deposited on GaAs wafers. The samples were then annealed in dry N2 in a 3-zone diffusion furnace at temperatures 200°C - 600°C for 5-180 minutes. Thin foils for TEM examinations were prepared by chemical polishing from the GaA.s side. TEM investigations were performed with JE0L- 100B and JE0L-200CX electron microscopes.

Strategic Role of Zakat in Multidimensional Quality of Life in Sijunjung, Indonesia

2018 ◽  
Vol 15 (1) ◽  
pp. 55-72
Author(s):  
Herlin Hamimi ◽  
Abdul Ghafar Ismail ◽  
Muhammad Hasbi Zaenal
Keyword(s):  
Quality Of Life ◽  
Positive Impact ◽  
Wealth Distribution ◽  
Absolute Poverty ◽  
Before And After ◽  
The Status ◽  
Being There ◽  
The Impact

Zakat is one of the five pillars of Islam which has a function of faith, social and economic functions. Muslims who can pay zakat are required to give at least 2.5 per cent of their wealth. The problem of poverty prevalent in disadvantaged regions because of the difficulty of access to information and communication led to a gap that is so high in wealth and resources. The instrument of zakat provides a paradigm in the achievement of equitable wealth distribution and healthy circulation. Zakat potentially offers a better life and improves the quality of human being. There is a human quality improvement not only in economic terms but also in spiritual terms such as improving religiousity. This study aims to examine the role of zakat to alleviate humanitarian issues in disadvantaged regions such as Sijunjung, one of zakat beneficiaries and impoverished areas in Indonesia. The researcher attempted a Cibest method to capture the impact of zakat beneficiaries before and after becoming a member of Zakat Community Development (ZCD) Program in material and spiritual value. The overall analysis shows that zakat has a positive impact on disadvantaged regions development and enhance the quality of life of the community. There is an improvement in the average of mustahik household incomes after becoming a member of ZCD Program. Cibest model demonstrates that material, spiritual, and absolute poverty index decreased by 10, 5, and 6 per cent. Meanwhile, the welfare index is increased by 21 per cent. These findings have significant implications for developing the quality of life in disadvantaged regions in Sijunjung. Therefore, zakat is one of the instruments to change the status of disadvantaged areas to be equivalent to other areas.

The Kenya National Commission on Human Rights under the 2010 Constitutional Dispensation

2018 ◽  
Vol 26 (2) ◽  
pp. 205-226
Author(s):  
Bonolo Ramadi Dinokopila ◽  
Rhoda Igweta Murangiri
Keyword(s):  
Human Rights ◽  
Transitional Justice ◽  
National Commission ◽  
Bill Of Rights ◽  
Institutional Perspective ◽  
Post Conflict ◽  
National Human ◽  
The Status ◽  
Protection Of Human Rights

This article examines the transformation of the Kenya National Commission on Human Rights (KNCHR) and discusses the implications of such transformation on the promotion and protection of human rights in Kenya. The article is an exposition of the powers of the Commission and their importance to the realisation of the Bill of Rights under the 2010 Kenyan Constitution. This is done from a normative and institutional perspective with particular emphasis on the extent to which the UN Principles Relating to the Status of National Institutions for the promotion and protection of human rights (the Paris Principles, 1993) have been complied with. The article highlights the role of national human rights commissions in transformative and/or transitional justice in post-conflict Kenya. It also explores the possible complementary relationship(s) between the KNCHR and other Article 59 Commissions for the better enforcement of the bill of rights.

Moderating Role of Gender in the Relationship between Cognitive Errors and Anxiety among Adolescents

2020 ◽  
Vol 4 (1) ◽  
pp. 86-102
Author(s):  
Tasnim Rehna ◽  
Rubina Hanif ◽  
Muhammad Aqeel
Keyword(s):  
Mental Health Problems ◽  
Adolescent Psychopathology ◽  
Future Research ◽  
Cognitive Errors ◽  
Adolescent Anxiety ◽  
Study Results ◽  
The Status ◽  
Manifest Anxiety ◽  
The Relationship

Background: Widespread social paradigms on which the status variances are grounded in any society, gender plays pivotal role in manifestation of mental health problems (Rutter, 2007). A hefty volume of research has addressed the issue in adults nonetheless, little is vividly known about the role of gender in adolescent psychopathology. Sample: A sample of 240 adolescents (125 boys, 115 girls) aging 12-18 years was amassed from various secondary schools of Islamabad with the approval of the Federal Directorate of Education (FDE), relevant authorities of the schools and the adolescents themselves. Instruments: Taylor Manifest Anxiety Scale (Taylor & Spence, 1953) and Children’s Negative Cognitive Errors Questionnaire (CNCEQ) by Leitenberg et al., (1986) were applied in present study. Results: Multiple regression analysis revealed that cognitive errors jointly accounted for 78% of variance in predicting anxiety among adolescents. Findings also exhibited that gender significantly moderated the relationship between cognitive errors and adolescent anxiety. Implications of the findings are discoursed for future research and clinical practice.

A Probable Role of Eosinophilia, IgE and Complement in Bullous Pemphigoid Patients

1975 ◽  
Vol 37 (4) ◽  
pp. 532-540 ◽  
Author(s):  
Zenro IKEZAWA ◽  
Yo KAMEDA ◽  
Mitsuaki UCHIYAMA ◽  
Hiroshi NAKAJIMA ◽  
Toru BABA
Keyword(s):  
Bullous Pemphigoid ◽  
Probable Role

FUNCTIONAL AND SEMANTIC CHARACTERS OF AN ADDRESS IN UKRAINIAN AND FRENCH

2019 ◽  
Vol 18 (28) ◽  
pp. 129-138 ◽  
Author(s):  
Tetiana Korolova ◽  
Nadiia Demianova
Keyword(s):  
Field Model ◽  
Semantic Field ◽  
The Status ◽  
Semantically Heterogeneous

The vocative function of an address being the basic one is supplemented and modified by a number of other functions actualized in communication, i.e. the phatic one (establishing and developing the contact with the addressee), the status one (reflecting the status responsibility of the communicants), the emotional and attitudinal one (characterizing the addressee and the attitude of the speaker towards the uttered information). Such modification explains the polyfunctional character of the address in communication. All units of address, just like the components of the addressing functional field, are polysemantic and polysemy comprises every type of an address. According to the communicative tasks the following functions can be stated within the vocative one: nominative (naming the addressee), deixis (identifying the addressee), vocative proper (attracting the addressee’s attention). The field model of addresses’ semantic structures allows to research standard and nonstandard vocatives. The standard addresses form the nucleus of the semantic field under research and characterize stability of their application in one of the above-mentioned functions. Nonstandard vocative lexemes (1 % of the total amount of the experimental material) can play the role of an address under certain circumstances. They form semantically heterogeneous (conditioned by a situation) group, located in the periphery area of the semantic field of addresses. The addresses that include anthroponyms form the most widely used group (64,5 % in Ukrainian and 68,1 % in French), the second place belongs to the addresses with appellatives (34,6 % and 29,9 %, correspondingly). As to the composition of appellatives in the status and role addresses they comprise 36,4 % in Ukrainian and 34,9 % in French. Attitudinal addresses reach 63 % and 65,1 %, correspondingly.

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