Effects of calcitonin and calcium medication in treatment of edentulous osteoporotic mandible

Background/Aim. In addition to damage of the bones that support the remaining teeth, degradation of osteoporotic oral bones also lead to a consequent reduction of supporting tissues and the loss of dentures retention. The aim of this study was to assess the clinical and radiographic outcomes following injection of a calcitonin and calcium solution into the buccal aspects of edentulous mandibles. Methods. The experimental group of 67 edentulous patients diagnosed with osteoporosis, and the control group of 19 nonosteoporotic edentulous patients were treated with the calcitonin and calcium once solution per month. Mandibular bone density was measured from panoramic radiographs, supplemented by T scores of skeletal density in the experimental group. Results. After the therapy, measurements showed moderate increases in bone density, compensating for up to 4% of the total loss of minerals and solidity of denture-bearing areas of osteoporotic mandibles. Osteoporosis affected women earlier than men in this study. Conclusion. Application of a calcitonin and calcium solution is a suitable method of preprosthetic therapy for edentulous osteoporotic patients.

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The evaluation of mandibular bone density in chronic periodontitis models

Dental Journal (Majalah Kedokteran Gigi) ◽

10.20473/j.djmkg.v51.i4.p210-215 ◽

2018 ◽

Vol 51 (4) ◽

pp. 210

Author(s):

Yuliana Mahdiyah Da’at Arina ◽

F. Ferdiansyah ◽

Mohamad Rubianto

Keyword(s):

Bone Density ◽

Chronic Periodontitis ◽

Orthodontic Treatment ◽

Radiographic Examination ◽

Control Group ◽

Mineral Density ◽

Control Groups ◽

Mandibular Bone ◽

Male Wistar Rats ◽

Group Members

Background: Bone density, an important factor in functional bone quality, can affect the success of implant osteointegration or orthodontic treatment. A number of studies report that chonic periodontitis constitutes one risk factor of osteoporosis characterized by low bone mineral density and that the mandible is susceptible to osteoporosis. Purpose: The purpose of this study was to evaluate mandibular bone density in animal subjects suffering from chronic periodontitis. Methods: 40 male Wistar rats were divided into four chronic periodontitis groups and four control groups (each group n=5). As chronic periodontitis models, the subjects were injected with 2×109 CFU/ml of Porphyromonas gingivalis in the sulcular gingiva, whereas control group members were injected with normal saline. After 2, 3, 4 and 6-week injection periods, the subjects were sacrificed and radiographic examination of the mandibular bone subsequently performed. Mandibular bone density was evaluated by histometric analysis. Results: The mandibular bone density in members of the chronic periodontitis group was significantly lower than those of the control group (p<0.05). The reduced mandibular bone density in the chronic periodontitis group was in line with the protracted bouts of periodontitis. Conclusion: Reduced mandibular bone density was found in the chronic periodontitis model. The longer the duration of a bout of chronic periodontitis, the greater the reduction in mandibular bone density.

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Human Umbilical Cord Mesenchymal Stem-Cell Therapy to Increase the Density of Osteoporotic Mandibular Bone

European Journal of Dentistry ◽

10.1055/s-0039-1688527 ◽

2019 ◽

Vol 13 (01) ◽

pp. 058-063

Author(s):

Nike Hendrijantini ◽

Poedjo Hartono ◽

Muhammad Dimas Aditya Ari ◽

Fedik Abdul Rantan

Keyword(s):

Stem Cell ◽

Bone Density ◽

Mesenchymal Stem Cell ◽

Trabecular Bone ◽

Control Group ◽

Human Umbilical Cord ◽

Bone Area ◽

Mandibular Bone ◽

Trabecular Bone Area

Abstract Objective The aim of this study is to evaluate the feasibility of human umbilical cord mesenchymal stem-cell (hUCMSC) therapy in increasing osteoporotic mandibular bone density in a rat model by determining changes in alkaline phosphatase (ALP), osteocalcin, type 1 collagen, and trabecular bone area after treatment. Materials and Methods This research adopted an experimental posttest-only control group design. Thirty female Wistar rats were randomly divided into six groups, namely, a control group with rats postsham surgery (T1), osteoporotic model postovariectomy rats (T2), postovariectomy rats 4 weeks after gelatin injection (T3), postovariectomy rats 8 weeks after gelatin injection (T4), postovariectomy rats 4 weeks after hUCMSC injection (T5), and postovariectomy rats 8 weeks after hUCMSC injection (T6). The rats were all sacrificed for histological and immunohistochemical examinations of ALP, osteocalcin, type 1 collagen, and trabecular bone area. Results Increased expression of ALP, type 1 collagen, and osteocalcin, as well as increased trabecular bone area, was observed in the treatment groups compared with that in the osteoporotic groups. Conclusion hUCMSCs produce significant osteogenic effects and increase osteoporotic mandibular bone density in the animal model. Increases in bone density are demonstrated by the higher levels of ALP, osteocalcin, and type 1 collagen, as well as increases in the trabecular bone area.

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Histological and Radiological Evaluation of Low-Intensity Pulsed Ultrasound Versus Whole Body Vibration on Healing of Mandibular Bone Defects in Rats

Medicina ◽

10.3390/medicina56090457 ◽

2020 ◽

Vol 56 (9) ◽

pp. 457

Author(s):

Milad Etemadi Sh ◽

Nan-Chen Hsieh ◽

Seyed Shahin Movahed Mohammadi ◽

Shahrooz Momeni ◽

Seyed Mohammad Razavi ◽

...

Keyword(s):

Bone Density ◽

Whole Body Vibration ◽

Bone Defects ◽

Whole Body ◽

Control Group ◽

Pulsed Ultrasound ◽

Mandibular Bone ◽

Body Vibration ◽

Low Intensity Pulsed Ultrasound ◽

Low Intensity

Background and Objectives: Mechanical stimulation can improve the structural properties of the fracture site and induce the differentiation of different cell types for bone regeneration. This study aimed to compare the effect of low-intensity pulsed ultrasound stimulation (LIPUS) versus whole body vibration (WBV) on healing of mandibular bone defects. Materials and Methods: A mandibular defect was created in 66 rats. The rats were randomly divided into two groups of rats. Each group was subdivided randomly by three groups (n = 11) as follows: (I) control group, (II) treatment with LIPUS, and (III) treatment with WBV. The radiographic changes in bone density, the ratio of lamellar bone to the entire bone volume, the ratio of the newly formed bone to the connective tissue and inflammation grade were evaluated after 1 and 2 months. Results: LIPUS significantly increased the radiographic bone density change compared to the control group at the first and second month postoperatively (p < 0.01). WBV only significantly increased the bone density compared to the control group at the second month after the surgery (p < 0.01). Conclusions: Application of LIPUS and WBV may enhance the regeneration of mandibular bone defects in rats. Although LIPUS and WBV are effective in mandibular bone healing, the effects of LIPUS are faster and greater than WBV.

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Comparison of vertical dimension of occlusion on edentulous and dentulous patients

Stomatoloski glasnik Srbije ◽

10.2298/sgs0401007s ◽

2004 ◽

Vol 51 (1) ◽

pp. 7-11

Author(s):

Ljiljana Strajnic

Keyword(s):

Vertical Dimension ◽

Class I ◽

Control Group ◽

Cephalometric Analysis ◽

Complete Dentures ◽

Skeletal Class ◽

Clinical Methods ◽

Natural Teeth ◽

Edentulous Patients ◽

Experimental Group

One of the existing methods for analysis of the vertical dimension of occlusion or occlusal face height is the cephalometric analysis of the distance from nasion to menton (N-Me). The vertical dimension of occlusion was measured in 30 lateral cephalometric radiographs of edentulous patients (experimental group), with models of complete dentures after clinical methods of determining the vertical and horizontal intermaxillary relation and 30 lateral cephalometric radiographs of participants with natural teeth (control group). The aims of the present study were: to analyse the vertical dimension of occlusion in participants with natural teeth skeletal class I, to cephalometrically evaluate the reconstructing vertical dimension of occlusion of edentulous patients skeletal class I , to compare examined variables between individuals with natural teeth and edentulous patients. The results indicated a remarkable correlation in the vertical dimension of occlusion established initially for the edentulous patients when compared with the measurements made for dentulous patients. The results showed the vertical dimension of occlusion span a range between 106,7 - 138 mm (X _ =122,24) in subjects with natural teeth. In edentulous patients the values of vertical dimension of occlusion span ranged between 109,8 - 141,6 mm (X _ =122,46). The vertical dimension of occlusion in male participans was increased in the group of persons with natural teeth as well as in edentulous patients. The results of t-test proved that there were no statistically significant differences in examined variables between persons with natural teeth and edentulous patients (p>0,01).

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Physical Improvement and Biological Maturity of Young Athletes (11-12 Years) with Systematic Training

Folia Medica ◽

10.1515/folmed-2015-0042 ◽

2016 ◽

Vol 57 (3-4) ◽

pp. 223-229

Author(s):

Konstantinos E. Tilkeridis ◽

Evaggelos F. Theodorou ◽

Jannis V. Papathanasiou ◽

Pelagia A. Chloropoulou ◽

Grigorios A. Trypsianis ◽

...

Keyword(s):

Physical Activity ◽

Physical Education ◽

Bone Density ◽

Biological Age ◽

Physical Growth ◽

Control Group ◽

Motor Ability ◽

Systematic Training ◽

Biological Maturity ◽

Experimental Group

AbstractAIM: The aim of this study was to investigate the infl uence of systematic training in physical growth and biological maturity in prepubertal males and estimate how this affects the physical growth and skeletal maturity. MATERIALS AND METHODS: 177 primary school students of the fifth and sixth grade, from schools in Alexandroupolis, participated voluntarily in our study. Questionnaires were used in order to measure physical activity levels. The subjects were subdivided into two groups; control group (prepubertal, whose physical activity was the physical education of their school and which had never participated in systematic training, n = 95) and experimental group (prepubertal, whose weekly physical activity included physical education in their schools and additionally 3-4 training units organized training in various sports clubs in the city, n = 82). The following parameters were recorded: biological age measured by determination of skeletal age; bone density measured by ultrasound methods; anthropometric and morphological features such as height, body composition, selected diameters, circumferences and skinfolds; motor ability features. RESULTS: The experimental group exhibited older biological age (p = 0.033), higher bone density (p < 0.001), lower BMI and body fat (p < 0.001), better anthropometric features and higher performance throughout all motor ability tests (p < 0.05), compared to the control group. CONCLUSION: The present study demonstrates that systematic physical activity has a positive effect on both the physical and biological maturity of pre-pubertal children. This effect is mainly expressed in bone strengthening as a result of the increased bone density and in improvement of the kinetic skills of pupils who participated in organized extracurricular sport-activities.

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Effects of removable dental prostheses on mandibular bone density in postmenopausal osteoporotic patients

International Dental Research ◽

10.5577/intdentres.2021.vol11.suppl1.29 ◽

2021 ◽

Vol 11 (Suppl. 1) ◽

pp. 206-209

Author(s):

Sinan Ateş ◽

Belgin Gülsün

Keyword(s):

Bone Density ◽

Native Speakers ◽

Whole Body ◽

Control Group ◽

Mandibular Bone ◽

Dental Prostheses ◽

Removable Dental Prostheses ◽

Group A ◽

Native Speakers Of English ◽

Significant Change

Aim: To investigate the effects of removable dental prostheses on mandibular bone density in postmenopausal osteoporotic patients. Methodology: The prospective study included 30 female patients aged 45–70 years who had been previously diagnosed with postmenopausal osteoporosis. The patients had no diseases affecting bone metabolism. The patients were divided into two groups: (i) patients who were using removable dental prostheses (n=15) and (ii) patients who were not using removable dental prostheses (n=15) (the control group). A whole-body dual energy x-ray absorptiometry (DXA) scan was performed to calculate the mandibular bone densities of the patients. Results: The use of removable mandibular prostheses did not cause a significant change in mandibular bone density. Conclusion: The fact that removable mandibular prostheses did not cause a significant change in mandibular bone density could be because the patients started using the removable prostheses long after they lost their teeth. How to cite this article: Akın Tartuk G, Kaya S. The effect of different final irrigation solutions on apical impermeability. Int Dent Res 2021;11(Suppl.1):201-5. https://doi.org/10.5577/intdentres.2021.vol11.suppl1.28 Linguistic Revision: The English in this manuscript has been checked by at least two professional editors, both native speakers of English.

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Efek konsumsi kopi arabika berlebih selama masa laktasi terhadap densitas tulang mandibula anak tikus WistarThe effect of excessive Arabica coffee consumption during lactation on the mandibular bone density of Wistar rats offspring

Jurnal Kedokteran Gigi Universitas Padjadjaran ◽

10.24198/jkg.v32i3.27480 ◽

2020 ◽

Vol 32 (3) ◽

pp. 170

Author(s):

Shabrina Widya Ardiningrum ◽

Amandia Dewi Permana Shita ◽

Dwi Kartika Apriyono

Keyword(s):

Bone Density ◽

Wistar Rats ◽

Coffee Consumption ◽

Control Group ◽

Lactation Period ◽

Mandibular Bone ◽

Arabica Coffee ◽

Significant Difference ◽

Female Wistar Rats ◽

One Way Anova

Pendahuluan: Laktasi merupakan periode penting dalam pertumbuhan dan perkembangan bayi. Salah satu faktor risiko yang menyebabkan penurunan densitas tulang mandibula adalah konsumsi kopi berlebih selama masa laktasi. Penelitian ini bertujuan untuk menganalisis pengaruh konsumsi kopi Arabika selama masa laktasi terhadap densitas tulang mandibula anak tikus Wistar. Metode: Penelitian eksperimental laboratoris dilakukan terhadap 12 ekor tikus Wistar betina yang sedang menyusui. Penghitungan besar sampel berdasarkan jumlah kelompok penelitian (tiga kelompok), yaitu dengan rumus Arifin, dan didapatkan hasil empat ekor tikus untuk setiap kelompok penelitian, sehingga total jumlah sampel adalah 12 ekor tikus. Tiga kelompok penelitian terdiri dari kelompok kontrol (K) yang diberi akuades, kelompok perlakuan yang diberi kopi dosis normal (P1), dan kelompok perlakuan yang diberi kopi dosis berlebih (P2). Akuades dan kopi diberikan selama 21 hari sejak tikus mulai menyusui anaknya. Masing-masing induk tikus diambil satu anaknya untuk di-euthanasia pada hari ke-22. Kemudian dilakukan pengambilan sampel tulang mandibula dan dilakukan pengambilan rontgen foto periapikal. Selanjutnya dilakukan pengukuran densitas tulang mandibula menggunakan densitometer. Data dianalisis menggunakan uji one-way ANOVA dan LSD. Hasil: Hasil dari uji one-way ANOVA dari densitas tulang mandibula anak tikus menunjukkan bahwa terdapat perbedaan signifikan (p=0,0001) diantara seluruh kelompok penelitian. Hasil uji LSD menunjukkan perbedaan yang signifikan (p=0,0001) antara kelompok kontrol dengan kelompok yang diberi kopi dosis normal maupun dengan kelompok kopi dosis berlebih, demikian juga antara kelompok yang diberi dosis normal dengan dosis berlebih. Simpulan: Konsumsi kopi Arabika dalam dosis berlebih selama masa laktasi pada tikus Wistar dapat menurunkan densitas tulang mandibula anak tikus Wistar. Kata kunci: Laktasi, kopi arabika, densitas tulang mandibula. ABSTRACTIntroduction: Lactation is an important period in the growth and development. One of the risk factors that cause a decrease in mandibular bone density is excessive coffee consumption during lactation. This study was aimed to analyse the effect of coffee consumption, especially Arabica coffee, during lactation period on the rats’ mandibular bone density. Methods: This study was an experimental laboratory study of 12 lactating female Wistar rats. The sample size calculation was based on the number of research groups (three groups), the Arifin formula, and the results were four rats for each research group, so the total number of samples was 12 rats. The three research groups consisted of control group (K) which was given aquadest, treatment group that was given a normal dose of coffee (P1), and a treatment group that was given an excessive dose of coffee (P2). Aquadest and coffee were given for 21 days since the initial lactation period. One offspring of each female rat was taken to be euthanised on the 22nd day. Afterwards, the mandibular bone samples were taken from the young rats, and then the periapical x-rays was performed. Furthermore, the mandibular bone density measurement was carried out using a densitometer. Data was analysed using the one-way ANOVA and LSD tests. Results: The one-way ANOVA test of the mandibular bone density of the rats’ offspring showed a significant difference (p = 0.0001) between all study groups. The LSD test results showed a significant difference (p = 0.0001) between the control group and the group was given the normal dose of coffee and the group with an excessive dose of coffee and between the group that was given the normal and the excessive dose. Conclusion: Consumption of Arabica coffee in excessive dose during lactation of female Wistar rats can reduce the mandibular bone density of the offspring.Keywords: Lactation, arabica coffee, mandibular bone density.

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Remodeling of the Mandibular Bone Induced by Overdentures Supported by Different Numbers of Implants

Journal of Biomechanical Engineering ◽

10.1115/1.4032937 ◽

2016 ◽

Vol 138 (5) ◽

Cited By ~ 2

Author(s):

Kai Li ◽

Haitao Xin ◽

Yanfang Zhao ◽

Zhiyuan Zhang ◽

Yulu Wu

Keyword(s):

Bone Density ◽

Bone Remodeling ◽

Strain Energy Density ◽

Strain Energy ◽

Neck Region ◽

Mandibular Bone ◽

Occlusal Force ◽

User Material Subroutine ◽

Edentulous Patients ◽

Almost All

The objective of this study was to investigate the process of mandibular bone remodeling induced by implant-supported overdentures. computed tomography (CT) images were collected from edentulous patients to reconstruct the geometry of the mandibular bone and overdentures supported by implants. Based on the theory of strain energy density (SED), bone remodeling models were established using the user material subroutine (UMAT) in abaqus. The stress distribution in the mandible and bone density change was investigated to determine the effect of implant number on the remodeling of the mandibular bone. The results indicated that the areas where high Mises stress values were observed were mainly situated around the implants. The stress was concentrated in the distal neck region of the distal-most implants. With an increased number of implants, the biting force applied on the dentures was almost all taken up by implants. The stress and bone density in peri-implant bone increased. When the stress reached the threshold of remodeling, the bone density began to decrease. In the posterior mandible area, the stress was well distributed but increased with decreased implant numbers. Changes in bone density were not observed in this area. The computational results were consistent with the clinical data. The results demonstrate that the risk of bone resorption around the distal-most implants increases with increased numbers of implants and that the occlusal force applied to overdentures should be adjusted to be distributed more in the distal areas of the mandible.

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A risk of developing osteopenia in children undergoing preventive treatment for tuberculosis infection

Voprosy detskoj dietologii ◽

10.20953/1727-5784-2021-1-11-15 ◽

2021 ◽

Vol 19 (1) ◽

pp. 11-15

Author(s):

N.Yu. Krutikova ◽

◽

A.V. Teshchenkov ◽

A.V. Krikova ◽

T.G. Avdeeva ◽

...

Keyword(s):

Bone Density ◽

Bone Strength ◽

Comparison Group ◽

Latent Tuberculosis ◽

Preventive Treatment ◽

Tuberculosis Infection ◽

Control Group ◽

Experimental Group ◽

Tubular Bones

Objective. To study bone strength in children with latent tuberculosis infection who receive anti-tuberculosis drugs. Patients and methods. A quantitative ultrasound examination of the strength of the tubular bones of the upper and lower extremities was conducted in 120 children with mycobacteria tuberculosis infection (experimentak group). У 73 children who received preventive treatment with anti-tuberculosis drugs (isoniazid, pyrazinamide) bone strength examination was repeated after 6 months (comparison group). The control group comprised 42 children belonging to the 2nd health status group. Results. At the first examination, according to osteodensitometry, children of the experimental group had a decreased bone density in tubular bones as compared to the age-related norms in 34.2% of cases, which had no statistically significant differences with the control group. The children of the comparison group were examined after 6 months, about 60% of children had a decrease of bone density of varied degree, the average Z-score 1.5 ± 0.8, which is significantly lower than in the experimental group. According to the study results, a significant statistical correlation was found between the intake of anti-tuberculosis drugs and bone strength in children with latent tuberculosis χ2 = 10.588, р < 0.012. Conclusion. As was found, a long-term intake of anti-tuberculosis drugs has an effect on bone strength in children. In the outpatient settings, clinical monitoring of bone strength permits to ensure the safety of the administered long-term preventive therapy of tuberculosis. Key words: children, bone strength, tuberculosis, treatment, osteodensitometry, chemoprophylaxis, anti-tuberculosis drugs

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Effect of Dentures on Palatal Rugae: An Investigation

Journal of Forensic Dental Sciences ◽

10.18311/jfds/12/1/2020.5 ◽

2021 ◽

pp. 45-59

Author(s):

Rajesh Akula ◽

H. P. Srinath ◽

Sohani Maroli ◽

Siva Kiran Babu Yarlagadda ◽

D. Uday Kiran Tej ◽

...

Keyword(s):

Dna Analysis ◽

Complete Denture ◽

Control Group ◽

Test Results ◽

Partial Denture ◽

Fixed Partial Denture ◽

Palatal Rugae ◽

Edentulous Patients ◽

Experimental Group ◽

Denture Treatment

Aims: The aim of this study is to evaluate the rugae pattern changes (rugae number, length, shape, direction, and unification) in completely edentulous patients treated with complete denture. Materials and Methods: A total of 100 subjects were selected for the study. The experimental group comprised 60 participants (30 males and 30 females) who had undergone complete denture treatment and the control group comprised 40 participants (20 males and 20 females) who were dentulous and patients with fixed partial denture treatment. Mucostatic maxillary alginate impressions were made for all the subjects, and casts were poured with gypsum. Patients were recalled at the regular intervals of 1, 6, and 18 months after the treatment. During those recalls, the same impression procedure was made, and all the palatal rugaes were observed for number, length, shape, direction, and unifications under magnifying lens. Changes in the palatal rugae were statistically analyzed using the unpaired t‑test. Results: A gradual decrease in the length was observed in primary, secondary, and fragmentary rugae for the experimental group after denture wearing (Group 1). Statistically, the change was significant (P < 0.001) in primary rugae only. A slight change in rugae shape was also observed in the experimental group after 18 months period of denture wearing which is statistically insignificant (P > 0.05). Conclusions: Significant decrease in primary rugae length in complete denture wearers was due to sustained mechanical stress posed by the dentures on palatal rugae. The other parameters such as rugae number, direction, and unification remained constant throughout the study. Palatal rugae analysis may not be helpful for human identification in complete denture wearers. Nevertheless, palatal rugae may serve as an adjuvant to other techniques such as DNA analysis and finger prints in forensic investigations.

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