The roles of fasting blood glucose to HDL-cholesterol ratio and monocyte to HDL-cholesterol ratio on coronary slow flow in non-diabetic patients

Background: The coronary slow-flow phenomenon (CSFP) is a multifactorial angiographic finding with no established pathogenesis. Objective: To investigate the role of clinical profile and laboratory findings in patients with CSFP. Methods: We prospectively recruited 69 patients with angiographically diagnosed CSFP and compared them with 88 patients with normal coronary flow. Demographic information, comorbidities and laboratory analysis, including complete blood count with differential, lipid profile and serum biochemical analysis, were documented and compared in univariate and multivariate analyses. Results: Patients with CSFP were more likely to be male and active smokers. Total cholesterol, triglyceride, hemoglobin and hematocrit, platelet count, mean platelet volume, platelet distribution width and red cell distribution width (RDW) were all higher in patients with CSFP. In multivariate regression analysis, including smoking, total cholesterol, hematocrit, fasting blood glucose and red cell distribution width, except fasting blood glucose, all variables were independently associated with CSFP. Receiver operating characteristic curve analysis revealed a cut-off point of 13.05% for RDW with a sensitivity of 74.6% and a specificity of 77.3% (p<0.001, AUC = 0.802) A cut-off value of 11.35% for PDW had a 89.9% sensitivity and 98.9% specificity for the prediction of CSFP (p<0.001, AUC = 0.970) Conclusion: The changes of circulating blood cell components in patients with CSFP may be indicative of underlying inflammation and endothelial dysfunction that should be investigated in experimental studies.

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Fasting blood glucose to HDL-C ratio as a novel predictor of clinical outcomes in non-diabetic patients after PCI

Bioscience Reports ◽

10.1042/bsr20202797 ◽

2020 ◽

Vol 40 (12) ◽

Author(s):

Qian-Qian Guo ◽

Ying-Ying Zheng ◽

Jun-Nan Tang ◽

Ting-Ting Wu ◽

Xu-Ming Yang ◽

...

Keyword(s):

Blood Glucose ◽

Clinical Outcomes ◽

Cox Regression ◽

Fasting Blood Glucose ◽

Density Lipoprotein ◽

Diabetic Patients ◽

Cardiac Events ◽

Bleeding Events ◽

Cox Regression Analysis ◽

Cholesterol Ratio

Abstract Background The present study was to assess the prognostic value of fasting blood glucose to high-density lipoprotein cholesterol ratio (GHR) in non-diabetic patients with coronary artery disease (CAD) undergoing percutaneous coronary intervention (PCI). Methods and results A total of 6645 non-diabetic patients from two independent cohorts, the CORFCHD-PCI study (n=4282) and the CORFCHD-ZZ (n=2363) study, were enrolled in Clinical Outcomes and Risk Factors of Patients with Coronary Heart Disease after PCI. Patients were divided into two groups according to the GHR value. The primary outcome included all-cause mortality (ACM) and cardiac mortality (CM). The average follow-up time was 36.51 ± 22.50 months. We found that there were significant differences between the two groups in the incidences of ACM (P=0.013) and CM (P=0.038). Multivariate Cox regression analysis revealed GHR as an independent prognostic factor for ACM. The incidence of ACM increased 1.284-times in patients in the higher GHR group (hazard ratio [HR]: 1.284 [95% confidence interval [CI]: 1.010–1.631], P<0.05). Kaplan–Meier survival analysis suggested that patients with high GHR value tended to have an increased accumulated risk of ACM. However, we did not find significant differences in the incidence of major adverse cardiac events, main/major adverse cardiovascular and cerebrovascular events (MACCE), stroke, recurrent myocardial infarction (MI) and bleeding events. Conclusions The present study indicates that GHR index is an independent and novel predictor of ACM in non-diabetic CAD patients who underwent PCI.

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High-fibre and low-fat diets in diabetes mellitus

British Journal Of Nutrition ◽

10.1079/bjn19810034 ◽

1981 ◽

Vol 46 (2) ◽

pp. 289-294 ◽

Cited By ~ 20

Author(s):

P. M. Dodson ◽

J. Stocks ◽

G. Holdsworth ◽

D. J. Galton

Keyword(s):

Blood Glucose ◽

Fasting Blood Glucose ◽

Density Lipoprotein ◽

Hdl Cholesterol ◽

Total Serum ◽

Diabetic Patients ◽

Low Fat ◽

Dietary Regimen ◽

High Fibre ◽

Insulin Dependent

1. Eight insulin-dependent and eight insulin-independent diabetic patients and twenty-eight non-diabetic essential hypertensive patients were given a high-fibre, high-unrefined carbohydrate and low-fat diet for 3 months duration.2. The effects of this dietary regimen on the patients' fasting blood glucose, hypoglycaemic therapy and weight was observed.3. Fasting lipid profiles were obtained before and after 3 months on the dietary regimen, and total serum lipids and lipoprotein fractions were analysed.4. The insulin-dependent and insulin-independent diabetic patients showed a reduction in hypoglycaemic therapy, with no significant change in fasting blood glucose. The insulin-independent and non-diabetic groups both showed significant weight loss.5. The three groups of patients showed a significant reduction in cardiovascular risk factors with either an elevation of high-density lipoprotein (HDL)-cholesterol or a fall in low-density lipoprotein (LDL)-cholesterol and a reduction in the total cholesterol: HDL-cholesterol value.

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LDL cholesterol/HDL cholesterol ratio in newly diagnosed type 2 diabetic patients complicated with metabolic syndrome

Academic Journal of Second Military Medical University ◽

10.3724/sp.j.1008.2014.01396 ◽

2014 ◽

Vol 35 (12) ◽

pp. 1396

Author(s):

Jue JIA ◽

Shu-qin YU ◽

Jing-jing YE ◽

Jiang-ning YIN ◽

Dong WANG ◽

...

Keyword(s):

Metabolic Syndrome ◽

Ldl Cholesterol ◽

Hdl Cholesterol ◽

Diabetic Patients ◽

Newly Diagnosed ◽

Type 2 Diabetic Patients ◽

Cholesterol Ratio ◽

Type 2 Diabetic

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Anti-Diabetic Effect of a Flavonoid and Sitosterol - Rich Aqueous Extract ofPleurotus tuberregiumSclerotia in Alloxan-Induced Diabetic Rabbits

Endocrine Metabolic & Immune Disorders - Drug Targets ◽

10.2174/1871530319666190206213843 ◽

2019 ◽

Vol 19 (8) ◽

pp. 1148-1156 ◽

Cited By ~ 3

Author(s):

Ifeanacho Mercy Onuekwuzu ◽

Ikewuchi Catherine Chidinma ◽

Ikewuchi Jude Chigozie

Keyword(s):

Diabetes Mellitus ◽

Blood Glucose ◽

Aqueous Extract ◽

Risk Index ◽

Fasting Blood Glucose ◽

Hdl Cholesterol ◽

The Body ◽

Atherogenic Index ◽

Atherogenic Indices ◽

Diabetic Rabbits

Objective:Traditionally prepared infusions and decoctions are commonly used in the management of diabetes mellitus, in southern Nigeria; one of such is the aqueous extract of the sclerotia of Pleurotus tuberregium (“usu” milk). In this study, the effects of the extract on the body weights, tissue/ organ weights, fasting blood glucose, blood/plasma lipid profiles and atherogenic indices were investigated in normal and alloxan-induced diabetic rabbits.Methods:Diabetes mellitus was induced by the injection of alloxan (120 mg/kg body weight) via the marginal ear vein. The extract was administered orally at 100, 200 and 300 mg/kg to normal and diabetic rabbits; while metformin was administered at 50 mg/kg. The crude extract was analyzed by gas chromatography, coupled to flame ionization detector.Results:Thirty-one known flavonoids were detected, consisting mainly of isoquercetin (28.5%), luteolin (24.3%), quercetin (18.8%) and kaempferol (11.3%). Sitosterol (82.0%) and stigmasterol (12.5%) were the most abundant of the seven phytosterols detected. Compared to the diabetic control, the treatment significantly (p<0.05) lowered the weights of the kidney and liver, as well as the levels of blood glucose and triglyceride, plasma VLDL, LDL and non-HDL cholesterol, atherogenic index of plasma, cardiac risk ratio, atherogenic coefficient and Castelli’s risk index II. It, however, significantly (p<0.05) increased plasma HDL cholesterol, without significantly affecting blood total cholesterol levels.Conclusion:This study showed that the extract was hypoglycemic, and improved lipid profile and atherogenic indices, thus highlighting its cardioprotective potential, thereby supporting its use in the management of diabetes mellitus.

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Daily Fasting Blood Glucose Rhythm in Male Mice: A Role of the Circadian Clock in the Liver

Endocrinology ◽

10.1210/en.2015-1376 ◽

2015 ◽

Vol 157 (2) ◽

pp. 463-469 ◽

Cited By ~ 15

Author(s):

Hitoshi Ando ◽

Kentaro Ushijima ◽

Shigeki Shimba ◽

Akio Fujimura

Keyword(s):

Blood Glucose ◽

Circadian Clock ◽

Mrna Expression ◽

Hepatic Glucose Production ◽

Critical Role ◽

Fasting Blood Glucose ◽

Glucose Production ◽

Diabetic Patients ◽

Dark Phase ◽

Dawn Phenomenon

Abstract Fasting blood glucose (FBG) and hepatic glucose production are regulated according to a circadian rhythm. An early morning increase in FBG levels, which is pronounced among diabetic patients, is known as the dawn phenomenon. Although the intracellular circadian clock generates various molecular rhythms, whether the hepatic clock is involved in FBG rhythm remains unclear. To address this issue, we investigated the effects of phase shift and disruption of the hepatic clock on the FBG rhythm. In both C57BL/6J and diabetic ob/ob mice, FBG exhibited significant daily rhythms with a peak at the beginning of the dark phase. Light-phase restricted feeding altered the phase of FBG rhythm mildly in C57BL/6J mice and greatly in ob/ob mice, in concert with the phase shifts of mRNA expression rhythms of the clock and glucose production–related genes in the liver. Moreover, the rhythmicity of FBG and Glut2 expression was not detected in liver-specific Bmal1-deficient mice. Furthermore, treatment with octreotide suppressed the plasma growth hormone concentration but did not affect the hepatic mRNA expression of the clock genes or the rise in FBG during the latter half of the resting phase in C57BL/6J mice. These results suggest that the hepatic circadian clock plays a critical role in regulating the daily FBG rhythm, including the dawn phenomenon.

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The Effect of A New Mixture of Sugar and Sugar-Alcohol (Lacritose) on Blood Glucose and Lipids and the Possible Adverse Reactions in Patients with Type 2 Diabetes: A Triple-Blind Randomized Clinical Trial

Journal of Nutrition and Food Security ◽

10.18502/jnfs.v6i4.7620 ◽

2021 ◽

Author(s):

Masoud Rahmanian ◽

Zohreh Mozafari ◽

Danial Chaleshi ◽

Marzieh Shukohifar ◽

Saeedeh Jam-Ashkezari

Keyword(s):

Clinical Trial ◽

Blood Glucose ◽

Randomized Clinical Trial ◽

Fasting Blood Glucose ◽

Resistance Index ◽

Primary Data ◽

Control Group ◽

Diabetic Patients ◽

Diabetes Research

Background: A new sweetener with the commercial name of Lacritose has been recently produced, which is a combination of four simple sugars (lactose, fructose, sucrose, erythritol), with specific ingredients and percentages. This study aimed to assess glycemic response and short term gastrointestinal reactions in type 2 diabetic patients. Methods: In this triple-blind randomized clinical trial, 30 diabetic patients referred to Yazd Diabetes Research Center in 2018 were included. After collecting the primary data, they were assigned into three groups, including sucrose consumers as the control group, sucrose-lactose, and lacritose as the groups of consumers group. They were followed for two weeks, and fasting blood glucose (FBG), 2-hour postprandial test (2HPP), fructose amine, SGOT, SGPT, urea, creatinine, and insulin resistance index (HOMA-IR) were assessed. Results: In lacritose consumers, significant reductions were seen in FBG and 2HPP (P < 0.001 and P = 0.05, respectively), although changes among the groups were not significant. In sucrose-lacritose consumers, FBG and cholesterol levels decreased (P = 0.04 and P = 0.03, respectively). In sucrose consumers, no reduction was seen. HOMA-IR did not significantly decrease, but intergroup changes were obvious. Conclusion: The lacritose effects on FBG and 2HPP were significantly evident, but the other metabolic indices did not show any significant change.

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Treatment outcome and its predictors among diabetic patients attending at selected hospitals of southern ethiopia.

10.21203/rs.3.rs-917406/v2 ◽

2021 ◽

Author(s):

Bereket Beyene ◽

Dawit Hoyiso ◽

Kinfe Woldu

Keyword(s):

Treatment Outcome ◽

Blood Glucose ◽

Health Care Expenditure ◽

Fasting Blood Glucose ◽

World Health ◽

Outcome Variable ◽

Southern Ethiopia ◽

Diabetic Patients ◽

Source Population ◽

Good Treatment Outcome

Abstract Background: Diabetes is one of the largest health emergencies of the 21st century. The World Health Organization (WHO) estimates that globally, hyperglycaemia is the third highest risk factor for premature mortality, after high blood pressure and tobacco use. It is an important cause of blindness, kidney failure, lower limb amputation and other long-term consequences that impact significantly on quality of life. It result peoples in a disease, death and increase a health care expenditure.Objectives: To determine treatment outcome of Diabetes mellitus and its predictors among patients attending diabetes treatments at selected hospitals of southern Ethiopia, 2021.Methods: All diabetic patients who attended selected hospitals of southern Ethiopia were a source population. Institution based cross-sectional study design was conducted at selected hospitals of southern Ethiopia. Patient’s data was collected using pretested questionnaire. After cleaning and checking for errors, the data was entered in to Epi-data to minimize error then exported to SPSS for analysis. Descriptive findings were presented by tables and charts. The outcome variable was analyzed by using logistic regression model to identify predictors after assumptions of regression analysis had checked. All the independent variables with p<0.25 was used as a candidate for multivariate analysis. Then the level of significance will be set at p<0.05 and AOR with 95% CL was done as the final model.Result: From the total sample; 277 (65.6%) were found to be good treatment outcome. The number of medication taken AOR 95%CI; 0.924 (0.869, 0.983), presence of complication AOR 95%CI; 0.425 (0.217, .832), increased fasting blood glucose AOR 95%CI; 0.080 (0.034, 0.188) were found to be independent predictors. Since the magnitude of treatment outcome found to be low, provision of health information about the adhering to prescribed medication and monitoring fasting blood glucose level will bring good clinical outcome.

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Metabolic characteristics and nutrition intake on women with normal body mass index

Food Research ◽

10.26656/fr.2017.4(s3).s13 ◽

2020 ◽

Vol 4 (S3) ◽

pp. 6-12

Author(s):

D.Y. Fitranti ◽

F.F. Dieny ◽

D.M. Kurniawati ◽

R. Purwanti ◽

B. Kusumaningnastiti ◽

...

Keyword(s):

Metabolic Syndrome ◽

Body Mass Index ◽

Blood Glucose ◽

Fasting Blood Glucose ◽

Hdl Cholesterol ◽

Normal Weight ◽

Normal Body Mass Index ◽

Metabolic Characteristics ◽

Low Hdl ◽

Nutrition Intake

Metabolic syndrome can be found on an individual with normal weight (Metabolically Obese Normal Weight/MONW). Eating habits and lifestyle changing in early adulthood can be the risk of metabolic syndrome in person with a normal body mass index (BMI). The purpose of this study was to identify metabolic characteristics in women with normal BMI and to analyze the correlation of nutrition intake with metabolic syndrome on women with normal BMI. This is an observational study with a cross-sectional design at five offices in Semarang. The sample in this study was 64 subjects. Inclusion criteria of study subject were women aged 25-40 years and BMI <25 kg/m2 . Study subject was chosen by using a consecutive sampling method. The data of nutrition intake was obtained by using the Food Frequency Questionnaire. HDL cholesterol, fasting blood glucose and triglyceride were analyzed. Analysis data was conducted by using Pearson correlation and Rank Spearman. MONW was present in 10.9% and more than 50% had pre metabolic syndrome. A total of 51.6% of the subjects had central obese and 26.6% had low HDL cholesterol. About 14.1% of the subjects have hypertension. There was a positive correlation between energy, fat intake and waist circumference. Carbohydrate intake was positively correlated with fasting blood glucose and triglyceride. The higher protein intake, the higher HDL cholesterol. The most common indicator of metabolic syndrome on women with normal BMI was central obesity and low HDL cholesterol. The factors related to the prevalence of metabolic syndrome on women with normal BMI was macronutrient intake.

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