scholarly journals Level of Vitamin D, TNF-Alpha and Calcium in Patients with Dengue Fever, Dengue Hemorrhagic Fever and Dengue Shock Syndrome

2018 ◽  
Vol 3 (10) ◽  
pp. 1-5
Author(s):  
Rabail Javed
Keyword(s):  
Vitamin D ◽  
Dengue Fever ◽  
Dengue Hemorrhagic Fever ◽  
Dengue Shock Syndrome ◽  
Hemorrhagic Fever ◽  
Tnf Alpha ◽  
P Value ◽  
Severity Of Disease ◽  
Vitamin D Levels ◽  
Tnf Α

Background: Vitamin D has been widely studied for its beneficial role in treating different diseases. Dengue epidemic has affected many house hold since last decade. Vitamin D seems a gate through in its treatment as it inhibits Th1 cytokine activities, responsible for the development of dengue complications.Objective: To determine the levels of vitamin D, TNF- α and calcium in patients with variation of dengue fever stages.Methods: A cross sectional analytical study conducted on dengue confirmed patients (fever, hemorrhagic, shock) admitted in tertiary care hospitals of Lahore (IRBNo.1165). After obtaining informed consent the study objectives were explained to the patients and data collected. Patients were classified into three groups (a) dengue fever (DF)  (b) dengue hemorrhagic fever(DHF) and (c) dengue shock syndrome (DSS) (40+30+10 cases). Serum from 5cc blood was stored at –20⁰ C until analysis. The data was analyzed using SPSS version 21.Results: The study was conducted in 4 hospitals of Lahore on 80 NS1confirmed cases (age: 5-70 years). The age difference, vitamin D and calcium levels were significant (p-values 0.030, 0.047 and 0.003 respectively). Calcium levels were lowest in DSS and significantly lower than DHF patients. Vitamin D levels were higher among those with higher severity of disease with p-value 0.031. The patients did not have significantly different TNF α levels. There were 90.0% of DSS cases that had TNF α levels > 100, (p-value 0.109).Conclusion: High levels of TNF-alpha are associated with dengue complications regardless of vitamin D levels and severity of disease.

scholarly journals Vitamin D serostatus and dengue fever progression to dengue hemorrhagic fever/dengue shock syndrome

2017 ◽  
Vol 145 (14) ◽  
pp. 2961-2970 ◽  
Author(s):  
E. VILLAMOR ◽  
L. A. VILLAR ◽  
A. LOZANO ◽  
V. M. HERRERA ◽  
O. F. HERRÁN
Keyword(s):  
Vitamin D ◽  
Dengue Fever ◽  
Dengue Hemorrhagic Fever ◽  
Dengue Shock Syndrome ◽  
Hemorrhagic Fever ◽  
Vitamin D Insufficiency ◽  
Acute Episode ◽  
Risk Of Progression ◽  
25 Hydroxy Vitamin D ◽  
Case Status

SUMMARYVitamin D could modulate pathways leading to dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS). We examined the associations of serum total 25-hydroxy vitamin D [25(OH)D] and vitamin D binding protein (VDBP) concentrations in patients with uncomplicated dengue fever (DF) with risk of progression to DHF/DSS. In a case–control study nested in a cohort of DF patients who were followed during the acute episode in Bucaramanga, Colombia, we compared 25(OH)D and VDBP at onset of fever between 110 cases who progressed to DHF/DSS and 235 DF controls who did not progress. 25(OH)D concentrations were also compared between the acute sample and a sample collected >1 year post-convalescence in a subgroup. Compared with 25(OH)D ⩾75 nmol/l, adjusted odds ratios (95% CI) for progression were 0·44 (0·22–0·88) and 0·13 (0·02–1·05) for 50 to 75 nmol/l (vitamin D insufficiency) and <50 nmol/l (vitamin D deficiency), respectively (P, trend = 0·003). Mean 25(OH)D concentrations were much lower post-convalescence compared with the acute episode, regardless of case status. Compared with controls, mean VDBP was non-significantly lower in cases. We conclude that low serum 25(OH)D concentrations in DF patients predict decreased odds of progression to DHF/DSS.

scholarly journals Dengue fever masquerading as hypokalemic paralysis: a case report

2017 ◽  
Vol 11 ◽  
Author(s):  
Rajesh Rajput ◽  
Deepak Jain ◽  
Ashima Mittal ◽  
Anoop Kumar ◽  
Vaibhav Pathak
Keyword(s):  
Case Report ◽  
Dengue Fever ◽  
Dengue Hemorrhagic Fever ◽  
Dengue Shock Syndrome ◽  
Hemorrhagic Fever ◽  
Neurological Manifestations ◽  
Neurotropic Virus ◽  
Tropical Countries ◽  
Hypokalemic Paralysis ◽  
Arboviral Disease

Dengue fever is a mosquito borne arboviral disease endemic in tropical countries. The spectrum of presentation of dengue fever ranges from classical flu like illness to dengue hemorrhagic fever and dengue shock syndrome. It is usually regarded as a non-neurotropic virus and neurological manifestations of dengue are rare and hypokalemic quadriparesis is even rarer. Here we present a case report of a patient who presented with hypokalemic quadriparesis due to dengue.

scholarly journals Serum levels of interleukin-6, tumor necrosis factor-alpha and interferon-gama in infants with and without dengue

2008 ◽  
Vol 41 (1) ◽  
pp. 6-10 ◽  
Author(s):  
Berta Nelly Restrepo ◽  
Diana María Isaza ◽  
Clara Lina Salazar ◽  
Ruth Ramírez ◽  
Marta Ospina ◽  
...  
Keyword(s):  
Dengue Fever ◽  
Dengue Hemorrhagic Fever ◽  
Primary Infection ◽  
Secondary Infection ◽  
Dengue Infection ◽  
Hemorrhagic Fever ◽  
Serum Levels ◽  
Tnf Alpha ◽  
Necrosis Factor Alpha ◽  
Ifn Gamma

This study compared the serum levels of IL-6, TNF-alpha and IFN-gamma, in children under 1 year of age with and without dengue. Sera were collected from a total of 41 children living in the Department of Antioquia, Colombia (27 patients with dengue and 14 controls). The results showed higher cytokine levels in children with dengue than without dengue, with statistically significant differences for IL-6 and IFN-gamma. No statistically significant differences were found between clinical forms, although IL-6 and IFN-gamma levels were higher in dengue fever cases than in dengue hemorrhagic fever cases. On the other hand, TNF-alpha levels were higher in dengue hemorrhagic fever than in dengue fever. The levels of IL-6 and TNF-alpha were higher in secondary infection than in primary infection, although IFN-gamma levels were higher in primary infection. These results suggest that IL-6, TNF-alpha and IFN-gamma are involved in dengue infection independently of the clinical form.

scholarly journals SIADH (Syndrome of Inappropriate ADH Secretion): Perplexing Look of Dengue Fever

2021 ◽  
pp. 1-4
Author(s):  
Richmond Ronald Gomes ◽  
Keyword(s):  
Dengue Virus ◽  
Dengue Fever ◽  
Dengue Hemorrhagic Fever ◽  
Animal Studies ◽  
Dengue Shock Syndrome ◽  
Hemorrhagic Fever ◽  
World Health ◽  
Fluid Extravasation ◽  
Health Organization ◽  
Expanded Dengue Syndrome

Dengue is a mosquito-borne disease (female mosquitoes of the Aedes genus, principally Aedes aegypti) caused by any one of four closely related dengue viruses. It is endemic in tropical and subtropical continent. World health organization (WHO) currently estimates there may be 50 -100 million dengue infections worldwide every year with over 2.5 billion people at risk of dengue. Symptomatic dengue virus infection may manifests as undifferentiated fever, classical dengue fever (with or without unusual hemorrhages), and dengue hemorrhagic fever (with or without shock). Isolated organopathy or expanded dengue syndrome (EDS) was coined by WHO in the year 2012 to describe cases, which do not fall into either dengue shock syndrome or dengue hemorrhagic fever. The atypical manifestations noted in expanded dengue are multisystemic and multifaceted with organ involvement, such as liver, brain, heart, kidney, central/peripheral nervous system, gastrointestinal tract, lympho reticular system. Dengue virus has long been considered as a non-neurotropic virus, as animal studies have shown that virus does not cross blood brain barrier. Hyponatremia may be found in association with dengue fever and is thought to be caused by peripheral fluid extravasation and resulting intravascular hypovolaemia. But hyponatremia due to syndrome of inappropriate secretion of anti-diuretic hormone (SIADH) in Dengue fever is rare. We report a 40 years old male who was diagnosed as Dengue fever (Dengue Ns1Ag positive) with thrombocytopenia and hyponatremia. He was admitted and further investigations revealed SIADH. He responded well to cautious sodium replacement and addition of tolvaptan. He recovered completely and was discharged after one week. Thus, all clinicians should keep in mind the possibility of SIADH as a part of expanded dengue syndrome.

scholarly journals DETERMINANTS OF HEALTH PREVENTION OF DENGUE HEMORRHAGIC FEVER

2019 ◽  
Vol 1 (2) ◽  
Author(s):  
Hendrikus Nara Kwureh
Keyword(s):  
Dengue Fever ◽  
Dengue Hemorrhagic Fever ◽  
Community Health Center ◽  
Sampling Technique ◽  
Hemorrhagic Fever ◽  
P Value ◽  
Cross Sectional ◽  
Prevention Effort ◽  
Health Officer ◽  
Information Media

Dengue hemorrhagic fever (DHF) is one of the infectious diseases transmitted by mosquito bites that are found in tropical and subtropical areas around the world. The high cases of dengue fever show a lack of prevention efforts against dengue hemorrhagic fever. The purpose of this research is to know the factors related to dengue fever prevention efforts (DHF) in Kapuas Kanan Hulu Village Working Area of Durian River Community Health Center in 2018. This research method is quantitative with a cross sectional approach. The sampling technique uses Sample Random Sampling. The sample used was 97 families. The results showed that there was a correlation between education and prevention of DHF in Kelurahan Kapuas Kanan Hulu Sintang District in 2018 with p value of 0.012. OR = 3,150, there is correlation between knowledge with prevention effort of DHF in Kelurahan Kapuas Kanan Hulu Kabupaten Sintang 2018 with p value equal to 0,025. OR = 2,786, there is correlation between attitude and prevention of DHF in Kelurahan Kapuas Kanan Hulu Kabupaten Sintang 2018 with p value 0,007. OR = 3,411, There is no correlation between information media with prevention effort of DHF in Kelurahan Kapuas Kanan Hulu Kabupaten Sintang 2018 with p value 0,907. OR = 0,877, There is correlation between health officer support and prevention effort of DHF in Kelurahan Kapuas Kanan Hulu Kabupaten Sintang 2018 with p value 0,004. OR = 3,700. Suggestions are expected for the community to carry out routine prevention of dengue hemorrhagic fever, both for those who have suffered from Dengue Hemorrhagic Fever or who have never suffered so as to reduce the incidence of Dengue Hemorrhagic Fever in the Kapuas Kanan Hulu Village.

scholarly journals Importance of Platelet Count and Hematocrit in Dengue Fever in Children

2021 ◽  
Vol 44 (2) ◽  
pp. 74-77
Author(s):  
Farhana Rahat ◽  
Morsheda Khanam ◽  
Kazi Iman ◽  
UK Ghosh ◽  
NK Ghosh
Keyword(s):  
Platelet Count ◽  
Dengue Fever ◽  
Dengue Hemorrhagic Fever ◽  
Dengue Infection ◽  
Tertiary Care ◽  
Dengue Shock Syndrome ◽  
Hemorrhagic Fever ◽  
Warning Signs ◽  
Care Hospital ◽  
Pediatric Age Group

Background: Dengue fever has become one of the most important public health concerns now a day due to increasing complications and fatal outcomes. Dengue hemorrhagic fever and dengue shock syndrome are life threatening but reversible complications of dengue fever. Objectives: This study was performed to evaluate the relationship between platelet count and hematocrit with the severity of dengue infection in pediatric age group. Materials & Methods: This was a prospective observational study which included 280 dengue seropositive children of 1 month to 15 years, conducted during 1st June to 30th November, 2018 in a tertiary care hospital of Dhaka. Results: Out of 280 dengue cases, 187(66.78%) had thrombocytopenia and 88(47%) had raised hematocrit. Among the thrombocytopenic patients 44% had dengue fever, 47% had dengue hemorrhagic fever and 9% dengue shock syndrome. A significant co-relation was observed between the severities of thrombocytopenia and raised hematocrit with the appearance of dengue warning signs in case of dengue hemorrhagic fever. Conclusion: Thrombocytopenia and raised hematocrit were related to the severity of dengue hemorrhagic fever. Bangladesh J Child Health 2020; VOL 44 (2) :74-77

scholarly journals Clinical profile of dengue fever infection in patients admitted in NC Medical College, Haryana in the year 2019

2020 ◽  
Vol 8 (8) ◽  
pp. 3027
Author(s):  
Mohd Y. Shah ◽  
Faisal Y. Shah ◽  
Ifrah S. Kitab ◽  
Faizan Y. Shah
Keyword(s):  
Dengue Virus ◽  
Dengue Fever ◽  
Dengue Hemorrhagic Fever ◽  
Clinical Symptoms ◽  
Wide Spectrum ◽  
Dengue Shock Syndrome ◽  
Hemorrhagic Fever ◽  
Clinical Profile ◽  
Host Immune Responses ◽  
Medical College

Background: Dengue infections can result in a wide spectrum of disease severity ranging from an influenza-like illness (dengue fever; DF) to the life-threatening dengue hemorrhagic fever (DHF)/dengue shock syndrome (DSS). The study was aimed to compare the clinical profile of all patients diagnosed with dengue viral infection at NCMC.Methods: This retrospective study included 24 patients infected with dengue virus, aged 19 years to 45 years. Laboratory and haematological data were included.Results Peak of infection occurred in November 2019 and no cases were recorded in October 2019. Common clinical symptoms were fever, joint pains, headache and rash. Common haematological abnormalities were thrombocytopenia. All patients survived. There was no case of dengue hemorrhagic fever or dengue shock syndrome.Conclusions: Significant differences in the clinical profile is possibly because of infection with different serotypes of dengue virus (DENV), concurrent/sequential infection of more than one serotype, and differences in host immune responses associated with host genetic variations.

scholarly journals The Correlation Between Blood Parameters as Early Detection on Dengue Hemorrhagic Fever (DHF) and Dengue Shock Syndrome (DSS) in Children

2020 ◽  
Vol 19 (2) ◽  
pp. 273-277
Author(s):  
Farindira Vesti Rahmasari ◽  
Dwi Wijayanti ◽  
Nurul Khaerani
Keyword(s):  
Dengue Hemorrhagic Fever ◽  
Medical Science ◽  
Secondary Data ◽  
Dengue Shock Syndrome ◽  
Hemorrhagic Fever ◽  
Blood Parameters ◽  
P Value ◽  
Chi Square ◽  
Test Analysis ◽  
Chi Square Test

Background: Dengue Shock Syndrome (DSS) is a severe manifestation of Dengue Hemorrhagic Fever (DHF) and affects more children and young adults. The age of susceptibility to DSS is 5-15 years old, due to an imperfect immune system. DHF patients with manifestations of DSS have propensity that can affect the platelet and hematocrit values as an initial laboratory parameter. Objective: This study is intended to find out the most effective platelet and hematocrit blood parameters and to find the correlation between platelet values and hematocrit on the incidence of DHF in Wirosaban Hospital of Yogyakarta Municipality in the period f March 2015 to July 2016. The data used were secondary data from medical records of pediatric patients aged 5-15 years old. Material and Methods: The research method used was to determine the correlation between platelet values and hematocrit on the incidence of DHF and DSS in children. Data analysis used chi-square to determine the correlation between platelet values and hematocrit on the incidence of DHF and DSS in children. Results and Discussion: In this study, the number of samples that fulfilled the inclusion and exclusion criteria was 74 on platelet examination while in the hematocrit examination there were 77 that met the criteria. The results of chi-square test for platelet examination obtained p value> 0.05, which means there was no significant correlation between platelet counts and the incidence of DHF, DHF grade II, and DSS. The results of the chi-square test analysis on hematocrit examination obtained p <0.05, which means that there was a significant correlation between hematocrit values and the incidence of DHF and DSS and it obtainedd r = 0.707. Conclusions: In this study the increase in hematocrit is one of the parameters to detect DHF with propensity to DSS. Bangladesh Journal of Medical Science Vol.19(2) 2020 p.273-277

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