scholarly journals Management of Hyperlipidaemia through Ayurvedic Intervention

2021 ◽  
Vol 3 (3) ◽  
pp. 4-7
Author(s):  
Jaya Saklani Kala ◽  
Swapnil Singhai
Keyword(s):  
Elevated Serum ◽  
Lipoprotein Metabolism ◽  
Serum Levels ◽  
Total Serum ◽  
Total Serum Cholesterol ◽  
Serum Triglycerides ◽  
Profile Parameter ◽  
The Difference ◽  
Obesity Hypertension ◽  
Elevated Lipid

The potential of hyperlipidemia to engage in the pathology of atherosclerotic diseases such as coronary heart disease, which dominates the scenario of diseases causing morbidity and mortality in the world. Hyperlipidemia is defined as elevated serum levels of cholesterol, triglycerides, or both. It is characterized by abnormally elevated lipid concentrations in blood caused by impaired lipid and lipoprotein metabolism and has the potential to cause a variety of complications such as cardiovascular disease, diabetes, obesity, hypertension, atherosclerosis, and so on. Hyperlipidemia is classified as Medoroga in Ayurveda. The results obtained for the lipid profile parameter demonstrated a significant change. The difference in total serum cholesterol is 36 mg/dl, serum triglycerides is 32 mg/dl, serum LDL is 40 mg/dl, serum VLDL is 15 mg/dl and serum HDL is -3 mg/dl.

scholarly journals PSVII-17 Program Chair Poster Pick: Reproductive function of cows depending on lipid metabolism

2020 ◽  
Vol 98 (Supplement_4) ◽  
pp. 293-294
Author(s):  
Murat Baymishev ◽  
Sergey Eremin ◽  
Kirill Plemyashov ◽  
Khamidulla Baymishev ◽  
Igor Konopel’tsev ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Live Weight ◽  
Reproductive Function ◽  
Serum Levels ◽  
Total Serum ◽  
Dry Period ◽  
Lipid Peroxidation Products ◽  
Synthetic Function ◽  
The Difference ◽  
Oxidized Products

Abstract The aim of the study was to determine the etiopathogenesis of reproductive dysfunction in highly productive cows. Studies were conducted on cows of black-motley breed, aged 3–5 lactations, with a live weight of 480–520 kg. Cows were divided into two groups. The first group included 20 cows effective inseminated after the first insemination. The second group included 17 cows that did not fertilize after the first insemination. Blood samples (n = 253) were taken from 4–7; 14–17; 24–34; 35–50; 88–95; 195–210 days of pregnancy; during the beginning of dry period (DP); 1–4 days before calving and on the first day after calving. The content of total serum lipids in pregnant animals was 15.8% higher compared to unfertilized animals. In non-pregnant cows, a decrease in free cholesterol (by 28.65%), especially in its ether-bound fraction (14.91%), indicates a lower synthetic function of the liver, which is confirmed by the low serum levels of vitamins A and E (a difference of 11.3 and 23.65%). The DP was characterized by a significant increase in the products of lipid peroxidation - malondialdehyde by 12–17%, diene and triene conjugates - by 10–15 and 8–15%, respectively, and 1–4 days before calving in cows, which subsequently had a pathological calving, in particular - retention of placenta (5 cows), were characterized by an increased content in the blood plasma of lipid peroxidation products. Thus, the difference in the number of dienes, trienes, and malondialdehyde products was 14.0, 12.0, and 23.5%, compared with animals without obstetric pathology. On the first day after calving, this difference increased even more. Cows with retention of placenta had a significantly higher level of lipid peroxidation products and were characterized by a predominance of oxidized products over the antiradical thiol disulfide and ascorbate systems restored in the antioxidant balance.

scholarly journals Effect of interventions with ingestion of legumes and/or supervised exercise on the lipid profile of young, healthy sedentary women

2010 ◽  
pp. 224-234 ◽  
Author(s):  
Luis F. Fajardo ◽  
Dora G. Castellanos ◽  
Myriam Chinchilla ◽  
Luz N. Vargas ◽  
Martha Guerra ◽  
...  
Keyword(s):  
Lipid Profile ◽  
Life Style ◽  
Ldl Cholesterol ◽  
Hdl Cholesterol ◽  
Serum Levels ◽  
Total Serum ◽  
Total Serum Cholesterol ◽  
Supervised Exercise ◽  
Healthy Life Style ◽  
Sedentary Women

Objective: To contribute to the knowledge of some aspects of the Healthy Life Style by studying the effects of including legumes in the diet and exercise at two intensity levels, along with the lipid profile of young sedentary women living at 2640 meters above sea level. Materials and methods: The study included a non-randomized clinical trial with four intervention groups: exercise at 45% VO2 peak plus legumes in diet, exercise at 65% VO2 peak plus legumes in diet, only exercise at 65% VO2 peak, and only inclusion of legumes in diet. In each group, 20 to 23 sedentary women were included. The intervention was carried out for four weeks, three days a week. Exercise prescription was based on measurement of VO2 peak by ergospirometry; and the current intervention was monitored with heart-rate monitors. The outcome variables were total serum cholesterol, LDL cholesterol, HDL cholesterol, and triacylglycerols measured at baseline and after two and four weeks of intervention. Results: The measurements taken of participants in the group of exercise at 65% VO2 peak plus legumes in diet showed a reduction of 19.8 mg/dl in total cholesterol, of 21.8 mg/dl of LDL cholesterol, of 20.7 mg/dl of tracylglycerol, and an increase of 6.2 mg/dl of HDL cholesterol. The serum levels of HDL also increased in the group of only exercise at 65% VO2 peak. No significant changes in serum levels were documented for participants in the group with only dietary modifications. Conclusions: The results suggest that different interventions that meet some of the criteria for healthy eating and life style show different effects with regards to the level of change in the lipid profile components.

Age-related changes in thoracic aorta of obese Zucker rats

1992 ◽  
Vol 262 (5) ◽  
pp. H1548-H1556 ◽  
Author(s):  
R. H. Cox ◽  
D. C. Kikta
Keyword(s):  
Blood Pressure ◽  
Thoracic Aorta ◽  
Muscle Activation ◽  
Systolic Pressure ◽  
Serum Levels ◽  
Zucker Rats ◽  
Total Serum ◽  
Total Serum Cholesterol ◽  
Arterial Blood ◽  
Age Related

Studies were performed on the ontogeny of arterial blood pressure and functional properties of the thoracic aorta in lean (L) and obese (O) male Zucker rats at ages of 6-36 wk. Body weight was larger in the O than the L at all ages, with differences reaching values of 200-250 g at ages over 24 wk (at 33-36 wk: L = 510 +/- 9 and O = 730 +/- 15 g). Systolic blood pressure was lower in young O compared with L (6-15 wk) but increased with age at a rate seven times greater in O than in L. For ages of 33-36 wk, systolic pressure was significantly higher in O compared with L (O = 132 +/- 2 vs. L = 122 +/- 2 mmHg). Total serum cholesterol (at 36 wk: L = 278 +/- 31 and O = 354 +/- 12 mg/dl) and triglycerides (at 36 wk: L = 493 +/- 71 and O = 1,618 +/- 220 mg/dl), as well as glucose levels, increased with age in both groups and were significantly higher in O at all ages. Serum levels of thyroxine but not triiodothyronine were significantly lower in O at all ages. No differences were found in passive mechanics at any age. Values of maximum active stress with smooth muscle activation by 75 mM K+ plus 10 microM norepinephrine were significantly higher at 24 and 36 wk in O (at 36 wk: L = 573 +/- 42 and O = 821 +/- 89 x 10(3) dyn/m2).(ABSTRACT TRUNCATED AT 250 WORDS)

Double Versus Single Phototherapy in Low Birth Weight Newborns

PEDIATRICS ◽  
1992 ◽  
Vol 90 (5) ◽  
pp. 674-677
Author(s):  
Paul C. Holtrop ◽  
Kathleen Ruedisueli ◽  
M. Jeffrey Maisels
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Bilirubin Level ◽  
Serum Bilirubin ◽  
Elevated Serum ◽  
Threshold Level ◽  
Serum Bilirubin Level ◽  
Total Serum ◽  
The Difference ◽  
To Receive

Conventional phototherapy systems that simultaneously irradiate the front and the back of the baby lower the serum bilirubin level more rapidly than one-sided systems, but they are impractical. Fiberoptic phototherapy makes it easy to administer conventional phototherapy from above while the infant lies on a fiberoptic phototherapy blanket. Newborns with birth weights less than 2500 g were randomly assigned to receive either single (n = 37) or double (n = 33) phototherapy. The groups were similar in clinical and laboratory characteristics. After 18 hours of therapy the serum bilirubin concentration declined by 31 ± 11% in the double and 16 ± 15% in the single phototherapy group (2.9 ± 1.1 vs 1.6 ± 1.4 mg/dL), and the difference in the total serum bilirubin levels after 18 hours of therapy was significant (double phototherapy group 7.1 ± 2.7 mg/dL vs single phototherapy group 8.2 ± 2.6 mg/dL). After 18 hours of treatment the serum bilirubin level was less than the phototherapy threshold level in 26 of 37 single phototherapy patients vs 32 of 33 double phototherapy patients. Double phototherapy was well tolerated. It is concluded that this type of double phototherapy is more effective than single phototherapy in low birth weight newborns. Double phototherapy may be useful when it is necessary to reduce an elevated serum bilirubin level as rapidly as possible or when the bilirubin level is rising with single phototherapy.

scholarly journals Serum Carbohydrate Antigen 199 as a Biomarker for Evaluating Patients with Choledocholithiasis

2020 ◽  
Vol 2020 ◽  
pp. 1-5 ◽  
Author(s):  
Wang Gu ◽  
Zhong Tong
Keyword(s):  
Correlation Analysis ◽  
White Cell Count ◽  
Elevated Serum ◽  
Serum Levels ◽  
Carbohydrate Antigen ◽  
Cell Counts ◽  
Blood Cell Counts ◽  
Serum Carbohydrate Antigen ◽  
The Difference ◽  
White Blood Cell Counts

Aims. Choledocholithiasis is a common and yet potentially debilitating disease of the biliary tract. While certain patients with this disease remain largely asymptomatic or experience mild discomfort, in several cases, patient can suffer biliary inflammation and other serious symptoms. Previous studies have detected elevated serum levels of carbohydrate antigen 199 in patients with choledocholithiasis. We wanted to know whether serum CA199 level in patients with choledocholithiasis is related to the level of inflammation in patients. Methods. In the present study, we separated a cohort of 135 choledocholithiasis patients into two groups based on their white blood cell counts, which were either 3.5−9.5×109/L or ≥9.5×109/L. We also divided patients into two groups according to CPR < 10 mg/L and CRP ≥ 10 mg/L. At the same time, the correlation between CA199 and CRP level was analyzed. Results. We then used a Rank-sum test to compare serum carbohydrate 199 levels between these groups, revealing significantly higher levels of this antigen in patients with a white cell count ≥9.5×109/L (Z=−3.584, P<0.01). The two groups were grouped by CRP, and the CA199 level was compared. The difference between the two groups was statistically significant (P<0.01). The correlation analysis between CA199 and CRP showed an obvious correlation (r=0.574). Conclusion. This suggests that in patients with choledocholithiasis, higher circulating carbohydrate antigen 199 levels may correspond to a higher degree of inflammation.

scholarly journals Genetic risk prediction in a small cohort of healthy adults in Atlanta

2013 ◽  
Vol 95 (1) ◽  
pp. 30-37 ◽  
Author(s):  
JING ZHAO ◽  
DALIA ARAFAT ◽  
KENNETH L. BRIGHAM ◽  
GREG GIBSON
Keyword(s):  
Genetic Risk ◽  
Well Being ◽  
Risk Scores ◽  
Total Serum ◽  
Total Serum Cholesterol ◽  
Unexpected Finding ◽  
Nucleotide Polymorphisms ◽  
Multiple Trait ◽  
Serum Triglycerides ◽  
Polygenic Scores

SummaryCompared with single markers, polygenic scores that evaluate the joint effects of multiple trait-associated variants are more effective in explaining the variance of traits and risk of diseases. In total, 182 CHDWB (Emory-Georgia Tech Center for Health Discovery and Well Being study) adults were genotyped to investigate the common variant contributions to three traits (height, BMI, serum triglycerides) and three diseases (coronary artery disease (CAD), type 2 diabetes (T2D) and asthma). Association was contrasted between weighted and simple allelic sum polygenic scores with quantitative traits, and with the Framingham risk scores for CAD and T2D. Although the cohort size is two or three orders of magnitude smaller than typical discovery cohorts, we were able to detect significant associations and to explain up to 5% of the traits by the genetic risk scores, despite a strong influence of outliers. An unexpected finding was that CAD-associated single nucleotide polymorphisms (SNPs) explain a significant amount of the variation for total serum cholesterol. Forward step-wise sequential addition of SNPs into the regression model showed that the top-ranked SNPs explain a large proportion of variance, whereas inclusion of gender and ethnicity also affect the performance of polygenic scores.

Results of a Phase IV Study Carried Out with Acipimox in Type II Diabetic Patients with Concomitant Hyperlipoproteinaemia

1989 ◽  
Vol 17 (4) ◽  
pp. 373-380 ◽  
Author(s):  
M. Lavezzari ◽  
G. Milanesi ◽  
E. Oggioni ◽  
F. Pamparana
Keyword(s):  
Adverse Events ◽  
Fasting Blood Glucose ◽  
Lipid Lowering ◽  
Total Serum ◽  
Total Serum Cholesterol ◽  
Diabetic Patients ◽  
Slight Reduction ◽  
Type Ii ◽  
Serum Triglycerides ◽  
Phase Iv

The aim of this phase IV study was to assess the tolerability and efficacy of acipimox, a lipid-lowering drug, in 3009 type II diabetic out-patients with types II and IV hyperlipoproteinaemia. The study was carried out by 150 Italian diabetes centres. Acipimox was given at the dosage of one capsule (250 mg), two or three times daily for at least 2 months. Acipimox produced a mean fall of 43% in serum triglycerides and of 18% in total serum cholesterol levels compared with baseline. The lipid-lowering effect was present throughout treatment, but was most pronounced at the end of treatment. An increase in the serum concentration of high density lipoprotein cholesterol (15%) was also observed at the end of the trial. Fasting blood glucose and glycosylated haemoglobin levels showed a slight reduction during the study. Adverse events were reported in 263 (8.8%) cases and 165 (5.4%) patients discontinued the treatment. The female trial population showed a nearly two-fold greater incidence of adverse events than the males. In the majority of cases the adverse events experienced by patients were transient episodes of flushing and mild gastro-intestinal disturbances (e.g. gastric pain and pyrexia).

Growth, Fecundity, and Energy Stores of White Sucker (Catostomus commersoni) from Lakes Containing Elevated Levels of Copper and Zinc

1988 ◽  
Vol 45 (8) ◽  
pp. 1355-1365 ◽  
Author(s):  
K. R. Munkittrick ◽  
D. G. Dixon
Keyword(s):  
Liver Glycogen ◽  
Nutritional Deficiencies ◽  
Total Serum ◽  
Total Serum Cholesterol ◽  
White Sucker ◽  
Food Groups ◽  
Catostomus Commersoni ◽  
Serum Triglycerides ◽  
Sediment Metals ◽  
Lipid Stores

White sucker (Catostomus commersoni) were collected from lakes with elevated levels of both copper (13–15 μg∙L−1) and zinc (209–253 μg∙L−1) and from control lakes. In all cases the fish reached maturity between 4 and 6 yr of age, and until 6 yr of age there were no differences in length or weight of fish collected from control and contaminated lakes. After this age, fish from contaminated sites were significantly smaller and shorter than those from control sites. In addition, female sucker from contaminated lakes failed to exhibit significant increases in either length or weight after the age of maturity. The fish from contaminated lakes also exhibited decreases in egg size and fecundity, no significant increases in fecundity with age, and an increased incidence of spawning failure. The failure of female fish to grow significantly after maturity, and the decreased energetic commitment to reproduction, suggests that the food base in the contaminated lakes was limiting the performance of the female sucker. These fish exhibited decreased muscle lipid stores, decreased serum lipid levels during the postspawning period, and an apparent decrease in visceral lipid stores during the autumn. There was no effect of collection site on body stores of liver glycogen, liver lipids, serum triglycerides, or total serum cholesterol. It is known that several major food groups were missing from the sediments of contaminated lakes and that sediments under water deeper than 5 m may be incapable of supporting macroinvertebrates. Most of the alterations in sucker growth and reproduction appear to be related to nutritional deficiencies as a result of the chronic effects of elevated sediment metals on the food base of the sucker.

scholarly journals An initial investigation of serum cytokine levels in patients with gadolinium retention

2020 ◽  
Vol 53 (5) ◽  
pp. 306-313
Author(s):  
Holden T. Maecker ◽  
Weiqi Wang ◽  
Yael Rosenberg-Hasson ◽  
Richard C. Semelka ◽  
Joseph Hickey ◽  
...  
Keyword(s):  
Linear Models ◽  
Elevated Serum ◽  
Serum Levels ◽  
Control Group ◽  
Serum Cytokine ◽  
Serum Samples ◽  
Flu Vaccination ◽  
Gadolinium Retention ◽  
Cytokine Levels ◽  
The Difference

Abstract Objective: To determine whether individuals with proposed gadolinium deposition disease (GDD) have elevated serum levels of pro-inflammatory and pro-fibrotic cytokines, and whether specific cytokines are correlated with certain symptoms. Materials and Methods: Twenty-four participants recruited between May 2016 and June 2017 met GDD diagnostic criteria. The 64 control subjects provided serum samples before prophylactic flu vaccination. Serum cytokine levels were obtained with Luminex serum cytokine assay using eBiosciences/Affymetrix human 62-plex kits. Wilcoxon rank-sum tests were performed to assess the difference between the median fluorescence intensity values for the participants and the control group. Generalized linear models were built to evaluate the association between each cytokine of interest and selected participant symptoms. Results: Serum levels of 14 cytokines, including nine pro-inflammatory cytokines, were statistically significantly elevated compared to controls (p ≤ 0.05). Hypotheses regarding pro-fibrotic cytokines and cytokine links to specific symptoms’ intensity were not confirmed. Conclusion: The statistically significantly elevated cytokines may be markers of susceptibility to GDD or agents of symptom induction. These findings suggest that individuals developing symptoms characteristic of GDD after a contrast-assisted magnetic resonance imaging should be studied to investigate whether gadolinium retention and elevated cytokines may be related to their symptoms.

scholarly journals Hypertriglyceridemia during infectious mononucleosis

2021 ◽  
Author(s):  
Emilio Manuel Páez-Guillán ◽  
Joaquín Campos-Franco ◽  
Mª del Rosario Alende-Sixto ◽  
Yago Garitaonaindía-Díaz ◽  
Arturo González-Quintela
Keyword(s):  
Acute Phase ◽  
Infectious Mononucleosis ◽  
Time Course ◽  
Control Sample ◽  
Serum Triglyceride ◽  
Total Serum ◽  
Total Serum Cholesterol ◽  
Serum Triglycerides ◽  
Cell Counts ◽  
Clinical Records

Abstract Background Hypertriglyceridemia can be observed in lymphoproliferative disorders. Epstein-Barr virus-induced infectious mononucleosis can be considered a self-limiting lymphoproliferative disorder. The aim of this study is to investigate serum triglyceride concentrations, associated factors, and time-course changes in patients with infectious mononucleosis. Methods We report on an adult patient with extreme hypertriglyceridemia (triglycerides > 1000 mg/dL) during infectious mononucleosis. We then reviewed the clinical records of 360 patients admitted to the hospital due to infectious mononucleosis (median age 19 years, range 15–87 years; 51.4% male). Serum triglyceride concentrations were compared with those of a control sample from the general population, aged 18–30 years (n = 75). A second measurement of serum triglyceride concentrations, obtained during convalescence (median of 30 days after the initial determination), was available for 160 patients. Results Triglyceride concentrations in the acute phase (median 156 mg/dL; range, 27–452 mg/dL) were significantly higher than those of controls (P < 0.001). A total of 194 patients (53.9%) showed hypertriglyceridemia (triglycerides > 150 mg/dL), which was more common in the older patients. A significant correlation was observed between serum triglycerides and white blood cell counts, total cholesterol levels, and markers of liver damage. Serum triglyceride concentrations tended to decrease during convalescence (P < 0.001) and were lower than the initial measurement in 83.7% of the cases. Conversely, total serum cholesterol concentrations during the acute phase were lower than those of the controls and increased during convalescence (P < 0.001). Conclusions Patients with severe (in-hospital) infectious mononucleosis frequently show mild, transient hypertriglyceridemia. Further studies are needed to elucidate the mechanisms underlying these findings.

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