Features of Arthroplasty in Bilateral Knee Osteoarthritis

Introduction. Hip and knee arthroplasty are the two of the most frequently used methods of surgical treatment. The techniques of drug support in the perioperative period, as well as the rehabilitation component, are of primary importance. However, due to the increase in number of operations the number of complications is also growing. At the same time, surgical approaches to the treatment of bilateral knee OA are still not sufficiently studied. The literature describes intervals between arthroplasty operations on knee joints from 3 months to 5 years. The epidemiological and pathogenetic aspects of functional recovery in bilateral knee OA patients are also in need of further research.Materials and methods. Authors analysed outcomes in 124 patients with gonarthrosis treated with arthroplasty. 32 patients underwent arthroplasty of the contralateral joint. The outcomes were evaluated with the KSS score and X-ray imaging at 1, 3 and 6 months postop.Results and discussions. In the first month after the operation functional recovery was noted due to the relief of pain, recovery of the muscle tone and regional hemodynamics in the area of the knee joint. It was also noted that the recovery of function in the period from month 1 to month 3 in patients with bilateral gonarthrosis occurs less intensively due to decompensation of the contralateral joint.Conclusion. The study demonstrates the recovery of function in patients in the postoperative period. There is, however, the issue of functional decompensation in the opposite limb, which in turn reduces the effectiveness of motor rehabilitation and leads to the need for endoprosthetic replacement of the second joint.

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Correlation of Ahlback grading and knee society score in patients with moderate to severe osteoarthritis of the knee

International Journal of Research in Orthopaedics ◽

10.18203/issn.2455-4510.intjresorthop20211617 ◽

2021 ◽

Vol 7 (3) ◽

pp. 606

Author(s):

Uma Phalswal ◽

Vandna Pandey ◽

Ashok Kumar ◽

Abhay Elhence

Keyword(s):

Quality Of Life ◽

Joint Pain ◽

Knee Society Score ◽

Functional Limitation ◽

Osteoarthritis Of The Knee ◽

Moderate Correlation ◽

X Ray ◽

Knee Oa ◽

Bilateral Knee

Background: Knee osteoarthritis (OA) is a most common rheumatological disorder that causes functional limitation and disability. The most common problem in knee OA are joint pain and stiffness. It will lead to decreased quality of life and it have a serious economic burden on any country due to effect of disability and treatment.Methods: A correlational study was conducted to find out correlation between Ahlback grading and knee society score (KSS) on a sample of 100 moderate to severe knee OA patients and 142 OA knees. Data was collected at orthopedics OPD, for a period of 3 months by purposive sampling.Results: On evaluation, mean age of the participants was 60.19±1.01. Out of 100 patients, 42 patients had bilateral knee OA, therefore total 142 knees included in the analysis. More than half (51%) participants were overweight. Only 34% subjects had compliament to physiotherapy. Around 76% subjects taking analgesics and massage therapy to reduce knee pain. Maximum 82.4% subjects had a poor knee condition in KSS and mean score is 49.07±1.06. Ahlback grading in X-ray had negative correlation -0.610 with KSS. Hence it is evaluated, both the scales have approximately same result as it is analyzed that both scales are moderately correlated. There is significant association of age, occupation and physiotherapy with Ahlback grading followed with KSS significant associated with BMI, occupation and physiotherapy.Conclusions: The study concluded that there is a moderate correlation found between Ahlback X-ray grading and knee society scoring. X-ray and knee society scoring (clinical evaluation) both are essential for effective treatment of OA.

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Surgical Approaches to Advanced Knee OA (TKA, UKA, Osteotomy)

Principles of Orthopedic Practice for Primary Care Providers ◽

10.1007/978-3-030-74625-4_25 ◽

2021 ◽

pp. 425-435

Author(s):

Adam S. Olsen ◽

Vivek M. Shah

Keyword(s):

Surgical Approaches ◽

Knee Oa

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Restoration of Neurological Function Following Peripheral Nerve Trauma

International Journal of Molecular Sciences ◽

10.3390/ijms21051808 ◽

2020 ◽

Vol 21 (5) ◽

pp. 1808 ◽

Cited By ~ 2

Author(s):

Damien P. Kuffler ◽

Christian Foy

Keyword(s):

Peripheral Nerve ◽

Functional Recovery ◽

Recovery Of Function ◽

Sensory Nerve ◽

Standard Technique ◽

Neurological Function ◽

Neurological Recovery ◽

Nerve Grafts ◽

Peripheral Nerve Trauma ◽

Nerve Trauma

Following peripheral nerve trauma that damages a length of the nerve, recovery of function is generally limited. This is because no material tested for bridging nerve gaps promotes good axon regeneration across the gap under conditions associated with common nerve traumas. While many materials have been tested, sensory nerve grafts remain the clinical “gold standard” technique. This is despite the significant limitations in the conditions under which they restore function. Thus, they induce reliable and good recovery only for patients < 25 years old, when gaps are <2 cm in length, and when repairs are performed <2–3 months post trauma. Repairs performed when these values are larger result in a precipitous decrease in neurological recovery. Further, when patients have more than one parameter larger than these values, there is normally no functional recovery. Clinically, there has been little progress in developing new techniques that increase the level of functional recovery following peripheral nerve injury. This paper examines the efficacies and limitations of sensory nerve grafts and various other techniques used to induce functional neurological recovery, and how these might be improved to induce more extensive functional recovery. It also discusses preliminary data from the clinical application of a novel technique that restores neurological function across long nerve gaps, when repairs are performed at long times post-trauma, and in older patients, even under all three of these conditions. Thus, it appears that function can be restored under conditions where sensory nerve grafts are not effective.

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Preoperative Function and Gender Predict Pattern of Functional Recovery After Hip and Knee Arthroplasty

The Journal of Arthroplasty ◽

10.1016/j.arth.2005.07.010 ◽

2006 ◽

Vol 21 (4) ◽

pp. 559-566 ◽

Cited By ~ 143

Author(s):

Deborah M. Kennedy ◽

Steven E. Hanna ◽

Paul W. Stratford ◽

Jean Wessel ◽

Jeffrey D. Gollish

Keyword(s):

Functional Recovery ◽

Knee Arthroplasty ◽

Hip And Knee Arthroplasty ◽

And Gender

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Efficiency of Structural Antigipoxants in Perioperative Period of Patients with Lower Limbs Fractures

Journal of Biomimetics Biomaterials and Biomedical Engineering ◽

10.4028/www.scientific.net/jbbbe.46.1 ◽

2020 ◽

Vol 46 ◽

pp. 1-7

Author(s):

Timur Minasov ◽

Ayaz Faizullin ◽

Radmir Saubanov ◽

Roman Kostiv ◽

Gulnara Gainanova ◽

...

Keyword(s):

Functional Recovery ◽

Comparison Group ◽

Life Quality ◽

Perioperative Period ◽

Blood Parameters ◽

Lower Limbs ◽

Infusion Therapy ◽

Isotonic Solution ◽

Control Groups ◽

And Control

The efficacy of pathogenetic correction of metabolism in 211 patients with diaphyseal hip and shin bones fractures had been analyzed. Patients were divided into the main and control groups. Intravenous infusions of 1.5% sodium meglumine succinate solution were administered, and infusion therapy with isotonic solution to the patients of the comparison group. The parameters of functional activity and peripheral blood dates had been analyzed. In the perioperative period main group provide better physical component of the life quality and blood parameters functional recovery.

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An Agonist of the CXCR4 Receptor Strongly Promotes Regeneration of Degenerated Motor Axon Terminals

Cells ◽

10.3390/cells8101183 ◽

2019 ◽

Vol 8 (10) ◽

pp. 1183 ◽

Cited By ~ 5

Author(s):

Negro ◽

Zanetti ◽

Mattarei ◽

Valentini ◽

Megighian ◽

...

Keyword(s):

Functional Recovery ◽

Neuromuscular Junctions ◽

Recovery Of Function ◽

Motor Axon ◽

Cxcr4 Antagonist ◽

Axon Terminals ◽

Stem Cell Migration ◽

Natural Ligand ◽

Nerve Recovery ◽

Strong Candidate

The activation of the G-protein coupled receptor CXCR4 by its ligand CXCL12α is involved in a large variety of physiological and pathological processes, including the growth of B cells precursors and of motor axons, autoimmune diseases, stem cell migration, inflammation, and several neurodegenerative conditions. Recently, we demonstrated that CXCL12α potently stimulates the functional recovery of damaged neuromuscular junctions via interaction with CXCR4. This result prompted us to test the neuroregeneration activity of small molecules acting as CXCR4 agonists, endowed with better pharmacokinetics with respect to the natural ligand. We focused on NUCC-390, recently shown to activate CXCR4 in a cellular system. We designed a novel and convenient chemical synthesis of NUCC-390, which is reported here. NUCC-390 was tested for its capability to induce the regeneration of motor axon terminals completely degenerated by the presynaptic neurotoxin α-Latrotoxin. NUCC-390 was found to strongly promote the functional recovery of the neuromuscular junction, as assayed by electrophysiology and imaging. This action is CXCR4 dependent, as it is completely prevented by AMD3100, a well-characterized CXCR4 antagonist. These data make NUCC-390 a strong candidate to be tested in human therapy to promote nerve recovery of function after different forms of neurodegeneration.

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Prognostic factors for inpatient functional recovery following total hip and knee arthroplasty: a systematic review

Acta Orthopaedica ◽

10.1080/17453674.2020.1744852 ◽

2020 ◽

Vol 91 (3) ◽

pp. 313-318

Author(s):

Nicola Hewlett-Smith ◽

Rodney Pope ◽

James Furness ◽

Vini Simas ◽

Wayne Hing

Keyword(s):

Systematic Review ◽

Prognostic Factors ◽

Functional Recovery ◽

Knee Arthroplasty ◽

Total Hip ◽

Hip And Knee Arthroplasty

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Effects of high levels of fatty acids on functional recovery of ischemic hearts from diabetic rats

AJP Endocrinology and Metabolism ◽

10.1152/ajpendo.1992.263.6.e1046 ◽

1992 ◽

Vol 263 (6) ◽

pp. E1046-E1053 ◽

Cited By ~ 6

Author(s):

G. D. Lopaschuk ◽

M. Saddik ◽

R. Barr ◽

L. Huang ◽

C. C. Barker ◽

...

Keyword(s):

Fatty Acids ◽

Functional Recovery ◽

Recovery Of Function ◽

Heart Function ◽

Diabetic Rats ◽

Diabetic Rat ◽

Mechanical Function ◽

Rat Hearts ◽

Reperfusion Period ◽

High Concentrations

In this study we determined the effects of high levels of fatty acids on recovery of heart function when present either during or after ischemia. Isolated working hearts from 6-wk streptozotocin diabetic and control rats perfused with 11 mM glucose were subjected to 25 min of global ischemia followed by 30 min of aerobic reperfusion. Four groups were studied: 1) 1.2 mM palmitate present before, during, and after ischemia; 2) 1.2 mM palmitate present before and during ischemia, followed by reperfusion in the absence of palmitate; 3) no palmitate before and during ischemia, followed by 1.2 mM palmitate during reperfusion; and 4) no palmitate before and during ischemia or during reperfusion. In control hearts, palmitate during reperfusion depressed recovery of function regardless of whether palmitate was present or absent during ischemia. In contrast, palmitate present during reperfusion did not depress recovery of mechanical function in the diabetic rat hearts. However, the presence of palmitate during ischemia itself in diabetic rat hearts was detrimental to recovery of mechanical function. The presence of palmitate during ischemia resulted in an accelerated rate of ATP loss and a decreased rate of lactate accumulation during ischemia, although this effect was similar in control and diabetic rat hearts. Our results demonstrate that high concentrations of fatty acids depress functional recovery of control rat hearts during the reperfusion period but depress recovery of function in diabetic rat hearts when present during ischemia itself.

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Cervical vertebral fractures in 56 dogs: a retrospective study

Journal of the American Animal Hospital Association ◽

10.5326/15473317-35-2-135 ◽

1999 ◽

Vol 35 (2) ◽

pp. 135-146 ◽

Cited By ~ 44

Author(s):

JC Hawthorne ◽

WE Blevins ◽

LJ Wallace ◽

N Glickman ◽

DJ Waters

Keyword(s):

Retrospective Study ◽

Surgical Treatment ◽

Functional Recovery ◽

Vertebral Fractures ◽

Perioperative Period ◽

Clinicopathological Features ◽

Neurological Deficits ◽

Perioperative Mortality ◽

Cervical Fractures

The clinicopathological features of cervical fractures in 56 dogs were reviewed. "Hit by car" (HBC) was the most common inciting cause, and the axis and atlas were the vertebrae most frequently affected. Surgical treatment was associated with high (36%) perioperative mortality. However, all dogs that survived the perioperative period achieved functional recovery. Functional recovery was achieved in 25 (89%) of 28 nonsurgically treated dogs with adequate follow-up. Overall, severity of neurological deficits (nonambulatory status) and prolonged interval (five days or longer) from trauma to referral were associated with poorer outcome. Nonsurgical treatment is a viable therapeutic approach for many dogs with cervical fractures. Early neck immobilization and prompt referral are recommended, because delay in referral decreases the likelihood of functional recovery.

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