scholarly journals FEATURES OF CARDIOVASCULAR ADAPTATION IN NEWBORNS BORN FROM MOTHERS WITH METABOLIC SYNDROME

2021 ◽  
Vol 11 (4(42)) ◽  
pp. 9-14
Author(s):  
V. Pokhylko ◽  
O. Kovalova ◽  
Y. Cherniavska ◽  
Y. Klymchuk ◽  
O. Yakovenko
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Lipid Metabolism ◽  
High Blood Pressure ◽  
Premature Infants ◽  
Negative Relationship ◽  
Main Group ◽  
Overweight And Obesity ◽  
The Metabolic Syndrome

Introduction. Overweight and obesity, the manifestations of metabolic syndrome during pregnancy, and their consequences are huge public health challenges. The effect of a mother`s metabolic syndrome on the condition of a newborn is insufficiently studied. The aim is to establish the features of cardiovascular adaptation of premature infants born from mothers with metabolic syndrome, and to identify metabolic maternal and infant risk factors that are mostly associated with high blood pressure and cardiopathy. Material and methods. A cohort prospective study was conducted, which included 97 premature newborns who were treated in the intensive care unit. Two groups were formed: the main group included premature infants born from mothers with metabolic syndrome (n = 40), and the comparison group included premature infants born from mothers without metabolic syndrome (n = 57). Results. Infants born from mothers with metabolic syndrome had significantly higher blood pressure than normal according to the gestational age of a child (45.5 ± 0.13 vs. 42.56 ± 0.13 mm Hg, p <0.001). High blood pressure in infants was significantly associated with maternal lipid metabolism disorders (OR 30.9) and hypertension (OR 4.8). The study found a significant positive relationship between blood pressure and overweight in an infant (Coef. 0.168), and a significant negative relationship with glucose level in blood serum (Coef. -0.037). It was found that cardiomyopathy is significantly more common in children of the main group (p = 0.010), its development is associated with the presence of diabetes in a mother (OR 7.57). The more components of the metabolic syndrome a woman has, the more likely a child is to have cardiomyopathy. The risk of developing cardiomyopathy is significantly influenced by a number of risk factors on the part of a newborn. Conclusions: High blood pressure in premature infants is significantly associated with a complex of components of the metabolic syndrome in mothers (hypertension and / or preeclampsia, obesity, diabetes and disorders of lipid metabolism in a mother (OR 14.71, p <0.001)). The role of carbohydrate metabolism disorders in a child in the development of high blood pressure has been demonstrated. It is proved that the development of cardiopathy in newborns is associated with risk factors from both a child and a mother, which indicates a complex effect of metabolic factors on the adaptation of the cardiovascular system.

Dietary Approaches to Stop Hypertension (DASH): potential mechanisms of action against risk factors of the metabolic syndrome

2019 ◽  
Vol 33 (1) ◽  
pp. 1-18 ◽  
Author(s):  
Masoumeh Akhlaghi
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Saturated Fat ◽  
Hdl Cholesterol ◽  
Reduce Blood Pressure ◽  
Overweight And Obesity ◽  
Cross Sectional ◽  
Dash Diet ◽  
The Metabolic Syndrome

AbstractThe metabolic syndrome is a cluster of disorders dominated by abdominal obesity, hypertriacylglycerolaemia, low HDL-cholesterol, high blood pressure and high fasting glucose. Diet modification is a safe and effective way to treat the metabolic syndrome. Dietary Approaches to Stop Hypertension (DASH) is a dietary pattern rich in fruits, vegetables and low-fat dairy products, and low in meats and sweets. DASH provides good amounts of fibre, K, Ca and Mg, and limited quantities of total fat, saturated fat, cholesterol and Na. Although DASH was initially designed for the prevention or control of hypertension, using a DASH diet has other metabolic benefits. In the present review, the effect of each dietary component of DASH on the risk factors of the metabolic syndrome is discussed. Due to limited fat and high fibre and Ca content, individuals on the DASH diet are less prone to overweight and obesity and possess lower concentrations of total and LDL-cholesterol although changes in TAG and HDL-cholesterol have been less significant and available evidence in this regard is still inconclusive. Moreover, high amounts of fruit and vegetables in DASH provide great quantities of K, Mg and fibre, all of which have been shown to reduce blood pressure. K, Mg, fibre and antioxidants have also been effective in correcting glucose and insulin abnormalities. Evidence is provided from cross-sectional investigations, cohort studies and randomised controlled trials, and, where available, from published meta-analyses. Mechanisms are described according to human studies and, in the case of a lack of evidence, from animal and cell culture investigations.

scholarly journals Dynamics of nutrition structure and metabolic syndrome risk factors in overweight and obese women with dietary counseling and remote monitoring

2021 ◽  
Vol 36 (3) ◽  
pp. 127-136
Author(s):  
R. A. Eganyan ◽  
A. M. Kalinina ◽  
B. E. Gornyi ◽  
A. V. Kontsevaya ◽  
O. M. Drapkina ◽  
...  
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Weight Loss ◽  
Lipid Metabolism ◽  
Cardiovascular Diseases ◽  
Remote Monitoring ◽  
Overweight And Obesity ◽  
Dietary Counseling ◽  
Low Consumption

Aim. To study the effects of diet optimization and weight loss on the dynamics of metabolic syndrome and cardiovascular risk factors in women with overweight and obesity in six-month dietary counseling and remote monitoring.Material and Methods. A balanced caloric restriction by 240–250 kcal a day on average was recommended to 119 women with overweight and obesity. Actual nutrition was evaluated using special computer software “1C Nutrition Evaluation”.Results. The study showed a significant nutritional imbalance with a relatively high consumption of fats (40.4%) and low consumption of carbohydrates (39.6%), mainly due to the low consumption of starch. On the contrary, the consumption level of monoand disaccharides (20.9%) was twice as high as recommended (10%) by the World Health Organization (WHO). Dietary restriction and nutritional optimization led to a significant decrease in the values of body weight, body mass index, waist circumference, blood pressure, and lipid metabolism. As a result, the risks and probability of metabolic syndrome and cardiovascular diseases decreased.Conclusion. Correction of eating habits allowed to establish a rational and balanced approach to dietary energy restriction and nutritional structure optimization. Achieved weight loss was associated with normalization of parameters of abdominal obesity, blood pressure, and lipid metabolism. Six-month dietary intervention in women promoted control of risk factors for metabolic syndrome and cardiovascular diseases. The results of the study may be used to improve the personalized technology of distant preventive counseling in primary health care aimed at weight loss to achieve both primary and secondary prophylactics of metabolic syndrome and chronic non-infectious diseases.

Components Analysis of Metabolic Syndrome in Acute Myocardial Infarction Patients

2018 ◽  
Vol 29 (2) ◽  
pp. 6-10
Author(s):  
Khan MMR ◽  
Sana NK ◽  
PM Basak ◽  
BC Sarker ◽  
M Akhtarul Islam ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Acute Myocardial Infarction ◽  
High Blood Pressure ◽  
Abdominal Obesity ◽  
Premature Death ◽  
Medical College ◽  
The Metabolic Syndrome ◽  
Low Hdl

Background: Metabolic syndrome confers the risk of developing acute myocardial infarction which is the most common form of coronary heart disease and the single most important cause of premature death worldwide. The frequency and association of different components of metabolic syndrome on AMI are not well understood and has not been well evaluated.Objective: The aim of this study was to assess the components of the metabolic syndrome and its association with AMI patients. This study will help in awareness building in reducing AMI by early detection of components of metabolic syndrome.Patients and methods: This was a prospective observational study consisted of 325 AMI patients who were aged >20 years. Patients with first time AMI arriving in CCU of Rajshahi medical college during the period of 2012-2014, were included. Data were collected through interview, clinical examination, and laboratory tests within 24 hrs of AMI. Five components of metabolic syndrome were defined according to criteria set by modified NCEP ATP III (according to ethnic variation).Results: In AMI patients (n=325), no metabolic components were in 24 (7.4%) patients, one in 53 (16.3%), 2 components in 91(28.0%), 3 components were in 61(18.8%), 4 in 67(20.6%) and all 5 components were in 29 (8.9%) patients. In this study, there was no component in 7.4% of AMI patients, at least 1 component was 92.6%, at least 2 components were 76.3%, at least 3 components were 48.3%, at least 4 components were 29.5% and at least 5 components were 8.9%. The Metabolic syndrome was 48.3% (n=157). Among metabolic syndrome (≥3 components) in AMI (n=157, 48.3%) 4 components (20.6%) were more, next was 3 components (18.8%) and than 5 components (8.9%). Overall frequencies of components in acute myocardial infarction (n=325) were in order of abdominal obesity (54.8%) > high blood pressure (54.5%) > high FPG (54.2%) > Triglyceride (46.2%) and low HDL-C (46.2%) in acute myocardial infarction. Highest percentage was observed in abdominal obesity (54.8%) followed by high blood pressure (54.5%) and FPG (54.2%).TAJ 2016; 29(2): 6-10

Association between Patients with Metabolic Syndrome and Other Various Factors Defining Metabolic Syndrome: A Cross-Sectional Study

2021 ◽  
Vol 8 (4) ◽  
pp. 12-17
Author(s):  
Basavaraj PG ◽  
Ashok P Yenkanchi ◽  
Chidanand Galagali
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Cardiovascular Diseases ◽  
Abdominal Obesity ◽  
Positive History ◽  
The Metabolic Syndrome ◽  
Study Results ◽  
History Of ◽  
The Mean

Background: Risk factors can lead to clinical conditions, like metabolic syndrome, that predisposes the development of cardiovascular diseases. Objective: The goal of this population-based, prospective and non-randomised cohort study was to study the association between patients with metabolic syndrome and other various factors defining metabolic syndrome. Methods: All the patients referred to the department of Medicine, Al-Ameen Medical college hospital and District Hospital, Vijayapur, Karnataka, India over a period of twenty-two months extending from December 2013 to September 2015 were considered in this study. Results: In the current study, out of 100 patients, 62.9% patients had metabolic syndrome with positive family history of hypertension, diabetes mellitus. 70.8% patients had metabolic syndrome with positive history of smoking. 64.3% patients had metabolic syndrome with positive history of alcohol .73.9% patients had metabolic syndrome with positive history of IHD. 87% of the patients with metabolic syndrome had SBP> 130 mmHg, and 78.85% patients had DBP>85 mmHg. And metabolic syndrome was observed in 71.8% patients on anti hypertensive drugs. The mean level of total cholesterol, LDL cholesterol, triglyceride is increased whereas the mean level of anti-atherogenic HDL cholesterol is low in subjects with MS. At least one lipid abnormality was present in > 95 % of cases. Around 81% subjects with BMI <25 (out of 38) had metabolic syndrome and 58% subjects with BMI>25(out of 62) had metabolic syndrome. Conclusion: All the components defining the metabolic syndrome correlated positively with the abdominal obesity. Systolic blood pressure values were significantly higher than diastolic blood pressure in subjects with abdominal obesity. Metabolic syndrome has multiple risk factors determined by various aspects like the race, the life style, geographical factors larger study is needed to understand the correlation between various components defining it. A healthy lifestyle, that includes avoiding tobacco exposure and proper weight control, must be encouraged in this high-risk population. Keywords: Cardiovascular diseases; Overweight; Risk factors; Smoking.

scholarly journals The metabolic syndrome – What is it and how should it be managed?

2019 ◽  
Vol 26 (2_suppl) ◽  
pp. 33-46 ◽  
Author(s):  
Peter M Nilsson ◽  
Jaakko Tuomilehto ◽  
Lars Rydén
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Waist Circumference ◽  
Elevated Blood Pressure ◽  
Elevated Blood ◽  
Successful Management ◽  
Unhealthy Lifestyle ◽  
The Metabolic Syndrome ◽  
Frail Elderly People

A cluster of metabolic factors have been merged into an entity named the metabolic syndrome. Although the characteristics of this syndrome have varied over time the presently used definition was established in 2009. The presence of three abnormal findings out of five components qualifies a person for the metabolic syndrome: elevated waist circumference, elevated triglycerides, reduced high-density lipoprotein cholesterol, elevated blood pressure and elevated fasting plasma glucose. Cut points have been defined for all components apart from waist circumference, for which national or regional values are used. The metabolic syndrome predicts cardiovascular disease and type 2 diabetes. This associated risk does not exceed its components whereof elevated blood pressure is the most frequent. A successful management should, however, address all factors involved. The management is always based on healthy lifestyle choices but has not infrequently to be supported by pharmacological treatment, especially blood pressure lowering drugs. The metabolic syndrome is a useful example of the importance of multiple targets for preventive interventions. To be successful management has to be individualized not the least when it comes to pharmacological therapy. Frail elderly people should not be over-treated. Knowledge transfer of how risk factors act should be accompanied by continuous trust building and motivation. In complex situations with a mix of biological risk factors, adverse social conditions and unhealthy lifestyle, everything cannot be changed at once. It is better to aim for small steps that are lasting than large, unsustainable steps with relapses to unhealthy behaviours. A person with the metabolic syndrome will always be afflicted by its components, which is the reason that management has to be sustained over a very long time. This review summarizes the knowledge on the metabolic syndrome and its management according to present state of the art.

scholarly journals The Metabolic Syndrome and Risk of Chronic Kidney Disease: Pathophysiology and Intervention Strategies

2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Heather A. LaGuardia ◽  
L. Lee Hamm ◽  
Jing Chen
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Intervention Strategies ◽  
Elevated Blood ◽  
The Metabolic Syndrome ◽  
Prevalence Of Obesity ◽  
Complications And Mortality

Metabolic syndrome is characterized by a clustering of cardiovascular risk factors, including abdominal obesity, elevated blood pressure and glucose concentrations, and dyslipidemia. The presence of this clinical entity is becoming more pervasive throughout the globe as the prevalence of obesity increases worldwide. Moreover, there is increased recognition of the complications and mortality related to this syndrome. This paper looks to examine the link between metabolic syndrome and the development of chronic kidney disease.

Abstract P202: The Metabolic Syndrome and Shift Work Among firefighters in South Korea

Hypertension ◽  
2017 ◽  
Vol 70 (suppl_1) ◽  
Author(s):  
Jee eun Choi ◽  
Mun-Joo Bae ◽  
Sungha Park ◽  
Ki-Soo Park ◽  
Changsoo Kim
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Shift Work ◽  
Work Group ◽  
Hdl Cholesterol ◽  
Common Disease ◽  
Multiple Risk Factors ◽  
The Metabolic Syndrome ◽  
History Of

Background/Aim: Multiple risk factors including dysipidemia, hypertension and hyperglycemia which cluster together are termed the metabolic syndrome. It means managing the metabolic syndrome is crucial to prevent cardiovascular disease (CVD). Several studies found that CVD is the common disease and the leading cause of on-duty death among firefighters. Although importance of understanding to investigate risk factors that causes CVD among firefighter has been emphasized, research about it is still behind. Thus, to understand risk factor of CVD among firefighters, this study was examined an association between metabolic syndrome and shift work among firefighters. Methods: A total of 257 men firefighters were included from Firefighter Research Enhancement of Safety & Heath (FRESH) cohort in Korea. No history of CV related disease including hypertension and diabetes were selected. Weight circumference, systolic blood pressure (SBP) and diastolic blood pressure (DBP) were measured. SBP and DBP were measured three times at interval of five minutes in resting and average of the three of SBP and DBP was used in this analysis. Fasting hyperglycaemia, Triglycerides and HDL cholesterol were analysed from blood sample collected from the participants. Metabolic syndrome, using the modified National Cholesterol Education Program (Adult Treatment Panel III) criteria, was defined. The information of shift works, smoking and alcohol consumption were self-reported from the participants and divided into three; no shift work, 24 hour shift work and 2 or 3 shifts works. To analysis the association between metabolic syndrome and shift works, logistic model was used, adjusting for age, BMI, smoking and alcohol. Results: 26 (10.1%) participants out of 257 were metabolic syndrome in the participants group. The unadjusted prevalence of the metabolic syndrome by shift works is 8.2% in no shift work group, 7.1% in 24 hour shift work group and 15.9% in 2 or 3 shifts work group. Adjusted Odds Ratio (OR) with 95% CI for 24 hours shift work was 1.51 [0.35 6.45] and 4.77 [1.08 20.9] for 3 shifts works. Conclusions: There is an association between metabolic syndrome and shift work in Korea firefighters, which implies shift work might be associated with CVD.

METABOLIC SYNDROME AS A GERONTOLOGICAL PROBLEM (LITERATURE REVIEW)

2020 ◽  
pp. 479-487
Author(s):  
В. А. Карпин
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Cardiovascular Diseases ◽  
Metabolic Disorders ◽  
Fat Metabolism ◽  
Peripheral Tissues ◽  
The Metabolic Syndrome ◽  
Tissue Sensitivity ◽  
Almost All

Метаболический синдром - это комплекс взаимосвязанных нарушений углеводного и жирового обмена, а также механизмов регуляции АД и функции эндотелия, в основе развития которых лежит снижение чувствительности тканей к инсулину. Следовательно, ведущим компонентом, патофизиологической основой и объединяющим фактором большинства симптомов, описываемых в рамках метаболического синдрома, является резистентность периферических тканей к действию инсулина, тесно коррелирующая с большинством метаболических нарушений. Необходимо подчеркнуть, что практически все составляющие метаболического синдрома являются установленными факторами риска развития сердечно-сосудистых заболеваний. Вероятность развития метаболического синдрома увеличивается с возрастом. В статье обсуждается возможность представления метаболического синдрома как геронтологической проблемы. Metabolic syndrome is a complex of interrelated disorders of carbohydrate and fat metabolism, as well as mechanisms for regulating blood pressure and endothelial function, which are based on a decrease in tissue sensitivity to insulin. Therefore, the leading component, pathophysiological basis and uniting factor of most of the symptoms described in metabolic syndrome is the resistance of peripheral tissues to the action of insulin, which is closely correlated with most metabolic disorders. It should be emphasized that almost all components of metabolic syndrome are established risk factors for developing cardiovascular diseases. The likelihood of developing metabolic syndrome increases with age. The article discusses the possibility of presenting the metabolic syndrome as a gerontological problem.

scholarly journals The Prevalence of the Metabolic Syndrome and Its Risk Factors in a Middle-Aged Swedish Population — Mainly a Function of Overweight?

2008 ◽  
Vol 7 (1) ◽  
pp. 21-26 ◽  
Author(s):  
Gunilla Hollman ◽  
Margareta Kristenson
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Risk Factor ◽  
Waist Circumference ◽  
Hdl Cholesterol ◽  
Population Based ◽  
Middle Aged ◽  
Swedish Population ◽  
The Metabolic Syndrome

Background: The prevalence of obesity, one risk factor for developing the metabolic syndrome (MS), has increased during the last decades. It has therefore been assumed that the prevalence of MS would also increase. Aims: The aim was to analyse the prevalence of MS and its risk factors in a middle-aged Swedish population. Methods: Data were obtained between 2003 and 2004 from a random population based sample of 502 men and 505 women, 45–69 years old. Measures of plasma glucose, serum lipids, blood pressure, weight, height, waist circumference and self-reported data concerning presence of disease, medication and lifestyle were obtained. Results: The prevalence of MS was 14.8% among men and 15.3% among women, with an increase by age among women only, 10% to 25% ( p = 0.029). Among individuals with MS the most frequent risk factor was large waist circumference, present in 85% of men and 99% of women, followed by high blood pressure, high triglycerides, high glucose and HDL cholesterol (38% and 47% respectively). Conclusion: The prevalence of MS was 15%, increasing with age only among women. Overweight was a dominant characteristic, and only half of the individuals with MS had glucose/HDL cholesterol levels beyond defined cut points of the syndrome.

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