scholarly journals ONTOGENETIC ASSESSMENT OF THE TYPOLOGICAL DIRECTIONALITY OF THE FUNCTIONAL AND PSYCHOLOGICAL STATUS OF PERSONS WITH DIFFERENT LEVELS OF MOTOR ACTIVITY

Author(s):  
T.V. Bespalova ◽  
Author(s):  
Ю.А. Бондарчук ◽  
О.В. Алексеева ◽  
И.И. Шахматов ◽  
Ю.Б. Лебедева ◽  
Е.Ю. Медведева

Введение. Психоэмоциональный стресс, связанный с риском для жизни и здоровья (витальный стресс), вызывает комплексную ответную реакцию всего организма. Система гемостаза, обеспечивающая жидкостные характеристики циркулирующей крови, играет существенную роль в формировании процессов адаптации или дезадаптации. Нарушения равновесия в процессах свертывания и противосвертывания вместе с изменениями микроциркуляции являются основой патогенеза острых и хронических заболеваний с развитием тромботических либо геморрагических осложнений. Цель исследования: оценить состояние системы гемостаза у крыс с разным уровнем двигательной активности после острой психогенной травмы в виде витального стресса. Материалы и методы. Исследования выполнены на 44 лабораторных половозрелых крысахсамцах линии Wistar, которые составили 2 экспериментальные группы с низкой (n 15) и высокой (n 15) двигательной активностью и контрольную группу интактных животных (n 14). Спонтанную двигательную активность оценивали с помощью теста открытое поле . В качестве острого психотравмирующего воздействия использовали модель психической травмы у крыс в виде витального стресса, вызванного переживанием гибели партнера от действий хищника. Результаты. Острое психотравмирующее воздействие у животных с низкой двигательной активностью вызывало угнетение агрегации тромбоцитов. В группе животных с высокой двигательной активностью была выявлена гиперкоагуляция по внешнему пути активации плазменного гемостаза, а также на конечных этапах коагуляции. В обеих экспериментальных группах наблюдали укорочение времени полимеризации фибринмономера, снижение уровня фибриногена, а также активности антитромбина III на фоне активации фибринолиза. Заключение. Изменения состояния системы гемостаза у крыс с разным уровнем двигательной активности после острого психоэмоционального стресса имели одинаковую направленность, но различную степень выраженности ответной реакции. Полученные результаты позволяют охарактеризовать однократное психоэмоциональное воздействие как не выходящее за рамки эустресса (по данным коагулограммы). Introduction. Psychoemotional stress associated with the risk to life and health (vital stress) causes a complex total body response. Hemostasis supports fluid characteristics of circulating blood and plays a significant role in the formation of adaptation or disadaptation processes. Imbalance in the processes of coagulation and anticoagulation with microcirculation changes are the basis of pathogenesis of acute and chronic diseases with the development of thrombotic or hemorrhagic complications. Aim: to assess hemostasis state in rats with different levels of motor activity after acute psychogenic trauma (vital stress). Materials and methods. The studies were performed on 44 laboratory matured Wistar male rats that were divided into 2 experimental groups with low (n 15) and high (n 15) motor activity and a control group of intact animals (n 14). Spontaneous motor activity was assessed using the open field test. A model of mental trauma was used for the formation of acute psychotraumatic effect in rats in the form of vital stress caused by the experience of partner death from a predator. Results. Acute psychotraumatic effect in animals with low motor activity caused inhibition of platelet aggregation. In animals with high motor activity, hypercoagulation was revealed in the external pathway of plasma hemostasis activation, as well as at the final stages of coagulation. Shortening of fibrin monomer polymerization time, decreasing of fibrinogen level and antithrombin III activity with fibrinolysis activation were observed in both experimental groups. Conclusion. After acute psychoemotional stress hemostasis changes in rats with different levels of motor activity had the same direction, but different intensity of response. The obtained results allow to characterize a single psychoemotional effect as not exceeding the limits of eustress (according to the coagulogram data).


2021 ◽  
Vol 23 (6) ◽  
pp. 10-17
Author(s):  
Raylyan A.L. ◽  
Galieva G.D. ◽  
Nikolaenko P.V. ◽  
Ivanova P.V.

During pregnancy, the cardiovascular system functions with an increased load. These changes are of a pronounced adaptive nature and provide optimal conditions for the transport of oxygen in the placenta and vital organs of the mother. According to domestic and foreign researchers, 20% of women during pregnancy are first diagnosed with a violation of blood pressure, which negatively affects both the health of the pregnant woman and the fetus. In this regard, for effective pre-gravidar preparation and minimizing the risks of cardiovascular complications, there is a need to develop criteria for pre-nosological diagnosis of various blood pressure disorders in women of reproductive age. The study made it possible to study the indicators of the cardiovascular system at rest and after stress testing in women with different levels of habitual motor activity. As a result, women with low and high habitual motor activity were assigned to the risk group for the development of arterial hypo - and hypertension. The results obtained are the basis for identifying criteria for prenosological diagnosis of early blood pressure disorders.


1981 ◽  
Vol 90 (4) ◽  
pp. 383-386 ◽  
Author(s):  
Toribio C. Flores ◽  
Frederick S. Cross ◽  
Richard D. Jones

Globus hystericus means the “hysterical ball or lump in the throat,” and is generally assumed to be of psychic origin. True dysphagia is usually absent. Twelve patients with the globus syndrome were studied at the Esophageal Motility Laboratory of the Saint Luke's Hospital of Cleveland. An organic cause for their symptomatology was ruled out by physical examination, laryngoscopy, esophagoscopy and cineesophagograms. Ten patients showed significant elevations in esophageal resting pressures and nine had evidence of disordered motor activity in the body of the esophagus. Knowing from previous investigations that a suprasternal discomfort may be elicited from stimulation of the esophagus at different levels, we propose that the globus sensation is a referred one coming from the hypertonic and frequently incoordinated body of the esophagus.


2015 ◽  
Vol 11 (1) ◽  
pp. 83-85
Author(s):  
D Nenenko Natalya

The study found differences in the immune status of individuals with different levels of motor activity living in Khanty-Mansiysk Autonomus Area - Yugra. Athletes of various specializations differed expressed suppression of humoral immunity. This fact may be the reason for the failure of adaptation and the increasing incidence of elite athletes.


2017 ◽  
Vol 2 (7) ◽  
pp. 119-125 ◽  
Author(s):  
N. A. Tarovyk ◽  
◽  
G. V. Korobeynikov ◽  
A. K. Dudnik ◽  
G. I. Vrzhesnevskaya ◽  
...  

BMJ Open ◽  
2019 ◽  
Vol 9 (2) ◽  
pp. e026401 ◽  
Author(s):  
Sigurd Evensen ◽  
Alan Kevin Bourke ◽  
Stian Lydersen ◽  
Olav Sletvold ◽  
Ingvild Saltvedt ◽  
...  

ObjectivesIt remains unclear if geriatric patients with different delirium motor subtypes express different levels of motor activity. Thus, we used two accelerometer-based devices to simultaneously measure upright activity and wrist activity across delirium motor subtypes in geriatric patients.DesignCross-sectional study.SettingsGeriatric ward in a university hospital in Norway.ParticipantsSixty acutely admitted patients, ≥75 years, with DSM-5-delirium.Outcome measuresUpright activity measured as upright time (minutes) and sit-to-stand transitions (numbers), total wrist activity (counts) and wrist activity in a sedentary position (WAS, per cent of the sedentary time) during 24 hours ongoing Delirium Motor Subtype Scalesubtyped delirium.ResultsMean age was 86.7 years. 15 had hyperactive, 20 hypoactive, 17 mixed and 8 had no-subtype delirium. We found more upright time in the no-subtype group than in the hypoactive group (119.3 vs 37.8 min, p=0.042), but no differences between the hyperactive, the hypoactive and the mixed groups (79.1 vs 37.8 vs 50.1 min, all p>0.28). The no-subtype group had a higher number of transitions than the hypoactive (54.3 vs 17.4, p=0.005) and the mixed groups (54.3 vs 17.5, p=0.013). The hyperactive group had more total wrist activity than the hypoactive group (1.238×104vs 586×104counts, p=0.009). The hyperactive and the mixed groups had more WAS than the hypoactive group (20% vs 11%, p=0.032 and 19% vs 11%, p=0.049).ConclusionsGeriatric patients with delirium demonstrated a low level of upright activity, with no differences between the hyperactive, hypoactive and mixed groups, possibly due to poor gait function. The hyperactive and mixed groups had more WAS than the hypoactive group, indicating true differences in motor activity across delirium motor subtypes, also in geriatric patients. Wrist activity appears more suitable than an upright activity for both diagnostic purposes and activity monitoring in geriatric delirium.


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