scholarly journals Human Development Management as the Basis for the Pre-Adaptation of Complex Systems in Conditions of Uncertainty and Unpredictability

wisdom ◽  
2021 ◽  
Vol 20 (4) ◽  
pp. 51-64
Author(s):  
Svetlana GUBANOVA

The article is devoted to the issue of managing the balanced development of human potential in a new socio-economic reality, which is characterized by a high degree of unpredictability, interconnectedness and interdependence, globalization and informatization of the environment and introduction of digital, cognitive and hybrid technologies. There is a need to recognize the dominant role of scientific knowledge and creative implementation, wise management and consumption. For the first time, the term “noo- management” was introduced: it is a method of intelligent management of the fundamental processes of personality development focused on higher-order values and creative implementation.

2012 ◽  
Vol 8 (S295) ◽  
pp. 176-176
Author(s):  
Jesús Gallego ◽  
Mercedes Prieto ◽  
M. Carmen Eliche-Moral ◽  
Marc Balcells ◽  
David Cristóbal-Hornillos ◽  
...  

AbstractSome recent observations seem to disagree with hierarchical theories of galaxy formation on the role of major mergers in a late build-up of massive early-type galaxies. We re-address this question by analysing the morphology, structural distortion level, and star formation enhancement of a sample of massive galaxies (M* > 5 × 1010M⊙) lying on the Red Sequence and its surroundings at 0.3 < z < 1.5. We have used an initial sample of ~1800 sources with Ks < 20.5 mag over an area ~155 arcmin2 on the Groth Strip, combining data from the Rainbow Extragalactic Database and the GOYA Survey. Red galaxy classes that can be directly associated to intermediate stages of major mergers and to their final products have been defined. For the first time we report observationally the existence of a dominant evolutionary path among massive red galaxies at 0.6 < z < 1.5, consisting in the conversion of irregular disks into irregular spheroids, and of these ones into regular spheroids. This result points to: 1) the massive red regular galaxies at low redshifts derive from the irregular ones populating the Red Sequence and its neighbourhood at earlier epochs up to z ~ 1.5; 2) the progenitors of the bulk of present-day massive red regular galaxies have been blue disks that have migrated to the Red Sequence majoritarily through major mergers at 0.6 < z < 1.2 (these mergers thus starting at z ~ 1.5); 3) the formation of E-S0's that end up with M* > 1011M⊙ at z = 0 through gas-rich major mergers has frozen since z ~ 0.6. Our results support that major mergers have played the dominant role in the definitive build-up of present-day E-S0's with M* > 1011M⊙ at 0.6 < z < 1.2, in good agreement with the hierarchical scenario proposed in the Eliche-Moral et al. (2010a) model (see also Eliche-Moral et al. 2010b). This study is published in Prieto et al. (2012).Supported by the Spanish Ministry of Science and Innovation (MICINN) under projects AYA2009-10368, AYA2006-12955, AYA2010-21887-C04-04, and AYA2009-11137, by the Madrid Regional Government through the AstroMadrid Project (CAM S2009/ESP-1496), and by the Spanish MICINN under the Consolider-Ingenio 2010 Program grant CSD2006-00070: “First Science with the GTC” (http://www.iac.es/consolider-ingenio-gtc/). S. D. H. & G.


2006 ◽  
Vol 26 (4) ◽  
pp. 1333-1346 ◽  
Author(s):  
Nirmal K. Singh ◽  
Natalia N. Singh ◽  
Elliot J. Androphy ◽  
Ravindra N. Singh

ABSTRACT Humans have two nearly identical copies of the Survival Motor Neuron (SMN) gene, SMN1 and SMN2. In spinal muscular atrophy (SMA), SMN2 is not able to compensate for the loss of SMN1 due to exclusion of exon 7. Here we describe a novel inhibitory element located immediately downstream of the 5′ splice site in intron 7. We call this element intronic splicing silencer N1 (ISS-N1). Deletion of ISS-N1 promoted exon 7 inclusion in mRNAs derived from the SMN2 minigene. Underlining the dominant role of ISS-N1 in exon 7 skipping, abrogation of a number of positive cis elements was tolerated when ISS-N1 was deleted. Confirming the silencer function of ISS-N1, an antisense oligonucleotide against ISS-N1 restored exon 7 inclusion in mRNAs derived from the SMN2 minigene or from endogenous SMN2. Consistently, this oligonucleotide increased the levels of SMN protein in SMA patient-derived cells that carry only the SMN2 gene. Our findings underscore for the first time the profound impact of an evolutionarily nonconserved intronic element on SMN2 exon 7 splicing. Considering that oligonucleotides annealing to intronic sequences do not interfere with exon-junction complex formation or mRNA transport and translation, ISS-N1 provides a very specific and efficient therapeutic target for antisense oligonucleotide-mediated correction of SMN2 splicing in SMA.


2020 ◽  
pp. 176-187
Author(s):  
T. M. Shkapenko ◽  
N. B. Milyavskaya

The pragmatic nature of the Me too speech act is studied in two different areas of functioning: outside the Internet environment and in cyberspace. It is noted that in normal communication Me too is a response cue that closes an adjacency pair and does not have a persuasive potential. On the Internet, this speech act undergoes radical changes, turning into a stimulus statement that initiates the mass participation of a certain target audience in the movement against sexual harassment. It is shown that the pragmatic transformation of the phrase is due to the action of both linguistic and extralinguistic factors. The transition from a responsive cue to an initial utterance is ensured by a common presupposition for all addressees, while the versatility of intentions acquired by the speech act (affirmation, recognition, accusation, appeal) together with the deictic pronoun of the first person endow it with a high degree of persuasiveness. As the psychological basis for the effective impact of the phrase, the ideas of the American psychological school about the importance of empathy and the therapeutic effect of public actions - confessions are successfully introduced into the consciousness of a globalized community. The novelty of the study is that for the first time the fact of the limited relevance of individual postulates of pragmalinguistic theories for the Internet space is established. The relevance of the work is associated with the need for a comprehensive understanding of the phenomenon of repragmatization of the Me too , which receives the role of a semiotic marker and a cultural symbol of a new wave of the feminist movement.


2021 ◽  
Vol 12 (4) ◽  
pp. 263-277
Author(s):  
Iryna Brushnevska ◽  
Julia Ribtsun ◽  
Liudmyla Stasiuk ◽  
Nataliia Ilina ◽  
Iryna Vasylehko ◽  
...  

The article addresses psycholinguistic preconditions for development of the communicative component of speech activity in 5-year-olds with general speech retardation (GSR). The development of speech activity is analyzed through the lens of psycholinguistic motivation for the emergence of speech units. The authors for the first time identified psychological mechanisms that underlie disorders in the development of the communication component of speech activity in 5-year-olds with GSR and suggested effective interventions. The research involved a study of probability prediction within the structure of the communicative component of speech activity of 5-year-olds with GSR. The author-developed classification of non-verbal and verbal probability prediction formed the basis for a theory-based diagnostic tool to assess the communicative component of speech activity in 5-year-olds with GSR. The research demonstrated the importance of probability prediction as a dynamic process and indicator of practical realization of utterance and holistically developed coherent speech. The analysis of disorders in cognitive and speech operations and functions identified in the study points to the dominant role of weak probability prediction function at non-verbal and verbal levels. Weak probability prediction was defined as the cause of poorly developed communication component of speech activity in 5-year-olds with GSR.


2020 ◽  
Vol 21 (3) ◽  
pp. 627-646
Author(s):  
Oskar Kosch ◽  
Marek Szarucki

The main objective of the paper is to identify and explore patterns and dynamics of transatlantic scientific collaboration in the field of strategic management between the United States (US) and European countries (EUC) during the last quarter century. Scholarly connections between countries, cities and institutions on the basis of co-author affiliations were analysed to determine the knowledge flow from a geographical perspective. This is the first time international scientific collaboration between researchers in the field of strategic management has been studied to such an extent. We employed all sources of relevant data from the Web of Science and Scopus databases and explored 453 results. Utilizing a bibliometric analysis, our study offers a comprehensive and up-todate identification and assessment of the current situation and dynamics of transatlantic scientific collaboration. The obtained results confirm the dominant role of the US in this type of collaboration. Also, the dominant role of several clusters in terms of collaboration, both on country and institution levels can also be observed. The study confirms the weaker position of Eastern and Central Europe countries in this collaboration and provides some recommendations to increase this type of knowledge exchange in the future.


2021 ◽  
Vol 13 (22) ◽  
pp. 4714
Author(s):  
Zhendi Liu ◽  
Qingfeng Li ◽  
Hanxian Fang ◽  
Ze Gao

The longitudinal structure in the altitude of the Sporadic E (Es) was investigated for the first time based on the S4 index provided by the Constellation Observing System for Meteorology, Ionosphere, and Climate (COSMIC) in low latitudes. The longitudinal structure is identified as a symmetrically located wavenumber-4 (WN4) pattern within 30°S–30°N. The WN4 occurs primarily during the daytime at the June solstice and equinoxes, with the largest amplitude at the September equinox and the smallest one at the March equinox. It moves eastward with a speed of ~90°/day. The strongest WN4 appears within 10–20°N and 5–15°S in the Northern and Southern hemispheres, respectively. At the June solstice and the September equinox, the WN4 is stronger in the Northern hemisphere than in the Southern hemisphere, while the situation is reversed at the March equinox. The altitude distribution of the convergence null in the diurnal eastward non-migrating tide with zonal wavenumber-3 (DE3) for the zonal wind is similar to that of the WN4. This and other similar features, such as the seasonal variation, eastward speed, and the symmetrical locations, support the dominant role of the DE3 tide for the formation of the WN4 structure.


2004 ◽  
Vol 70 (9) ◽  
pp. 5323-5330 ◽  
Author(s):  
Karin Elbing ◽  
Christer Larsson ◽  
Roslyn M. Bill ◽  
Eva Albers ◽  
Jacky L. Snoep ◽  
...  

ABSTRACT The yeast Saccharomyces cerevisiae predominantly ferments glucose to ethanol at high external glucose concentrations, irrespective of the presence of oxygen. In contrast, at low external glucose concentrations and in the presence of oxygen, as in a glucose-limited chemostat, no ethanol is produced. The importance of the external glucose concentration suggests a central role for the affinity and maximal transport rates of yeast's glucose transporters in the control of ethanol production. Here we present a series of strains producing functional chimeras between the hexose transporters Hxt1 and Hxt7, each of which has distinct glucose transport characteristics. The strains display a range of decreasing glycolytic rates resulting in a proportional decrease in ethanol production. Using these strains, we show for the first time that at high glucose levels, the glucose uptake capacity of wild-type S. cerevisiae does not control glycolytic flux during exponential batch growth. In contrast, our chimeric Hxt transporters control the rate of glycolysis to a high degree. Strains whose glucose uptake is mediated by these chimeric transporters will undoubtedly provide a powerful tool with which to examine in detail the mechanism underlying the switch between fermentation and respiration in S. cerevisiae and will provide new tools for the control of industrial fermentations.


2020 ◽  
Vol 12 (1) ◽  
pp. 42-48
Author(s):  
Andriy Gurduz

In Ukrainian prose of the first decades of the ХХІ century nearly greatest attention to the artistic word cleanness is spared by Olena Pechorna, her scantily explored novels deserve a system study. The novel The Witch occupies an important place in her artistic work and it is organic for her idiostyle paradigm, but while did not get a professional estimation. In our article we carry out an attempt to define the specific of dominant water concept in the novel The Witch for the first time. The key in the article become the study of the realization type of the water concept of in the book, and also the research of changes of its expression by comparison to the previous novels of authoress, finding out of method of subordination of The Witch poetics to the named concept. In the article are used psychoanalytic, system and comparable methods of research, elements of corporeal-mimetic method. The Witch continues a row of pseudomystic novels, where the expressed corporalness and system personification of the natural phenomena, objects, abstractions, etc. assists to the irrational atmosphere. Personification here is more electoral, its receptions are carried in descriptions of the emotional state, landscape, interior. «Circular elements» go out on the first plan and they assists to conceptualization of the different phenomena row. That are leit-motif imitations: updating; elements of application of meal and / whether taste feelings; the anatomy-type description of the phenomena, objects, abstractions, etc.; expressed corporalness. In The Witch system of images and microimages a separate place belongs to the water concept. As well as in «The Circles on the Water» or «A Fortress for the Heart», a water is living here, but already not anatomic and it is more frequent represented in description of processes and states. The accordingly executed descriptions of personages experiencing and properties complement a water dictate in the novel. The dominating woman beginning, incident to the pantheistic picture of the authoress’ art world, is underlined by the dominant role of water element and by proper key concept. This concept is realized through variant poetics and subordinates the work structure, co-operates with the analogical clusters of personification, leit-motif imitations, with the concepts of memory, returning, paradise, hell, etc. The named water concept also assists in forming in the novel of the mosaic mythopoetic paradigm. The concepts of memory, «winged» woman are actualized in the novel.


2012 ◽  
Vol 67 (1) ◽  
pp. 5-43
Author(s):  
Matteo Cataldi ◽  
Vincenzo Emanuele ◽  
Aldo Paparo

In 2011 Italian local elections we observed high electoral mobility: in Milan, for example, the center-left gained his first-time victory in the Berlusconi era, while in Naples there was a significant split voting in the first round and a huge turnaround between the first and the second ballot. A general research question emerged: are the shifts in the results understandable trough a left-right axis (political nature hypothesis of these elections) or were there cross-cutting mechanisms (local nature hypothesis of the elections with a strong role of personal aspects)?To answer the question we analyze the voting ecological estimates in the three biggest cities involved in 2011 elections: Milan, Naples and Turin. For every matrix we generated the estimates both applying the traditional Goodman model (for the whole city and splitting by district) and the hierarchical multinomial-dirichlet model developed by Rosen, Jiang, King and Taner.The most important result of our study is the strong political polarization of the vote in the two northern cities and a great importance of the local factors in Naples, where only a dominant role of the candidates can make sense of the detected shifts in voting behaviour.


Author(s):  
Р.П. Кулумбегов

В статье рассматриваются гендерные различия в традиционной религиозной обрядности осетинского народа. Участие женщин в сакральных практиках намного значительнее, чем принято считать. Недооценка роли женщины в религиозной жизни общества обусловлена устоявшимися стереотипами, в основе которых лежит представление о том, что место женщины в этой сфере второстепенно и является всего лишь производной от мужской, главенствующей роли. Женская обрядность сопровождалась ритуальными действиями, содержание которых менялось в зависимости от аграрного календаря. Зимой и весной они были связаны с необходимостью уберечь нивы от оползней и наводнений, успешным прорастанием злаков, летом — с просьбами к небесным силам уберечь нивы от града и засухи, а осенью — с магическими действиями, направленными на сохранность урожая, защиту зерна от грызунов и червей. Женщина начинала участвовать в сакральных практиках уже в течение первого года после замужества. Молодая невестка в качестве субъекта обрядовых действий впервые выступала во время празднования Доныскъæфæн. Именно с этого дня молодая женщина формально допускалась в сакральную сферу своей новой семьи, а через нее и в религиозную жизнь всего сельского общества. В Осетии помимо ситуационной обрядности, вызываемой текущими проблемами (ливни, засуха), существовали ежегодные, имевшие строгие временные координаты, женские праздники. Среди последних наиболее известны Остæлти кувд и Фыдуани. В основном женщины всегда находились в числе активных участников всех ритуалов, кроме тех, где участие мужчин было исключительным. Но даже в этом случае женщины вносят свой вклад в отправление обряда посредством выпекания ритуальных пирогов, приготовления хмельных напитков. Особенностью части обрядов аграрных верований с участием женщин была их эротическая составляющая. Это было обусловлено представлениями о плодовитости природы, которую необходимо стимулировать эротическими действиями. Рассмотренный в статье материал позволяет сделать вывод о том, что в осетинском обществе женская сакральность была объективной реальностью, при этом она отличалась от мужской, являясь ее ярким дополнением. Women’s participation in sacred practices could have been much more significant than it is commonly believed. The underestimation of the role of women in the religious life of the society is due to the established stereotypes, which are based on the idea that the place of women in this area is secondary and subordinate to the dominant role of men. Female ritualism was accompanied by sacral actions the contents of which varied according to the agrarian calendar. During winter and spring they were related to the need to protect crop field from flow slides and floods, to provide successful seeds germination, in summer — to request the heavenly host to protect crop fields from hail and drought, in autumn — to provide magical actions, focused on keeping harvest in safety, protecting corn from rodents and worms. Woman would become involved in sacral practices during the first year after her marriage. As a participant of ritual actions a young wife appeared for the first time during the celebration of Donyskafan. From that day on young woman was allowed to sacral sphere of her new family, and through this sphere to the religious life of the whole rural community. Besides situational ritualism, caused by current problems (rainstorms, drought), annual female holidays existed in Ossetia. The most famous among them are Ostalty Kuvd and Fyduani. Mostly, women were important participants in rituals, except exclusively men’s ceremonies. But even in these cases, women gave a boost in ceremonies by baking ritual pies, brewing hopped beverages. Rituals of agricultural beliefs were often accompanied by erotic actions, which in accordance with the ideas of the fertility of nature were supposed to stimulate it. The material of the article suggests that special female sacralization existed in the Ossetian society, which differed from the male sacralization, being its objective complement.


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