scholarly journals ANALYSIS OF POTENTIAL INTERACTIONS OF RAMIPRIL -AMBON BANANA (Musa paradisiaca var. sapientum (L.) Kunt.) ON HYPERKALEMIA RISK IN WHITE RATS

2021 ◽  
Vol 3 (2) ◽  
pp. 91
Author(s):  
I Gusti Ayu Sintia Dewi ◽  
Made Krisna Adi Jaya ◽  
Ni Putu Rutin Seciolini Agristy ◽  
Ida Ayu Gendari
Keyword(s):  
Drug Therapy ◽  
Serum Potassium ◽  
Potassium Level ◽  
Serum Potassium Level ◽  
Uv Spectrophotometry ◽  
Test Results ◽  
Anova Test ◽  
White Rats ◽  
Significant Difference ◽  
One Way Anova

Introduction: Drug and food interaction is a condition in which nutritional factors present in food have an influence significant effect on drug therapy, both potentially increasing or decreasing the effect of drug therapy. Indonesian people have a habit of taking medicine by using food or drink. Bananas are the primadona that are often consumed to speed up the swallowing process and reduce the bitter taste of medicine. It turns out that the consumption of bananas together with ACE inhibitors can increase the risk of hyperkalemia. Lack of information about the effects caused by drug and food interactions, so it is necessary to do related research.  Objective: This study aims to determine the interaction of giving ramipril together with Ambon banana on the risk of hyperkalemia. Methods: A real experimental study while still adhering to the Covid'19 health protocol. White rats were divided into 4 groups, conditioned by hypertension, then intervened with ramipril and Ambon banana. Blood serum was taken and analyzed using UV spectrophotometry to obtain serum potassium levels. The levels obtained were analyzed using the One Way Anova Test. Results: The mean serum potassium level of the positive control group was 4.93±0.58; negative control 4.13±0.60; normal control 4.76±0.59 and treatment 5.10±0.38. The highest serum potassium level was in the ramipril treatment group together with Ambon banana, but still in the normal range of 3.60–5.50 mmol/L. One Way Anova test results (p = 0.054). (p>0.05) showed no significant difference. Conclusion: There is no specific increase in levels of ramipril concurrently with Ambon banana so it does not have the potential to cause the risk of hyperkalemia.   Keywords: Drug Interaction, Ramipril, Ambon Banana, Serum Potassium, Hyperkalemia

scholarly journals P0935ASSOCIATION OF DIETARY INTAKE WITH SERUM LEVELS OF PHOSPHORUS AND POTASSIUM IN KOREAN HEMODIALYSIS PATIENTS USING NEWLY DEVELOPED SEMI QUANTITATIVE FOOD FREQUENCY QUESTIONNAIRE(SEMI-FFQ)

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
Jung-Hyun Kim ◽  
Dong-Ryeol Ryu ◽  
Hyun-Jung Kim ◽  
Min-Sook Kyung
Keyword(s):  
Dietary Intake ◽  
Serum Potassium ◽  
Potassium Level ◽  
Serum Potassium Level ◽  
Daily Intake ◽  
Serum Phosphorus ◽  
High Potassium ◽  
Significant Difference ◽  
Phosphorus And Potassium ◽  
Korean Food

Abstract Background and Aims Dietary intake patterns in hemodialysis (HD) patients in Korea are diverse and unique comparing with those of other countries. Hyperphosphatemia and hyperkalemia are closely related to intake of dietary phosphorus and potassium. Dietary intake of Korean HD patients was analyzed using newly developed semi-FFQ for Korean food in order to get the baseline data for improving a dietary management guide for Korean HD patients. Method We investigate the effects of consumed food on serum phosphorus and potassium levels of 128 HD patients(74 males and 54 females) in 6 tertiary referral hospitals using semi-FFQ consisting of 23 food meal items based on the Korean usual diets. Results The mean age was 59.7±11.6 years for males and 58.9± 9.3 years for females and the hemodialysis duration was 5.4±5.6 years for men and 5.4±3.9 years for women, respectively. Mean serum phosphorus level was 4.50±1.52 mg/dl and mean serum potassium level was 4.74±0.73 mEq/L. Hyperphosphatemia was found in 45.8% of the subjects, and hyperkalemia in 35.4%. Energy, protein and other nutrients intake were significantly lower than the recommended intakes for HD patients (p<0.05). Serum phosphorus levels showed positive correlation with intake of mixed grain meals (p<0.05). There was a significant difference in the daily intake frequency of cooked rice between males (2.5±0.76/day) and females (2.15±0.86/day)(p<0.001). The noodle intake frequency also showed a significant difference between males (0.09±0.14/day) and females (0.04±0.06/day) (p<0.001). Serum potassium level showed positive correlation with intake of potatoes, high-potassium vegetables & fruits and Kimchi (p<0.05). There was a significant gender difference in the daily intake frequency of Kimchi between males (1.28±0.11/day) and females (1.07±0.99/day)(p<0.05). In case of medium and high potassium vegetables & fruits, consumption was higher in females than in males (p<0.05). Intake of white rice showed negative correlation with serum potassium levels (p<0.05). Conclusion Intake of white rice meals rather than mixed grains meals is an important factor for maintaining normal serum phosphorus and potassium levels. Intake of potatoes, medium and high potassium vegetables & fruits is recommended to be reduced to less than three serving per week. Considering abundance of potassium and phosphorus in Korean food pattern, customized dietary management as well as medical treatment is essential in all HD patients.

scholarly journals Serum potassium level as a biomarker for acute caffeine poisoning

2020 ◽  
Vol 7 (1) ◽  
Author(s):  
Tomoatsu Tsuji ◽  
Seiji Morita ◽  
Takeshi Saito ◽  
Yoshihide Nakagawa ◽  
Sadaki Inokuchi
Keyword(s):  
Serum Potassium ◽  
Potassium Level ◽  
Serum Potassium Level

scholarly journals The Case of Bradycardia Occured in the Setting of Hyperkalemia in a Patient in Ambulatory Hemodialysis Department

2021 ◽  
Vol 11 (1) ◽  
pp. 60-66
Author(s):  
G. A. Ignatenko ◽  
G. G. Taradin ◽  
A. E. Bagry ◽  
I. V. Rakitskaya ◽  
K. E. Mogilevskaya ◽  
...  
Keyword(s):  
Serum Potassium ◽  
Potassium Level ◽  
Serum Potassium Level ◽  
Kidney Diseases ◽  
Clinical Manifestations ◽  
Junctional Rhythm ◽  
Chronic Kidney Diseases ◽  
Electrolyte Disorder ◽  
Ambulatory Treatment ◽  
Dangerous Condition

The presented article contains the clinical observation of bradycardia development in 64-year-old patient with chronic kidney disease who was in ambulatory treatment at the hemodialysis department. During electrocardiogram recording an arrhythmia was detected as a junctional rhythm. The specific changes on electrocardiogram, presence of risk factors, and data of additional collection of history disease allowed purposing the development of dangerous condition — hyperkalemia. The diagnosis was confirmed after detection of the serum potassium level. This case illustrates the necessity to consider the possibility of hyperkalemia in patients with chronic kidney diseases including those who undergoing hemodialysis treatment. Relevant clinical manifestations and changes on the electrocardiogram require the urgent assessment of the serum potassium level for timely and adequate correction of the electrolyte disorder.

scholarly journals ANALISIS PERBANDINGAN KINERJA KEUANGAN BANK SYARIAH DI INDONESIA, MALAYSIA, BRUNEI DAN THAILAND PERIODE 2011-2016

2019 ◽  
Vol 5 (10) ◽  
pp. 835
Author(s):  
Adyagunita Karini ◽  
Dian Filianti
Keyword(s):  
Financial Performance ◽  
Capital Adequacy ◽  
Anova Test ◽  
Islamic Bank ◽  
Brunei Darussalam ◽  
Analysis Technique ◽  
Capital Adequacy Ratio ◽  
Significant Difference ◽  
Standards And Regulations ◽  
One Way Anova

Comparing the financial performance of banks with other countries would show if the different standards and regulations affect their performance. This research aims to know if there is a significant difference in financial performance of sharia banks between Indonesia, Malaysia, Brunei and Thailand during 2011-2016. The samples used in this research consist of one sharia bank from each country: Bank Syariah Mandiri, Maybank Islamic Berhad, Bank Islam Brunei Darussalam and Islamic Bank of Thailand. This research uses a comparative quantitativeapproach using Non Performing Financing (NPF), Financing to Deposit Ratio (FDR), Return on Asset (ROA), and Capital Adequacy Ratio (CAR) as variables to indicate financial performance. One-Way ANOVA is used as the analysis technique. Results of the ANOVA test show there is a significant difference in NPF, FDR, ROA and CAR between sharia banks in Indonesia, Malaysia, Brunei and Thaiand as indicated by a significance value of 0,000 and 0,002.

scholarly journals PENGARUH VARIASI KONSENTRASI EKSTRAK DAUN BELIMBING WULUH (Averrhoa bilimbi L) TERHADAP KARAKTERISTIK SEDIAAN SALEP DENGAN MENGGUNAKAN BASIS PEG 4000 dan PEG 400

2021 ◽  
Vol 2 (02) ◽  
pp. 7
Author(s):  
Tri Puji Lestari
Keyword(s):  
Leaf Extract ◽  
Homogeneity Test ◽  
Test Results ◽  
Peg 400 ◽  
Cell Tissue ◽  
Peg 4000 ◽  
Significant Difference ◽  
Ointment Formulation ◽  
The Difference ◽  
One Way Anova

ABSTRAK Daun Belimbing Wuluh (Averrhoa bilimbi L) memiliki kandungan tanin dan flavonoid. Kandungan Flavonoid dan Tanin yang terdapat dalam belimbing wuluh mampu memberikan efek untuk menyembuhkan kulit yang mengalami kerusakan jaringan sel akibat luka bakar. Ada beberapa cara untuk pemanfaatan Daun Belimbing Wuluh antara lain dengan dibuat dalam sediaan salep. Pada penelitian ini salep dibuat dengan variasi konsentrasi ekstrak daun belimbing wuluh sebesar 10%, 15%, dan 20%  mengguankan basis PEG 4000 dan PEG 400. Ekstrak daun belimbing wuluh diperoleh menggunakan metode maserasi dengan menggunakan etanol 70% sebagai pelarutnya. Salep yang sudah dibuat kemudian dilakukan uji karakteristik meliputi uji organoleptis, homogenitas, daya lekat dan uji daya sebar. Hasil uji organoleptis dan homogenitas di analisa secara deskrisptif kemudian hasil uji daya lekat dan uji daya sebar di analisa dengan menggunakan analisa statistik one-way ANOVA.  Hasil penelitian menunjukan bahwa salep berbentuk semipadat dengan warna hijau muda sampai hijau kehitaman. Hasil uji homogenitas di dapatkan untuk ketiga formula adalah homogen. Nilai daya sebar pada ketiga formula menunjukan perbedaan yang signifikan, pada hasil uji daya lekat dan pH didapatkan tidak ada perbedaan yang signifikan terhadap ketiga formulasi. Dengan demikian perbedaan konsentrasi zat aktif yang digunakan berpengaruh terhadap daya sebar sediaan salep ekstrak daun belimbing wuluh. Kata kunci: Averrhoa bilimbi L; Salep; PEG   ABSTRACT Carambola leaf Wuluh (Averrhoa bilimbi L) contains tannins and flavonoids. The content of flavonoids and tannins contained in starfruit able to give effect to heal skin damaged cell tissue from burns. There were several ways for  utilization  of  Averrhoa  bilimbi  L.  among  others,  made  some  preparations, especially ointment formulation. This study aims to formulate leaf extract ointment preparation starfruit (Averrhoa bilimbi L) with various concentrations of 10%, 15%, and 20% using the PEG 4000 and PEG 400 as a base. Leaf extract obtained from meserasi leaf Averrhoa bilimbi  L  with  70%  ethanol. The ointment that has been made is then subjected to characteristic tests including organoleptic tests, homogeneity, adhesion and spreadability tests. The results of the organoleptic test and homogeneity were analyzed descriptively, then the results of the adhesion test and the spreadability test were analyzed using one-way ANOVA statistical analysis. The results showed that the ointment was semisolid, light green to blackish green. The homogeneity test results obtained for the three formulas are homogeneous. The value of the spreadability of the three formulas showed a significant difference, the results of the adhesion and pH test showed no significant difference between the three formulations. Thus the difference in the concentration of the active substance used affects the spreadability of the starfruit leaf extract ointment. Keywords: Averrhoa bilimbi L; ointment; PEG

scholarly journals Serum Potassium Levels and Adverse Outcomes in Patients with Acute Myocardial Infarction

Esculapio ◽  
2021 ◽  
Vol 17 (1) ◽  
pp. 5-8
Author(s):  
Rizwan Abbas ◽  
Tazeen Nazar ◽  
Bilal Aziz ◽  
Furqan Saeed ◽  
Kashif Nawaz ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Serum Potassium ◽  
Potassium Level ◽  
Adverse Outcome ◽  
Serum Potassium Level ◽  
Computer Software ◽  
Case Series ◽  
Adverse Outcomes ◽  
Low Serum

Objective: To determine the effect of serum potassium levels on short term mortality outcomes in patients with acute myocardial infarction. Methods: This Descriptive Case Series was conducted in the CCU of Mayo Hospital Lahore from 15th November, 2017 to 15th May, 2018. A total of 156 patients of either sex between the age group of 30-60 years and diagnosed as cases of myocardial infarction with symptoms of less than 24 hours duration and serum potassium level of <3.5 mEq/L were included in the study. Patients were then followed up for 7 days and adverse outcome was recorded. Data was analyzed using computer software SPSS Version 22.0. Results: Out of the 156 patients, 119 (76.3%) were males and 37 (23.7%) were females. Mean age of the patients was 47.88±6.24 years, mean weight 85.31±13.14 Kg, mean duration of presenting complaints was 10.269±4.51 hours and mean Serum Potassium levels were 3.05±0.25 mEq/L. Adverse outcome in the form of mortality due to arrhythmias was seen in 15 (9.6%) patients. Conclusion: Low serum potassium level (<3.5mEq/L/L) was significantly associated with increased adverse outcome in acute myocardial infarction patients. Keywords: Acute myocardial infarction, Low serum potassium levels, Adverse outcome How to cite: Abbas R., Nazar T, Aziz B., Saeed F., Nawaz K., Nabeel M. serum potassium levels and adverse outcomes in patients with acute myocardial infarction. Esculapio 2021;17(01):5-8

The effect of serum potassium level on in-hospital and long-term mortality in ST elevation myocardial infarction

2016 ◽  
Vol 221 ◽  
pp. 505-510 ◽  
Author(s):  
Muhammed Keskin ◽  
Adnan Kaya ◽  
Mustafa Adem Tatlısu ◽  
Mert İlker Hayıroğlu ◽  
Osman Uzman ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Serum Potassium ◽  
Potassium Level ◽  
Serum Potassium Level ◽  
St Elevation Myocardial Infarction ◽  
St Elevation ◽  
Long Term Mortality

The Incidence And Risk Factors of Serum Hypokalemia After Primary Total Joint Arthroplasty

2021 ◽  
Author(s):  
Pin Pan ◽  
Zitao Zhang ◽  
Xiaofeng Zhang ◽  
Qing Jiang ◽  
Zhihong Xu
Keyword(s):  
Risk Factors ◽  
Red Blood Cells ◽  
Knee Replacement ◽  
Serum Potassium ◽  
Total Joint Arthroplasty ◽  
Blood Cells ◽  
Potassium Level ◽  
Serum Potassium Level ◽  
Joint Arthroplasty ◽  
Regular Monitoring

Abstract Background: Regular monitoring of serum potassium after total joint arthroplasty (TJA) is a routine examination, which can detect abnormal serum potassium and reduce adverse events timely caused by postoperative hypokalemia. In this study, we aimed to investigate the incidence and risk factors of hypokalemia after primary total hip and knee replacement.Methods: This study included patients who underwent unilateral total knee or hip arthroplasty in our department from April 2017 to March 2018. The serum potassium level before and after operation was collected and retrospectively analyzed. The differences in age, BMI and other factors between hypokalemia patients and non-hypokalemia patients at different time points after surgery were compared, and then the risk factors of postoperative hypokalemia were analyzed based on multiple logistic regression.Results: The total incidence of postoperative hypokalemia was 53.1%, while the respective rate on the first, third and fifth postoperative day was 12.5%, 40.7% and 9.6%. The serum potassium level on the first, third and fifth postoperative day was 3.84±0.32mmol/l, 3.59±0.34mmol/l and 3.80±0.32mmol/l, while among which, the level on the third day was the lowest (p=0.015). The independent risk factors for hypokalemia after total hip and knee replacement were the level of preoperative serum potassium (p=0.011), preoperative red blood cells (p=0.027), and a history of diabetes (p=0.007).Conclusion: Regular monitoring of serum potassium should be performed after TJA due to hypokalemia was a very common complication. We need to pay more attention to patients’ preoperative potassium and red blood cells, especially patients with diabetes.

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