scholarly journals Reduction of Liver Fibrosis After Treatment with Elbasvir/Grazoprevir in Patients with Hepatitis C Infection in Chronic Kidney Disease on Hemodialysis, a Quasi-Experimental Study

2021 ◽  
Vol 22 (1) ◽  
pp. 21-28
Author(s):  
Bayu Laksono ◽  
Nenny Agustanti ◽  
Rudi Supriyadi ◽  
Muhammad Begawan Bestari ◽  
Siti Aminah Abdurachman
Keyword(s):  
Chronic Kidney Disease ◽  
Experimental Study ◽  
Hepatitis C ◽  
Kidney Disease ◽  
Liver Fibrosis ◽  
Hemodialysis Patients ◽  
Hcv Rna ◽  
Before And After ◽  
Apri Score ◽  
Quasi Experimental

Background: Approximately 5-60% of hemodialysis patients have comorbid of hepatitis C virus (HCV) infection. The survival rate of hemodialysis patients HCV is lower than those without HCV due to the risk of liver fibrosis and cardiovascular disease. The combination of Elbasvir and Grazoprevir is the drug of choice for these patients with HCV genotype 1 and 4 which mainly inherited in populations in Indonesia. However, a high cost is required for this genome testing.  Eradication of HCV might reduce liver fibrosis. One of the methods to evaluate liver fibrosis is by using APRI score. The aim of this study is to assess liver fibrosis using APRI score after  Elbasvir/Grazoprevir therapy completion.Method: This was a quasi-experimental study without a control group which conducted during April-November 2019 in Dr. Hasan Sadikin Hospital, Bandung. Patients with reactive anti HCV, detected HCV RNA without genotype test, and sustained virological response (SVR) 12 achieved were included. APRI score and HCV RNA tests were performed before and after 12 weeks end of therapy (SVR12). The data were analyzed using paired T-test at a 95% confidence level.Results: Approximately 30% of hemodialysis patients had HCV infection. A total of 37 HCV patients in the hemodialysis unit were given Elbasvir/Grazoprevir for 12 weeks. The APRI score before and after 12 weeks after therapy were 0.336 and 0.270 (p = 0.002) respectively.Conclusion: The combination of Elbasvir/Grazoprevir might reduce the degree of liver fibrosis based on APRI score from 0.336 to 0.270  in HCV patients with chronic kidney disease on hemodialysis

Hepatitis C in Chronic Kidney Disease: Predialysis Patients Present More Severe Histological Liver Injury than Hemodialysis Patients?

2007 ◽  
Vol 27 (2) ◽  
pp. 191-196 ◽  
Author(s):  
Lara B. Lemos ◽  
Renata M. Perez ◽  
Marcelo M. Lemos ◽  
Valéria P. Lanzoni ◽  
Sergio A. Draibe ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Hepatitis C ◽  
Kidney Disease ◽  
Liver Injury ◽  
Hemodialysis Patients

scholarly journals Optimization of Thirst Management on CKD Patients Undergoing Hemodialysis by Sipping Ice Cube

2019 ◽  
Vol 2 (1) ◽  
pp. 38
Author(s):  
Yunie Armiyati ◽  
Khoiriyah Khoiriyah ◽  
Ahmad Mustofa
Keyword(s):  
Chronic Kidney Disease ◽  
Experimental Study ◽  
Kidney Disease ◽  
Fluid Intake ◽  
Average Length ◽  
Hemodialysis Patients ◽  
Fluid Restriction ◽  
Compliance Management ◽  
Ice Cube ◽  
Significant Difference

Excess fluid is a major problem in patients with Chronic Kidney Disease (CKD). CKD patients undergoing hemodialysis must keep limiting fluid intake during the interdialysis period so that excess fluid does not occur. Consequently limiting fluid intake arises thirst and will affect fluid restriction compliance. Management of thirst that can be done in hemodialysis patients, among others, suck ice cubes, gurgling the ripe water and gurgling with mouthwash, each of which has a different action against patients thirst. The purpose of this study was to compare the three interventions "thirst management", namely sipping ice cubes, gargling ripe water and gargling with mouthwash against patient thirst. This study was an experimental study in 27 samples of CKD patients who underwent hemodialysis at Roemani Muhammadiyah Hospital in Semarang divided into 3 groups with each group 9 samples. The results showed that the duration of holding thirst for the group sipping on ice cubes averaged 93 minutes, the gurgling group of ripe water averaged 55 minutes and the average length of time holding the thirst group who gurgling with mouthwash was 69.71 minutes. There was no significant difference in the duration of holding thirst after sucking on ice cubes and gargling ripe water, and gargling with mouthwash (ρ value 0.061). Sipping ice cubes can fight the longest thirst compared to gargling ripe water or gargling with mouthwash. The recommendations of this study are expected to intervene to sipping ice cubes, gargling ripe water and gargling with mouthwash can be used for thirst management in hemodialysis patients.  Hemodialysis patients can choose interventions to reduce the thirst that is most appropriate.

scholarly journals The Effectiveness of Murottal Al-Qur’an Therapy by Surah Ar-Rahman toward Anxiety of Crhonic Kidney Disease (CKD) which is being Hemodialysis at Gambiran Hospital Kediri

2019 ◽  
Vol 8 (2) ◽  
pp. 129-135
Author(s):  
Byba Melda Suhita ◽  
Dini Yulianita Arini
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Random Sampling ◽  
Simple Random Sampling ◽  
Hemodialysis Patients ◽  
Control Group ◽  
Irreversible Damage ◽  
Paired Sample ◽  
A Value ◽  
Quasi Experimental

ABSTRACT Chronic kidney disease is a decrease in the function of kidney which is caused by a process of irreversible damage, thus requiring hemodialysis therapy as a replacement therapy for the function of kidney. Hemodialysis patients often experience psychosocial problem. It is an anxiety. This research aims to analyze the effectiveness of Murottal Al-Qur’an therapy by surah Ar-Rahman toward anxiety of Chronic Kidney Disease (CKD) which is being hemodialysis. The research was conducted at Gambiran Hospital Kediri. The research used Quasi Experimental with a control group pretest-posttest design approach with samples using simple random sampling of 58 respondents. Paired sample t-test was used to analyze the data by a value of α = 0.05. 

scholarly journals THE EFFECTIVENESS OF BENSON’S RELAXATION THERAPY TO DECREASE THE LEVEL OF INSOMNIA ON CHRONIC KIDNEY DISEASE PATIENTS UNDERGOING HEMODIALYSIS

2016 ◽  
Vol 1 (1) ◽  
pp. 61
Author(s):  
Dwi Retno Sulistyaningsih ◽  
Erna Melastuti
Keyword(s):  
Chronic Kidney Disease ◽  
Treatment Group ◽  
Kidney Disease ◽  
Sleep Disorder ◽  
Severity Index ◽  
Routine Care ◽  
Control Group ◽  
Relaxation Techniques ◽  
Before And After ◽  
Quasi Experimental

AbstractAlmost 50 – 80 % patients with chronic kidney disease undergoing hemodialysis were reported to sleep disorder.  Insomnia is the highest prevalence  sleep disorder in the dialysis patients. This study aims to determine the effectiveness of Benson’s relaxation of the level of patients’ insomnia with chronic kidney disease in dyalisis patients. The design of this study is quasi-experimental with pretest-posttest design with control group. Fourty-two hemodyalisis patiens were recruited purposively from the hemodyalisis Islamic Hospital, Sultan Agung , Semarang. The sample was divided into two groups (treatment and control). Patients in the treatment group received Benson’s relaxation techniques during hemodialysis for 4 weeks and the control group received routine care. The insomnia severity index was used to measure  insomnia level. The result showed that there was significantly different score of insomnia level before and after relaxation Benson in the treatment group (p = 0.000). This study found that relaxation Benson seemed to be effective in decreasing the level of insomnia on chronic kidney disease patients undergoing hemodyalisis. Key words: Benson relaxation, insomnia, hemodialysis, chronic kidney disease

scholarly journals THE APPLICATION OF ART THERAPY TO REDUCE THE LEVEL OF DEPRESSION IN PATIENTS WITH HEMODIALYSIS

2018 ◽  
Vol 4 (3) ◽  
pp. 329-335
Author(s):  
Atikah Fatmawati ◽  
M. Rachmat Soelaeman ◽  
Imas Rafiyah
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Art Therapy ◽  
Intervention Group ◽  
Psychological Adaptation ◽  
Control Group ◽  
P Value ◽  
Control Group Design ◽  
Before And After ◽  
Quasi Experimental

Background: Depression can occur in patients with chronic kidney disease undergoing hemodialysis and can lead to decreased quality of life, and will have a two-fold risk for the occurrence of death and hospitalization. Objective: The purpose of this study was to identify the effects of art therapy on the level of depression patients with hemodialysis.Methods: This study used a quasi-experimental method with pretest posttest with control group design. Collecting data using questionnaires of Beck Depression Inventory (BDI-II) versions of Indonesia, which was done twice, before and after art therapy intervention. Data were analyzed using paired t-test and unpaired t-test.Results: The results showed that after given intervention of art therapy there were differences in the average scores of depression in the intervention group (t = 0.764; p-value = 0.000). Art therapy is a medium to expose and express the feelings, fears or perceived problem, so it can be used as an adaptive coping method in patients with chronic kidney disease undergoing hemodialysis. Conclusion: It is concluded that art therapy could reduce depression in patients with chronic kidney disease undergoing hemodialysis. Nurses can act as a facilitator to provide art-based therapy in order to improve the ability of psychological adaptation in patients with chronic kidney disease undergoing hemodialysis. 

scholarly journals Prevalence of hepatitis C in patients with chronic kidney disease at a tertiary care hospital in north India: a retrospective analysis

2019 ◽  
Vol 7 (6) ◽  
pp. 2198
Author(s):  
Amrit Dhar ◽  
Vijant S. Chandail ◽  
Viney Sambyal ◽  
Vinu Jamwal
Keyword(s):  
Chronic Kidney Disease ◽  
Hepatitis C ◽  
Kidney Disease ◽  
Retrospective Analysis ◽  
Tertiary Care ◽  
False Negative ◽  
Hcv Infection ◽  
Hcv Rna ◽  
Care Hospital ◽  
Genotype 1

Background: Hepatitis C and chronic kidney disease (CKD) both present an unsolved public health problem Hepatitis C virus (HCV) is easily transmitted in haemodialysis units and by kidney transplantation. HCV leads to increased mortality and morbidity due to cirrhosis and hepatocellular carcinoma, while accelerating the progression of CKD. The aim of the  study was to describe the demographic, clinical/biochemical profile and prevalence of patients with CKD who have HCV infection.Methods: This was a retrospective analysis of patients with CKD who presented to out/in patient department of medicine in a tertiary care center in Jammu from a period of Feb 2016 to Nov 2018. Detailed clinical history along with previous lab reports were noted and tests for HCV infection were conducted in all patients. Diagnosis of HCV was made via HCV RNA(RT PCR) and positive  Anti HCV IgG serology.Results: Total 67 patients were included with median age of 54 years (range 43-72 years) with majority 76.1% being males, and 71.6% within 41-60 years age group. 31.4% were HCV positive out of which 81% were males. 7 patients were found to have co-infection with HIV and HBsAg. Genotype 1 (72%) was found to be more common than Genotype 3. Ultrasonography and Upper GI endoscopy showcased 57% with dilated spleenoportal axis  and oesophageal varices respectively.Conclusions: Prevalence of HCV infection in CKD patients is high with genotype 1 being commonest. False negative Anti HCV antibody is common hence screening with HCV RNA is recommended. Strict universal precautions should be employed in hospitals and dialysis units to prevent transmission.

scholarly journals Reliability and validity of the Persian version of 5-D itching scale among patients with chronic kidney disease

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Amin Kordi Yoosefinejad ◽  
Fatemeh Karjalian ◽  
Marzieh Momennasab ◽  
Shahrokh Ezzatzadegan Jahromi
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Psychometric Properties ◽  
Internal Consistency ◽  
Reliability And Validity ◽  
Hemodialysis Patients ◽  
Life Questionnaire ◽  
Retest Reliability ◽  
Persian Version ◽  
Test Retest Reliability

Abstract Background Hemodialysis is considered a major therapeutic method for patients with chronic kidney disease. Pruritus is a common complaint of hemodialysis patients. The 5-D pruritus scale is amongst the most common tools to evaluate several dimensions of itch. Psychometric properties of the 5-D scale have not been evaluated in Persian speaking population with hemodialysis; hence, the objective of this study was to assess reliability and validity of the Persian version of the scale. Methods Ninety hemodialysis patients (men: 50, women: 40, mean age: 54.4 years) participated in this cross-sectional study. The final Persian version of 5-D scale was given to the participants. Tests Compared: One-third of the participants completed the scale twice within 3–7 days apart to evaluate test- retest reliability. Other psychometric properties including internal consistency, absolute reliability, convergent, discriminative and construct validity, floor/ceiling effects were also evaluated. Results The Persian 5-D scale has strong test-retest reliability (ICC= 0.98) and internal consistency (Cronbach’s alpha= 0.99). Standard error of measurement and minimal detectable change were 0.33 and 0.91, respectively. Regarding convergent validity, the scale had moderate correlation with numeric rating scale (r =0.67) and quality of life questionnaire related to itch (r = 0.59). Exploratory factor analysis revealed two factors within the scale. No floor or ceiling effect was found for the scale. Conclusion The Persian version of 5-D the itching scale is a brief instrument with acceptable reliability and validity. Therefore, the scale could be used by experts, nurses, and other health service providers to evaluate pruritus among Persian speaking hemodialysis patients.

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