scholarly journals Of quality indicators determination and study of the stability of pessaries with acyclovir and essential oils

2017 ◽  
Vol 0 (3(51)) ◽  
pp. 14-19
Author(s):  
O. N. Litvinova ◽  
Ju. V. Levachkova ◽  
V. M. Chushenko
Keyword(s):  
Essential Oils ◽  
Quality Indicators ◽  
The Stability

Criteria for evaluation of the coordinate measurements quality of parts geometric parameters at pilot-experimental production

2019 ◽  
pp. 3-8
Author(s):  
N.Yu. Bobrovskaya ◽  
M.F. Danilov
Keyword(s):  
Quality Indicators ◽  
Quality Management System ◽  
Technical Specification ◽  
Experimental Production ◽  
Technological Heredity ◽  
Coordinate Measurements ◽  
Reasonable Choice ◽  
The Stability ◽  
Geometric Elements

The criteria of the coordinate measurements quality at pilot-experimental production based on contemporary methods of quality management system and traditional methods of the measurements quality in Metrology are considered. As an additional criterion for quality of measurements, their duration is proposed. Analyzing the problem of assessing the quality of measurements, the authors pay particular attention to the role of technological heredity in the analysis of the sources of uncertainty of coordinate measurements, including not only the process of manufacturing the part, but all stages of the development of design and technological documentation. Along with such criteria as the degree of confidence in the results of measurements; the accuracy, convergence, reproducibility and speed of the results must take into account the correctness of technical specification, and such characteristics of the shape of the geometric elements to be controlled, such as flatness, roundness, cylindrical. It is noted that one of the main methods to reduce the uncertainty of coordinate measurements is to reduce the uncertainty in the initial data and measurement conditions, as well as to increase the stability of the tasks due to the reasonable choice of the basic geometric elements (measuring bases) of the part. A prerequisite for obtaining reliable quality indicators is a quantitative assessment of the conditions and organization of the measurement process. To plan and normalize the time of measurements, the authors propose to use analytical formulas, on the basis of which it is possible to perform quantitative analysis and optimization of quality indicators, including the speed of measurements.

scholarly journals Critical Concentration of Lecithin Enhances the Antimicrobial Activity of Eugenol against Escherichia coli

2017 ◽  
Vol 83 (8) ◽  
Author(s):  
Haoshu Zhang ◽  
Edward G. Dudley ◽  
P. Michael Davidson ◽  
Federico Harte
Keyword(s):  
Escherichia Coli ◽  
Essential Oils ◽  
Food Systems ◽  
Critical Concentration ◽  
Physical Stability ◽  
Antimicrobial Properties ◽  
Content Type ◽  
Antimicrobial Effects ◽  
Wide Range ◽  
The Stability

ABSTRACT Lecithin is a natural emulsifier used in a wide range of food and nonfood applications to improve physical stability, with no known bioactive effects. In this study, the effect of lecithin on the antimicrobial performance of a constant eugenol concentration was tested against three Escherichia coli strains (C600, 0.1229, and O157:H7 strain ATCC 700728). This is the first study, to our knowledge, focusing on lecithin at concentrations below those commonly used in foods to improve the stability of oil in water emulsions (≤10 mg/100 ml). For all three cultures, significant synergistic antimicrobial effects were observed when E. coli cultures were exposed to a constant eugenol concentration (ranging from 0.043 to 0.050% [wt/wt]) together with critical lecithin concentrations ranging from 0.5 to 1 mg/100 ml. Increasing the concentration of lecithin above 1 mg/100 ml (up to 10 mg/100 ml lecithin) diminished the antibacterial effect to values similar to those with eugenol-only treatments. The formation of aggregates (<100 nm) at the critical lecithin concentration was observed using cryo-transmission electron microscopy (cryo-TEM), together with a reduction in light absorbance at 284 nm. At critically low concentrations of lecithin, the formation of nanoscale aggregates is responsible for improving eugenol antimicrobial effects. IMPORTANCE Essential oils (EOs) are effective natural antimicrobials. However, their hydrophobicity and strong aromatic character limit the use of essential oils in food systems. Emulsifiers (e.g., lecithin) increase the stability of EOs in water-based systems but fail to consistently improve antimicrobial effects. We demonstrate that lecithin, within a narrow critical concentration window, can enhance the antimicrobial properties of eugenol. This study highlights the potential bioactivity of lecithin when utilized to effectively control foodborne pathogens.

scholarly journals Effect of Some Spice Essential Oils on the Stability of Frying Oils

2013 ◽  
Vol 25 (16) ◽  
pp. 9277-9284
Author(s):  
Ebru Sandal Tanriverdi ◽  
Mehmet Musa Özcan ◽  
Fahad Al Juhaimi
Keyword(s):  
Essential Oils ◽  
Frying Oils ◽  
The Stability

scholarly journals INFLUENCE OF THE AVERAGE WEIGHTED ESTIMATION TYPE ON THE DEPENDENCE OF THE COMPLEX QUALITY INDEX ON THE PARAMETERS OF OBJECT

2017 ◽  
Vol 8 (4) ◽  
pp. 398-407 ◽  
Author(s):  
A. M. Dolzhanskiy ◽  
O. A. Bondarenko ◽  
Ye. A. Petlyovaniy
Keyword(s):  
Quality Indicators ◽  
Quality Index ◽  
Informed Choice ◽  
Experiment Planning ◽  
Weighted Estimate ◽  
Arithmetic Average ◽  
Weighted Estimates ◽  
Control Factors ◽  
Calculation Results ◽  
The Stability

Objects quality is usually assessed by a complex indicator. It includes single quality indicators with their significance factors. The convolution of the corresponding dependencies represents average weighted quantities: arithmetic, geometric, harmonic, quadratic, etc. At the same time, the influence of the convolution type on the level of the complex quality index, the stability of the calculation results and, the reliability of the quality comparison among a number of similar objects is unknown in advance. Therefore, the aim of the study was to assess the influence of the average weighted type on the level and stability of the calculating results of the complex quality index in different objects compressing.For typical private objects compared the values of the complex quality index calculated according to the formulas of various average weighted estimates. Significance of the corresponding unit quality indicators, incompleteness of the object description and control factors influence on the object took into account.The results of the research were got using the method of virtual experiment planning. They showed that the influencing parameters changes, the calculated levels and stability of the complex quality index essentially depend on the type of convolution. It was shown that under the priori uncertainty of the necessary convolution for the best representative choosing of the corresponding class of objects, the arithmetic average weighted estimate is the best for using.The obtained data can serve as a basis for an informed choice of the type of average weighted in the quality assessment of various objects and decision-making on rational levels of controlled factors.

scholarly journals 75 Evaluating the in vitro release of essential oils from microparticles in simulated swine gastric and intestinal fluids and the essential oil stability in microparticles during feed pelleting process

2019 ◽  
Vol 97 (Supplement_3) ◽  
pp. 70-70
Author(s):  
Janghan Choi ◽  
Lucy Wang ◽  
Joshua Gong ◽  
Ludovic Lahaye ◽  
Song Liu ◽  
...  
Keyword(s):  
Essential Oil ◽  
Essential Oils ◽  
In Vitro Release ◽  
Oil Stability ◽  
Positive Effects ◽  
Intestinal Fluids ◽  
Gastric Fluids ◽  
The Stability ◽  
Vitro Release

Abstract Essential oils are defined as plant-derived natural bioactive compounds with positive effects on animal growth and health due to their antimicrobial and antioxidative properties. However, essential oils are very volatile, can evaporate rapidly and be rapidly absorbed in the upper gastrointestinal tract. In addition, due to their labile nature, the stability of essential oils during feed processing is often questionable, leading to variable final concentrations in feeds. Micro-encapsulation has become one of the most popular methods to deliver essential oils into the lower gut. The objective of the present study was double: 1) to validate and demonstrate the slow release of essential oils, such as thymol, micro-encapsulated in combination with organic acids in a matrix of triglycerides, in simulated swine gastric and intestinal fluids and 2) to evaluate the essential oil stability in the microparticles during feed pelleting process. In the in vitro release experiments, the microparticles were incubated in simulated gastric fluids for 2 hours and then the samples were incubated in simulated intestinal fluids for 0, 1, 2, 3, 4, 6, 8, 10, and 24 hours at 39°C. In the pelleting experiment, a wheat-corn basal diet with 2 kg of micro-encapsulated product was formulated and pelleted. The thymol content in the samples was analyzed by gas chromatography with flame-ionization detection. The results showed that 27.65% thymol was released in simulated gastric fluids and the rest of thymol was progressively released in intestinal fluids until completion, which was achieved by 24 hours. The thymol concentration was not significantly different between the mash feeds and pelleted feeds (P &gt; 0.05). In conclusion, the micro-encapsulated organic acid and essential oil product was able to maintain the stability of thymol under a commercial pelleting process and allow a slow and progressive release of its active ingredients as thymol in simulated digestive fluids.

scholarly journals Investigation of quality indicators and studying the stability of “Propolis-AK” gel for the treatment of acne disease

2019 ◽  
pp. 64-75
Author(s):  
А. I. Tykhonov ◽  
T. G. Yarnykh ◽  
S. G. Bobro ◽  
O. S. Shpychak
Keyword(s):  
Quality Control ◽  
Shelf Life ◽  
Quality Indicators ◽  
Room Temperature ◽  
Storage Period ◽  
Storage Conditions ◽  
Social Adaptation ◽  
Control Methods ◽  
Aluminum Tubes ◽  
The Stability

In modern conditions, the incidence of acne, which is a polymorphic multifactorial disease of the sebaceous glands of the skin, has a tendency to significant growth. Localization of lesions on the face in almost all patients indicates the fact that acne has an effect on their psycho-emotional sphere and social adaptation, which makes this problem urgent and indicates the feasibility of creating new effective domestic medicines for treating this pathology. The aim of the work was to conduct research on the investigation of quality indicators and studying the stability of «Propolis-AK» gel of anti-inflammatory and antimicrobial action for the treatment of acne disease. The objects of research were model test-samples of «Propolis-AK» gel, for which were developed methodic for analyzing the qualitative composition and quantitative content of the active substances – propolis phenolic hydrophobic drug (PPHD) and azelaic acid (AA) in this dosage form, comprehensively allowing to evaluate the quality and criteria for the stability of the gel during the entire storage period for the following indicators: description, identification, homogeneity, tightness of the container, pH, package contents, microbiological purity, quantification. In addition, the requirements for packaging, labeling, transportation, storage conditions and shelf life were included in the draft of quality control methods. According to the results of the study of organoleptic and physical-chemical parameters of the developed «Propolis-AK» gel during storage at two temperature conditions (8‒15 °C and 15‒25 °C), it was found that the test samples of the gel under study remained fairly stable according to the studied indicators for 2 years and 3 months, which allows us to recommend a shelf life of 2 years at room temperature in aluminum tubes for the studied gel. According to the results of research, a specification for «Propolis-AK» gel for external use was developed as a component of the draft of quality control methods for the studied medicine. Studies have been conducted to establish the main indicators and methods of quality control of the developed «Propolis-AK» gel for the treatment of acne disease. According to the results of the tests, a “Specification” was developed, which was included in the draft of quality control methods and experimentally proved the stability of «Propolis-AK» gel prepared in pharmaceutical and industrial conditions for a prescribed shelf life of 24 months when stored in aluminum tubes with an internal lacquer coating in a cool place (8‒15 °C) and at room temperature (15‒25 °C).

scholarly journals Microencapsulation of Jeringau Rhizome essential oils (Acorus calamus L.) using β-Cyclodextrin

2021 ◽  
pp. 189-194
Author(s):  
Ledianasari ◽  
Deby Tristiyanti ◽  
Elva Maulydha Tanjung ◽  
Lovelyta Barani
Keyword(s):  
Essential Oil ◽  
Essential Oils ◽  
Ambient Temperature ◽  
Half Life ◽  
Freeze Drying ◽  
Acorus Calamus ◽  
Test Results ◽  
The Stability ◽  
Microencapsulation Method ◽  
The Way

Background: The way to improve the stability of jeringau rhizome essential oils is microencapsulation using β-cyclodextrin. Objective: To determine the efficiency of coating the jeringau rhizome essential oil with β-cyclodextrin and examine its thermostability. Method: The microencapsulation method used was freeze-drying with a ratio of 1:20 and 1:30. Results: The microcapsule efficiency at the ratio of 1:20 and 1:30 was 81.67% and 60.70%, respectively. The thermostability test results showed that the degradation constant of 1:20 microcapsule at 50oC and ambient temperature was 0.0054 and 0.0029, respectively, with a half-life of 128.33 hours and 238.97 hours. Meanwhile, the degradation constant of 1:30 microcapsule was 0.0182 and 0.0080, with a half-life of 38.07 hours and 86.63 hours. Conclusion: The highest efficiency is in the ratio of 1:20 with a percentage of 81.67%. In the thermostability test, the 1:20 microcapsule was better protected and had a longer half-life than the 1:30 microcapsule.

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