A Sequential Convolution Network for Population Flow Prediction with Explicitly Correlation Modelling

Population flow prediction is one of the most fundamental components in many applications from urban management to transportation schedule. It is challenging due to the complicated spatial-temporal correlation.While many studies have been done in recent years, they fail to simultaneously and effectively model the spatial correlation and temporal variations among population flows. In this paper, we propose Convolution based Sequential and Cross Network (CSCNet) to solve them. On the one hand, we design a CNN based sequential structure with progressively merging the flow features from different time in different CNN layers to model the spatial-temporal information simultaneously. On the other hand, we make use of the transition flow as the proxy to efficiently and explicitly capture the dynamic correlation between different types of population flows. Extensive experiments on 4 datasets demonstrate that CSCNet outperforms the state-of-the-art baselines by reducing the prediction error around 7.7%∼10.4%.

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A Bird’s-Eye View of Cell Sources for Cell-Based Therapies in Blood Cancers

Cancers ◽

10.3390/cancers12051333 ◽

2020 ◽

Vol 12 (5) ◽

pp. 1333

Author(s):

Benjamin Motais ◽

Sandra Charvátová ◽

Matouš Hrdinka ◽

Michal Šimíček ◽

Tomáš Jelínek ◽

...

Keyword(s):

Hematological Malignancies ◽

Antigen Receptors ◽

Chimeric Antigen Receptors ◽

Blood Cancer ◽

Cell Based Therapy ◽

Cell Source ◽

Different Types ◽

Cell Sources ◽

The One ◽

Initial Results

Hematological malignancies comprise over a hundred different types of cancers and account for around 6.5% of all cancers. Despite the significant improvements in diagnosis and treatment, many of those cancers remain incurable. In recent years, cancer cell-based therapy has become a promising approach to treat those incurable hematological malignancies with striking results in different clinical trials. The most investigated, and the one that has advanced the most, is the cell-based therapy with T lymphocytes modified with chimeric antigen receptors. Those promising initial results prepared the ground to explore other cell-based therapies to treat patients with blood cancer. In this review, we want to provide an overview of the different types of cell-based therapies in blood cancer, describing them according to the cell source.

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Analytical Determination of the Brake Temperature Mode During Repetitive Short-Term Braking

Materials ◽

10.3390/ma14081912 ◽

2021 ◽

Vol 14 (8) ◽

pp. 1912

Author(s):

Aleksander Yevtushenko ◽

Katarzyna Topczewska ◽

Michal Kuciej

Keyword(s):

Friction Pair ◽

Thermal Sensitivity ◽

Finite Difference Methods ◽

Temporal Variations ◽

Frictional Heat ◽

Maximum Temperature ◽

Analytical Determination ◽

Flash Temperature ◽

Short Term ◽

The One

An algorithm to determine the maximum temperature of brake systems during repetitive short-term (RST) braking mode has been proposed. For this purpose, the intermittent mode of braking was given in the form of a few cyclic stages consisting of subsequent braking and acceleration processes. Based on the Chichinadze’s hypothesis of temperature summation, the evolutions of the maximum temperature during each cycle were calculated as the sum of the mean temperature on the nominal contact surface of the friction pair elements and temperature attained on the real contact areas (flash temperature). In order to find the first component, the analytical solution to the one-dimensional thermal problem of friction for two semi-spaces taking into account frictional heat generation was adapted. To find the flash temperature, the solution to the problem for the semi-infinite rod sliding with variable velocity against a smooth surface was used. In both solutions, the temperature-dependent coefficient of friction and thermal sensitivity of materials were taken into account. Numerical calculations were carried out for disc and drum brake systems. The obtained temporal variations of sliding velocity, friction power and temperature were investigated on each stage of braking. It was found that the obtained results agree well with the corresponding data established by finite element and finite-difference methods.

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Plausibility and Aesthetic Interpretation

Canadian Journal of Philosophy ◽

10.1080/00455091.1977.10717022 ◽

1977 ◽

Vol 7 (2) ◽

pp. 327-340 ◽

Cited By ~ 5

Author(s):

Denis Dutton

Keyword(s):

Scientific Inquiry ◽

The Other ◽

Inquiry Science ◽

Works Of Art ◽

Different Types ◽

Logical Structures ◽

The One

If a catalogue were made of terms commonly used to affirm the adequacy of critical interpretations of works of art, one word certain to be included would be “plausible.” Yet this term is one which has received precious little attention in the literature of aesthetics. This is odd, inasmuch as I find the notion of plausibility central to an understanding of the nature of criticism. “Plausible” is a perplexing term because it can have radically different meanings depending on the circumstances of its employment. ln the following discussion, I will make some observations about the logic of this concept in connection with its uses in two rather different contexts: the context of scientific inquiry on the one hand, and that of aesthetic interpretation on the other. In distinguishing separate senses of “plausible,” I shall provide reason to resist the temptation to imagine that because logical aspects of two different types of inquiry—science and criticism—happen to be designated by the same term, they may to that extent be considered to have similar logical structures.

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Fluid turbulence simulations of divertor heat load for ITER hybrid scenario using BOUT++

Nuclear Fusion ◽

10.1088/1741-4326/ac3b8a ◽

2021 ◽

Author(s):

Xueyun Wang ◽

Xueqiao Xu ◽

Philip B Snyder ◽

Zeyu Li

Keyword(s):

Heat Flux ◽

Steady State ◽

Energy Loss ◽

Heat Load ◽

Type I ◽

Fluid Turbulence ◽

Drift Model ◽

Steady State Operation ◽

Different Types ◽

The One

Abstract The BOUT++ six-field turbulence code is used to simulate the ITER 11.5MA hybrid scenario and a brief comparison is made among ITER baseline, hybrid and steady-state operation (SSO) scenarios. Peeling-ballooning instabilities with different toroidal mode numbers dominate in different scenarios and consequently yield different types of ELMs. The energy loss fractions (ΔWped/Wped) caused by unmitigated ELMs in the baseline and hybrid scenarios are large (~2%) while the one in the SSO scenario is dramatically smaller (~1%), which are consistent with the features of type-I ELMs and grassy ELMs respectively. The intra ELM divertor heat flux width in the three scenarios given by the simulations is larger than the estimations for inter ELM phase based on Goldston’s heuristic drift model. The toroidal gap edge melting limit of tungsten monoblocks of divertor targets imposes constraints on ELM energy loss, giving that the ELM energy loss fraction should be smaller than 0.4%, 1.0%, and 1.2% for ITER baseline, hybrid and SSO scenarios, correspondingly. The simulation shows that only the SSO scenario with grassy ELMs may satisfy the constraint.

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Evaluation of a Handheld Gluten Detection Device

Journal of Food Protection ◽

10.4315/0362-028x.jfp-18-184 ◽

2018 ◽

Vol 81 (10) ◽

pp. 1723-1728 ◽

Cited By ~ 8

Author(s):

STEVE L. TAYLOR ◽

JULIE A. NORDLEE ◽

SHYAMALI JAYASENA ◽

JOSEPH L. BAUMERT

Keyword(s):

Ice Cream ◽

Weight Basis ◽

Processed Foods ◽

Gluten Free ◽

Specific Enzyme ◽

Different Types ◽

Food Matrices ◽

The One ◽

Addition Level ◽

Positive Results

ABSTRACT A portable, handheld gluten detection device, the Nima sensor, is now available for consumers wishing to determine if gluten is present in food. By U.S. regulation, gluten-free foods should contain <20 ppm of gluten. Thirteen gluten-free foods (muffins, three different types of bread, three different types of pasta, puffed corn snack, ice cream, meatballs, vinegar and oil salad dressing, oatmeal, and dark chocolate) were prepared; each food was spiked on a weight to weight basis with gluten levels of 0, 5, 10, 20, 30, 40, and 100 ppm before processing or preparation. Unprocessed and processed foods were tested with the handheld gluten sensor and by two gluten-specific enzyme-linked immunosorbent assays (ELISAs) on the basis of the R5 and G12 monoclonal antibodies, respectively. The portable gluten detection device detected gluten in all food types at the 30-ppm addition level, failing to detect gluten in only 5 (6.4%) of 78 subsamples. At the 20-ppm addition level, the portable gluten detection device failed to detect gluten in one type of pasta but detected gluten residues in 63 (87.5%) of 72 other subsamples. The device was able to detect gluten at the 10-ppm addition level in 9 of the 13 food matrices (41 of 54 subsamples, 75.9%) but not in the three types of pasta and the puffed corn snack. The gluten-sensing device did not perform reliably at the 5-ppm addition level in 11 of 13 food matrices (exceptions: ice cream and muffins). In contrast, the ELISA methods were highly reliable at gluten addition levels of ≥10 ppm in all food matrices. The portable gluten detection device yielded a low percentage of false-positive results (4 of 111, 3.6%) in these food matrices. Thus, this handheld portable gluten sensor performed reliably in the detection of gluten in foods having ≥20 ppm of added gluten with only 18 (5.9%) of 306 failures, if results of the one type of pasta are excluded. The device worked with greater reliability as the gluten levels in the foods increased.

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Modular Turbulence Modeling Applied to an Engine Intake

Journal of Turbomachinery ◽

10.1115/1.4025232 ◽

2013 ◽

Vol 136 (5) ◽

Cited By ~ 8

Author(s):

Ugochukwu R. Oriji ◽

Paul G. Tucker

Keyword(s):

Surface Roughness ◽

Turbulence Modeling ◽

Fluid Dynamic ◽

Navier Stokes ◽

Test Cases ◽

Laminar Separation ◽

Streamline Curvature ◽

Favorable Pressure Gradient ◽

Flow Features ◽

The One

The one equation Spalart–Allmaras (SA) turbulence model in an extended modular form is presented. It is employed for the prediction of crosswind flow around the lip of a 90 deg sector of an intake with and without surface roughness. The flow features around the lip are complex. There exists a region of high streamline curvature. For this, the Richardson number would suggest complete degeneration to laminar flow. Also, there are regions of high favorable pressure gradient (FPG) sufficient to laminarize a turbulent boundary layer (BL). This is all terminated by a shock and followed by a laminar separation. Under these severe conditions, the SA model is insensitive to capturing the effects of laminarization and the reenergization of eddy viscosity. The latter promotes the momentum transfer and correct reattachment prior to the fan face. Through distinct modules, the SA model has been modified to account for the effect of laminarization and separation induced transition. The modules have been implemented in the Rolls-Royce HYDRA computational fluid dynamic (CFD) solver. They have been validated over a number of experimental test cases involving laminarization and also surface roughness. The validated modules are finally applied in unsteady Reynolds-averaged Navier–Stokes (URANS) mode to flow around an engine intake and comparisons made with measurements. Encouraging agreement is found and hence advances made towards a more reliable intake design framework.

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Posthuman oder Übermensch. War Nietzsche ein Transhumanist?

Nietzsche Studien ◽

10.1515/niet.2013.42.1.256 ◽

2013 ◽

Vol 42 (1) ◽

Author(s):

Michael Skowron

Keyword(s):

Genetic Manipulation ◽

Linguistic Analysis ◽

The Other ◽

The Internet ◽

Jürgen Habermas ◽

Eternal Recurrence ◽

Different Types ◽

The Future ◽

The One ◽

Michael Sandel

AbstractRecent discussions (especially in the Internet) about the question whether Nietzsche was a Transhumanist or at least a forerunner of the Transhumanist movement have drawn new attention to Nietzsche’s concept of the Overhuman and the relation to the Posthuman. The article is taking a critical stance by turning suggested analogies between education and genetic manipulation of humans into an argument against the latter, by relating self-education to self-overcoming and eternal recurrence of the same (which is excluded by Transhumanists), and by reminding of Nietzsche’s distinction between ‘Overhuman’ and ‘last human’ as two different ways to the future. Linguistic analysis of the epitheta used in speaking of the different ‘types’ in question as well as structural analogies between critical considerations in Michael Sandel and Jürgen Habermas on the one hand, Nietzsche on the other are also evidence that Nietzsche would not have endorsed the technological path to perfection of the human but would emphasize his own way of self-overcoming instead.

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Architecture of Evolution

10.12737/1079356 ◽

2021 ◽

Author(s):

Alla Packevich

Keyword(s):

Planetary System ◽

Conflict Situation ◽

Point Of View ◽

Science Students ◽

Present Stage ◽

Male And Female ◽

Different Types ◽

New Energy ◽

The One ◽

Insight Into

The monograph, on the one hand, examines the period of development of the descending cycle of evolution and the associated progressive changes that show the irreversibility of the processes of formation of the planetary system. The end of one cycle and the beginning of another leads to the transformation of the system of life and the expansion of consciousness at a new energy level. On the other hand, the questions of potential opportunities for the development of the ascending phase of evolution, which goes both along the path of complexity of the organization and along the path of diversity, are considered. In the ascending evolutionary stream, what has been differentiated into the corresponding levels in the descending cycle is brought together and thus prepared to enter into new, more perfect forms of unity. It is shown that the development of humanity along its entire path depends on the interaction of energies of various forms and potentials. Understanding the relationships between different types of energy and their use provides insight into many important issues in the evolution of society. The material introduces the modern features of the existence of the male and female sexes from the energy point of view. The idea of a way out of the current conflict situation that has arisen between the sexes at the present stage of evolution is proposed. It will be useful for those interested in the problems of scientific knowledge, architects, philosophers,historians, physicists and methodologists of science, students and students of secondary schools.

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The Surface Longwave Cloud Radiative Effect from Space Lidar Observations

10.5194/egusphere-egu21-2064 ◽

2021 ◽

Author(s):

Assia Arouf

Keyword(s):

Cloud Cover ◽

Temporal Variations ◽

Radiative Effect ◽

Cloud Properties ◽

Cloud Radiative Effect ◽

Long Time ◽

The One ◽

Natural Climate ◽

The Impact ◽

Lidar Observations

Clouds exert important effects on Earth's surface energy balance through their effects on longwave (LW) and shortwave (SW) radiation. Indeed, clouds radiatively warm the surface in the LW domain by emitting LW radiation back to the ground. The surface LW cloud radiative effect (CRE) quantifies this warming effect. To study the impact of clouds on the interanual natural climate variability, we need to observe them on a long time scale over all kinds of surfaces. The CALIPSO space lidar provides these observations by sampling the atmosphere along its track over all kinds of surfaces for over than 14 years (2006-2020).In this work, we propose new estimates of the surface LW CRE from space-based lidar observations only. Indeed, we show from 1D atmospheric column radiative transfer calculations, that surface LW CRE at sea level linearly decreases with the cloud altitude. Thus, these computations allow to establish simple relationships between the surface LW CRE, and five cloud properties observed by the CALIPSO space lidar: the opaque cloud cover and altitude, the thin cloud cover, altitude, and emissivity. Over the 2008&#8211;2011, CALIPSO-based retrieval (27.7 W m-2) is 1.2 W m-2 larger than the one derived from combined space radar, lidar, and radiometer observations. Over the 2008&#8211;2018 period, the global mean CALIPSO-based retrieval (27.5 W m-2) is 0.1 W m-2 larger than the one derived from CERES space radiometer. Our estimates show that globally, opaque clouds warm the surface by 23.3 W m-2 and thin clouds contribute only by 4.2 W m-2. At high latitudes North and South over oceans, the largest surface LW opaque CRE occurs in fall (40.4 W m-2, 31.6 W m-2) due to the formation of additional opaque low clouds after sea ice melting over a warmer ocean.To quantify the cloud property that drives the temporal variations of the surface LW CRE, the surface LW CRE needs to be related by simple relationships to a finite number of cloud properties such as cloud opacity, cloud altitude and cloud cover. This study allows a decomposition and attribution approach of the surface LW CRE variations and shows that they are driven by the variations occurring in the opaque cloud properties. Moreover, opaque cloud cover drives over than 73% of global surface LW CRE interannual variations.

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