Serum Leptin and Lipid Profiles in Thai Obese and Overweight Subjects

2001 ◽  
Vol 71 (1) ◽  
pp. 74-81 ◽  
Author(s):  
Rungsunn Tungtrongchitr ◽  
Praneet Pongpaew ◽  
Benjaluck Phonrat ◽  
Siriwan Tribunyatkul ◽  
Duangkamol Viroonudomphol ◽  
...  
Keyword(s):  
Lipid Profiles ◽  
Control Group ◽  
Serum Leptin ◽  
Control Subjects ◽  
Waist Hip Ratio ◽  
Median Serum ◽  
Low Hdl ◽  
Obese Subjects ◽  
Males And Females ◽  
Overweight Subjects

The weight, height, body mass index (BMI), waist/hip ratio, serum leptin and lipid profiles of 48 overweight (BMI _ 25.00) Thai males and 166 overweight Thai females, compared with 26 males and 81 females in a control group (BMI = 18.5–24.9 kg/m2), were investigated. Subjects for the study were those persons who turned up regularly for physical check-ups at the out-patient department, general practice section of the Rajvithi Hospital, Bangkok. The study was conducted between March–October, 1998. Statistically significantly higher levels of serum leptin, cholesterol, LDL-C, LDL-C/HDL-C ratio and triglyceride were found in the overweight compared with the control subjects. The median serum leptin concentration in overweight subjects was 19.6 (2.0–60.0 ng/ml) compared with 9.0 (range 1.0–30.0 ng/ml) in the control subjects (p < 0.001). The median values of leptin serum concentrations in the overweight and obese males were significantly higher than those of the overweight and obese females. A total of 66.7% (32 out of 48) of the overweight and obese males had elevated leptin levels, while elevated leptin levels were found in 87.3% (145 out of 166) of the overweight and obese females. A total of 18.8% and 21.1% of the overweight and obese males and females respectively had cholesterol concentrations of _ 6.48 mmol/l. However, the prevalence of low HDL-C (HDL-C _ 0.91 mmol/l) was found to be 41.7% in the overweight and obese males and 4.2% in the overweight and obese females. Statistically significant associations were found between weight, height, BMI, waist, hip, waist/hip ratio, HDL-C, and serum leptin in both overweight male and female subjects. A negative correlation was found between serum leptin and LDL-C/HDL-C ratio in both the overweight and obese subjects.

scholarly journals Circulating Level of Soluble Leptin Receptor and its Association with Cardiometabolic Risk Factors among Obese Subjects in Kerala, South India

2021 ◽  
pp. 232-239
Author(s):  
K. S. Manju ◽  
K. B. Leena ◽  
L. Vijayalekshmi ◽  
K. T. Shenoy
Keyword(s):  
Risk Factors ◽  
Insulin Resistance ◽  
Cardiometabolic Risk ◽  
Leptin Receptor ◽  
Obese Group ◽  
Serum Leptin ◽  
Control Subjects ◽  
Soluble Leptin Receptor ◽  
Significant Difference ◽  
Obese Subjects

Background and Aims: Leptin, the peptide hormone secreted mainly by adipose tissue is reported to play the central role in the pathogenesis of obesity. Leptin exerts its biological effects through specific receptor molecules present in target tissues. Among the different isoforms of leptin receptor, the Soluble Leptin Receptor (SLR) is the major leptin binding protein seen in circulation which modulates the bioavailability of leptin. Our objectives were to analyse the level of circulating SLR among obese subjects and its association with biomarkers of obesity, serum leptin, insulin and cardiometabolic risk factors in comparison with healthy age and sex matched control subjects. Methods: About 173 study participants of both genders were selected and grouped as case (n=102) and control (n=71) with a cut off point of BMI 25kg/m2. Waist to hip ratio (WHR) and body fat percentage (BF%) were calculated from anthropometric measurements. Leptin, insulin, soluble leptin receptor were estimated in fasting blood samples by sandwich ELISA method. Fasting plasma glucose and lipid profile were measured by standard enzymatic methods in autoanalyzer. Homeostasis Model Assessment of Insulin resistance (HOMA-IR) was calculated. Comparison between groups was done by independent sample ‘t’ test. P values <.05 were considered statistically significant. Results: The SLR level was found to be increased in obese group in comparison with control group(P =.001). A significant increase in serum leptin and insulin level was observed in obese group when compared to control (P =.001). Obese group showed more than two fold increase in insulin resistance expressed as HOMA-IR when compared to control subjects (P =.001). But no significant difference in the synthesis of insulin expressed as HOMA-beta between the groups. No significant difference in serum lipoprotein levels was observed between the two groups. Conclusion: Increased level of circulating soluble leptin receptor has been observed in obese subjects in comparison with control subjects and is associated with hyperleptinemia, hypertension and insulin resistance.

scholarly journals LIPID ALTERATION

2011 ◽  
Vol 18 (04) ◽  
pp. 663-666
Author(s):  
KAMAL ELDIN AHMED ABDELSALAM ◽  
MANAHIL ALI SHARWANI ◽  
SHAZA SALIH TAHA
Keyword(s):  
Lipid Profile ◽  
Cross Sectional Study ◽  
Control Group ◽  
P Value ◽  
Diabetic Patients ◽  
Obese Patients ◽  
Sectional Study ◽  
Cross Sectional ◽  
Obese Subjects ◽  
Males And Females

Objective: determine serum lipid profile in diabetic and obese non-diabetic patients. Materials: 300 subjects comprising three groups, the first group included 100 diabetic patients (non-obese) with duration of diabetes over 5 years, the second group (obese) included 100 obese subjects (non-diabetic) with duration of obesity over 5 years, and the third group (control) included 100 healthy subjects. Methods: Lipid profile on the serum was performed with an auto analyzer using standard methods. Study design and period: Prospective Analytical Cross Sectional Study conducted in period from September 2006 to January 2008. Results: A significant (p value<0.05) increase in lipid profile results of diabetic and obese patients comparing to control while HDL-C showed significant decreasing. The cholesterol is significantly increased in females than males in diabetic patients, while the triglycerides are significantly decreased in diabetic females. The parameters showed insignificant variations between males and females in obese patients. Conclusions: In comparison to control group, DM & obese groups showed significantly increase in TG, TC, and LDL-C, but significantly decrease in HDL-C. Females showed significant increasing in TC and significant decreasing in DM group, while in obese group females showed insignificant decreasing in TG and TC. 

scholarly journals Thermic effect of glucose in obese subjects studied by direct and indirect calorimetry

1976 ◽  
Vol 35 (2) ◽  
pp. 281-292 ◽  
Author(s):  
Ph. Pittet ◽  
Ph. Chappuis ◽  
K. Acheson ◽  
F. De Techtermann ◽  
E. JÉquier
Keyword(s):  
Indirect Calorimetry ◽  
Heat Losses ◽  
Thermal Balance ◽  
Obese Group ◽  
Control Group ◽  
Glucose Load ◽  
Fasting Period ◽  
Control Subjects ◽  
Obese Subjects ◽  
Thermic Effect

1. The thermic effect of a glucose load (50 g) was studied in ten control and eleven obese female subjects, using both direct and indirect calorimetry simultaneously. Experiments were done under conditions of thermal equilibrium (28° and 30% relative humidity)..2. Thermal balance (heat production measured by indirect calorimetry minus heat losses measured directly) was negative in the control group during the fasting period (heat deficit – 14.2 ± 5.0 kJ/m2 per h), whereas that of the obese group was in equilibrium (+ 1.4 ± 4.8 kJ/m2 per h)..3. After the glucose load, metabolic rate increased 13.0 ± 1.5 and 5.2 ± 1.3% in the control and obese groups respectively..4. In contrast to the metabolic rate, total heat losses were not significantly altered in either group after the glucose load. Total heat losses of the obese group were significantly lower than those of the control group throughout the experimental period..5. During the experiments the amount of heat stored was increased in both groups. Thermal balance in the control group became positive while that of the obese group remained positive..6. During the fasting period, the control subjects oxidized more carbohydrates (90.4 mg/min) than lipids (68.8 mg/min), whereas obese subjects oxidized more lipids (103.7 mg/min) than carbohydrates (50.2 mg/min). After the glucose load, the oxidation rate of carbohydrates was increased in both groups to 158.1 mg/min in control subjects and 95.6 mg/min in obese subjects..7. The mean skin temperature of the control subjects was significantly higher than that of the obese subjects and remained higher throughout the postprandial period..8. These results indicate that: (a) during the fasting period, the energy sources utilized and the thermal balance of the two groups were different; (b) the thermic effect of glucose was less in the obese subjects and, therefore, might be a factor contributing to their low energy expenditure.

Serum Homocysteine, B12 and Folic Acid Concentration in Thai Overweight and Obese Subjects

2003 ◽  
Vol 73 (1) ◽  
pp. 8-14 ◽  
Author(s):  
R. Tungtrongchitr ◽  
P. Pongpaew ◽  
C. Tongboonchoo ◽  
N. Vudhivai ◽  
S. Changbumrung ◽  
...  
Keyword(s):  
Folic Acid ◽  
Vitamin C ◽  
Negative Correlation ◽  
Vitamin B ◽  
Control Subjects ◽  
Serum Homocysteine ◽  
Significant Difference ◽  
Obese Subjects ◽  
Serum Folic Acid ◽  
Overweight Subjects

This study investigated levels of serum homocysteine, vitamin B12, folic acid, vitamin B62 and vitamin C, in 37 male and 112 female overweight and obese Thai volunteers (body mass index; BMI ≥ 25.00), and 23 male and 90 female normal-weight Thai volunteers, who came for a physical check-up at the Out-patient Department, General Practice Section, Rajvithi Hospital, Bangkok from March to October of 2000. Data included anthropometric measurements and waist/hip ratios. All anthropometric variables, except height, were significantly higher for the overweight subjects than for the normal subjects. Statistically significantly higher levels of serum homocysteine were found in the overweight subjects. Serum homocysteine concentrations in overweight and obese males were significantly higher than in overweight and obese females. Serum folic acid and vitamin C in the overweight and obese were found to be statistically significantly lower than in the control subjects. No statistically significant difference in vitamin B12 was found in the overweight and obese subjects compared with the normal control subjects. The medians of serum folic acid and vitamin C concentrations for the overweight and obese males were significantly lower than those of the overweight and obese females. A negative correlation was found between serum folic acid and homocysteine concentrations in all overweight and obese subjects. A significant negative correlation between serum folic acid and vitamin B6 was observed in both male and female overweight and obese subjects. The results of the investigation suggest that homocysteine levels in overweight and obese subjects seem to be caused by insufficient dietary folic acid intake and probably not by B12 deficiency.

EFFECT OF JAPAN WATER THERAPY INFUSED WITH CINNAMON ON BODY WEIGHT, WAIST/HIP RATIO, AND BODY MASS INDEX OF OVERWEIGHT AND OBESE SUBJECTS

2019 ◽  
pp. 302-305
Author(s):  
SHIVANI BHATIA ◽  
SHUBHRA SARASWAT
Keyword(s):  
Body Mass Index ◽  
Body Composition ◽  
Body Weight ◽  
Body Mass ◽  
Control Group ◽  
Waist Hip Ratio ◽  
Group A ◽  
Obese Subjects ◽  
Water Therapy ◽  
Group B

Objective: The objective of this study was to discover the effect of Japan water therapy with cinnamon on body composition in overweight and obese subjects. Methods: The study was conducted with 36 subjects divided into three groups, namely, Group A – water therapy with cinnamon (n=12), Group B – water therapy (n=12), and Group C – warm water (n=12), where Groups A and B were test groups and Group C was a control group. This study was carried out for 8 weeks. Body weight, waist/hip ratio (WHR), and body mass index (BMI) were measured every 15th day. Data were statistically analyzed by mean, standard deviation, and paired t-test using Getcalc.com Results: Out of all the groups, Group A showed desirable reduction in weight, WHR, and BMI, but statistically it was non-significant on WHR. Similarly, Group B had non-significant result with content to WHR but showed a moderate reduction in all categories. However, Group C as a control group both had either constant or minimal reduction in WHR and BMI being statistically non-significant. Conclusion: The findings of the study concluded that consumption of Japan water therapy with cinnamon helps in reduction of weight, WHR, and BMI within 8 weeks. Plain water therapy only had a moderate effect on reducing body composition in the same duration of time.

scholarly journals THE EFFECTS OF PAPAYA LEAVES JELLY IN LIPID PROFILE AMONG OVERWEIGHT WOMEN

2020 ◽  
Vol 9 (4) ◽  
pp. 290-295
Author(s):  
Choirun Nissa ◽  
Syafira Noor Pratiwi ◽  
Siti Majidah ◽  
Nadia Rahma ◽  
Ratih Paramastuti ◽  
...  
Keyword(s):  
Physical Activity ◽  
Treatment Group ◽  
Total Cholesterol ◽  
Cholesterol Oxidase ◽  
Lipid Profiles ◽  
T Test ◽  
Control Group ◽  
Overweight Women ◽  
Group Design ◽  
Obese Subjects

Background : Insulin resistance that occurred in diabetic state could promote endothelial dysfunction which lead to metabolic disease in obese subjects. Although several studies showed papaya leaves had antidiabetic and antihyperlipidemic agent, the effect of papaya leaves jelly is rarely studied on lipid profiles among overweight women.Objectives : We aimed to examine the effect of papaya leaves jelly on lipid profiles in women with overweight. Methods : This study was a pre-posttest controlled group design with both of the groups were overweight. The treatment group consumed papayq leaves jelly with 24.6 grams papaya leaves jelly that contains 182.4 mg chlorophyll, while the control group consumed 24.6 grams jelly with green dye for 20 days in a row. Three-day recall in three non-consecutive days and physical activity using International Physical Activity (IPAQ) were taken three times. Fasting blood sugar was measured using Glucose Oxidase Phenol 4-Aminophenazone (GODPAP). LDL, HDL, total cholesterol, triglyceride levels were measured using Cholesterol Oxidase Para Aminophenazone (CHOD-PAP). Statistical analysis using Paired t-test was used within group, while Independent t-test and Mann-Whitney were used in between groups. Papaya leaves jelly effects on lipid profiles was analyzed using multiple linear regression after considering energy, protein, fat, and carbohydrate intakes. Results : Triglyceride levels was reduced significantly (p=0.014) in the treatment group despite there were no differences in triglyceride (p= 0.407), LDL (p= 0.923), HDL (p= 0.749) and total cholesterol (p= 0.277) between 2 groups. Conclusion : Papaya leaves jelly consumption could lower triglyceride levels significantly in the treatment group.

Withdrawn: Hepatoprotective effects of Tribulus terrestris L. (Zygophyllales: Zygophyllaceae) hydro-alcholic extract on non-alcoholic fatty liver-induced rats

2016 ◽  
Vol 3 (5) ◽  
pp. 143
Author(s):  
Fatemeh Almasi ◽  
Mozafar Khazaei ◽  
Shima Chehrei ◽  
Ali Ghanbari
Keyword(s):  
Fatty Liver ◽  
Liver Tissue ◽  
Serum Lipid ◽  
Histopathological Examination ◽  
Serum Levels ◽  
Lipid Profiles ◽  
Control Group ◽  
Tribulus Terrestris ◽  
Protective Effects ◽  
Alcoholic Fatty Liver

Non-alcoholic fatty liver induces many complications to the liver tissue and also serum related parameters. Medicinal plants are the safe therapeutic strategy for the treatment of diseases. In this regards, the present study was conducted to evaluate the effect of Tribulus terrestris L. (Zygophyllales: Zygophyllaceae) extract on non-alcoholic fatty liver in rats. In this experimental study, thirty male Wistar rats were divided into five groups (n = 6). Animals in experimental groups were received high fructose diet (70%) (HDF) daily alone or in combined with daily intraperitoneal injection of 500, 700 and 1,000 mg/kg extract of T. terrestris. Control group of rats was feed with standard chow. The serum levels of biomarkers of liver and serum lipid profiles were assessed, also histopathological examination of liver tissue done. Data were analyzed using One-way ANOVA method followed by Tukey’s post-hoc multiple comparison test and P < 0.05 was considered statistically significant. There were significant improvements for biomarkers of liver tissue (P < 0.05) and serum lipid profiles (P < 0.01) in the HFD-fed rats that were treated with T. terrestris extract compare to HFD-fed group. In addition, accumulation of lipids in hepatocytes was significantly reduced in the HFD-fed + extract administrated groups in comparison to HFD-fed rats (P < 0.01). T. terrestris extract has protective effects against non-alcoholic fatty liver by changing biomarkers of liver tissue, serum lipid profiles and histopathological anomalies of liver tissue, to normal range.

scholarly journals Changes in the Composition and Function of Lipoproteins after Bariatric Surgery in Patients with Severe Obesity

2021 ◽  
Vol 10 (8) ◽  
pp. 1716
Author(s):  
Idoia Genua ◽  
Núria Puig ◽  
Inka Miñambres ◽  
Sonia Benítez ◽  
Pedro Gil ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Lipid Profile ◽  
Healthy Subjects ◽  
Control Group ◽  
Morbidly Obese ◽  
Qualitative Properties ◽  
Ldl Particles ◽  
Obese Subjects ◽  
Lipoprotein Composition ◽  
Qualitative Characteristics

The effect of bariatric surgery on lipid profile and the qualitative characteristics of lipoproteins was analyzed in morbidly obese subjects. Thirteen obese patients underwent bariatric surgery. Plasma samples were obtained before surgery and at 6 and 12 months after the intervention. Thirteen healthy subjects comprised the control group. Lipid profile, hsCRP, and the composition and functional characteristics of VLDL, LDL, and HDL were assessed. At baseline, plasma from subjects with obesity had more triglycerides, VLDLc, and hsCRP, and less HDLc than the control group. These levels progressively normalized after surgery, although triglyceride and hsCRP levels remained higher than those in the controls. The main differences in lipoprotein composition between the obese subjects and the controls were increased apoE in VLDL, and decreased cholesterol and apoJ and increased apoC-III content in HDL. The pro-/anti-atherogenic properties of LDL and HDL were altered in the subjects with obesity at baseline compared with the controls, presenting smaller LDL particles that are more susceptible to modification and smaller HDL particles with decreased antioxidant capacity. Bariatric surgery normalized the composition of lipoproteins and improved the qualitative characteristics of LDL and HDL. In summary, patients with obesity present multiple alterations in the qualitative properties of lipoproteins compared with healthy subjects. Bariatric surgery reverted most of these alterations.

scholarly journals Psychological Traits and Behavioural Influences in Patients with Dystonia—An Observational Cohort Study in a Romanian Neurology Department

Life ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 612
Author(s):  
Eugenia Irene Davidescu ◽  
Irina Odajiu ◽  
Delia Tulbă ◽  
Iulia Mitrea ◽  
Camelia Cucu ◽  
...  
Keyword(s):  
Cohort Study ◽  
Informed Consent ◽  
Personality Traits ◽  
Patient Group ◽  
Observational Cohort Study ◽  
Control Group ◽  
Inclusion Criteria ◽  
Control Subjects ◽  
Observational Cohort ◽  
Idiopathic Dystonia

(1) Background: Emerging evidence indicates that non-motor symptoms significantly influence the quality of life in dystonic patients. Therefore, it is essential to evaluate their psychological characteristics and personality traits. (2) Methods: Subjects with idiopathic dystonia and a matched control group were enrolled in this prospective observational cohort study. Inclusion criteria for patient group included idiopathic dystonia diagnosis, evolution exceeding 1 year, and signed informed consent. Inclusion criteria for the control group included lack of neurological comorbidities and signed informed consent. All subjects completed the DECAS Personality Inventory along with an additional form of demographic factors. Data (including descriptive statistics and univariate and multivariate analysis) were analyzed with SPSS. (3) Results: In total, 95 participants were included, of which 57 were in the patient group. Females prevailed (80%), and the mean age was 54.64 ± 12.8 years. The most frequent clinical features of dystonia were focal distribution (71.9%) and progressive disease course (94.73%). The patients underwent regular treatment with botulinum toxin (85.95%). In addition, patients with dystonia obtained significantly higher openness scores than controls, even after adjusting for possible confounders (p = 0.006). Personality traits were also different between the two groups, with patients more often being fantasists (p = 0.007), experimenters (p = 0.022), sophists (p = 0.040), seldom acceptors (p = 0.022), and pragmatics (p = 0.022) than control subjects. (4) Conclusion: Dystonic patients tend to have different personality profiles compared to control subjects, which should be taken into consideration by the treating neurologist.

scholarly journals Circulating tumour DNA methylation in hepatocellular carcinoma diagnosis using digital droplet PCR

2021 ◽  
Vol 49 (3) ◽  
pp. 030006052199296
Author(s):  
Juan Wang ◽  
Liu Yang ◽  
Yanjun Diao ◽  
Jiayun Liu ◽  
Jinjie Li ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Dna Methylation ◽  
Likelihood Ratio ◽  
Predictive Value ◽  
Positive Likelihood Ratio ◽  
Negative Likelihood Ratio ◽  
Control Group ◽  
Control Subjects ◽  
Droplet Pcr ◽  
Healthy Control

Objective To evaluate the performance of a DNA methylation-based digital droplet polymerase chain reaction (ddPCR) assay to detect aberrant DNA methylation in cell-free DNA (cfDNA) and to determine its application in the detection of hepatocellular carcinoma (HCC). Methods The present study recruited patients with liver-related diseases and healthy control subjects. Blood samples were used for the extraction of cfDNA, which was then bisulfite converted and the extent of DNA methylation quantified using a ddPCR platform. Results A total of 97 patients with HCC, 80 healthy control subjects and 46 patients with chronic hepatitis B/C virus infection were enrolled in the study. The level of cfDNA in the HCC group was significantly higher than that in the healthy control group. For the detection of HCC, based on a cut-off value of 15.7% for the cfDNA methylation ratio, the sensitivity and specificity were 78.57% and 89.38%, respectively. The diagnostic accuracy was 85.27%, the positive predictive value was 81.91% and the negative predictive value was 87.20%. The positive likelihood ratio of 15.7% in HCC diagnosis was 7.40, while the negative likelihood ratio was 0.24. Conclusions A sensitive methylation-based assay might serve as a liquid biopsy test for diagnosing HCC.

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