THE ASSOCIATION BETWEEN THE GLY972ARG POLYMORPHISM IN IRS1 GENE AND THE RISK OF PREDIABETES AMONG VIETNAMESE WOMEN

Insulin receptor substrate 1 (IRS1) is a ligand of the insulin receptor tyrosine kinase and participates in the insulin receptor signal transduction pathway. Dysregulations in IRS1 expression and function increase incidence of insulin-resistant states such as prediabetes and type 2 diabetes. The study aimed to investigate the association of the Gly972Arg (rs1801278) polymorphism in IRS1 gene with prediabetes in Northern Vietnamese women. The case-control study consisted of 1617 women (250 prediabetic cases and 1367 normoglycemic controls). The IRS1 Gly972Arg polymorphism was genotyped in these subjects using polymerase chain reaction–restriction fragment length polymorphism. The frequency of the ‘‘A’’ allele of the Gly972Arg (G>A) polymorphism was similar between the normal glucose and prediabetic subjects (2.7% and 2.6%, respectively). There was no significant difference in the genotypic frequency between the control and prediabetic cases (P = 0.673). The IRS1 Gly972Arg polymorphism was not associated with the risk of prediabetes in Vietnamese women before and after adjusted for socio-economic, lifestyles and clinical factors (P > 0.05).

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Insulin receptor tyrosine-kinase activity is altered in both muscle and adipose tissue from non-obese normoglycaemic insulin-resistant subjects

Diabetologia ◽

10.1007/bf02369353 ◽

1995 ◽

Vol 38 (1) ◽

pp. 55-61 ◽

Cited By ~ 15

Author(s):

G. Grasso ◽

L. Frittitta ◽

M. Anello ◽

P. Russo ◽

G. Sesti ◽

...

Keyword(s):

Adipose Tissue ◽

Tyrosine Kinase ◽

Insulin Receptor ◽

Receptor Tyrosine Kinase ◽

Kinase Activity ◽

Tyrosine Kinase Activity ◽

Insulin Receptor Tyrosine Kinase ◽

Insulin Resistant

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P277 RV remodeling by echo parameters in endurance and strength sport training

European Heart Journal - Cardiovascular Imaging ◽

10.1093/ehjci/jez319.133 ◽

2020 ◽

Vol 21 (Supplement_1) ◽

Author(s):

M Moshkani Farahani ◽

M Shirdel

Keyword(s):

Endurance Exercise ◽

Performance Status ◽

Exercise Group ◽

Strength Group ◽

Sport Training ◽

Significant Difference ◽

Before And After ◽

The Mean ◽

And Gender ◽

And Function

Abstract Introduction With regular and long-term exercises, the heart undergoes changes that are called the adaptation of the heart in response to exercise or physiological changes, which contrasts with the pathological changes caused by hypertension and aortic valve stenosis. However, the exact effects of exercise on the structure and function of the heart depend on the type, intensity and duration of exercise, the amount of physical fitness, inheritance, and gender. Materials and Methods In this prospective clinical trial study, 40 subjects, including 20 in the endurance exercise group and 20 in the exercise group, were evaluated. Echocardiography was performed for all of these subjects before and after the exercises that was performed professionally for 8 weeks under the supervision of the trainer and the changes were recorded. The data were analyzed statistically by SPSS20 software. A significant level of 0.05 was considered. Results The mean ± standard deviation of the age was 20/80 ± 1/42 years. Significant decrease in mean RVSM was observed only in the strength group (P = 0.008). There was no significant difference in the endurance group . There was no significant difference between the two groups before the test in the mean TAPSE (P = 0.46). The mean of TAPSE in the endurance group was 0.22 ± 1.99 and in the strength group was 0.31 ± 1.95. There was no significant difference between the two groups (P 0.46). There was no significant difference between the two groups before the test in the mean E / e (P = 0.51). The mean E / e "in the endurance group was 0.47 ± 4.75 and in the strength group was 0.54 ± 5.50, and there was a significant difference between the two groups (P <0.001). The mean SWDT in the endurance group was 0.12 ± 0.95 and in the strength group was 0.11 ± 1.06, and there was a significant difference between the two groups (P = 0.002). There was a significant increase in mean SWDT in the strength group after the test (P <0.001) .There was a significant increase in mean PAP in the strength group (P = 0.007) . There was a significant increase in mean LV mass index in the strength group (P <0.001),with no significant difference between the two groups in mean FAC. Conclusion It seems that any kind of strength and endurance exercise affects the performance status, however, strength exercises have more effects which causes RV dysfunction. All indexes measured changed within normal level except for PAP that had abnormal changes after endurance exercise .

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Insulin receptor tyrosine kinase structure and function

Biochemical Society Transactions ◽

10.1042/bst0190426 ◽

1991 ◽

Vol 19 (2) ◽

pp. 426-432 ◽

Cited By ~ 10

Author(s):

Leland Ellis ◽

Jeremy M. Tavaré ◽

Barry A. Levine

Keyword(s):

Tyrosine Kinase ◽

Insulin Receptor ◽

Receptor Tyrosine Kinase ◽

Structure And Function ◽

Insulin Receptor Tyrosine Kinase ◽

And Function ◽

Kinase Structure

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Insulin receptor tyrosine kinase activity is reduced in monocytes from non-obese normoglycaemic insulin-resistant subjects

Diabetologia ◽

10.1007/bf00401061 ◽

1993 ◽

Vol 36 (11) ◽

pp. 1163-1167 ◽

Cited By ~ 17

Author(s):

L. Frittitta ◽

G. Grasso ◽

M. E. Munguira ◽

R. Vigneri ◽

V. Trischitta

Keyword(s):

Tyrosine Kinase ◽

Insulin Receptor ◽

Receptor Tyrosine Kinase ◽

Kinase Activity ◽

Tyrosine Kinase Activity ◽

Insulin Receptor Tyrosine Kinase ◽

Insulin Resistant

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Effects of a Newly Developed Therapeutic Deep Heating Device Using High Frequency in Patients with Shoulder Pain and Disability: A Pilot Study

Pain Research and Management ◽

10.1155/2019/8215371 ◽

2019 ◽

Vol 2019 ◽

pp. 1-9

Author(s):

Gi-Wook Kim ◽

Yu Hui Won ◽

Sung-Hee Park ◽

Jeong-Hwan Seo ◽

Dae-hyun Kim ◽

...

Keyword(s):

Los Angeles ◽

Shoulder Pain ◽

High Frequency ◽

Constant Score ◽

Frequency Wave ◽

Heating Device ◽

Significant Difference ◽

Before And After ◽

And Function ◽

The University

Objectives. The newly developed therapeutic deep heating device can generate deep heat in focal tissue using high-frequency wave stimulation. The objective of this study was to evaluate and compare the effectiveness of this deep heating device (HIPER-500®) with ultrasound in alleviating pain and improving function in patients with shoulder disability. Methods. This noninferiority trial was designed to compare the treatment effect of HIPER-500® to that of SonoStim® (ultrasound) on shoulder pain and disability. Thirty-eight patients with shoulder problems were assigned to either the HIPER-500® or SonoStim® group, and each participated in 10 min therapy sessions, five days a week for two weeks (for a total of ten sessions). Shoulder pain and disability were evaluated using the Visual Analogue Scale (VAS), the University of California at Los Angeles score (UCLA score), the Shoulder Pain and Disability Index (SPADI), and the Constant score in both groups before, immediately after, and four weeks after treatment. Statistical analysis was performed to compare the effects of treatment within and between the groups. Results. A total of 34 patients completed the study. The 18 patients in the HIPER-500® group and 16 patients in the SonoStim® group all showed significant improvements in shoulder pain and function when comparing pretreatment values with the results immediately after treatment and four weeks later. The results before and after treatment did not show a statistically significant difference between the two groups. Conclusions. The newly developed HIPER-500® for high-frequency deep heat therapy showed similar effects to those of SonoStim® for relieving pain and improving physical performance in the patients of this study. HIPER-500® may be a useful modality for treating shoulder pain and improving physical activity in patients with shoulder disease.

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The Effect of Cold Compress on Pain Intensity in Fractured Patients at RSUP H. Adam Malik Medan

Jurnal Keperawatan Soedirman ◽

10.20884/1.jks.2021.16.2.1692 ◽

2021 ◽

Vol 16 (2) ◽

Author(s):

Citra Amelia Lubis ◽

Dudut Dudut Tanjung ◽

Asrizal Asrizal Asrizal

Keyword(s):

Pain Intensity ◽

T Test ◽

Control Group ◽

P Value ◽

Nursing Interventions ◽

Significant Difference ◽

Before And After ◽

Quasi Experimental ◽

Equivalent Control ◽

And Function

<em><span lang="EN-US">Fracture occurs due to the damage of the shape and function of the bone, and the fractured patients generally experience pain. One of the interventions to reduce pain intensity in fracture patients is cold compress. This study aims to identify the effectiveness of cold compress on pain intensity in fracture patients in H. Adam Malik Hospital Medan. This is a quantitative study with a quasi-experimental design approach with an equivalent control group pretest-posttest design. The number of samples is 70 respondents consisting of 35 people for each intervention and control group, respectively, which was collated by consecutive sampling. Data analysis used paired t-test and independent t-test. The results showed that there was a significant influence before and after cold compress intervention on pain intensity (p value 0.001 (p = <0.05)). There is a significant difference between the intervention with cold compresses and the hospital standard intervention on pain intensity in fracture patients (p value 0.001 (p = <0.05)). It can be concluded that cold compress has a significant effect on the pain intensity in fracture patients. Cold compress is one of the nursing interventions that can help to reduce the intensity of fracture pain.</span></em>

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Validation of Career Planning Guidebook for College Students

Jurnal Psikologi ◽

10.22146/jpsi.41478 ◽

2020 ◽

Vol 47 (2) ◽

pp. 151

Author(s):

Dian Kinayung ◽

Difa Ardiyanti ◽

Muhammad Hidayat

Keyword(s):

Career Guidance ◽

Career Planning ◽

Professional Judgment ◽

Career Intervention ◽

Intervention Models ◽

Significant Difference ◽

Before And After ◽

Validity Tests ◽

The Many ◽

And Function

Career exploration is one of the career development tasks that individuals commonly go through. In reality, these activities may cause problems for specific individuals, including students. Career guidance can assist individuals in successfully passing through this stage of a person’s life. Of the many career intervention models available, no previous research has utilized career planning guidebooks as a form of intervention to help students make career plans. This study aimed to validate a career planning guidebook created by the researcher and test its content and functional validity. Tests of content validity were conducted through professional judgment, while tests of functional validity were conducted via a quasi-experiment. The results showed that all the contents of the career planning guidebook were aligned with the goals of the career planning guidebook (Average of V= 0.6). The experiment results indicated significant difference in perceptions of career planning before and after the intervention (Z=-3.987; p=0.000). The findings concluded that the career planning guidebook is valid, both in terms of content and function.

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PENGARUH KEBERADAAN PANGKALAN PENDARATAN IKAN (PPI) SAIJAAN KOTABARU TERHADAP PENDAPATAN PENGUSAHA PERIKANAN DI KECAMATAN PULAU LAUT UTARA KABUPATEN KOTABARU PROVINSI KALIMANTAN SELATAN

Fish Scientiae ◽

10.20527/fs.v4i7.1131 ◽

2016 ◽

Vol 4 (7) ◽

pp. 59

Author(s):

Syahruddin Syahruddin ◽

Idiannor Mahyudin ◽

Emmy Sri Mahreda

Keyword(s):

Wilcoxon Test ◽

P Value ◽

Test Results ◽

Internal Factors ◽

Fishing Vessels ◽

Significant Difference ◽

Before And After ◽

Descriptive Approach ◽

And Function ◽

Relationship Of

Fish landing base (PPI) is a container that can support development and the development of a better fishery.Accordence with the increasing number of fishing vessels that enter the territory Kotabaru, either the ships from itself or the ships that come from the outside area. Making the existence of the PPI Saijaan Kotabaru a medium which accommodates fishery activities to make a direct relevance relationship of upriver and downstream activities. This research was conducted: identifying facilities, conditions and function of the PPI Saijaan Kotabaru; Analyzing changes in the income of entrepreneur fishery before and after the PPI Saijaan Kotabaru in District Stagen Kotabaru; Formulating a strategy of economic development of the PPI Saijaan Kotabaru as an area of fisheries.Analysis Technique of the research uses qualitative and quantitative method with descriptive approach. The results obtained that the basic, functional and additional facilities of the PPI Saijaan Kotabaru have been fulfilled by 90 % and have not been fulfilled by 10 % thatneed to be developed. Condition and function facilities of the PPI Saijaan Kotabaru, is only 90 % facilities are function optimally and 10 % is not function optimally.Wilcoxon test results in Statistics Test, shows that value of Wilcoxon test p-value is 0.003 (< 0.05),then Ho is rejected and H1 is accepted, meaning that there is a very significant difference from the increased income of entrepreneur fishery after the construction of the PPI Saijaan Kotabaru as well. The results of the value to external factors (EFAS) is = 2.85, while for internal factors (IFAS) is = 2.55. So the value of EFAS >IFAS value, then a qualitative activity and capacity of existing facilities of the PPI Saijaan Kotabaru still very likely to be developed.

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Plasma Leptin Concentrations are Independently Associated with Insulin Sensitivity in Lean and Overweight Cats

Journal of Feline Medicine and Surgery ◽

10.1053/jfms.2002.0166 ◽

2002 ◽

Vol 4 (2) ◽

pp. 83-93 ◽

Cited By ~ 36

Author(s):

DJ Appleton ◽

JS Rand ◽

GD Sunvold

Keyword(s):

Insulin Sensitivity ◽

Glucose Tolerance ◽

Test Meal ◽

Early Morning ◽

Normal Glucose Tolerance ◽

Insulin Resistant ◽

Before And After ◽

Normal Glucose ◽

The Difference ◽

Plasma Leptin

This study investigated relationships between plasma leptin, insulin concentrations, insulin sensitivity and glucose tolerance in lean and overweight cats. Leptin concentrations were measured in 16 cats during glucose tolerance tests before and after gaining weight, and after feeding a test meal in overweight cats. An important finding of this study is that in both lean (r=-0.79) and overweight (r=-0.89) cats, the higher the leptin concentrations, the more insulin resistant the cat, independent of the degree of adiposity. Leptin concentrations at baseline and after consuming a meal tended to be higher in overweight cats with glucose intolerance, compared to overweight cats with normal glucose tolerance, although the difference was not significant. After feeding the test meal to overweight cats in the early morning, plasma leptin concentrations initially decreased before subsequently rising to peak 15 h later, which coincided with late evening. The leptin peak occurred 9 h after the insulin peak following ingestion of the test meal. Importantly, this study suggests that increased leptin concentrations may contribute to the diminished insulin sensitivity seen in overweight cats. Alternatively, the compensatory hyperinsulinaemia found with insulin resistance in overweight cats could stimulate leptin production.

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