Nowe surowce roślinne w Farmakopei Europejskiej. Część 7. Ilex paraguariensis A. St.-Hil. (ostrokrzew paragwajski) – źródło nowego surowca alkaloidowego

2020 ◽  
Vol 21 (2) ◽  
Author(s):  
Halina Ekiert ◽  
Agnieszka Kulig ◽  
Radosław Jan Ekiert ◽  
Agnieszka Szopa

One of the newest pharmacopoeial documents, the European Pharmacopoeia Supplement 9.4 contains monographs of several new raw materials of plant origin, long used in East Asian and South American medicine. Part 1 and 2 presents characteristics of the plant species providing new saponin raw materials (Bupleurum sp., Platycodon grandiflorus). Part 3 describes Ligusticum chuanxiong, which is the source of a new raw material rich in volatile oil. Part 4 is dedicated to Houttuynia cordata and Part 5 to Paeonia x suffruticosa. These plants supply a new flavonoid and terpenoid-phenolic raw materials. Part 6 is focused on characteristics of Paullinia cupana (a source of alkaloid raw material). On the other hand, Part 7 presents botanical, ecological and chemical characteristics of Ilex paraguariensis (yerba-mate). Mate folium, a raw material derived from this species has long been used by indigenous peoples of Argentine, Brazil, Paraguay and Uruguay in the form of infusion as a traditional stimulating drink. This raw material is particularly rich in caffeine and theobromine, chlorogenic acid, dicaffeoylquinic acids and catechins. The backbone of the article is made up of a review of therapeutic applications of this raw material confirmed by scientific studies. Mate folium appears as a kind of “panacea” efficient in lifestyle diseases currently threatening the mankind. The aim of the article is to popularize professional knowledge of this species, to date insufficiently known in Poland, in pharmaceutical and medical community.

2020 ◽  
Vol 21 (3) ◽  
Author(s):  
Halina Ekiert ◽  
Agnieszka Kulig ◽  
Marta Klimek-Szczykutowicz ◽  
Agnieszka Szopa

In Supplement 9.4 to the European Pharmacopoeia, one of the newest pharmacopoeial documents, there are eight new monographs raw materials of plant origin. They are derived from both East Asian and South American species. The first two parts of the series of articles are devoted to the characteristics of plants, which are a source of saponin raw materials: Bupleurum sp. and Platycodon grandiflorus. The next parts: 3, 4 and 5 describe the East Asian species: Ligusticum huanxiong, Houttuynia cordata and Paeonia x suffruticosa, which provide raw materials rich in volatile oil, flavonoids and terpenoid-phenolic compounds, respectively. Two South American alkaloid-rich species: Paullinia cupana and Ilex paraguariensis are presented in parts 6 and 7. Part 8 characterizes Camellia sinensis, as a source of Camelliae sinensis non fermentata folia. This raw material is a rich source of polyphenols: catechins (e.g. epigallocatechin, gallocatechin and epicatechin gallates), purine alkaloids (mostly caffeine) and a unique non-protein amino acid, theanine. It has been proven that the raw material possesses among others a number of medicinal properties, including antioxidant, anticancer, antimicrobial, hypolipemic, hypocholesterolemic, hepatoprotective and antidiabetic properties. The aim of the present article is to draw attention of pharmaceutical and medical community to the numerous therapeutic, health-promoting and cosmetic values of this raw material proven by professional scientific studies.


2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Paweł Kubica ◽  
Agnieszka Kulig ◽  
Agnieszka Szopa ◽  
Karolina Turcza ◽  
Halina Ekiert

One of the most recent pharmacopoeial documents, the European Pharmacopoeia Supplement 9.4, inventories five new raw materials long known in Traditional Chinese Medicine (TCM). Part 1 and 2 present species providing new saponin raw materials: Bupleurum sp. and Platycodon grandiflorus. Part 3 describes Ligusticum chuanxiong which is a source of a new volatile oil-containing material. Part 4 is focused on Houttuynia cordata and Part 5 on Paeonia x suffruticosa (sources of a new flavonoid and terpenoid-phenolic raw material, respectively). Moreover, Supplement 9.4 describes two South American raw materials: guarana seed and mate leaf and an East Asian raw material – green tea leaf. Part 6 of the series of articles deals with botanical, ecological, chemical and pharmacological characterization of Paullinia cupana (guarana) which is a source of new alkaloid raw material – Guaranae semen. This material has long been known and used not only in South American countries but also in Europe as a psychostimulant due to a high content of caffeine. Currently, it advanced to be included in the list of pharmacopoeial raw materials in the European Union countries. The aim of the article is to provide the pharmaceutical and medical community with professional knowledge on Paullinia cupana, indispensable in contacts with patients.


2019 ◽  
Vol 20 (3) ◽  
Author(s):  
Inga Kwiecień ◽  
Agnieszka Kulig ◽  
Agnieszka Szopa ◽  
Halina Ekiert

The European Pharmacopoeia Supplement 9.4 introduces several new plant-derived raw materials long known in East-Asian medicine but previously not used in official European medicine. A series of articles in Part 1 and 2 presents species providing new saponin raw materials: Bupleuri radix and Platycodi radix. In part 3, the species which is a source of a new essential oil raw material, namely Ligusticum chuanxiong is characterized. Part 4 is dedicated to outlining the basic botanical-ecological-chemical characteristic of Houttuynia cordata (chameleon plant). The raw material sourced from this species – Houttuyniae herba, has long been known and used not only in traditional Chinese medicine (TCM) but also in traditional Japanese, Thai and Nepalese medicine. Most attention was devoted to reviewing the professional pharmacological studies of extracts of this raw material. This review documents very important lines of action of the raw material, namely its antioxidant, anticancer and anti-inflammatory properties. In addition, the article highlights the significance of this species as a food product in some Asian countries and as a source of cosmetic raw materials. The aim of the article is to popularize basic knowledge on this new pharmacopoeial species among pharmacists and medical doctors.


2019 ◽  
Vol 20 (4) ◽  
Author(s):  
Halina Ekiert ◽  
Agnieszka Sondej ◽  
Marta Klimek-Szczykutowicz ◽  
Agnieszka Szopa

The European Pharmacopoeia Supplement 9.4, one of the newest pharmacopoeial documents, contains monographs of new raw materials long known in Traditional Chinese Medicine (TCM) but earlier unknown in official European medicine. Part 1 and 2 comprise characterization of two new saponin raw materials: Bupleuri radix (root of Bupleurum chinense and Bupleurum scorzonerifolium) and Platycodi radix (root of Platycodon grandiflorus ? balloon flower). Part 3 presents therapeutic values of a new essential oil raw material ? Ligustici chuanxiong rhizoma (rhizome of Ligustici chuanxiong), while part 4 portrays a new flavonoid raw material Houttuynia cordata herba (herb of Houttuynia cordata). Part 5 presents botanical-chemical-pharmacological characterization of tree peony (Paeonia × suffruticosa). It was highlighted how important role this plant plays in Traditional Chinese Medicine (TCM). Numerous possible applications of the raw material ? Moutan cortex (root bark) were depicted based on modern professional pharmacological studies documenting its very valuable medicinal values including antioxidant, anticancer, cardioprotective and neuroprotective activities. Moreover, the significance of this plant (its different organs) in the production of cosmetics was underlined. Also other species of Paeonia sp. known in TCM and in recent years incorporated in official European medicine are underscored. The aim of the paper was to introduce Polish pharmacists and medical doctors to the basic knowledge of Paeonia x suffruticosa.


2020 ◽  
pp. 102-107
Author(s):  
Karyna Hordiei ◽  
Tetiana Gontova ◽  
Valentina Gaponenko

The search for new sources of biologically active substances is an actual issue of pharmaceutical science. Feverfew is a prospective member of the Tanacetum genus. Recently an interest to this plant has grown. Sesquiterpene lactones and phenolic compounds are known to be cause its anti-inflammatory and antimigraine activity. The study of volatile compounds and chemosystematics of the feverfew in this group of BAS has not been conducted before. The aim of the research was to obtain the volatile oil from the feverfew herb, studying of the component composition, an identification of compounds, that can be used for chemosystematics of the genus and establishing of the pharmacological activity according to the chemical content of volatile oil. Materials and methods. The object of research was the samples of the feverfew herb grown and collected in the period of its mass flowering. The volatile oil obtained by steam distillation from the feverfew herb was studied using gas chromatography–mass spectrometry. Results. The comparative characteristic of the representatives of the genus Tanacetum according to chemosystematic features was carried out. As a result of the research of the volatile oil 44 compounds were found, from which 40 were identified. According to the research, the raw material contained 34.71 % of camphor, this is a typical feature of all species of the genus Tanacetum. Fenchyl acetate was identified in a high enough content – 7,44 % in the domestic raw material, but this compound was not identified in the foreign samples. Chrysanthenyl acetate is accumulated in representatives of the genus Tanacetum in the form of a cis or trans isomer. In our study, the content of trans-chrysanthene acetate was 23.30 %. In the domestic raw materials, monoterpenes – α- and β- thujone – were not identified, which are associated with the toxicity of the raw material. Conclusions. In the volatile oil 44 compounds were found, from which 40 were identified. Monoterpenes prevailed among terpenes, namely camphor, trans-chrysanthenyl acetate and fenchyl acetate, which are typical and can be used for chemosystematic issues of the genus Tanacetum. The identified compounds require anti-inflammatory, antiseptic, antispasmodic, analgesic activities of the volatile oil, therefore creation of the medicinal herbal remedy based on the volatile oil of the feverfew herb is prospective.


2019 ◽  
Vol 16 (3) ◽  
pp. 334-351
Author(s):  
A. S. Mavlyanov ◽  
E. K. Sardarbekova

Introduction. The objective of the research is to study the effect of the complex activation of the alumina raw material on the rheological properties of the ceramic mass. In addition, the authors investigate solutions for the application of optimal coagulation structures based on loams and ash together with plastic certificates.Materials and methods. The authors used the local forest like reserves of clay loams at the BashKarasu, ash fields of the Bishkek Central Heating Centre (BTEC) and plasticizer (sodium naphthenate obtained from alkaline chemical production wastes) as fibrous materials. Moreover, the authors defined technological properties of raw materials within standard laboratory methodology in accordance with current GOSTs.Results. The researchers tested plastic durability on variously prepared masses for the choice of optimal structures. The paper demonstrated the plastic durability of complexly activated compounds comparing with non-activated and mechanically activated compounds. The sensitivity coefficient increased the amount of clay loams by mechanically and complexly activated, which predetermined the possibility of intensifying the process of drying samples based on complexly activated masses.Discussion and conclusions. However, mechanical activation of clay material reduces the period of relaxation and increases the elasticity coefficient of ceramic masses by 1.8–3.4 times, meanwhile decreases elasticity, viscosity and the conventional power during molding, which generally worsens the molding properties of the masses. Сomplex activation of ash-clay material decreases the period of relaxation and provides an increase in elasticity, plasticity of ceramic masses by 46–47%, reduction in viscosity by 1.5–2 times, conventional power on molding by 37–122% in comparison with MA clay loams. Ceramic masses based on spacecraft alumina raw materials belong to the SMT with improved rheological properties; products based on them pass through the mouthpiece for 5–7 seconds.


2018 ◽  
Vol 7 (2) ◽  
Author(s):  
Firman L. Sahwan

Organic materials that are generally used as raw material for organic fertilizer granules (POG) is a natural organic material that has been degrade, smooth and dry. One of the main raw materials are always used with a very high percentage of usage, is manure. Manure potential in Indonesia is very high, amounting to 113.6 million tons per year, or 64.7 million tons per year to the island of Java. From this amount, it will be generated numbers POG production potential of 17.5 million tons per year (total Indonesia) or 9.9 million tons per year for the island of Java. While the realistic POG production predictions figures made from raw manure is 2.5 million tons annually, a figure that has been unable to meet the number requirement of POG greater than 4 million tons per year. Therefore, in producing POG, it should be to maximize the using of the potential of other organic materials so that the use of manure can be saved. With the use of a small amount of manure (maximum 30% for cow manure), it would be useful also to avoid the production of POG with high Fe content.keywods: organic material, manure, granule organic fertilizer


Food Industry ◽  
2020 ◽  
Vol 5 (2) ◽  
pp. 61-70
Author(s):  
Oliya Fazullina ◽  
Stanislav Smirnov

Health indicators of the population depend significantly on the food quality and nutritional value. Simple carbohydrates excess of and lack of protein, dietary fiber, vitamins, minerals, antioxidants and other physiologically active substances increase the risk of socially significant disease progress. The development and production of mass-consumed products with high nutritional and biological value, including affordable non-traditional raw materials use, are promising areas of the food industry development aimed at improving the nutritional status of the population. The article presents the research results on the developed Noodle products recipes from non-traditional raw materials that meet modern healthy nutrition requirements, intended for dietary treatment and dietary prevention of people with overweight / obesity. The research aimed at expanding the range of macaroni products with these characteristics. As the main raw material, a man selected whole-wheat flour – new spelt flour, and as additional raw materials – buckwheat flour, broccoli and celery powders. The researchers found that the introduction of macaroni products from buckwheat spelt, broccoli and celery powders into the recipe had a multidirectional effect, reducing or increasing various indicators of its nutritional value. The changes range did not affect the overall characteristics. The satisfaction degree of the average daily need for food substances and energy when consuming a portion of 100 g for each sample of developed Noodle products allows them to be classified as functional products that are protein and dietary fiber sources, according to the requirements of the TR CU 022/2011.


1982 ◽  
Vol 21 (4) ◽  
pp. 329-333
Author(s):  
Rashid Aziz

The book under review is a concise but fairly in-depth study of the prospects for export diversification from the Less Developed Countries (henceforth labeled as LDCs) particularly to Developed Countries (henceforth labeled as OCs). Given the multiple problems faced by the LOCs in exporting to the OCs - protectionist policies with regards to manufactured exports, volatility of prices obtained for raw material exports, etc. - the study analyses the potential for following an intermediate route. The important issues in the export of semi -processed and wholly processed raw materials are discussed. 111ese issues range from the problems and potentials for the location of processing facilities in the LOCs to the formulation of appropriate policies to encourage an export of processed goods rather than raw materials. Such policies will be useful both in solving the balance of-payments problems of the LDCs and in attaining the goal of the Lima Declaration and Plan of Action on Industrial Development and Co-operation, that called for 2S percent of world industrial production to be located in the LOCs by the year 2000.


MANAJERIAL ◽  
2018 ◽  
Vol 1 (1) ◽  
pp. 66
Author(s):  
BAYU YRI WIDHARTO

The purpose of the research was to know the affect of many factors which affected to the production volume in PT. Kelola Mina Laut Gresik. What the price of raw materials was and the used of raw materials partially and simultan eously affected on the production volume. The analysis tool which used was a model of multiple linear regression. Hypothesis testing used t test and F test, both at the significant level 5%. Based of the analysis of research on PT Kelola Mina Laut Gresik. Partially, inventory raw material price had not significant effect on the production volume, consumption of raw material inventory affected significantly of the production volume. Inventory of raw material price and the use of raw material simultan eously affect significantly to the production volume.


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