scholarly journals Effect of Inhibin-B hormone and its relationship with a number of sex hormones in men with Azoospermia

2019 ◽  
Vol 24 (3) ◽  
pp. 11
Author(s):  
Alaa Abdullah ali ◽  
Hadeel Abdulhadi Omear1 ◽  
Mazin Anwar alobaydi2
Keyword(s):  
Positive Relationship ◽  
Sperm Count ◽  
Feedback Mechanism ◽  
Inhibin B ◽  
Negative Feedback Mechanism ◽  
The Mean ◽  
Follicular Stimulation ◽  
Normal Men ◽  
The Relationship ◽  
Mean Concentration

Inhibin-B is produced by sertoli cells and acts as a negative feedback mechanism of follicular stimulation hormone (FSH). In order to evaluate the effect of Inhibin-B in men with Azoospermia, the study measured the concentrations of the following hormones: Inhibin-B, FSH, Luteinizing Hormone Prolactin (PRL), (LH) and Testosterone (Testo). Serum for 30 normal men semen and 50 men with Azoespermia (zero sperm count in sperm). The mean concentration of the hormone Inhibin-B in patients with Azoospermia was (135.7 ±87.6) pg/ml, while in normal men (175.6 ±47.9) Pg / ml with a significant value of the group of healthy patients at a significant level (p≤0.01). The mean serum FSH concentration in patients was (13.7 ± 12.27) lU / L whereas in normal men (4.1 ± 2.84) lU / L, the relationship was significant between patients and healthy at a significant level (P≤0.01) the correlation with the Inhibin-B  hormone is reversible relationship. The mean concentration of LH in patients was (12.8±11.87) IU/L and in the healthy (7.9±5.57) IU/L and the relationship between them was significant  (P≤0.05) and the correlation with the Inhibin-B hormone is positive relationship. The mean concentration of the  Testosterone In the patients was  (2.37 ± 1.22) IU / L and in the healthy (5.1 ± 1.96) IU/ L, the relationship was of significant value at P≤0.01 and the correlation with the Inhibin-B hormone is positive relationship, and there is a difference in the mean concentration of PRL between the patients and the healthy where it reaches (8.88 ±5.16) IU / L in patients and (8.03 ± 4.2) IU / L in the healthy. where the relationship was non-significant value between both patients and healthy and the correlation with the Inhibin-B hormone is positive relationship .   http://dx.doi.org/10.25130/tjps.24.2019.042

scholarly journals Inhibin B in male reproduction: pathophysiology and clinical relevance

2001 ◽  
Vol 145 (5) ◽  
pp. 561-571 ◽  
Author(s):  
SJ Meachem ◽  
E Nieschlag ◽  
M Simoni
Keyword(s):  
Germ Cells ◽  
Sertoli Cells ◽  
Clinical Relevance ◽  
Feedback Mechanism ◽  
Male Reproduction ◽  
Inhibin B ◽  
Testicular Sperm Extraction ◽  
Specific Marker ◽  
Negative Feedback Mechanism ◽  
Normal Men

The recent availability of specific inhibin assays has demonstrated that inhibin B is the relevant circulating inhibin form in the human male. Inhibin B is a dimer of an alpha and a betaB subunit. It is produced exclusively by the testis, predominantly by the Sertoli cells in the prepubertal testis, while the site of production in the adult is still controversial. Inhibin B controls FSH secretion via a negative feedback mechanism. In the adult, inhibin B production depends both on FSH and on spermatogenic status, but it is not known in which way germ cells contribute to inhibin B production. The regulation of inhibin B production changes during life. There is an inhibin B peak in serum shortly after birth only partly correlated with an increase in serum FSH, probably reflecting the proliferating activity of the Sertoli cells during this phase of life. Afterwards, inhibin B levels decrease and remain low until puberty, when they rise again, first as a consequence of FSH stimulation and then as a result of the combined regulation by FSH and the ongoing spermatogenesis. In the adult, serum inhibin B shows a clear diurnal variation closely related to that of testosterone. The administration of FSH increases the secretion of inhibin B in normal men, but is much more pronounced in males with secondary hypogonadism. The treatment of infertile men with FSH, however, does not result in an unequivocal inhibin B increase. There is a clear inverse relationship between serum inhibin B and FSH in the adult. Serum inhibin B levels are strongly positively correlated with testicular volume and sperm counts. In infertile patients, inhibin B decreases and FSH increases. In general, there is very good correlation with the degree of spermatogenetic damage, with the arrest at the earlier stages having the lowest inhibin B levels. However, for unknown reasons, there are cases of Sertoli-cell-only syndrome with normal inhibin B levels. Inhibin B and FSH together are a more sensitive and specific marker for spermatogenesis than either one alone. However, the inhibin B concentrations are not a reliable predictor of the presence of sperm in biopsy samples for testicular sperm extraction. Suppression of spermatogenesis with testosterone and gestagens leads to a partial reduction of inhibin B in serum but it is never completely suppressed. In contrast, testicular irradiation in monkeys or humans leads to a rapid and dramatic decrease of inhibin B, which becomes undetectable when germ cells are completely absent. In summary, although inhibin B is a valuable index of spermatogenesis, the measurement of serum inhibin B levels is still of limited clinical relevance for individual patients.

scholarly journals The Effect of Surgery on the Concentration of Circulating Megakaryocytes and Platelets

Blood ◽  
1968 ◽  
Vol 32 (3) ◽  
pp. 393-401 ◽  
Author(s):  
ALEXANDER BRESLOW ◽  
RICHARD M. KAUFMAN ◽  
ALAN R. LAWSKY
Keyword(s):  
Maximal Level ◽  
Men And Women ◽  
The Third ◽  
Antecubital Vein ◽  
Platelet Concentration ◽  
The Mean ◽  
Normal Men ◽  
Mean Concentration

Abstract The mean concentration of megakaryocytes in antecubital vein blood of 43 normal men and women was 3.4/ml. (range 0-13). No circulating megakaryocytes were found in 6 patients with thrombocytopenia due to marrow failure. Following surgery the average maximal megakaryocyte level increased to 50/ml. (range 15-190) from a preoperative mean of 8/ml. The maximal level was reached on about the third postoperative day with the platelet concentration reaching maximal levels 3 to 6 days later.

PROTEIN BINDING OF CORTISOL IN HEALTH AND IN PREGNANCY

1961 ◽  
Vol 23 (1) ◽  
pp. 25-35 ◽  
Author(s):  
MOLLIE BOOTH ◽  
P. F. DIXON ◽  
C. H. GRAY ◽  
J. M. GREENAWAY ◽  
N. J. HOLNESS
Keyword(s):  
Pregnant Women ◽  
Binding Sites ◽  
Plasma Cortisol ◽  
Equilibrium Constants ◽  
Qualitative Difference ◽  
Mean Values ◽  
The Mean ◽  
Normal Men ◽  
Mean Concentration ◽  
In Pregnancy

SUMMARY The binding of plasma cortisol to transcortin at 37° c was studied in normal men and in non-pregnant and pregnant women. The mean concentrations of transcortin were 8, 11·5 and 14 × 10−7 moles/l. and the percentages of the binding sites occupied by cortisol were 45, 24 and 40%, respectively. The mean values of the equilibrium constants were 2·9, 1·8 and 4·6 × 107 l./mole, suggesting that there might be a qualitative difference in transcortin from the three groups. The mean concentration of diffusible cortisol was 1·12 μg./100 ml. in men and 0·65 μg./100 ml. in non-pregnant and pregnant women. The significance of these findings is discussed.

scholarly journals Relationship of TSH with BMI in subclinical hypothyroid patients

2019 ◽  
Vol 9 (4) ◽  
pp. 4193-4198
Keyword(s):  
Thyroid Hormones ◽  
Negative Correlation ◽  
Subclinical Hypothyroidism ◽  
Inverse Correlation ◽  
Feedback Mechanism ◽  
Negative Feedback Mechanism ◽  
Body Development ◽  
Relationship Of ◽  
The Relationship ◽  
Hypothyroid Patients

Thyroid hormones (T3 and T4) synthesized by thyroid gland and play an essential role in normal body development and tissue metabolism. Iodine is an essential factor that is required for the synthesis of thyroid hormones. The secretion of thyroid hormones is regulated by Negative feedback mechanism. After reached in blood circulation the majority of T4 and T3 bound with carrier proteins called thyroxine binding proteins (TBG) which shows higher affinity for T4. The common diseases related to thyroid hormones include Hypothyroidism, hyperthyroidism, thyroiditis, goiter, nodes, and tumors of thyroid glands (benign and malignant). Subclinical hypothyroidism also called mild thyroid failure is defined as normal thyroid hormones but mildly elevated TSH (5 – 10 uIU/ml) with no or mild sign and symptoms. The thyroid disorders are more prevalent in females than males. Hypothyroidism is associated with obesity and various studies conducted to find out the relationship between TSH and BMI observed different finding in the particular study. In the present study, a poor positive correlation between TSH and BMI was observed in the total euthyroid subjects. A poor negative association between TSH and BMI in euthyroid males and poor positive (r value – 0.21) relationship was observed in euthyroid females. In Subclinical hypothyroid patients (total, male and female), Poor negative correlation was observed between TSH and BMI. The conclusion of this study is, as TSH increased the BMI will also increase in (mostly females) euthyroid subjects. The Inverse or poor negative correlation was observed within TSH and BMI among euthyroid males and an inverse correlation was noticed in patients with subclinical hypothyroidism.

scholarly journals The Relationship between Eating Wild Animal Meat with the Level of Uric Acid in Langowan Minahasa, Indonesia

2019 ◽  
Author(s):  
Mandias Reagen ◽  
Mandias Reagen
Keyword(s):  
Uric Acid ◽  
Research Method ◽  
Positive Relationship ◽  
Negative Impact ◽  
Wild Animal ◽  
Natural Ecosystems ◽  
Animal Products ◽  
The Mean ◽  
The Government ◽  
The Relationship

Background; Some researchers have proven that there was a relationship between eatingmeatanduricacidlevels.Therehavebeennospecificstudiesontherelationship between eating wild animal products and uric acid levels. LangowanMinahasa is one of the tribes in Indonesia whose people love to eat wild animal meat from hunting. Objectives; The purpose of this study was to determine the relationship between consumption of wild animal meat and uric acid levels in the LangowanMinahasa community. Methods; The research method used wascross sectional with 35 respondents selected using purposive sampling. Results; 42.9% of respondents eat wild animal meat more than three times a week and the mean of uric acid was 6.78mg/dL (SD = 1.27). There was a positive relationshipbetween consumption of wild animal meat with uric acid levels in the MinahasaLangowan community (r = 0.562), (p = 0.000). Conclusions; consumption of wild animal meat with uric acid levels have a positive relationship. This study recommend that the LangowanMinahasa people should reduce or even stop consuming wild animal meat and switch to consuming other protein sources. The researcher also recommended to village officials and the government to provide information to the community on the negative impact of consuming meat from hunted products, both on health and natural ecosystems.

Bicarbonate transport by isolated perfused rabbit proximal convoluted tubules

1977 ◽  
Vol 233 (4) ◽  
pp. F307-F314 ◽  
Author(s):  
M. Burg ◽  
N. Green
Keyword(s):  
Hydrogen Ion ◽  
Bicarbonate Transport ◽  
Fluid Absorption ◽  
The Mean ◽  
Tubule Cells ◽  
The Relationship ◽  
Convoluted Tubules ◽  
Mean Concentration ◽  
Proximal Convoluted Tubules

Proximal convoluted tubules were dissected from rabbit kidneys and perfused in vitro in order to investigate the relationship between the reabsorption of fluid and of bicarbonate. Bicarbonate was absorbed when it was initially present in the perfusate. At slow rates of perfusion the mean concentration of total CO2 was 9 mM in collected fluid with 25 mM bicarbonate in the bath. At faster rates of perfusion the mean rate of reabsorption was 13.6 pmol cm-1 tubule length s-1. Absorption of bicarbonate was inhibited to a large but not complete extent by elimination of sodium from the perfusate and bath or potassium from the bath, and by addition of ouabain. It was not inhibited by elimination of the organic solutes from the perfusate nor by elimination of chloride from the perfusate and bath. Considered with previous measurements of fluid absorption these results are consistent with the existence of a linked sodium-for-hydrogen ion exchange mechanism at the luminal border of the tubule cells, but there are other possibilities which are discussed. Additionally, the effect of acetazolamide was investigated. The drug virtually completely inhibited bicarbonate absorption and inhibited fluid absorption by 30-40%.

Interpulse interval of GnRH stimulation independently modulates LH secretion

1989 ◽  
Vol 256 (4) ◽  
pp. E510-E515
Author(s):  
L. S. O'Dea ◽  
J. S. Finkelstein ◽  
D. A. Schoenfeld ◽  
J. P. Butler ◽  
W. F. Crowley
Keyword(s):  
Positive Relationship ◽  
Important Determinant ◽  
Pulse Amplitude ◽  
Gonadotropin Releasing Hormone ◽  
Interpulse Interval ◽  
The Mean ◽  
Normal Men ◽  
Low Amplitude ◽  
Lh Secretion ◽  
Independent Determinant

To examine the importance of the interpulse interval of gonadotropin-releasing hormone (GnRH) stimulation in modulating gonadotroph responsiveness, a fixed individualized dose of GnRH was administered to eight GnRH-deficient men at intervals selected randomly from the distribution of luteinizing hormone (LH) interpulse intervals of normal men. The responses were compared with data derived from a study of LH pulses in 20 normal men. A positive relationship was found between LH pulse amplitude and the preceding interpulse interval both in the GnRH-deficient (P less than 0.05) and in the normal (P less than 0.003) men. The distributions of LH pulse amplitudes appeared to differ between the two groups with failure of the study paradigm to reproduce the distribution of low-amplitude pulses of the normal men in the GnRH-deficient men. There was significantly more variability about the line that related interpulse interval and LH amplitude in the normal men (P less than 0.004) in whom the amount of GnRH could vary physiologically. This difference remained significant both for pulses with amplitudes below (P less than 0.01) or above (P less than 0.03) the mean of the normal men. These studies demonstrate that the GnRH interpulse interval is an independent determinant of pituitary responsiveness and that alterations in the amount of GnRH secreted from the hypothalamus are an important determinant of LH pulse amplitude in men.

Research on SIQRS Spreading Dynamic Model with Feedback Mechanism on Scale-Free Networks

2014 ◽  
Vol 989-994 ◽  
pp. 4524-4527
Author(s):  
Tao Li ◽  
Yuan Mei Wang ◽  
You Ping Yang
Keyword(s):  
Dynamic Model ◽  
Mean Field Theory ◽  
Mean Field ◽  
Feedback Mechanism ◽  
Epidemic Spreading ◽  
Scale Free ◽  
Spreading Dynamics ◽  
Scale Free Networks ◽  
The Mean ◽  
The Relationship

A modified spreading dynamic model with feedback-mechanism based on scale-free networks is presented in this study. Using the mean field theory, the spreading dynamics of the model is analyzed. The spreading threshold and equilibriums are derived. The relationship between the spreading threshold, the epidemic steady-state and the feedback-mechanism is analyzed in detail. Theoretical results indicate the feedback-mechanism can increase the spreading threshold, resulting in effectively controlling the epidemic spreading.

scholarly journals LGU’S FUNCTIONS IN PRESERVATION OF CONSCIOUSNESS ON CULTURE OF THE CITIZENS

2021 ◽  
pp. 80-88
Author(s):  
Timothy John A. Litan
Keyword(s):  
Data Collection ◽  
Cultural Heritage ◽  
Significant Relationship ◽  
Positive Relationship ◽  
The Self ◽  
The Mean ◽  
Relationship Of ◽  
The Relationship ◽  
Descriptive Method ◽  
Very High

The aim of this study is to understand and identify the relationship of the LGU’s functions to the preservation of the consciousness of the citizens. It sought to answer the following questions, (1) the mean level of the LGU’s functions in the preservation of consciousness on the culture of the citizens, (1.1) education, (1.2) laws implementation, (1.3) cultural heritage; (2) the mean level of the citizens’ consciousness of their culture, (2.1) customs, (2.2) habits, (2.3) values, (3) the significant relationship between the LGU’s functions in the preservation of consciousness on the culture of the citizens. Descriptive method of research was used to analyze the data systematically. The researcher looked for the population of the Pagsanjan, Laguna. From the population, the researcher used purposive sampling were in the members of the population are selected based on the objective of the study. The researcher formulated the self-made questionnaire and made it validated by set of experts before it was distributed through MS Forms. The approval of the municipal mayor of Pagsanjan, Laguna was also seeking by the respondents as courtesy for the implementation of the study. After the data collection, the researcher analyzed, presented and interpreted them. The best performed LGU’s function identified by the respondents to preserve the culture is laws implementation which rated 4.73 followed by education which rated 4.33, both are in a very high extend and lastly is the preservation of cultural heritage that rated 3.88 as high extent. The respondents are said to be most conscious in their culture in terms of both Habits and Values which rated 4.42 as very high while customs rated 4.07 as high. LGU’s functions in the preservation of the culture provide a ‘positive relationship’ to the citizens’ consciousness of their culture. The hypothesis which stated that there is no significant relationship between the LGU’s functions in the preservation of consciousness on the culture of its citizens is ‘not supported’. KEYWORDS: Cultural Heritage, Custom, Education, Habit, Laws Implementation, Programs, Values

scholarly journals ​Association of Bio-acoustic Features of Vocal Signals with Age and Semen Quality in Sahiwal Bulls

2021 ◽  
Author(s):  
Indu Devi ◽  
Kuldeep Dudi ◽  
Ranjana Sinha ◽  
R. Vikram
Keyword(s):  
Semen Quality ◽  
Sperm Count ◽  
Acoustic Features ◽  
Seminal Parameters ◽  
Sperm Abnormality ◽  
The Mean ◽  
Live Sperm ◽  
The Relationship ◽  
The Voice

Background: Bio-acoustic features of animal’s voice can provide meaningful information about their biological and physical characteristics. The present study was conducted to get indicators of age from voice analysis and explore the relationship between voice features and seminal parameters in Sahiwal bulls. Methods: Voice samples were collected from healthy bulls (n=20), maintained at ICAR-NDRI, Karnal. Bulls were classified into two groups i.e. young bulls and adult bulls. The voice signals were analyzed by Adobe Premium software and acoustic features were extracted by using PRAAT software. Result: The mean of acoustic features viz. call duration (sec), mean intensity (dB), total energy (P2S), amplitude (P), pitch (Hz), unvoiced frame (%), jitter (%), bandwidth (Hz) mean N/H ratio (%) have been found significantly different while mean H/N ratio (dB), shimmer (%) and pulses were not found statistically (P greater than 0.05) different between adult and young bulls. The seminal parameters viz mass activity (0-5 scale), individual progressive motility (%), live sperm count (%) and total sperm abnormality (%) were found significantly different between adult and young bulls. No significant association between voice features and semen quality of bulls was observed. Hence, voice signals of male might provide some clues about their age but for semen quality, there is further need to explore the interesting relationship between voice features and fertility of breeding bulls.

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